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The evolution and development of complex, learned motor skills are thought to be closely associated with other locomotor movement and cognitive functions. However, it remains largely unknown how different neuromuscular programs may interconnect during the protracted developmental process. Here we use a songbird to examine the behavioral and neural substrates between the development of locomotor movement and vocal-motor learning. Juvenile songbirds escalate their locomotor activity during the sensitive period for vocal learning, followed by a surge of vocal practice. Individual variability of locomotor production is positively correlated with precision of tutor imitation and duration of multi-syllable sequences. Manipulation of juvenile locomotion significantly impacts the precision of vocal imitation and neural plasticity. The locomotor program developed during the sensitive period of vocal learning may enrich the neural substrates that promote the subsequent development of vocal learning. Increased movement is associated with improved vocal activity in young zebra finches, while reducing locomotion leads to poor vocal learning. These results suggest that exercise in juvenile birds may actually promote their ability to learn and produce songs. [ABSTRACT FROM AUTHOR]

In the vocal learning model, the juvenile first memorizes a model sound, and the imprinted memory gradually converts into vocal-motor output during the sensorimotor integration. However, early acquired memory may not precisely represent the fine structures of a model sound. How do juveniles ensure precise model imitation? Here we show that juvenile songbirds develop an auditory learning program by actively and attentively engaging with tutor's singing during the sensorimotor phase. The listening/approaching behavior requires previously acquired model memory and the individual variability of approaching behavior correlates with the precision of tutor song imitation. Moreover, it is modulated by dopamine and associated with forebrain regions for sensory processing. Overall, precise vocal learning may involve two steps of auditory processing: a passive imprinting of model memory occurs during the early sensory period; the previously acquired memory then guides an active and selective engagement of the re-exposed model to fine tune model imitation. Wan-Chun Liu et al. demonstrate that the sensory phase of vocal learning in zebra finches is split across two stages: (1) passive listening and formation of a memory, and (2) active listening and behavioral engagement of juveniles with adult tutors. Furthermore, they show that approach behavior is correlated with song imitation quality, and immediate early gene expression in the caudal medial nidopallium linked to auditory behavior. [ABSTRACT FROM AUTHOR]

Speech and vocal impairments characterize many neurological disorders. However, the neurogenetic mechanisms of these disorders are not well understood, and current animal models do not have the necessary circuitry to recapitulate vocal learning deficits. We developed germline transgenic songbirds, zebra finches (Taneiopygia guttata) expressing human mutant huntingtin (mHTT), a protein responsible for the progressive deterioration of motor and cognitive function in Huntington's disease (HD). Although generally healthy, the mutant songbirds had severe vocal disorders, including poor vocal imitation, stuttering, and progressive syntax and syllable degradation. Their song abnormalities were associated with HD-related neuropathology and dysfunction of the cortical-basal ganglia (CBG) song circuit. These transgenics are, to the best of our knowledge, the first experimentally created, functional mutant songbirds. Their progressive and quantifiable vocal disorder, combined with circuit dysfunction in the CBG song system, offers a model for genetic manipulation and the development of therapeutic strategies for CBG-related vocal and motor disorders. [ABSTRACT FROM AUTHOR]

Prenatal auditory stimulation is known to critically affect the development of acoustic preference and species recognition throughout ontogeny in birds. We focus our review on experimental studies that have used birds as model systems to explore the effects of prenatal auditory stimulation on the developing organism. To begin, we introduce concepts and terms of embryonic stages and learning and review the development of auditory perception and responsivity to acoustic stimulation in avian embryos. We then analyze studies that provide specific details of the effects of prenatal acoustic stimulation on the behavior, social preferences, and vocal production of both pre- and postnatal birds and discuss nuanced effects of the social and perceptual environment to which embryos may be exposed. We conclude that acoustic stimulation of avian embryos is a viable and critical model for future studies on the role of early experiences on the development of neural substrates and the resulting social affiliation patterns. [ABSTRACT FROM AUTHOR]