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Objective: To perform a systematic review to assess the effectiveness and safety of Reduning Injection versus neuraminidase inhibitors in treatment of influenza. Methods: The MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Bio-medical Literature and Retrieval System (Sinomed), China National Knowledge Infrastructure Database (CNKI), China Science and Technology Journal Database (VIP), Wanfang Data Knowledge Service Platform and ClinicalTrails.gov were systematically searched from inception dates to May 2021 for randomized controlled trials (RCTs) exploring Reduning Injection alone or in combination with neuraminidase inhibitors in patients with influenza. Statistical analysis was performed using RevMan 5.4 and Stata 15.1. The qualities of the involved studies were assessed by the risk of bias according to the Cochrane handbook. The evidence quality of each outcome was evaluated by GRADEpro GDT. Results: Twelve trials with 1,460 patients were included. The included studies had a certain unclear or high risk of bias. Reduning Injection appeared to be more effective in shortening the fever clearance time (MD: −16.20 h, 95% CI: −19.40 to −12.99, 7 trials, 814 patients, I2=94%, very low certainty), fever alleviation time (MD: −4.09 h, 95% CI: −4.22 to −3.96, 3 trials, 366 patients, I2=0%, low certainty), cough alleviation time (MD: −21.34 h, 95% CI: −41.56 to −1.11, 2 trials, 228 patients, I2=89%, very low certainty), fatigue alleviation time (MD: −31.83 h, 95% CI: −36.88 to −26.77, 2 trials, 270 patients, I2=0%, low certainty), sore throat alleviation time (MD: −28.66 h, 95% CI: −32.23 to −25.10, 1 trial, 150 patients, low certainty), and improving the total effective rate (RR: 1.15, 95% CI: 1.06 to 1.25, 10 trials, 1,074 patients, I2=76%, very low certainty). Besides, Reduning Injection seemed generally safe. Conclusions: This study provided low or very low evidence indicating Reduning Injection may be effective in the treatment of influenza and might be safe. Further rigorously designed studies are needed to confirm the effectiveness and safety of Reduning Injection and support it as a recommendation for influenza. [ABSTRACT FROM AUTHOR]

Objective: To systematically evaluate the efficacy and safety of Tanreqing Injection (痰热清注射液, TRQI) combined with conventional treatment on clinical outcomes in the treatment of patients with influenza. Methods: The electronic databases searched were Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), MEDLINE (PubMed), EMbase (OvidSP), Chinese Bio-medical Literature and Retrieval System (Sinomed), China National Knowledge Infrastructure Database (CNKI), China Science and Technology Journal Database (VIP) and WanFang Data Knowledge Service Platform, and we checked the reference sections of the retrieved articles as well. The search was performed in October 2018, and we used the randomized controlled trials (RCTs) that corresponded to the new diagnostic criteria for influenza. Two review authors independently screened the internalized articles in accordance with the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) statement checklist. We evaluated the quality of the articles and extracted the data from the studies using the Revmen5.3 software. Results: We included 12 RCTs of over 882 cases in this meta-analysis. Compared to conventional treatment, TRQI combined with conventional treatment could increase the total effective rate [9 RCTs, n=648, odds ratio (OR): 4.92, 95% confidence interval (CI): 2.94, 8.24, P<0.0001, random effects model], decrease the average time for fever clearance [7 RCTs, n=564, mean difference (MD): −1.08, 95% CI: −1.68, −0.48, P=0.0004, random effects model] and decrease the time for resolution of cough (5 RCTs, n=362, MD: −1.76, 95% CI: −2.63, −0.90, P<0.0001, random effects model). Conclusion: Based on this meta-analysis of RCTs, TRQI combined with conventional treatment had a statistically significant benefit in increasing the total effective treatment rate and reducing the time for fever clearance as well as time for resolution of cough. [ABSTRACT FROM AUTHOR]

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The Mesozoic granitoids in the Dabie Orogen are of particular geological interest as indicators for Mesozoic lithospheric evolution because of their close association with porphyry Mo mineralization. Here, we present a study using petrogeochemistry data to constrain the petrogenesis of the Xiaofan granites in the Dabie Mo mineralization belt (DMB), Henan Province, China. Field investigations show that the Xiaofan pluton mainly consists of porphyritic granite. The Xiaofan granites have high SiO2 contents of 74.29 wt%-76.07 wt% (average: 75.18 wt%), Al2O3 contents of 11.66 wt%-12.83 wt% (average: 12.13 wt%), and K2O contents of 5.37 wt%-7.90 wt% (average: 6.86 wt%) and low MgO (0.06 wt%-0.16 wt%), TiO2 (0.09 wt%-0.10 wt%), and P2O5 (0.047 wt%-0.103 wt%) contents. They are enriched in Rb, U, K and Hf but depleted in Ba, Nb, Ta, Sr and Ti. By geochemical and mineralogical features, we propose that the Xiaofan granites belong to A-type type granite and dominantly sourced from the crust. The granites from the Xiaofan Mo deposit may have formed in a post-collision extensional setting. [ABSTRACT FROM AUTHOR]

A depth-averaged quasi single-phase mixture model is proposed for debris flows over inclined bed slopes based on the shallow water hydrosediment-morphodynamic theory with multi grain sizes. The stresses due to fluctuations are incorporated based on analogy to turbulent flows, as estimated using the depth-averaged k − ε turbulence model and a modification component. A fully conservative numerical algorithm, using wellbalanced slope limited centred scheme, is deployed to solve the governing equations. The present quasi single-phase model using four closure relationships for the bed shear stresses is evaluated against USGS experimental debris flow and compared with traditional quasi single-phase models and a recent physically enhanced two-phase model. It is found that the present quasi single-phase model performs much better than the traditional models, and is attractive in terms of computational cost while the two-phase model performs even better appreciably. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of Qiguiyin Decoction (芪归银方, QGYD) on multidrug-resistant Pseudomonas aeruginosa infection in Sprague-Dawley (SD) rats. Methods: A pseudomonal infection model in SD rats was established by injecting multidrug-resistant P. aeruginosa intraperitoneally. Infected rats were randomized into four groups treated with Pure water, QGYD, ceftazidime, or combined QGYD and ceftazidime. Blood samples were obtained from the abdominal aorta. Serum was then collected and analyzed by peptide array for immune responsiveness to multidrug-resistant beta-lactamase proteins, including Verona integronen-coded metallo-beta-lactamase 1 (VIM-1), Sao Paulo metallo-beta-lactamase 1 (SPM-1), and Temoniera (TEMs). Blood levels of interleukin-1β (IL-1β), interleukin-4 (IL-4), and interferon-γ (IFN-γ) were assessed by enzyme-linked immunosorbent assay. Results: QGYD enhanced antibody reactivity against VIM-1 [epitopes 7-11 and 36-40] and TEM-1 [epitopes 26-27, 52-55, and 66-70]. QGYD treatment restored the compromised antibody reactivity against VIM-1 [epitopes 53-54 and 56-58] and SPM-1 [epitopes 16-19 and 82-85] following pseudomonal infection. Serum levels of IL-1β and Th1/Th2 in the rats were significantly elevated following pseudomonal infection ( P<0.05 or P<0.01). In contrast, QGYD and combination QGYD and ceftazidime treatment restored the elevated serum IL-1β and Th1/Th2 levels to normal ( P>0.05). Conclusions: QGYD improves the immune response to pseudomonal infection in rats by stimulating the production of protective antibodies against drug-resistant proteins VIM-1, SPM-1, and TEM-1. In addition, it protects the immune system and maintains immune responsiveness by restoring IL-1β and Th1/Th2 levels. [ABSTRACT FROM AUTHOR]

In this paper, the hydrodynamic characteristics of water flow in Chaohu Lake are studied by using the finite volume coastal ocean model (FVCOM), which is verified by the observed data. The typical flow field and the 3-D flow structure are obtained for the lake. The flow fields under extreme conditions are analyzed to provide a prospective knowledge of the water exchange and the transport process. The influence of the wind on the flow is determined by the cross spectrum method. The results show that the wind-driven flow dominates most area of the lake. Under prevailing winds in summer and winter, the water flows towards the downwind side at the upper layer while towards the upwind side at the lower layer in most area except that around the Chaohu Sluice. The extreme wind speed is not favorable for the water exchange while the sluice's releasing water accelerates the process. The water velocity in the lake is closely related with the wind speed. [ABSTRACT FROM AUTHOR]

Based on the remote sensing images of algae, the present work analyzes the horizontal distribution characteristics of algal blooms in Chaohu Lake, China, which also reveals the frequency of algal blooms under different wind directions. Further, an unstructured-grid, three-dimensional finite-volume coastal ocean model (FVCOM) is applied to investigate the wind-induced currents and the transport process to explain the reason why algal blooms occur at the detected places. We first deduce the primary distribution of biomass from overlaid satellite images, and explain the formation mechanism by analyzing the pollution sources, and simulating the flow field and transportation process under prevailing wind over Chaohu Lake. And then, we consider the adjustment action of the wind on the corresponding day and develop a two-time scale approach to describe the whole formation process of algae horizontal distribution in Chaohu Lake. That is, on the longer time scale, i.e., during bloom season, prevailing wind determines the primary distribution of biomass by inducing the characteristic flow field; on the shorter time scale, i.e., on the day when bloom occurs, the wind force adjusts the primary distribution of biomass to form the final distribution of algal bloom. [ABSTRACT FROM AUTHOR]

The Adomian decomposition method (ADM) is an approximate analytic method for solving nonlinear equations. Generally, an approximate solution can be obtained by using only a few terms. However, in applications, we need to use it flexibly according to the real problem. In this paper, based on the ADM, we give a modified asymptotic Adomian decomposition method and use it to solve the nonlinear Boussinesq equation describing groundwater flows. The example shows effectiveness of the modified asymptotic Adomian decomposition method. [ABSTRACT FROM AUTHOR]

We discuss semi-convergence of the modified Hermitian and skew-Hermitian splitting (MHSS) iteration method for solving a broad class of complex symmetric singular linear systems. The semi-convergence theory of the MHSS iteration method is established. In addition, numerical examples show the effectiveness of the MHSS iteration method when it is used as a solver or as a preconditioner (for the restarted GMRES method). [ABSTRACT FROM AUTHOR]

The flow through a single fracture is numerically studied by means of the Fluent Software. The results show that the roughness of the fracture significantly affects the hydraulic conductivity in the fracture as compared with the cubic law model widely used to describe the flow between two smooth parallel plates. A new model is proposed in this paper, the non-symmetric sinusoidal fracture model, to simulate the flow in a real fracture. This model involves two sinusoidal-varying walls with different phases to replace the flat planes in the cubic law model. The relationships between the effective hydraulic apertures and the phase retardation for different relative amplitudes and wavelengths are numerically investigated. A simple expression of the effective hydraulic aperture of the fracture is obtained, together with the law of the effective hydraulic aperture against the amplitude, the phase retardation and the wavelength of two sinusoidal-varying walls. [ABSTRACT FROM AUTHOR]

The First author's name was wrong and it should be replaced as HUANG Jing(黄晶)1, 3. [ABSTRACT FROM AUTHOR]