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1,352 results on '"Linn, A"'

1. Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity

Author: Stefan Prekovic, Theofilos Chalkiadakis, Merel Roest, Daniel Roden, Catrin Lutz, Karianne Schuurman, Mark Opdam, Liesbeth Hoekman, Nina Abbott, Tanja Tesselaar, Maliha Wajahat, Amy R Dwyer, Isabel Mayayo‐Peralta, Gabriela Gomez, Maarten Altelaar, Roderick Beijersbergen, Balázs Győrffy, Leonie Young, Sabine Linn, Jos Jonkers, Wayne Tilley, Theresa Hickey, Damir Vareslija, Alexander Swarbrick, and Wilbert Zwart
Subjects: breast cancer, glucocorticoids, luminal breast cancer subtypes, nuclear receptors, ZBTB16, Medicine (General), R5-920, Genetics, QH426-470
Abstract: Abstract Glucocorticoid receptor (GR) is a transcription factor that plays a crucial role in cancer biology. In this study, we utilized an in silico‐designed GR activity signature to demonstrate that GR relates to the proliferative capacity of numerous primary cancer types. In breast cancer, the GR activity status determines luminal subtype identity and has implications for patient outcomes. We reveal that GR engages with estrogen receptor (ER), leading to redistribution of ER on the chromatin. Notably, GR activation leads to upregulation of the ZBTB16 gene, encoding for a transcriptional repressor, which controls growth in ER‐positive breast cancer and associates with prognosis in luminal A patients. In relation to ZBTB16's repressive nature, GR activation leads to epigenetic remodeling and loss of histone acetylation at sites proximal to cancer‐driving genes. Based on these findings, epigenetic inhibitors reduce viability of ER‐positive breast cancer cells that display absence of GR activity. Our findings provide insights into how GR controls ER‐positive breast cancer growth and may have implications for patients' prognostication and provide novel therapeutic candidates for breast cancer treatment.
Published: 2023
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2. Comparable improvement and resolution of obesity-related comorbidities in endoscopic sleeve gastroplasty vs laparoscopic sleeve gastrectomy: single-center study.

Author: Joseph, Stephanie, Vandruff, Vanessa N., Amundson, Julia R., Che, Simon, Zimmermann, Christopher, Ishii, Shun, Kuchta, Kristine, Hedberg, H. Mason, Denham, Woody, Linn, John, and Ujiki, Michael B.
Abstract: Background: Despite excellent surgical outcomes, a minority of qualified patients undergo weight loss surgery. Endoscopic Sleeve Gastroplasty (ESG), an incisionless procedure, has proven to be effective in achieving weight loss and comorbidity improvement. We aim to compare outcomes of ESG to those of Laparoscopic Sleeve Gastrectomy (LSG). Method: A retrospective review of a prospective database of patients who underwent ESG and LSG at NorthShore University HealthSystem from 2016 to 2023 was completed. Demographic and outcome data were analyzed. Pre- and post-surgical data were compared using chi-square and two-sample t tests. Improvement or resolution of obesity-related comorbidities were also assessed. Results: A total of 212 LSG and 68 ESG patients were reviewed. ESG patients were older (47 ± 10 vs. 43 ± 12, p = 0.006) and less obese (BMI 37.0 ± 5.5 vs. 45.8 ± 0.4, p < 0.001) than LSG patients. Median length of stay after ESG was 0 days and after LSG 1 day (p < 0.001). Severe adverse events were seen less frequent after ESG (1.47%, vs 3.77%). LSG achieved more significant %TBWL at 6 months (25.2 ± 8.9 vs 14.9 ± 7.4), 1 year (27.5 ± 10.8 vs 14.1 ± 9.8), and 2 years (25.7 ± 10.8 vs 10.5 ± 8.8, all p < 0.001) after surgery when compared to ESG. LSG achieved significantly greater %EWL compared to ESG at 6 months (57.0 ± 20.7 vs 50.4 ± 29.2, p = 0.137), 1 year (61.4 ± 24.6 vs 46.5 ± 34.0, p = 0.026), and 2 years postoperatively (59.7 ± 25.5 vs 32.6 ± 28.2, p = 0.001). There were no statistically significant differences in rates of improvement or resolution of diabetes, obstructive sleep apnea, hyperlipidemia, or hypertension. Conclusion: ESG is an effective procedure for weight loss and comorbidity resolution. Obesity-related comorbidities are comparably improved and resolved following ESG vs LSG. Although the weight loss in LSG is significantly higher, patients can expect a shorter hospital length of stay and a lower rate of complications after ESG. ESG continues to show promise for long-term weight loss and improvement in health. [ABSTRACT FROM AUTHOR]
Published: 2024
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3. Designing for learning across disciplines: leveraging graphs to improve knowledge integration in science.

Author: Boda, Phillip A., Bathia, Shruti, Gerard, Libby, and Linn, Marcia C.
Subjects: REPRESENTATIONS of graphs, SCIENCE education, MIDDLE school students, SUBGROUP growth, DESIGN science
Abstract: Advances in graphing technologies and learning sciences pedagogy have the potential to equitably support students when exploring complex systems depicting dynamic relationships across multiple disciplinary topics in Science, Technology, Engineering, and Mathematics (STEM). We report on the cumulative impact of science units designed in a Research Practice Partnership (RPP) that leveraged Knowledge Integration (KI) pedagogy to support middle school students to generalize insights to new graph representations and science topics. Teachers across 11 schools incorporated the graph-science units into their curriculum plans. We analyzed ~ 8000 responses to validated and reliable graph-science KI assessment items administered before the first year and after one, two, or three years of instruction aligned with KI pedagogy. With random coefficient, multi-level, mixed-effect regression modeling, we analyzed performance after one-, two-, and three-years of graph-science KI instruction. We also analyzed the growth trajectories of subgroups, i.e., multilingual learners. Data suggest two years of graph-science KI instruction is needed to make significant impacts on student learning and ameliorated the disparity between students with different native language fluencies. These results illustrate the value of technology-enhanced, pedagogically aligned K-12 science instruction that is designed to support connecting diverse graph data and science knowledge comprehensively and cumulatively. [ABSTRACT FROM AUTHOR]
Published: 2024
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4. Forest structural complexity and ignition pattern influence simulated prescribed fire effects.

Author: Bonner, Sophie R., Hoffman, Chad M., Linn, Rodman R., Tinkham, Wade T., Atchley, Adam L., Sieg, Carolyn H., Varner, J. Morgan, O'Brien, Joseph J., and Hiers, J. Kevin
Subjects: PRESCRIBED burning, COMPUTATIONAL fluid dynamics, ENERGY consumption, FOREST fires, FOREST canopies, FOREST thinning
Abstract: Copyright of Fire Ecology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2024
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5. Using the Infant Sibling-Design to Explore Associations Between Autism and ADHD Traits in Probands and Temperament in the Younger Siblings.

Author: Andersson Konke, Linn, Falck-Ytter, Terje, Jones, Emily J. H., Goodwin, Amy, and Brocki, Karin
Subjects: *GENETICS of autism, *SCALE analysis (Psychology), *PEARSON correlation (Statistics), *MATHEMATICAL variables, *TEMPERAMENT, *INFANT psychology, *ATTENTION-deficit hyperactivity disorder, *RESEARCH funding, *CRONBACH'S alpha, *INFANT development, *QUESTIONNAIRES, *INDEPENDENT variables, *MULTIVARIATE analysis, *DESCRIPTIVE statistics, *ASPERGER'S syndrome, *PHENOTYPES, *COGNITION, *REGRESSION analysis
Abstract: The purpose of the current study was to use the infant sibling design to explore whether proband traits of autism and ADHD could provide information about their infant sibling's temperament. This could help us to gain information about the extent to which infant temperament traits are differentially associated with autism and ADHD traits. We used parent-ratings of autistic traits and ADHD traits (CRS-3) in older siblings diagnosed with autism (age range 4 to 19 years), and their infant siblings' temperament traits (IBQ) at 9 months of age in 216 sibling pairs from two sites (BASIS, UK, and EASE, Sweden) to examine associations across siblings. We found specific, but modest, associations across siblings after controlling for sex, age, developmental level and site. Proband autistic traits were specifically related to low levels of approach in the infant siblings, with infant developmental level explaining part of the variance in infant approach. Proband ADHD traits were specifically related to high levels of infant activity even after controlling for covariates. Our findings suggest that proband traits of autism and ADHD carry information for infant sibling's temperament, indicating that inherited liability may influence early emerging behaviours in infant siblings. The impact of sex, age, developmental level and site are discussed. [ABSTRACT FROM AUTHOR]
Published: 2024
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6. Efficient Production and Purification of Bioactive E50-52-Class IIa Peptidic Bacteriocin Is Achieved through Fusion with the Catalytic Domain of Lysostaphin-Class III Bacteriocin.

Author: Phrutpoom, Nichakarn, Khaokhiew, Tararat, Linn, Aung Khine, Sakdee, Somsri, Imtong, Chompounoot, Jongruja, Nujarin, and Angsuthanasombat, Chanan
Abstract: E50-52, a class IIa-peptidic bacteriocin produced by a strain of Enterococcus faecium, has broad-spectrum antimicrobial activity against various foodborne pathogens. However, effective utilization of the E50-52 has been limited by low production yields and challenges associated with separation and purification of this 39-amino acid antimicrobial peptide. In this study, we have successfully produced a biologically active recombinant form of E50-52 by fusing it with the 16-kDa catalytic domain of lysostaphin-class III bacteriocin (LssCAT), which resulted in high-yield production. Initially, the LssCAT-E50-52 chimeric protein was insoluble upon over-expression in Escherichia coli, but it became soluble using phosphate buffer (pH 7.4) supplemented with 8 M urea. Purification using immobilized-Ni2+ affinity chromatography under urea denaturing conditions resulted in consistent production a homogenous products (LssCAT-E50-52) with >95% purity. The purified protein was refolded using an optimized stepwise dialysis process. The resulting refolded LssCAT-E50-52 protein exhibited dose-dependent inhibitory activity against Helicobacter pylori, a Gram-negative, flagellated, helical bacterium that is associated with gastric cancer. Overall, the optimized protocol described in this study effectively produced large quantities of high-purity recombinant LssCAT-E50-52 protein, yielding approximately 100 mg per liter of culture. To the best of our knowledge, this is the first report on the impact of LssCAT-E50-52 on H. pylori. This finding could pave the way for further research into bactericidal mechanism and potential applications of this bacteriocin in biomedical industry. [ABSTRACT FROM AUTHOR]
Published: 2024
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7. Dispensed prescription medications and short-term risk of pulmonary embolism in Norway and Sweden.

Author: Aune, Dagfinn, Vardaxis, Ioannis, Lindqvist, Bo Henry, Brumpton, Ben Michael, Strand, Linn Beate, Horn, Jens Wilhelm, Bakken, Inger Johanne, Romundstad, Pål Richard, Mukamal, Kenneth J., Ljung, Rickard, Janszky, Imre, and Sen, Abhijit
Subjects: FUROSEMIDE, OPIOID analgesics, PULMONARY embolism, DRUG side effects, ANGIOTENSIN-receptor blockers
Abstract: Scandinavian electronic health-care registers provide a unique setting to investigate potential unidentified side effects of drugs. We analysed the association between prescription drugs dispensed in Norway and Sweden and the short-term risk of developing pulmonary embolism. A total of 12,104 pulmonary embolism cases were identified from patient- and cause-of-death registries in Norway (2004–2014) and 36,088 in Sweden (2005–2014). A case-crossover design was used to compare individual drugs dispensed 1–30 days before the date of pulmonary embolism diagnosis with dispensation in a 61–90 day time-window, while controlling for the receipt of other drugs. A BOLASSO approach was used to select drugs that were associated with short-term risk of pulmonary embolism. Thirty-eight drugs were associated with pulmonary embolism in the combined analysis of the Norwegian and Swedish data. Drugs associated with increased risk of pulmonary embolism included certain proton-pump inhibitors, antibiotics, antithrombotics, vasodilators, furosemide, anti-varicose medications, corticosteroids, immunostimulants (pegfilgrastim), opioids, analgesics, anxiolytics, antidepressants, antiprotozoals, and drugs for cough and colds. Mineral supplements, hydrochlorothiazide and potassium-sparing agents, beta-blockers, angiotensin 2 receptor blockers, statins, and methotrexate were associated with lower risk. Most associations persisted, and several additional drugs were associated, with pulmonary embolism when using a longer time window of 90 days instead of 30 days. These results provide exploratory, pharmacopeia-wide evidence of medications that may increase or decrease the risk of pulmonary embolism. Some of these findings were expected based on the drugs' indications, while others are novel and require further study as potentially modifiable precipitants of pulmonary embolism. [ABSTRACT FROM AUTHOR]
Published: 2024
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8. Evaluating crown scorch predictions from a computational fluid dynamics wildland fire simulator.

Author: Atchley, Adam L., Hoffman, Chad M., Bonner, Sophie R., Ritter, Scott M., O'Brien, Joseph, and Linn, Rodman R.
Subjects: COMPUTATIONAL fluid dynamics, BUDS, FOREST canopies, WILDFIRES, ENVIRONMENTAL management
Abstract: Copyright of Fire Ecology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2024
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9. Repeated cognitive assessments show stable function over time in patients with ALS.

Author: Öijerstedt, Linn, Foucher, Juliette, Lovik, Anikó, Yazdani, Solmaz, Juto, Alexander, Kläppe, Ulf, Fang, Fang, and Ingre, Caroline
Subjects: *AMYOTROPHIC lateral sclerosis, *MONTREAL Cognitive Assessment, *COGNITION disorders, *EXECUTIVE function, *SOCIAL perception
Abstract: Background: Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with not only motor symptoms but also extra-motor features including cognitive impairment. The most common cognitive profile observed in patients with ALS includes deficits in executive function, language, and social cognition. However, longitudinal studies on cognitive changes over time in ALS are sparse. We aimed to investigate the presence and nature of cognitive impairment at the time of ALS diagnosis and its association with survival as well as explore longitudinal cognitive change. Method: Patients (n = 216) were recruited at the Karolinska University Hospital in Stockholm, Sweden. Follow-up visits (n = 307 in total) were performed every 6 months. Cognitive impairment was assessed using the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and/or Montreal Cognitive Assessment (MoCA). Results: Cognitive impairment was observed in 38% of the patients at the time of ALS diagnosis, and the majority of these patients had deficits in executive function and/or language. Patients with cognitive impairment at the time of diagnosis had a more rapid decline in ALSFRS-R at 12- and 18-months follow-up, and a shorter survival. Cognitive function was stable during the first 2 years after diagnosis, and did not follow the trajectories of decline in motor functions. Conclusion: Cognitive impairment in ALS was associated with a faster decline of motor functions, and shorter survival. However, cognitive function did not deteriorate over time. Cognitive assessment is essential for the patients and caregivers to understand the phenotypic expression of ALS. [ABSTRACT FROM AUTHOR]
Published: 2024
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10. The role of functional emotion circuits in distinct dimensions of psychopathology in youth.

Author: Karl, Valerie, Engen, Haakon, Beck, Dani, Norbom, Linn B., Ferschmann, Lia, Aksnes, Eira R., Kjelkenes, Rikka, Voldsbekk, Irene, Andreassen, Ole A., Alnæs, Dag, Ladouceur, Cecile D., Westlye, Lars T., and Tamnes, Christian K.
Published: 2024
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11. The Epistemic Condition for Character Responsibility.

Author: Linn, Marcella
Subjects: EPISTEMICS, RESPONSIBILITY, EMPIRICAL research
Abstract: If responsibility for character requires (among other things) having knowledge of the quality of one's character, and this knowledge requires having at least some good aspects of character, we seem to come to startling conclusions. First, as Neil Levy argues, the worse one is morally speaking, the less one is responsible for being morally bad. Second, the truly bad are excused for their bad characters. I present several arguments against Levy's view. First, I argue that the initial conclusion does not follow. It is not the case that the worse a person is, the less responsible she is for her character. A person may still have other aspects of character that enable her to fulfill this part of the epistemic condition. Further, both Aristotle and empirical research on character indicate that most people have such aspects. Second, I consider the truly morally bad. I show that most people voluntarily develop their characters and so – aside from rare cases of abuse, neglect, or congenital disorders – the vicious become so voluntarily. In this vein, I thirdly show that partial moral understanding is sufficient to meet the epistemic condition for character responsibility and most people have this. [ABSTRACT FROM AUTHOR]
Published: 2024
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12. Magnetic field-dependent rheological behavior of thermoresponsive poly(N-isopropylacrylamide) solutions.

Author: Neal, Christopher A. P., Shetty, Abhishek M., Linn, Jason D., Quan, Michelle C., Casas, Joseph D., and Calabrese, Michelle A.
Subjects: THERMORESPONSIVE polymers, POLYMER solutions, POLY(ISOPROPYLACRYLAMIDE), MAGNETORHEOLOGY, MOLECULAR weights, POLYMERS, MAGNETIC fields
Abstract: Magnetic (B) fields are an intriguing route for manipulating soft materials. While most research on B field manipulation of diamagnetic polymers has focused on alignment of ordered structures or anisotropic domains, our recent work uncovered a previously unrecognized effect: B fields alter hydration and hydrogen bonding in thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) solutions. Despite the well-known thermoreversible coil-to-globule transition and hydrogel formation upon heating, the impact of magnetic fields on these structural and rheological transitions has been largely unexplored. In this study, we thoroughly examined the temperature-dependent magnetorheology of PNIPAM solutions, varying B field strength, polymer content, and molecular weight. Linear magnetorheology reveals that increasing the B field intensity decreases the dynamic moduli of the resulting physical hydrogel, across polymer concentrations (5–20% wt) and molecular weights (30–108 kDa), by up to an order of magnitude. Conversely, the gelation onset temperature does not change substantially. This weakening effect is more pronounced at longer magnetization times and slower temperature ramp rates. Nonlinear magnetorheology following hydrogel formation reveals a two-step yielding process characteristic of attractive-driven glasses, suggesting that magnetization decreases both the stress and length scales associated with mesoglobule cage breaking. We propose that B fields impact the hydrogel rheology by altering the mesoglobule size and water content. This work uncovers essential understanding of how B fields alter hydrogel formation in PNIPAM solutions, broadening the scope of magnetic field manipulation of diamagnetic polymer solutions. [ABSTRACT FROM AUTHOR]
Published: 2024
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13. Parental developmental experience affects vocal learning in offspring.

Author: Kraft, Fanny-Linn H., Crino, Ondi L., Adeniran-Obey, Saidat O., Moraney, Raven A., Clayton, David F., George, Julia M., and Buchanan, Katherine L.
Subjects: *BIRDSONGS, *HEREDITY, *GENE expression, *SOCIAL learning, *COGNITIVE learning, *ZEBRA finch
Abstract: Cultural and genetic inheritance combine to enable rapid changes in trait expression, but their relative importance in determining trait expression across generations is not clear. Birdsong is a socially learned cognitive trait that is subject to both cultural and genetic inheritance, as well as being affected by early developmental conditions. We sought to test whether early-life conditions in one generation can affect song acquisition in the next generation. We exposed one generation (F1) of nestlings to elevated corticosterone (CORT) levels, allowed them to breed freely as adults, and quantified their son's (F2) ability to copy the song of their social father. We also quantified the neurogenetic response to song playback through immediate early gene (IEG) expression in the auditory forebrain. F2 males with only one corticosterone-treated parent copied their social father's song less accurately than males with two control parents. Expression of ARC in caudomedial nidopallium (NCM) correlated with father-son song similarity, and patterns of expression levels of several IEGs in caudomedial mesopallium (CMM) in response to father song playback differed between control F2 sons and those with a CORT-treated father only. This is the first study to demonstrate that developmental conditions can affect social learning and neurogenetic responses in a subsequent generation. [ABSTRACT FROM AUTHOR]
Published: 2024
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14. A European survey of older peoples' preferences, and perceived barriers and facilitators to inform development of a medication-related fall-prevention patient portal.

Author: Ploegmakers, Kim J., Linn, A. J., Medlock, S., Seppälä, L. J., Bahat, G., Caballero-Mora, M. A., Ilhan, B., Landi, F., Masud, T., Morrissey, Y., Ryg, J., Topinkova, E., van der Velde, N., and van Weert, J. C. M.
Abstract: Key summary points: Aim: To explore content preferences, potential barriers and facilitators as perceived by European older adults who have experienced falls with regards to using a fall-prevention patient portal, and to explore regional differences between European participants. Findings: About two-thirds of the participants (n = 121) reported interest in a fall-prevention patient portal providing information on risk factors for falls, relevant medical conditions, Fall-Risk Increasing Drugs (FRIDs), and advice on how to manage fall-related conditions. Fees for use and privacy concerns appeared to be the most important barriers, while a user-friendly portal with easily-accessible information and a physician recommendation seemed to be the most important facilitators. A recommendation for portal use by a family member appeared to be a more important facilitator for participants from Southern and Eastern Europe compared to the other regions. Message: There is considerable interest in a fall-prevention patient portal providing personalized treatment advice, used in addition to a consultation with a physician. The barriers and facilitators to using a portal as identified by participants should be taken into account when developing future fall-prevention patient portals in order to optimize clinical effectiveness. Purpose: Falls are a major and growing health care problem in older adults. A patient portal has the potential to provide older adults with fall-prevention advice to reduce fall-risk. However, to date, the needs and preferences regarding a patient portal in older people who have experienced falls have not been explored. This study assesses content preferences, potential barriers and facilitators with regard to using a patient portal, as perceived by older people who have experienced falls, and explores regional differences between European participants. Methods: We conducted a survey of older adults attending an outpatient clinic due to a fall or fall-related injury, to explore their content preferences, perceived barriers, and facilitators with respect to a fall-prevention patient portal. Older adults (N = 121, 69.4% female, mean age: 77.9) were recruited from seven European countries. Results: Almost two-thirds of respondents indicated they would use a fall-prevention patient portal. The portal would preferably include information on Fall-Risk-Increasing Drugs (FRIDs), and ways to manage other related/relevant medical conditions. Facilitators included a user-friendly portal, with easily accessible information and physician recommendations to use the portal. The most-commonly-selected barriers were privacy issues and usage fees. A family member's recommendation to use the portal was seemingly more important for Southern and Eastern European participants compared to the other regions. Conclusion: The majority of older people with lived falls experience expressed an interest in a fall-prevention patient portal providing personalized treatment advice to prevent further falls. The results will be used to inform the development of a fall-prevention patient portal. The fall-prevention patient portal is intended to be used in addition to a consultation with a physician. Future research is needed to explore how to prevent falls in older patients who are not interested in a fall-prevention patient portal. [ABSTRACT FROM AUTHOR]
Published: 2024
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15. Implementation of quality indicators for vulvar cancer in gynaecological cancer centres certified by the German Cancer Society (DKG)

Author: Stuebs, Frederik A., Beckmann, Matthias W., Dannecker, Christian, Follmann, Markus, Nothacker, Monika, Schnürch, Hans-Georg, Woelber, Linn, and Wesselmann, Simone
Abstract: Purpose: In 2018, the first guideline-based quality indicators (QI) for vulvar cancer were implemented in the data-sheets of certified gynaecological cancer centres. The certification process includes guideline-based QIs as a fundamental component. These indicators are specifically designed to evaluate the level of care provided within the centres. This article aims to give an overview of the developing process of guideline based-QIs for women with vulvar cancer and presents the QIs results from the certified gynaecological cancer centres. Methods: The QIs were derived in a standardized multiple step process during the update of the 2015 S2k guideline “Diagnosis, Therapy, and Follow-Up Care of Vulvar Cancer and its Precursors” (registry-number: no. 015/059) and are based on strong recommendations. Results: In total, there are eight guideline-based QIs for vulvar cancer. Four QIs are part of the certification process. In the treatment year 2021, 2.466 cases of vulvar cancer were treated in 177 centres. The target values in the centres for pathology reports on tumour resection and lymphadenectomy as well as sentinel lymph nodes have increased since the beginning of the certification process and have been above 90% over the past three treatment years (2019–2021). Discussion: QIs based on strong guideline recommendations, play a crucial role in measuring and allowing to quantify essential aspects of patient care. By utilizing QIs, centres are able to identify areas for process optimization and draw informed conclusions. Over the years the quality of treatment of vulvar cancer patients measured by the QIs was improved. The certification system is continuously reviewed to enhance patient care even further by using the outcomes from QIs revaluation. [ABSTRACT FROM AUTHOR]
Published: 2024
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16. Assessing the Longitudinal Associations Between Decision-Making Processes and Attention Problems in Early Adolescence.

Author: Wiker, Thea, Pedersen, Mads L., Ferschmann, Lia, Beck, Dani, Norbom, Linn B., Dahl, Andreas, von Soest, Tilmann, Agartz, Ingrid, Andreassen, Ole A., Moberget, Torgeir, Westlye, Lars T., Huster, Rene J., and Tamnes, Christian K.
Subjects: CHILD Behavior Checklist, NEURAL development, PATHOLOGICAL psychology, BEHAVIOR disorders in children, COGNITIVE development
Abstract: Cognitive functions and psychopathology develop in parallel in childhood and adolescence, but the temporal dynamics of their associations are poorly understood. The present study sought to elucidate the intertwined development of decision-making processes and attention problems using longitudinal data from late childhood (9–10 years) to mid-adolescence (11–13 years) from the Adolescent Brain Cognitive Development (ABCD) Study (n = 8918). We utilised hierarchical drift-diffusion modelling of behavioural data from the stop-signal task, parent-reported attention problems from the Child Behavior Checklist (CBCL), and multigroup univariate and bivariate latent change score models. The results showed faster drift rate was associated with lower levels of inattention at baseline, as well as a greater reduction of inattention over time. Moreover, baseline drift rate negatively predicted change in attention problems in females, and baseline attention problems negatively predicted change in drift rate. Neither response caution (decision threshold) nor encoding- and responding processes (non-decision time) were significantly associated with attention problems. There were no significant sex differences in the associations between decision-making processes and attention problems. The study supports previous findings of reduced evidence accumulation in attention problems and additionally shows that development of this aspect of decision-making plays a role in developmental changes in attention problems in youth. [ABSTRACT FROM AUTHOR]
Published: 2024
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17. Pre-clinical evaluation of biomarkers for the early detection of nephrotoxicity following alpha-particle radioligand therapy.

Author: Li, Mengshi, Robles-Planells, Claudia, Liu, Dijie, Graves, Stephen A., Vasquez-Martinez, Gabriela, Mayoral-Andrade, Gabriel, Lee, Dongyoul, Rastogi, Prerna, Marks, Brenna M., Sagastume, Edwin A., Weiss, Robert M., Linn-Peirano, Sarah C., Johnson, Frances L., Schultz, Michael K., and Zepeda-Orozco, Diana
Subjects: ALPHA rays, NEPHROTOXICOLOGY, LIPOCALIN-2, URINATION, ACUTE kidney failure, CHRONIC kidney failure
Abstract: Purpose: Cancer treatment with alpha-emitter-based radioligand therapies (α-RLTs) demonstrates promising tumor responses. Radiolabeled peptides are filtered through glomeruli, followed by potential reabsorption of a fraction by proximal tubules, which may cause acute kidney injury (AKI) and chronic kidney disease (CKD). Because tubular cells are considered the primary site of radiopeptides' renal reabsorption and potential injury, the current use of kidney biomarkers of glomerular functional loss limits the evaluation of possible nephrotoxicity and its early detection. This study aimed to investigate whether urinary secretion of tubular injury biomarkers could be used as an additional non-invasive sensitive diagnostic tool to identify unrecognizable tubular damage and risk of long-term α-RLT nephrotoxicity. Methods: A bifunctional cyclic peptide, melanocortin 1 ligand (MC1L), labeled with [203Pb]Pb-MC1L, was used for [212Pb]Pb-MC1L biodistribution and absorbed dose measurements in CD-1 Elite mice. Mice were treated with [212Pb]Pb-MC1L in a dose-escalation study up to levels of radioactivity intended to induce kidney injury. The approach enabled prospective kidney functional and injury biomarker evaluation and late kidney histological analysis to validate these biomarkers. Results: Biodistribution analysis identified [212Pb]Pb-MC1L reabsorption in kidneys with a dose deposition of 2.8, 8.9, and 20 Gy for 0.9, 3.0, and 6.7 MBq injected [212Pb]Pb-MC1L doses, respectively. As expected, mice receiving 6.7 MBq had significant weight loss and CKD evidence based on serum creatinine, cystatin C, and kidney histological alterations 28 weeks after treatment. A dose-dependent urinary neutrophil gelatinase-associated lipocalin (NGAL, tubular injury biomarker) urinary excretion the day after [212Pb]Pb-MC1L treatment highly correlated with the severity of late tubulointerstitial injury and histological findings. Conclusion: Urine NGAL secretion could be a potential early diagnostic tool to identify unrecognized tubular damage and predict long-term α-RLT-related nephrotoxicity. [ABSTRACT FROM AUTHOR]
Published: 2024
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18. Can Building Subway Systems Improve Air Quality? New Evidence from Multiple Cities and Machine Learning.

Author: Xie, Lunyu, Zou, Tianhua, Linn, Joshua, and Yan, Haosheng
Subjects: AIR quality, CITIES & towns, MACHINE learning, SUBWAYS, PUBLIC transit, AIR pollution
Abstract: Public investments in subway systems are often motivated by improving local air quality. Recent studies, however, have reached different conclusions on the air quality benefits of subway investment. To reconcile these findings, this paper examines the air quality effects of all 359 subway line openings in China between 2013 and 2018. The machine learning method adopted in this paper substantially improves the consistency and precision of the estimates by purging seasonality, volatility, and the nonlinear effects of meteorological conditions in air quality data. The empirical results suggest an insignificant short-term effect and a significant long-term effect, which is expected as the adjustment of commuting mode takes time. Using the causal forest approach, the heterogeneity analysis find that a city that is experiencing rapid economic growth from a lower income level and currently has fewer subway lines is more likely to experience statistically significant improvements in air quality from a subway opening. These findings help reconcile the different findings in the literature and shed light on air pollution reduction as one of the objectives of public transit investment. [ABSTRACT FROM AUTHOR]
Published: 2024
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19. Emotionale Kompetenzen bei Menschen mit chronifizierten Schmerzen: Ein Selbst- und Fremdbild.

Author: Körner, Anne Juliane, Sabatowski, Rainer, Burdic, Lisa, Beyer, Linn, Gärtner, Anne, Schönbach, Benjamin, and Kaiser, Ulrike
Abstract: Copyright of Der Schmerz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2024
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20. Cost-utility analysis and impact on the environment of videoconference in pressure injury. A randomized controlled trial in individuals with spinal cord injury.

Author: Irgens, Ingebjørg, Kleven, Linn, Midelfart-Hoff, Jana, Jelnes, Rolf, Alexander, Marcalee, Stanghelle, Johan K., and Rekand, Tiina
Published: 2024
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21. Rivers and tidal flats as sources of dissolved organic matter and trace metals in the German Bight (North Sea).

Author: Speidel, Linn G., Carvalho da Silva, Roger, Beck, Melanie, Dellwig, Olaf, Wollschläger, Jochen, Dittmar, Thorsten, and Seidel, Michael
Subjects: *DISSOLVED organic matter, *TRACE metals, *TIDAL flats, *CHEMICAL formulas, *CARBON-black, *ORGANIC compounds, *MASS spectrometry
Abstract: The German Bight in the southern North Sea receives nutrients, dissolved organic matter (DOM), and trace metals from rivers, porewater reflux, and porewater outwelling. We studied the marine, riverine, and porewater sources analyzing molecular transformations of solid-phase extracted (SPE) DOM in the German Bight. We applied a combination of ultrahigh-resolution mass spectrometry (FT-ICR-MS) with quantitative data of dissolved organic sulfur (DOS), dissolved black carbon (DBC), dissolved trace metals (Ba, Co, Gd, Mo, Mn, W), and nutrients (nitrite, nitrate, phosphate, silicate). While aromatic DOM and DBC mainly originated from the rivers, nitrogen-containing, more saturated DOM was enriched offshore suggesting greater contributions of marine (algal) sources. Except for dissolved Mo, rivers were the primary source of trace metals and nutrients. However, tidal flats contributed to dissolved nutrient (e.g., dissolved phosphate), trace metal and DOS inventories of the southern North Sea. The input of DOS from intertidal flats was identified by the molecular index derived from sulfidic porewaters (ISuP), non-conservative behavior of elemental sulfur-to-carbon ratio and sulfur content of molecular formulae (from FT-ICR-MS). Dissolved Mn and Si were removed in the German Bight, likely due to precipitation as Mn(hydr)oxides and biological uptake, respectively. Preliminary estimates suggest that DOS from porewater outwelling is approximately four times higher than DOS discharged by the three main rivers in the region. Our study therefore highlights the need to consider porewater discharge in addition to riverine sources to comprehensively assess elemental budgets within the complex interplay and transformations of DOM, nutrients, and trace metals in coastal ecosystems. [ABSTRACT FROM AUTHOR]
Published: 2024
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22. Benefits and Harms of Mammography Screening in 75 + Women to Inform Shared Decision-making: a Simulation Modeling Study.

Author: Jayasekera, Jinani, Stein, Sarah, Wilson, Oliver W. A., Wojcik, Kaitlyn M., Kamil, Dalya, Røssell, Eeva-Liisa, Abraham, Linn A., O'Meara, Ellen S., Schoenborn, Nancy Li, Schechter, Clyde B., Mandelblatt, Jeanne S., Schonberg, Mara A., and Stout, Natasha K.
Subjects: MEDICAL screening, MAMMOGRAMS, FAMILY history (Medicine), AMERICAN women, OLDER women
Abstract: Background: Guidelines recommend shared decision-making (SDM) around mammography screening for women ≥ 75 years old. Objective: To use microsimulation modeling to estimate the lifetime benefits and harms of screening women aged 75, 80, and 85 years based on their individual risk factors (family history, breast density, prior biopsy) and comorbidity level to support SDM in clinical practice. Design, Setting, and Participants: We adapted two established Cancer Intervention and Surveillance Modeling Network (CISNET) models to evaluate the remaining lifetime benefits and harms of screening U.S. women born in 1940, at decision ages 75, 80, and 85 years considering their individual risk factors and comorbidity levels. Results were summarized for average- and higher-risk women (defined as having breast cancer family history, heterogeneously dense breasts, and no prior biopsy, 5% of the population). Main Outcomes and Measures: Remaining lifetime breast cancers detected, deaths (breast cancer/other causes), false positives, and overdiagnoses for average- and higher-risk women by age and comorbidity level for screening (one or five screens) vs. no screening per 1000 women. Results: Compared to stopping, one additional screen at 75 years old resulted in six and eight more breast cancers detected (10% overdiagnoses), one and two fewer breast cancer deaths, and 52 and 59 false positives per 1000 average- and higher-risk women without comorbidities, respectively. Five additional screens over 10 years led to 23 and 31 additional breast cancer cases (29–31% overdiagnoses), four and 15 breast cancer deaths avoided, and 238 and 268 false positives per 1000 average- and higher-risk screened women without comorbidities, respectively. Screening women at older ages (80 and 85 years old) and high comorbidity levels led to fewer breast cancer deaths and a higher percentage of overdiagnoses. Conclusions: Simulation models show that continuing screening in women ≥ 75 years old results in fewer breast cancer deaths but more false positive tests and overdiagnoses. Together, clinicians and 75 + women may use model output to weigh the benefits and harms of continued screening. [ABSTRACT FROM AUTHOR]
Published: 2024
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23. Analyse zur Häufigkeit einer gerinnungshemmenden Medikation bei Patientinnen mit kognitiven Störungen und zerebraler Amyloidangiopathie (CAA).

Author: Haußmann, R., Homeyer, P., Haußmann, M., Sauer, C., Linn, J., Donix, M., Brandt, M., and Puetz, V.
Subjects: BLOOD platelet aggregation, ANTICOAGULANTS, HEMORRHAGE
Abstract: Copyright of Der Nervenarzt is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2024
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24. A Godunov-type stabilization scheme for the Boltzmann transport equation of III-V devices with a 3D k-space.

Author: Leenders, Hendrik, Luckner, Paul, Linn, Tobias, and Jungemann, Christoph
Abstract: This paper presents a deterministic approach for solving the Boltzmann transport equation (BTE) together with the Poisson equation (PE) for III-V semiconductor devices with a three-dimensional k -space. The BTE is stabilized using Godunov's scheme, whose linearity in the distribution function simplifies the application of the Newton–Raphson method to the coupled discrete BTE and PE. The formulation of the discrete equations ensures the nonnegativity of the distribution function regardless of the scattering rate, which can include the Pauli exclusion principle, and exhibits excellent numerical stability under steady state as well as transient conditions. In the latter case, both implicit and explicit time integration methods can be used and even slow processes (e.g., recombination) can be handled using this approach. In addition, the direct solution of the BTE can be easily extended to the small-signal case for arbitrary frequencies. Exemplary BTE results are shown for a GaAs N + NN + -structure, revealing, inter alia, that the approximations of the drift-diffusion model can fail for large built-in fields in III-V devices. [ABSTRACT FROM AUTHOR]
Published: 2024
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25. Intra- and inter-individual cognitive variability in schizophrenia and bipolar spectrum disorder: an investigation across multiple cognitive domains.

Author: Haatveit, Beathe, Westlye, Lars T., Vaskinn, Anja, Flaaten, Camilla Bärthel, Mohn, Christine, Bjella, Thomas, Sæther, Linn Sofie, Sundet, Kjetil, Melle, Ingrid, Andreassen, Ole A., Alnæs, Dag, and Ueland, Torill
Published: 2023
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26. Digital mammography and digital breast tomosynthesis for detecting invasive lobular and ductal carcinoma.

Author: Onega, Tracy, Abraham, Linn, Miglioretti, Diana L., Lee, Christoph I., Henderson, Louise M., Kerlikowske, Karla, Tosteson, Anna N. A., Weaver, Donald, Sprague, Brian L., Bowles, Erin J. Aiello, and di Florio-Alexander, Roberta M.
Abstract: Purpose: Invasive lobular carcinoma (ILC) is a distinct histological subtype of breast cancer that can make early detection with mammography challenging. We compared imaging performance of digital breast tomosynthesis (DBT) to digital mammography (DM) for diagnoses of ILC, invasive ductal carcinoma (IDC), and invasive mixed carcinoma (IMC) in a screening population. Methods: We included screening exams (DM; n = 1,715,249 or DBT; n = 414,793) from 2011 to 2018 among 839,801 women in the Breast Cancer Surveillance Consortium. Examinations were followed for one year to ascertain incident ILC, IDC, or IMC. We measured cancer detection rate (CDR) and interval invasive cancer rate/1000 screening examinations for each histological subtype and stratified by breast density and modality. We calculated relative risk (RR) for DM vs. DBT using log-binomial models to adjust for the propensity of receiving DBT vs. DM. Results: Unadjusted CDR per 1000 mammograms of ILC overall was 0.33 (95%CI: 0.30–0.36) for DM; 0.45 (95%CI: 0.39–0.52) for DBT, and for women with dense breasts- 0.33 (95%CI: 0.29–0.37) for DM and 0.54 (95%CI: 0.43–0.66) for DBT. Similar results were noted for IDC and IMC. Adjusted models showed a significantly increased RR for cancer detection with DBT compared to DM among women with dense breasts for all three histologies (RR; 95%CI: ILC 1.53; 1.09–2.14, IDC 1.21; 1.02–1.44, IMC 1.76; 1.30–2.38), but no significant increase among women with non-dense breasts. Conclusion: DBT was associated with higher CDR for ILC, IDC, and IMC for women with dense breasts. Early detection of ILC with DBT may improve outcomes for this distinct clinical entity. [ABSTRACT FROM AUTHOR]
Published: 2023
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27. Effect of dissolved iron (II) and temperature on growth of the Southern Ocean phytoplankton species Fragilariopsis cylindrus and Phaeocystis antarctica.

Author: Aflenzer, Helene, Hoffmann, Linn, Holmes, Thomas, Wuttig, Kathrin, Genovese, Cristina, and Bowie, Andrew Ross
Subjects: IRON, PRIMARY productivity (Biology), TERRITORIAL waters, PHYTOPLANKTON, SEAWATER, CARBON sequestration, OCEAN
Abstract: Low bioavailability of the vital element iron (Fe) limits primary production in large regions of the Southern Ocean, thus impacting phytoplankton community structures. Primary productivity seems to be particularly sensitive to the reduced form of iron (Fe(II)), which is thought to be the most readily bioavailable redox form of Fe in the ocean. Here, we investigated the impact of temperature (3 °C, 5 °C and 7 °C) and Fe(II) additions (+ 5 nM) on growth of two Southern Ocean phytoplankton species Fragilariopsis cylindrus and Phaeocystis antarctica in coastal and open ocean water. At all tested temperatures, growth rates of P. antarctica were significantly higher with added iron, compared to the treatments without added iron in both waters. Temperature only had a significant effect on the growth rate of this species when it was raised to 7 °C in all treatments. For F. cylindrus, growth rates only significantly increased with iron addition at 7 °C in both water types. Temperature did not affect the growth rate of F. cylindrus except for a significant reduction without iron addition at 7 °C in coastal water. These results highlight the complex interactions between Fe bioavailability and temperature on Southern Ocean phytoplankton growth. Thus, certain Southern Ocean phytoplankton species may have higher growth rates in regions of the ocean that will warm the most and possibly experience greater Fe supply under future climate conditions, such as coastal regions. This may result in changes in phytoplankton community structures with implications for carbon sequestration efficiency under future climate conditions. [ABSTRACT FROM AUTHOR]
Published: 2023
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28. Maternal prenatal cholesterol levels predict offspring weight trajectories during childhood in the Norwegian Mother, Father and Child Cohort Study

Author: Øyri, L. K. (Linn K. L.), Christensen, J. J. (Jacob J.), Sebert, S. (Sylvain), Thoresen, M. (Magne), Michelsen, T. M. (Trond M.), Ulven, S. M. (Stine M.), Brekke, H. K. (Hilde K.), Retterstøl, K. (Kjetil), Brantsæter, A. L. (Anne Lise), Magnus, P. (Per), Bogsrud, M. P. (Martin P.), Holven, K. B. (Kirsten B.), Øyri, L. K. (Linn K. L.), Christensen, J. J. (Jacob J.), Sebert, S. (Sylvain), Thoresen, M. (Magne), Michelsen, T. M. (Trond M.), Ulven, S. M. (Stine M.), Brekke, H. K. (Hilde K.), Retterstøl, K. (Kjetil), Brantsæter, A. L. (Anne Lise), Magnus, P. (Per), Bogsrud, M. P. (Martin P.), and Holven, K. B. (Kirsten B.)
Abstract: Background: Numerous intrauterine factors may affect the offspring’s growth during childhood. We aimed to explore if maternal and paternal prenatal lipid, apolipoprotein (apo)B and apoA1 levels are associated with offspring weight, length, and body mass index from 6 weeks to eight years of age. This has previously been studied to a limited extent. Methods: This parental negative control study is based on the Norwegian Mother, Father and Child Cohort Study and uses data from the Medical Birth Registry of Norway. We included 713 mothers and fathers with or without self-reported hypercholesterolemia and their offspring. Seven parental metabolites were measured by nuclear magnetic resonance spectroscopy, and offspring weight and length were measured at 12 time points. Data were analyzed by linear spline mixed models, and the results are presented as the interaction between parental metabolite levels and offspring spline (age). Results: Higher maternal total cholesterol (TC) level was associated with a larger increase in offspring body weight up to 8 years of age (0.03 ≤ Pinteraction ≤ 0.04). Paternal TC level was not associated with change in offspring body weight (0.17 ≤ Pinteraction ≤ 0.25). Higher maternal high-density lipoprotein cholesterol (HDL-C) and apoA1 levels were associated with a lower increase in offspring body weight up to 8 years of age (0.001 ≤ Pinteraction ≤ 0.005). Higher paternal HDL-C and apoA1 levels were associated with a lower increase in offspring body weight up to 5 years of age but a larger increase in offspring body weight from 5 to 8 years of age (0.01 ≤ Pinteraction ≤ 0.03). Parental metabolites were not associated with change in offspring height or body mass index up to 8 years of age (0.07 ≤ Pinteraction ≤ 0.99). Conclusions: Maternal compared to paternal TC, HDL-C, and apoA1 levels were more strongly and consistently associated with offspring body weight during childhood, supporting a direct intrauterine effect.
Published: 2023

29. Next generation pan-cancer blood proteome profiling using proximity extension assay

Author: Alvez, Maria Bueno, Edfors, Fredrik, von Feilitzen, Kalle, Zwahlen, Martin, Mardinoglu, Adil, peedq227, Per-Henrik D, Sjöblom, Tobias, Lundin, Emma, Rameika, Natallia, Enblad, Gunilla, Lindman, Henrik, Höglund, Martin, Hesselager, Göran, Stålberg, Karin, Enblad, Malin, Simonson, Oscar, Häggman, Michael, Axelsson, Tomas, Åberg, Mikael, Nordlund, Jessica, Zhong, Wen, Karlsson, Max, Gyllensten, Ulf B., Ponten, Fredrik, Fagerberg, Linn, Uhlen, Mathias, Alvez, Maria Bueno, Edfors, Fredrik, von Feilitzen, Kalle, Zwahlen, Martin, Mardinoglu, Adil, peedq227, Per-Henrik D, Sjöblom, Tobias, Lundin, Emma, Rameika, Natallia, Enblad, Gunilla, Lindman, Henrik, Höglund, Martin, Hesselager, Göran, Stålberg, Karin, Enblad, Malin, Simonson, Oscar, Häggman, Michael, Axelsson, Tomas, Åberg, Mikael, Nordlund, Jessica, Zhong, Wen, Karlsson, Max, Gyllensten, Ulf B., Ponten, Fredrik, Fagerberg, Linn, and Uhlen, Mathias
Abstract: Comprehensive and scalable proteomic profiling of plasma samples can improve the screening and diagnosis of cancer patients. Here, the authors use the Olink Proximity Extension Assay technology to characterise the plasma proteomes of 1477 patients across twelve cancer types, and use machine learning to obtain a protein panel for cancer classification. A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding of the disease etiology, resulting in earlier diagnosis, risk stratification and better monitoring of the different cancer subtypes. Here, we describe the use of next generation protein profiling to explore the proteome signature in blood across patients representing many of the major cancer types. Plasma profiles of 1463 proteins from more than 1400 cancer patients are measured in minute amounts of blood collected at the time of diagnosis and before treatment. An open access Disease Blood Atlas resource allows the exploration of the individual protein profiles in blood collected from the individual cancer patients. We also present studies in which classification models based on machine learning have been used for the identification of a set of proteins associated with each of the analyzed cancers. The implication for cancer precision medicine of next generation plasma profiling is discussed.
Published: 2023
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30. Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation

Author: Jin, Han, Zhang, Cheng, Zwahlen, Martin, von Feilitzen, Kalle, Karlsson, Max, Shi, Mengnan, Yuan, Meng, Song, Xiya, Li, Xiangyu, Yang, Hong, Turkez, Hasan, Fagerberg, Linn, Uhlén, Mathias, Mardinoglu, Adil, Jin, Han, Zhang, Cheng, Zwahlen, Martin, von Feilitzen, Kalle, Karlsson, Max, Shi, Mengnan, Yuan, Meng, Song, Xiya, Li, Xiangyu, Yang, Hong, Turkez, Hasan, Fagerberg, Linn, Uhlén, Mathias, and Mardinoglu, Adil
Abstract: Cell lines are valuable resources as model for human biology and translational medicine. It is thus important to explore the concordance between the expression in various cell lines vis-à-vis human native and disease tissues. In this study, we investigate the expression of all human protein-coding genes in more than 1,000 human cell lines representing 27 cancer types by a genome-wide transcriptomics analysis. The cell line gene expression is compared with the corresponding profiles in various tissues, organs, single-cell types and cancers. Here, we present the expression for each cell line and give guidance for the most appropriate cell line for a given experimental study. In addition, we explore the cancer-related pathway and cytokine activity of the cell lines to aid human biology studies and drug development projects. All data are presented in an open access cell line section of the Human Protein Atlas to facilitate the exploration of all human protein-coding genes across these cell lines., QC 20230913
Published: 2023
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31. The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern

Author: Zhong, Wen, Danielsson, Hanna, Brusselaers, Nele, Wackernagel, Dirk, Sjobom, Ulrika, Savman, Karin, Hansen Pupp, Ingrid, Ley, David, Nilsson, Anders K., Fagerberg, Linn, Uhlén, Mathias, Hellström, Ann, Zhong, Wen, Danielsson, Hanna, Brusselaers, Nele, Wackernagel, Dirk, Sjobom, Ulrika, Savman, Karin, Hansen Pupp, Ingrid, Ley, David, Nilsson, Anders K., Fagerberg, Linn, Uhlén, Mathias, and Hellström, Ann
Abstract: Background Preterm birth is the leading cause of neonatal mortality and morbidity. Early diagnosis and interventions are critical to improving the clinical outcomes of extremely premature infants. Blood protein profiling during the first months of life in preterm infants can shed light on the role of early extrauterine development and provide an increased understanding of maturation after extremely preterm birth and the underlying mechanisms of prematurity-related disorders. Methods We have investigated the blood protein profiles during the first months of life in preterm infants on the role of early extrauterine development. The blood protein levels were analyzed using next generation blood profiling on 1335 serum samples, collected longitudinally at nine time points from birth to full-term from 182 extremely preterm infants. Results The protein analysis reveals evident predestined serum evolution patterns common for all included infants. The majority of the variations in blood protein expression are associated with the postnatal age of the preterm infants rather than any other factors. There is a uniform protein pattern on postnatal day 1 and after 30 weeks postmenstrual age (PMA), independent of gestational age (GA). However, during the first month of life, GA had a significant impact on protein variability. Conclusions The unified pattern of protein development for all included infants suggests an age-dependent stereotypic development of blood proteins after birth. This knowledge should be considered in neonatal settings and might alter the clinical approach within neonatology, where PMA is today the most dominant age variable. Plain language summary Being born too early can affect a baby's health. We looked at how babies born extremely preterm, meaning more than 12 weeks earlier than a full-term baby, develop. We looked at the proteins present in their blood from the day they were born until their original due date. Our study of 182 extremely preterm babies bor, QC 20230824
Published: 2023
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32. Characterization of the pathogenic α-Synuclein Variant V15A in Parkinson´s disease.

Author: Diaw, Sokhna Haissatou, Borsche, Max, Streubel-Gallasch, Linn, Dulovic-Mahlow, Marija, Hermes, Julia, Lenz, Insa, Seibler, Philip, Klein, Christine, Brüggemann, Norbert, Vos, Melissa, and Lohmann, Katja
Published: 2023
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33. Laparoscopic rectal cancer resection yields comparable clinical and oncological results with shorter hospital stay compared to open access: a 5-year national cohort.

Author: Myrseth, Elisabeth, Gjessing, Petter Fosse, Nymo, Linn Såve, Kørner, Hartwig, Kvaløy, Jan Terje, and Norderval, Stig
Subjects: RECTAL cancer, ONCOLOGIC surgery, LYMPHADENECTOMY, GASTROINTESTINAL surgery, SURGICAL margin
Abstract: Purpose: Although widely applied, the results following laparoscopic rectal resection (LRR) compared to open rectal resection (ORR) are still debated. The aim of this study was to assess clinical short- and long-term results as well as oncological resection quality following LRR or ORR for cancer in a 5-year national cohort. Methods: Data from the Norwegian Registry for Gastrointestinal Surgery and the Norwegian Colorectal Cancer Registry were retrieved from January 2014 to December 2018 for patients who underwent elective resection for rectal cancer. Primary end point was 5-year overall survival. Secondary end points were local recurrence rates within 5 years, oncological resection quality, and short-term outcome measures. Results: A total of 1796 patients were included, of whom 1284 had undergone LRR and 512 ORR. There was no difference in 5-year survival rates between the groups after adjusting for relevant covariates with Cox regression analyses. Crude 5-year survival was 77.1% following LRR compared to 74.8% following ORR (p = 0.015). The 5-year local recurrence rates were 3.1% following LRR and 4.1% following ORR (p = 0.249). Length of hospital stay was median 8.0 days (quartiles 7.0–13.0) after ORR compared to 6.0 (quartiles 4.0–8.0) days after LRR. After adjusting for relevant covariates, estimated additional length of stay after ORR was 3.1 days (p < 0.001, 95% CI 2.3–3.9). Rates of positive resection margins and number of harvested lymph nodes were similar. There were no other significant differences in short-term outcomes between the groups. Conclusion: LRR was performed with clinical and oncological outcomes similar to ORR, but with shorter hospital stay. [ABSTRACT FROM AUTHOR]
Published: 2023
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34. Volatility spillovers, structural breaks and uncertainty in technology sector markets.

Author: Arnell, Linn, Engström, Emma, Uddin, Gazi Salah, Hasan, Md. Bokhtiar, and Kang, Sang Hoon
Subjects: VOLATILITY (Securities), ECONOMIC uncertainty, STRUCTURAL break (Economics), ASSETS (Accounting)
Abstract: This study uses the dynamic conditional correlation to investigate how technology subsector stocks interact with financial assets in the face of economic and financial uncertainty. Our results suggest that structural breaks have diverse effects on financial asset connectedness and that the level of bond linkage increases when the trend breaks. We see a growing co-movement between the technology sector and major financial assets when uncertainty is considered. Overall, our findings indicate that the connectedness response varies depending on the type of uncertainty shock. [ABSTRACT FROM AUTHOR]
Published: 2023
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35. Telephonic Outreach to Engage Patients with Substance Use Disorder Post-Hospitalization During the COVID-19 Pandemic.

Author: King, Carla, Douglas, Drezzell, Avalone, Lynsey, Appleton, Noa, Linn-Walton, Rebecca, Barron, Charles, and McNeely, Jennifer
Subjects: CORONAVIRUS diseases, SUBSTANCE abuse, COUNSELING, TELEMEDICINE, ACUTE medical care
Abstract: During the initial COVID-19 surge, one public hospital in NYC updated their post-discharge outreach approach for patients with substance use disorder, as part of the CATCH (Consult for Addiction Treatment and Care in Hospitals) program. Beginning April 1, 2020, three peers and two addiction counselors attempted telephonic outreach to patients who received a CATCH consultation during hospitalization from program launch (October 7, 2019) through March 31, 2020 (n = 329). Outreach calls could include counseling, in-depth peer support, and referrals to substance use services (SUS)—a significant expansion of the services offered via outreach pre-pandemic. CATCH staff successfully reached 29.5% of patients and provided 77.6% of them with supportive counseling and referrals. Thirty percent of unsuccessful calls were due to inactive numbers, and only 8% of patients without housing were reached. Telephonic outreach established a low-barrier connection between patients and SUS that may be valuable during any period, including non-COVID times. Future interventions that address social determinants such as housing and cell phone access concomitantly with substance use should be considered by addiction consultation services to potentially reduce acute care utilization and improve health outcomes. [ABSTRACT FROM AUTHOR]
Published: 2023
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36. Bioactivity profile of dissolved organic matter and its relation to molecular composition.

Author: Catalá, Teresa S., Speidel, Linn G., Wenzel-Storjohann, Arlette, Dittmar, Thorsten, and Tasdemir, Deniz
Published: 2023
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37. Bidirectional genetic overlap between autism spectrum disorder and cognitive traits.

Author: Hope, Sigrun, Shadrin, Alexey A., Lin, Aihua, Bahrami, Shahram, Rødevand, Linn, Frei, Oleksandr, Hübenette, Saira J., Cheng, Weiqiu, Hindley, Guy, Nag, Heidi, Ulstein, Line, Efrim-Budisteanu, Magdalena, O'Connell, Kevin, Dale, Anders M., Djurovic, Srdjan, Nærland, Terje, and Andreassen, Ole A.
Published: 2023
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38. Black carbon scavenging by low-level Arctic clouds.

Author: Zieger, Paul, Heslin-Rees, Dominic, Karlsson, Linn, Koike, Makoto, Modini, Robin, and Krejci, Radovan
Subjects: CARBON-black, SPRING, AIR masses, LOW temperatures, SEA ice, HAZE
Abstract: Black carbon (BC) from anthropogenic and natural sources has a pronounced climatic effect on the polar environment. The interaction of BC with low-level Arctic clouds, important for understanding BC deposition from the atmosphere, is studied using the first long-term observational data set of equivalent black carbon (eBC) inside and outside of clouds observed at Zeppelin Observatory, Svalbard. We show that the measured cloud residual eBC concentrations have a clear seasonal cycle with a maximum in early spring, due to the Arctic haze phenomenon, followed by cleaner summer months with very low concentrations. The scavenged fraction of eBC was positively correlated with the cloud water content and showed lower scavenged fractions at low temperatures, which may be due to mixed-phase cloud processes. A trajectory analysis revealed potential sources of eBC and the need to ensure that aerosol-cloud measurements are collocated, given the differences in air mass origin of cloudy and non-cloudy periods. Black carbon in the Arctic has pronounced climatic effects, whilst residing in the atmosphere or after being deposited. Here long-term observations of black carbon inside Arctic clouds are used to study their seasonality, sources and links to other meteorological parameters. [ABSTRACT FROM AUTHOR]
Published: 2023
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39. Embodied Learning Activities Focusing on Letter-Sound Knowledge Increase Spelling Performance in 1st Grade Children with Low and High Reading Ability.

Author: Damsgaard, Linn, Nielsen, Anne-Mette Veber, Topor, Marta Katarzyna, Hansen, Rasmus Ahmt, Jensen, Søren Kildahl, Markers, Rebekka Læssøe, Gejl, Anne Kær, Malling, Anne Sofie Bøgh, and Wienecke, Jacob
Abstract: The study aimed to investigate the effect of embodied learning on children’s literacy skills and whether the activities were particularly beneficial for children at risk for reading difficulties. We conducted a randomized controlled trial during 4 weeks for grade 1 children (n = 52, age = 7.1). Children were randomly assigned to receive regular classroom teaching (CON) or to receive teaching focusing on letter-sound couplings with the use of the body (i.e., movement-phonemes) (MOVE). Children were evaluated on letter knowledge, word reading, and spelling performance before the intervention (T1) and after the intervention (T2). A significantly improvement for MOVE compared to CON from T1 to T2 was observed in children’s ability to name letter-sounds (p < 0.001), conditional sounds (p <0.001), and for spelling performance (p = 0.002). Within CON and MOVE, children were divided into low (LP) and high performers (HP) based on word reading performance at baseline. A significantly higher improvement for LP in MOVE was observed compared to LP in CON from T1 to T2 in letter-sounds (p < 0.0001), conditional letter-sounds (p <0.0001), and for spelling performance (p = 0.037). No differences were observed between LP-MOVE and HP-MOVE. Our results demonstrate that a short intervention based on movement-phonemes increase children’s letter knowledge and spelling performance. The results also demonstrate that LP and HP have similar improvements and therefore, this type of activities are not particularly beneficial for children at risk for reading difficulties. We suggest that this teaching method could be beneficial for all school children at this age. [ABSTRACT FROM AUTHOR]
Published: 2023
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40. Gezamenlijk medicatieverspilling voorkomen.

Author: van Wijck, Frank, Dobrowolski, Linn, and Claessen, Susanne
Abstract: Copyright of Huisarts En Wetenschap is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2023
Full Text: View/download PDF

41. Role of Small Molecule Ligands in IgE-Mediated Allergy.

Author: Khatri, Kriti, O'Malley, Andrea, Linn, Christina, Kowal, Krzysztof, and Chruszcz, Maksymilian
Abstract: Purpose of Review: A significant fraction of allergens bind small molecular ligands, and many of these compounds are classified as lipids. However, in most cases, we do not know the role that is played by the ligands in the allergic sensitization or allergic effector phases. Recent Findings: More effort is dedicated toward identification of allergens' ligands. This resulted in identification of some lipidic compounds that can play active immunomodulatory roles or impact allergens' molecular and allergic properties. Summary: Four allergen families (lipocalins, NPC2, nsLTP, and PR-10) are among the best characterized in terms of their ligand-binding properties. Allergens from these four families are able to bind many chemically diverse molecules. These molecules can directly interact with human immune system and/or affect conformation and stability of allergens. While there is more data on the allergens and their small molecular ligands, we are just starting to understand their role in allergy. [ABSTRACT FROM AUTHOR]
Published: 2023
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42. A 13-year experience with biologic and biosynthetic absorbable mesh reinforced laparoscopic paraesophageal hernia repair.

Author: Amundson, Julia R., Kuchta, Kristine, Wu, Hoover, VanDruff, Vanessa N., Haggerty, Stephen P., Linn, John, and Ujiki, Michael B.
Subjects: HERNIA surgery, LAPAROSCOPIC surgery, SURGICAL meshes, OPERATIVE surgery, AGE differences, REPAIRING, SURGICAL robots
Abstract: Background: Mesh reinforced cruroplasty during laparoscopic paraesophageal hernia repair remains controversial due to wide variation in surgical technique and mesh composition. This study aims to review outcomes and rates of recurrence following laparoscopic paraesophageal hernia repair (LPEHR) with mesh reinforced cruroplasty utilizing absorbable mesh at a single institution. Methods: A retrospective review of all patients who underwent LPEHR with mesh was performed. Medical records were reviewed for patient reported, radiographic or endoscopic evidence of recurrence, defined as > 2 cm of vertical intrathoracic stomach. If no studies were available for review, patients were considered to have no recurrence. Outcomes and mesh-related complications were also reviewed. Results: Between 10/2008 and 9/2021, 473 patients underwent LPEHR with absorbable mesh; 1.3% type 2 hernias, 86.0% type 3 hernias, 12.7% type 4 hernias. Three types of mesh were used: initially biologic mesh (n = 83), then heavyweight synthetic bioabsorbable mesh (n = 261), and finally lightweight synthetic bioabsorbable mesh (n = 111). There were no significant differences in age, ASA, BMI, gender, smoking status, chronic steroid use, preoperative acid suppression, hernia type, or recurrent hernia between groups. There were no significant differences in 30-day postoperative outcomes. Reflux Symptom Index, GERD-HRQL, and Dysphagia Scores at 1- and 2-year postoperative timepoints were not significantly different. The overall recurrence rate was 16.7%, with no significant differences in recurrence rates between biologic, heavyweight or lightweight biosynthetic absorbable mesh through 2 years after surgery. A shorter median time to recurrence (10 months, p = 0.016) was seen in the lightweight group. Conclusion: LPEHR with absorbable mesh reinforced cruroplasty is feasible and safe, with equivalent patient-reported outcomes, including dysphagia, up to 2-years postop regardless of mesh choice. No significant differences in recurrence rates between biologic, heavyweight, or lightweight synthetic bioabsorbable mesh were seen up to 2 years after LPEHR. [ABSTRACT FROM AUTHOR]
Published: 2023
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43. Genome-wide analysis of anorexia nervosa and major psychiatric disorders and related traits reveals genetic overlap and identifies novel risk loci for anorexia nervosa.

Author: Bang, Lasse, Bahrami, Shahram, Hindley, Guy, Smeland, Olav B., Rødevand, Linn, Jaholkowski, Piotr P., Shadrin, Alexey, Connell, Kevin S. O', Frei, Oleksandr, Lin, Aihua, Rahman, Zillur, Cheng, Weiqiu, Parker, Nadine, Fan, Chun C., Dale, Anders M., Djurovic, Srdjan, Bulik, Cynthia M., and Andreassen, Ole A.
Published: 2023
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44. Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders.

Author: Aas, Monica, Andreassen, Ole A., Gjerstad, Johannes, Rødevand, Linn, Hjell, Gabriela, Johansen, Ingrid Torp, Lunding, Synve Hoffart, Ormerod, Monica B. E. G., Lagerverg, Trine V., Steen, Nils Eiel, Djurovic, Srdjan, and Akkouh, Ibrahim
Subjects: ADVERSE childhood experiences, MENTAL illness, CHILD sexual abuse, SCHIZOPHRENIA, AFFECT (Psychology), CHILDREN of people with mental illness
Abstract: Exposure to early life trauma increases the risk of psychopathology later in life. Here we investigated if ANK3 mRNA levels influence the relationship between childhood trauma experiences and clinical characteristics in mental disorders. A sample of 174 patients with bipolar disorder and 291 patients with schizophrenia spectrum disorder were included. Patients were diagnosed using the Structured Clinical Interview for DSM-IV, and childhood trauma was assessed using the childhood trauma questionnaire. Age at illness onset and number of psychotic and affective episodes were assessed from interview and medical records. Current depressive symptoms were measured using the calgary depression scale for schizophrenia and the inventory for depressive symptomatology. ANK3 expression was analyzed in whole blood using the Illumina HumanHT-12 v4 Expression BeadChip. Analyses were carried out with the Process adjusted for confounders. Within the total sample, patients with both high ANK3 expression and with the most severe childhood sexual abuse had more manic/hypomanic episodes and an earlier age at onset of the first episode. ANK3 mRNA levels also moderated the relationship between emotional neglect and manic/hypomanic episodes. Our results suggest that ANK3 expression levels moderate the association between specific types of childhood trauma and affective traits in mental disorders. [ABSTRACT FROM AUTHOR]
Published: 2023
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45. Pazopanib with Topotecan weekly for patients with platinum-resistant or intermediate-sensitive recurrent ovarian cancer: results of a multicentre, open label phase I/II study (TOPAZ).

Author: Chekerov, Radoslav, Arndt, Tjadina, Pietzner, Klaus, Canzler, Ulrich, Wimberger, Pauline, Strauß, Hans-Georg, Mahner, Sven, Woelber, Linn, de Gregorio, Nikolaus, Stocker, Gertraud, von Abel, Ekkehard, Neunhoeffer, Tanja, Belau, Antje Kristina, Mustea, Alexander, Yalinkaya, Isil, Braicu, Elena Ioana, Richter, Rolf, and Sehouli, Jalid
Subjects: TOPOTECAN, OVARIAN cancer, HEPATOTOXICOLOGY, PROGRESSION-free survival, DISEASE remission, LEUCOPENIA
Abstract: Purpose: Pazopanib has promising antiangiogenetic activity in solid cancers. The investigator-initiated phase I/II trial evaluated the combination of Topotecan with Pazopanib in platinum-resistant or intermediate-sensitive recurrent ovarian cancer (ROC). Methods: Patients (≥ 18 years) with first or second recurrence were enrolled in this multicentre open-label trial. Phase I analysed Topotecan 4 mg/m2 (day 1, 8, 15, ever 28 days) for six cycles to identify the maximum tolerated dose (MTD) of Pazopanib added in a dose-escalating scheme with 400 mg starting dose. The phase II analysed safety and efficacy aspects. For all patients with clinical remission a maintenance with Pazopanib until progression was allowed. This trial is registered with ClinicalTrials.gov, number NCT 01600573. Results: Between June 2012 and February 2017, 11 patients were enrolled in the phase I, and 50 patients in the phase II study. The MTD of Pazopanib was determined by 400 mg/daily. Haematological and liver toxicities determined the dose limiting toxicities (DLT) and the most common grade 3–4 adverse events: leucopenia (25%), neutropenia (22%), thrombocytopenia (19%), accumulation of cholestatic (20%) and hepatocellular damage (15%), which often caused dose modifications, but no new life-threatening events. Overall response was 16% and clinical benefit rate 68%. Median progression-free survival (PFS) was 3.5 months (95% CI 2.0—5.0). Due to early progression only 20% of the patients were able to start with maintenance treatment. Conclusion: The combination of pazopanib and weekly topotecan is feasible, resulting in a manageable haematological and liver toxicity, but despite its encouraging response rate, was not associated with a significant survival benefit. [ABSTRACT FROM AUTHOR]
Published: 2023
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46. Triangulating brain alterations in anorexia nervosa: a multimodal investigation of magnetic resonance spectroscopy, morphometry and blood-based biomarkers.

Author: Doose, Arne, Tam, Friederike I., Hellerhoff, Inger, King, Joseph A., Boehm, Ilka, Gottloeber, Kim, Wahl, Hannes, Werner, Annett, Raschke, Felix, Bartnik-Olson, Brenda, Lin, Alexander P., Akgün, Katja, Roessner, Veit, Linn, Jennifer, and Ehrlich, Stefan
Published: 2023
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47. Persistent SARS-CoV-2 PCR Positivity Despite Anti-viral Treatment in Immunodeficient Patients.

Author: Chan, Michele, Linn, Me Me Nay, O'Hagan, Thomas, Guerra-Assunção, José Afonso, Lackenby, Angie, Workman, Sarita, Dacre, Anna, Burns, Siobhan O., Breuer, Judith, Hart, Jennifer, Tadros, Susan, and Lowe, David M.
Subjects: *SARS-CoV-2, *OPTIMISM, *COVID-19, *B cells, *COVID-19 treatment
Abstract: Purpose: COVID-19 infection in immunodeficient individuals can result in chronically poor health, persistent or relapsing SARS-CoV-2 PCR positivity, and long-term infectious potential. While clinical trials have demonstrated promising outcomes using anti-SARS-CoV-2 medicines in immunocompetent hosts, their ability to achieve sustained viral clearance in immunodeficient patients remains unknown. We therefore aimed to study long-term virological outcomes in patients treated at our centre. Methods: We followed up immunocompromised inpatients treated with casirivimab-imdevimab (Ronapreve) between September and December 2021, and immunocompromised patients who received sotrovimab, molnupiravir, nirmatrelvir/ritonavir (Paxlovid), or no treatment from December 2021 to March 2022. Nasopharyngeal swab and sputum samples were obtained either in hospital or in the community until sustained viral clearance, defined as 3 consecutive negative PCR samples, was achieved. Positive samples were sequenced and analysed for mutations of interest. Results: We observed sustained viral clearance in 71 of 103 patients, none of whom died. Of the 32/103 patients where sustained clearance was not confirmed, 6 died (between 2 and 34 days from treatment). Notably, we observed 25 cases of sputum positivity despite negative nasopharyngeal swab samples, as well as recurrence of SARS-CoV-2 positivity following a negative sample in 12 cases. Patients were then divided into those who cleared within 28 days and those with PCR positivity beyond 28 days. We noted lower B cell counts in the group with persistent PCR positivity (mean (SD) 0.06 (0.10) ×109/L vs 0.22 (0.28) ×109/L, p = 0.015) as well as lower IgA (median (IQR) 0.00 (0.00–0.15) g/L vs 0.40 (0.00–0.95) g/L, p = 0.001) and IgM (median (IQR) 0.05 (0.00–0.28) g/L vs 0.35 (0.10–1.10) g/L, p = 0.005). No differences were seen in CD4+ or CD8+ T cell counts. Antiviral treatment did not impact risk of persistent PCR positivity. Conclusion: Persistent SARS-CoV-2 PCR positivity is common among immunodeficient individuals, especially those with antibody deficiencies, regardless of anti-viral treatment. Peripheral B cell count and serum IgA and IgM levels are predictors of viral persistence. [ABSTRACT FROM AUTHOR]
Published: 2023
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48. Inactivation of zearalenone (ZEN) and deoxynivalenol (DON) in complete feed for weaned piglets: Efficacy of ZEN hydrolase ZenA and of sodium metabisulfite (SBS) as feed additives.

Author: Dänicke, Sven, Carlson, Linn, Heymann, Ann-Katrin, Grümpel-Schlüter, Angelika, Doupovec, Barbara, Schatzmayr, Dian, Streit, Barbara, Kersten, Susanne, and Kluess, Jeannette
Abstract: Female pigs respond sensitive both to DON and ZEN with anorexia and endocrine disruption, respectively, when critical diet concentrations are exceeded. Therefore, the frequent co-contamination of feed by DON and ZEN requires their parallel inactivation. The additive ZenA hydrolyzes ZEN while SBS inactivates DON through sulfonation. Both supplements were simultaneously added (+, 2.5 g SBS and 100 U ZenA/kg) to a control diet (CON−, 0.04 mg DON and < 0.004 mg ZEN/kg; CON+, 0.03 mg DON and < 0.004 mg ZEN/kg) and a Fusarium toxin contaminated diet (FUS−, 2.57 mg DON and 0.24 mg ZEN/kg; FUS+, 2.04 mg DON and 0.24 mg ZEN/kg). The 4 diets were fed to 20 female weaned piglets each (6 kg initial body weight) for 35 days; the piglets were sacrificed thereafter for collecting samples. Supplements improved performance and modified metabolism and hematology independent of dietary DON contamination. The mechanisms behind these changes could not be clarified and require further consideration. SBS reduced DON concentration in feed by approximately 20% and to the same extent in blood plasma and urine suggesting that no further DON sulfonate formation occurred in the digestive tract before absorbing DON in the upper digestive tract or that additionally formed DON sulfonates escaped absorption. DON sulfonates were detected in feces suggesting that unabsorbed DON sulfonates reached feces and/or that unabsorbed DON was sulfonated in the hindgut. The observed reduction rate of 20% was evaluated to be insufficient for feeding practice. Galenic form of SBS added to dry feed needs to be improved to support the DON sulfonation in the proximal digestive tract.ZenA was active in the digestive tract as demonstrated by the presence of its hydrolyzed none-estrogenic reaction products hydrolyzed ZEN (HZEN) and decarboxylated and hydrolyzed ZEN (DHZEN) both in feces, systemic circulation, and urine of group FUS+ compared to group FUS−. The presence of these hydrolysis products was paralleled by a significant decrease in high-estrogenic ZEN concentrations which, in turn, was related to a decrease in relative weights of uteri and ovaries when compared to group FUS−. Thus, ZenA was proven to be effective; both in terms of biomarkers and biological effects. [ABSTRACT FROM AUTHOR]
Published: 2023
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49. Erratum to: Measurement of the top quark mass with lepton+jets final states using pp collisions at √s=13TeV

Author: Sirunyan, Albert M, Tumasyan, Armen, Escalante Del Valle, Alberto, Caputo, Claudio, Radburn-Smith, Benjamin Charles, Seo, Seon-hee, Yang, Unki, Yoo, Hwi Dong, Yu, Geum Bong, Kim, Hyunyong, Kim, Ji Hyun, Lee, Jason Sang Hun, Park, Inkyu, Choi, Young-Il, Caudron, Adrien, Hwang, Chanwook, Lee, Jongseok, Yu, Intae, Dudenas, Vytautas, Juodagalvis, Andrius, Vaitkus, Juozas, Ahmed, Ijaz, Ibrahim, Zainol Abidin, Md Ali, Mohd Adli Bin, Mohamad Idris, Faridah, David, Pieter, Wan Abdullah, Wan Ahmad Tajuddin, Yusli, Mohd Nizam, Zolkapli, Zukhaimira, Duran-Osuna, Cecilia, Castilla-Valdez, Heriberto, De La Cruz-Burelo, Eduard, Ramirez-Sanchez, Gabriel, Heredia-De La Cruz, Ivan, Rabadán-Trejo, Raúl Iraq, Lopez-Fernandez, Ricardo, De Visscher, Simon, Mejia Guisao, Jhovanny, Reyes-Almanza, Rogelio, Sánchez Hernández, Alberto, Carrillo Moreno, Salvador, Oropeza Barrera, Cristina, Vazquez Valencia, Fabiola, Eysermans, Jan, Pedraza, Isabel, Salazar Ibarguen, Humberto Antonio, Uribe Estrada, Cecilia, Delaere, Christophe, Morelos Pineda, Antonio, Krofcheck, David, Bheesette, Srinidhi, Butler, Philip H, Ahmad, Ashfaq, Ahmad, Muhammad, Hassan, Qamar, Hoorani, Hafeez R, Saddique, Asif, Shah, Mehar Ali, Delcourt, Martin, Shoaib, Muhammad, Waqas, Muhammad, Bialkowska, Helena, Bluj, Michal, Boimska, Bozena, Frueboes, Tomasz, Górski, Maciej, Kazana, Malgorzata, Nawrocki, Krzysztof, Szleper, Michal, Francois, Brieuc, Traczyk, Piotr, Zalewski, Piotr, Bunkowski, Karol, Byszuk, Adrian, Doroba, Krzysztof, Kalinowski, Artur, Konecki, Marcin, Krolikowski, Jan, Misiura, Maciej, Olszewski, Michal, Giammanco, Andrea, Pyskir, Andrzej, Walczak, Marek, Bargassa, Pedrame, Beirão Da Cruz E Silva, Cristóvão, Di Francesco, Agostino, Faccioli, Pietro, Galinhas, Bruno, Gallinaro, Michele, Hollar, Jonathan, Leonardo, Nuno, Krintiras, Georgios, Lloret Iglesias, Lara, Nemallapudi, Mythra Varun, Seixas, Joao, Strong, Giles, Toldaiev, Oleksii, Vadruccio, Daniele, Varela, Joao, Baginyan, Andrey, Golutvin, Igor, Kamenev, Alexey, Lemaitre, Vincent, Karjavine, Vladimir, Korenkov, Vladimir, Kozlov, Guennady, Lanev, Alexander, Malakhov, Alexander, Matveev, Viktor, Mitsyn, Valeri Valentinovitch, Moisenz, Petr, Palichik, Vladimir, Perelygin, Victor, Flechl, Martin, Magitteri, Alessio, Shmatov, Sergey, Smirnov, Vitaly, Trofimov, Vladimir, Yuldashev, Bekhzod S, Zarubin, Anatoli, Zhiltsov, Victor, Ivanov, Yury, Kim, Victor, Kuznetsova, Ekaterina, Levchenko, Petr, Mertens, Alexandre, Murzin, Victor, Oreshkin, Vadim, Smirnov, Igor, Sosnov, Dmitry, Sulimov, Valentin, Uvarov, Lev, Vavilov, Sergey, Vorobyev, Alexey, Andreev, Yuri, Dermenev, Alexander, Musich, Marco, Gninenko, Sergei, Golubev, Nikolai, Karneyeu, Anton, Kirsanov, Mikhail, Krasnikov, Nikolai, Pashenkov, Anatoli, Tlisov, Danila, Toropin, Alexander, Epshteyn, Vladimir, Gavrilov, Vladimir, Piotrzkowski, Krzysztof, Lychkovskaya, Natalia, Popov, Vladimir, Pozdnyakov, Ivan, Safronov, Grigory, Spiridonov, Alexander, Stepennov, Anton, Stolin, Viatcheslav, Toms, Maria, Vlasov, Evgueni, Zhokin, Alexander, Quertenmont, Loic, Aushev, Tagir, Bylinkin, Alexander, Chadeeva, Marina, Parygin, Pavel, Philippov, Dmitry, Polikarpov, Sergey, Popova, Elena, Rusinov, Vladimir, Andreev, Vladimir, Azarkin, Maksim, Saggio, Alessia, Dremin, Igor, Kirakosyan, Martin, Rusakov, Sergey V, Terkulov, Adel, Baskakov, Alexey, Belyaev, Andrey, Boos, Edouard, Bunichev, Viacheslav, Dubinin, Mikhail, Dudko, Lev, Vidal Marono, Miguel, Klyukhin, Vyacheslav, Korneeva, Natalia, Lokhtin, Igor, Miagkov, Igor, Obraztsov, Stepan, Perfilov, Maxim, Petrushanko, Sergey, Savrin, Viktor, Snigirev, Alexander, Blinov, Vladimir, Wertz, Sébastien, Shtol, Dmitry, Skovpen, Yuri, Azhgirey, Igor, Bayshev, Igor, Bitioukov, Sergei, Elumakhov, Dmitry, Godizov, Anton, Kachanov, Vassili, Kalinin, Alexey, Konstantinov, Dmitri, Zobec, Joze, Mandrik, Petr, Petrov, Vladimir, Ryutin, Roman, Sobol, Andrei, Troshin, Sergey, Tyurin, Nikolay, Uzunian, Andrey, Volkov, Alexey, Babaev, Anton, Adzic, Petar, Aldá Júnior, Walter Luiz, Cirkovic, Predrag, Devetak, Damir, Dordevic, Milos, Milosevic, Jovan, Alcaraz Maestre, Juan, Álvarez Fernández, Adrian, Bachiller, Irene, Barrio Luna, Mar, Cerrada, Marcos, Colino, Nicanor, Friedl, Markus, Alves, Fábio Lúcio, De La Cruz, Begona, Delgado Peris, Antonio, Fernandez Bedoya, Cristina, Fernández Ramos, Juan Pablo, Flix, Jose, Fouz, Maria Cruz, Gonzalez Lopez, Oscar, Goy Lopez, Silvia, Hernandez, Jose M, Josa, Maria Isabel, Alves, Gilvan, Moran, Dermot, Pérez-Calero Yzquierdo, Antonio María, Puerta Pelayo, Jesus, Redondo, Ignacio, Romero, Luciano, Senghi Soares, Mara, Triossi, Andrea, Albajar, Carmen, de Trocóniz, Jorge F, Cuevas, Javier, Brito, Lucas, Erice, Carlos, Fernandez Menendez, Javier, Folgueras, Santiago, Gonzalez Caballero, Isidro, González Fernández, Juan Rodrigo, Palencia Cortezon, Enrique, Sanchez Cruz, Sergio, Vischia, Pietro, Vizan Garcia, Jesus Manuel, Cabrillo, Iban Jose, Correia Silva, Gilson, Calderon, Alicia, Chazin Quero, Barbara, Duarte Campderros, Jordi, Fernandez, Marcos, Fernández Manteca, Pedro José, García Alonso, Andrea, Garcia-Ferrero, Juan, Gomez, Gervasio, Lopez Virto, Amparo, Marco, Jesus, Hensel, Carsten, Martinez Rivero, Celso, Martinez Ruiz del Arbol, Pablo, Matorras, Francisco, Piedra Gomez, Jonatan, Prieels, Cédric, Rodrigo, Teresa, Ruiz-Jimeno, Alberto, Scodellaro, Luca, Trevisani, Nicolò, Vila, Ivan, Moraes, Arthur, Vilar Cortabitarte, Rocio, Abbaneo, Duccio, Akgun, Bora, Auffray, Etiennette, Baillon, Paul, Ball, Austin, Barney, David, Bendavid, Joshua, Bianco, Michele, Bocci, Andrea, Pol, Maria Elena, Botta, Cristina, Camporesi, Tiziano, Cepeda, Maria, Cerminara, Gianluca, Chapon, Emilien, Chen, Yi, D'Enterria, David, Dabrowski, Anne, Daponte, Vincenzo, David Tinoco Mendes, Andre, Rebello Teles, Patricia, De Gruttola, Michele, De Roeck, Albert, Deelen, Nikkie, Dobson, Marc, Du Pree, Tristan, Dünser, Marc, Dupont, Niels, Elliott-Peisert, Anna, Everaerts, Pieter, Fallavollita, Francesco, Belchior Batista Das Chagas, Ewerton, Franzoni, Giovanni, Fulcher, Jonathan, Funk, Wolfgang, Gigi, Dominique, Gilbert, Andrew, Gill, Karl, Glege, Frank, Gulhan, Doga, Hegeman, Jeroen, Innocente, Vincenzo, Carvalho, Wagner, Jafari, Abideh, Janot, Patrick, Karacheban, Olena, Kieseler, Jan, Knünz, Valentin, Kornmayer, Andreas, Krammer, Manfred, Lange, Clemens, Lecoq, Paul, Lourenco, Carlos, Fruehwirth, Rudolf, Chinellato, Jose, Lucchini, Marco Toliman, Malgeri, Luca, Mannelli, Marcello, Martelli, Arabella, Meijers, Frans, Merlin, Jeremie Alexandre, Mersi, Stefano, Meschi, Emilio, Milenovic, Predrag, Moortgat, Filip, Coelho, Eduardo, Mulders, Martijn, Neugebauer, Hannes, Ngadiuba, Jennifer, Orfanelli, Styliani, Orsini, Luciano, Pantaleo, Felice, Pape, Luc, Perez, Emmanuel, Peruzzi, Marco, Petrilli, Achille, Melo Da Costa, Eliza, Petrucciani, Giovanni, Pfeiffer, Andreas, Pierini, Maurizio, Pitters, Florian Michael, Rabady, Dinyar, Racz, Attila, Reis, Thomas, Rolandi, Gigi, Rovere, Marco, Sakulin, Hannes, Da Silveira, Gustavo Gil, Schäfer, Christoph, Schwick, Christoph, Seidel, Markus, Selvaggi, Michele, Sharma, Archana, Silva, Pedro, Sphicas, Paraskevas, Stakia, Anna, Steggemann, Jan, Stoye, Markus, De Jesus Damiao, Dilson, Tosi, Mia, Treille, Daniel, Tsirou, Andromachi, Veckalns, Viesturs, Verweij, Marta, Zeuner, Wolfram Dietrich, Bertl, Willi, Caminada, Lea, Deiters, Konrad, Erdmann, Wolfram, Fonseca De Souza, Sandro, Horisberger, Roland, Ingram, Quentin, Kaestli, Hans-Christian, Kotlinski, Danek, Langenegger, Urs, Rohe, Tilman, Wiederkehr, Stephan Albert, Backhaus, Malte, Bäni, Lukas, Berger, Pirmin, Malbouisson, Helena, Casal, Bruno, Chernyavskaya, Nadezda, Dissertori, Günther, Dittmar, Michael, Donegà, Mauro, Dorfer, Christian, Grab, Christoph, Heidegger, Constantin, Hits, Dmitry, Hoss, Jan, Medina Jaime, Miguel, Klijnsma, Thomas, Lustermann, Werner, Marionneau, Matthieu, Meinhard, Maren Tabea, Meister, Daniel, Micheli, Francesco, Musella, Pasquale, Nessi-Tedaldi, Francesca, Pata, Joosep, Pauss, Felicitas, Melo De Almeida, Miqueias, Perrin, Gaël, Perrozzi, Luca, Quittnat, Milena, Reichmann, Michael, Ruini, Daniele, Sanz Becerra, Diego Alejandro, Schönenberger, Myriam, Shchutska, Lesya, Tavolaro, Vittorio Raoul, Theofilatos, Konstantinos, Mora Herrera, Clemencia, Vesterbacka Olsson, Minna Leonora, Wallny, Rainer, Zhu, De Hua, Aarrestad, Thea Klaeboe, Amsler, Claude, Brzhechko, Danyyl, Canelli, Maria Florencia, De Cosa, Annapaola, Del Burgo, Riccardo, Donato, Silvio, Ghete, Vasile Mihai, Mundim, Luiz, Galloni, Camilla, Hreus, Tomas, Kilminster, Benjamin, Neutelings, Izaak, Pinna, Deborah, Rauco, Giorgia, Robmann, Peter, Salerno, Daniel, Schweiger, Korbinian, Seitz, Claudia, Nogima, Helio, Takahashi, Yuta, Zucchetta, Alberto, Chang, Yu-Hsiang, Cheng, Kai-yu, Doan, Thi Hien, Jain, Shilpi, Khurana, Raman, Kuo, Chia-Ming, Lin, Willis, Pozdnyakov, Andrey, Sanchez Rosas, Luis Junior, Yu, Shin-Shan, Chang, Paoti, Chao, Yuan, Chen, Kai-Feng, Chen, Po-Hsun, Fiori, Francesco, Hou, George Wei-Shu, Hsiung, Yee, Kumar, Arun, Liu, Yueh-Feng, Santoro, Alberto, Lu, Rong-Shyang, Paganis, Efstathios, Psallidas, Andreas, Steen, Arnaud, Tsai, Jui-fa, Asavapibhop, Burin, Kovitanggoon, Kittikul, Singh, Gurpreet, Srimanobhas, Norraphat, Bat, Ayse, Sznajder, Andre, Boran, Fatma, Cerci, Salim, Damarseckin, Serdal, Demiroglu, Zuhal Seyma, Dozen, Candan, Dumanoglu, Isa, Girgis, Semiray, Gokbulut, Gul, Guler, Yalcin, Hos, Ilknur, Thiel, Mauricio, Kangal, Evrim Ersin, Kara, Ozgun, Kayis Topaksu, Aysel, Kiminsu, Ugur, Oglakci, Mehmet, Onengut, Gulsen, Ozdemir, Kadri, Sunar Cerci, Deniz, Tali, Bayram, Tok, Ufuk Guney, Tonelli Manganote, Edmilson José, Turkcapar, Semra, Zorbakir, Ibrahim Soner, Zorbilmez, Caglar, Karapinar, Guler, Ocalan, Kadir, Yalvac, Metin, Zeyrek, Mehmet, Atakisi, Ismail Okan, Gülmez, Erhan, Kaya, Mithat, Torres Da Silva De Araujo, Felipe, Kaya, Ozlem, Tekten, Sevgi, Yetkin, Elif Asli, Agaras, Merve Nazlim, Atay, Serhat, Cakir, Altan, Cankocak, Kerem, Komurcu, Yildiray, Grynyov, Boris, Levchuk, Leonid, Vilela Pereira, Antonio, Ball, Fionn, Beck, Lana, Brooke, James John, Burns, Douglas, Clement, Emyr, Cussans, David, Davignon, Olivier, Flacher, Henning, Goldstein, Joel, Heath, Greg P, Ahuja, Sudha, Heath, Helen F, Kreczko, Lukasz, Newbold, Dave M, Paramesvaran, Sudarshan, Sakuma, Tai, Seif El Nasr-storey, Sarah, Smith, Dominic, Smith, Vincent J, Bell, Ken W, Belyaev, Alexander, Hrubec, Josef, Bernardes, Cesar Augusto, Brew, Christopher, Brown, Robert M, Cieri, Davide, Cockerill, David JA, Coughlan, John A, Harder, Kristian, Harper, Sam, Linacre, Jacob, Olaiya, Emmanuel, Petyt, David, Calligaris, Luigi, Shepherd-Themistocleous, Claire, Thea, Alessandro, Tomalin, Ian R, Williams, Thomas, Womersley, William John, Auzinger, Georg, Bainbridge, Robert, Bloch, Philippe, Borg, Johan, Breeze, Shane, Tomei, Thiago, Buchmuller, Oliver, Bundock, Aaron, Casasso, Stefano, Colling, David, Corpe, Louie, Dauncey, Paul, Davies, Gavin, Della Negra, Michel, Di Maria, Riccardo, Haddad, Yacine, De Moraes Gregores, Eduardo, Hall, Geoffrey, Iles, Gregory, James, Thomas, Komm, Matthias, Lane, Rebecca, Laner, Christian, Lyons, Louis, Magnan, Anne-Marie, Malik, Sarah, Mastrolorenzo, Luca, Mercadante, Pedro G, Matsushita, Takashi, Nash, Jordan, Nikitenko, Alexander, Palladino, Vito, Pesaresi, Mark, Richards, Alexander, Rose, Andrew, Scott, Edward, Seez, Christopher, Shtipliyski, Antoni, Novaes, Sergio F, Strebler, Thomas, Summers, Sioni, Tapper, Alexander, Uchida, Kirika, Vazquez Acosta, Monica, Virdee, Tejinder, Wardle, Nicholas, Winterbottom, Daniel, Wright, Jack, Zenz, Seth Conrad, Padula, Sandra, Cole, Joanne, Hobson, Peter R, Khan, Akram, Kyberd, Paul, Morton, Alexander, Reid, Ivan, Teodorescu, Liliana, Zahid, Sema, Borzou, Ahmad, Call, Kenneth, Romero Abad, David, Dittmann, Jay, Hatakeyama, Kenichi, Liu, Hongxuan, Pastika, Nathaniel, Smith, Caleb, Bartek, Rachel, Dominguez, Aaron, Buccilli, Andrew, Cooper, Seth, Henderson, Conor, Ruiz Vargas, José Cupertino, Rumerio, Paolo, West, Christopher, Arcaro, Daniel, Avetisyan, Aram, Bose, Tulika, Gastler, Daniel, Rankin, Dylan, Richardson, Clint, Rohlf, James, Sulak, Lawrence, Aleksandrov, Aleksandar, Zou, David, Benelli, Gabriele, Cutts, David, Hadley, Mary, Hakala, John, Heintz, Ulrich, Hogan, Julie Managan, Kwok, Ka Hei Martin, Laird, Edward, Landsberg, Greg, Jeitler, Manfred, Hadjiiska, Roumyana, Lee, Jangbae, Mao, Zaixing, Narain, Meenakshi, Pazzini, Jacopo, Piperov, Stefan, Sagir, Sinan, Syarif, Rizki, Yu, David, Band, Reyer, Brainerd, Christopher, Iaydjiev, Plamen, Breedon, Richard, Burns, Dustin, Calderon De La Barca Sanchez, Manuel, Chertok, Maxwell, Conway, John, Conway, Rylan, Cox, Peter Timothy, Erbacher, Robin, Flores, Chad, Funk, Garrett, Marinov, Andrey, Ko, Winston, Lander, Richard, Mclean, Christine, Mulhearn, Michael, Pellett, Dave, Pilot, Justin, Shalhout, Shalhout, Shi, Mengyao, Smith, John, Stolp, Dustin, Misheva, Milena, Taylor, Devin, Tos, Kyle, Tripathi, Mani, Wang, Zhangqier, Zhang, Fengwangdong, Bachtis, Michail, Bravo, Cameron, Cousins, Robert, Dasgupta, Abhigyan, Florent, Alice, Rodozov, Mircho, Hauser, Jay, Ignatenko, Mikhail, Mccoll, Nickolas, Regnard, Simon, Saltzberg, David, Schnaible, Christian, Valuev, Vyacheslav, Bouvier, Elvire, Burt, Kira, Clare, Robert, Shopova, Mariana, Ellison, John Anthony, Gary, J William, Ghiasi Shirazi, Seyyed Mohammad Amin, Hanson, Gail, Karapostoli, Georgia, Kennedy, Elizabeth, Lacroix, Florent, Long, Owen Rosser, Olmedo Negrete, Manuel, Paneva, Mirena Ivova, Sultanov, Georgi, Si, Weinan, Wang, Long, Wei, Hua, Wimpenny, Stephen, Yates, Brent, Branson, James G, Cittolin, Sergio, Derdzinski, Mark, Gerosa, Raffaele, Gilbert, Dylan, Dimitrov, Anton, Hashemi, Bobak, Holzner, André, Klein, Daniel, Kole, Gouranga, Krutelyov, Vyacheslav, Letts, James, Masciovecchio, Mario, Olivito, Dominick, Padhi, Sanjay, Pieri, Marco, Litov, Leander, Sani, Matteo, Sharma, Vivek, Simon, Sean, Tadel, Matevz, Vartak, Adish, Wasserbaech, Steven, Wood, John, Würthwein, Frank, Yagil, Avraham, Zevi Della Porta, Giovanni, Pavlov, Borislav, Amin, Nick, Bhandari, Rohan, Bradmiller-Feld, John, Campagnari, Claudio, Citron, Matthew, Dishaw, Adam, Dutta, Valentina, Franco Sevilla, Manuel, Gouskos, Loukas, Heller, Ryan, Krammer, Natascha, Petkov, Peicho, Incandela, Joe, Ovcharova, Ana, Qu, Huilin, Richman, Jeffrey, Stuart, David, Suarez, Indara, Yoo, Jaehyeok, Anderson, Dustin, Bornheim, Adolf, Bunn, Julian, Fang, Wenxing, Lawhorn, Jay Mathew, Newman, Harvey B, Nguyen, Thong, Pena, Cristian, Spiropulu, Maria, Vlimant, Jean-Roch, Wilkinson, Richard, Xie, Si, Zhang, Zhicai, Zhu, Ren-Yuan, Gao, Xuyang, Andrews, Michael Benjamin, Ferguson, Thomas, Mudholkar, Tanmay, Paulini, Manfred, Russ, James, Sun, Menglei, Vogel, Helmut, Vorobiev, Igor, Weinberg, Marc, Cumalat, John Perry, Yuan, Li, Ford, William T, Jensen, Frank, Johnson, Andrew, Krohn, Michael, 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Jim, Harris, Robert M, Hasegawa, Satoshi, Chen, Ye, Hirschauer, James, Hu, Zhen, Jayatilaka, Bodhitha, Jindariani, Sergo, Johnson, Marvin, Joshi, Umesh, Klima, Boaz, Kortelainen, Matti J, Kreis, Benjamin, Lammel, Stephan, Krätschmer, Ilse, Jiang, Chun-Hua, Lincoln, Don, Lipton, Ron, Liu, Miaoyuan, Liu, Tiehui, Lopes De Sá, Rafael, Lykken, Joseph, Maeshima, Kaori, Magini, Nicolo, Marraffino, John Michael, Mason, David, Leggat, Duncan, McBride, Patricia, Merkel, Petra, Mrenna, Stephen, Nahn, Steve, O'Dell, Vivian, Pedro, Kevin, Prokofyev, Oleg, Rakness, Gregory, Ristori, Luciano, Savoy-Navarro, Aurore, Liao, Hongbo, Schneider, Basil, Sexton-Kennedy, Elizabeth, Soha, Aron, Spalding, William J, Spiegel, Leonard, Stoynev, Stoyan, Strait, James, Strobbe, Nadja, Taylor, Lucas, Tkaczyk, Slawek, Liu, Zhenan, Tran, Nhan Viet, Uplegger, Lorenzo, Vaandering, Eric Wayne, Vernieri, Caterina, Verzocchi, Marco, Vidal, Richard, Wang, Michael, Weber, Hannsjoerg Artur, Whitbeck, Andrew, Wu, Weimin, 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Kravchenko, Ilya, Carrillo Montoya, Camilo Andres, Monroy, Jose, Siado, Joaquin Emilo, Snow, Gregory R, Stieger, Benjamin, Godshalk, Andrew, Harrington, Charles, Iashvili, Ia, Nguyen, Duong, Parker, Ashley, Rappoccio, Salvatore, Chaparro Sierra, Luisa Fernanda, Roozbahani, Bahareh, Alverson, George, Barberis, Emanuela, Freer, Chad, Hortiangtham, Apichart, Massironi, Andrea, Morse, David Michael, Orimoto, Toyoko, Teixeira De Lima, Rafael, Wamorkar, Tanvi, Florez, Carlos, Wang, Bingran, Wisecarver, Andrew, Wood, Darien, Bhattacharya, Saptaparna, Charaf, Otman, Hahn, Kristan Allan, Mucia, Nicholas, Odell, Nathaniel, Schmitt, Michael Henry, Sung, Kevin, González Hernández, Carlos Felipe, Trovato, Marco, Velasco, Mayda, Bucci, Rachael, Dev, Nabarun, Hildreth, Michael, Hurtado Anampa, Kenyi, Jessop, Colin, Karmgard, Daniel John, Kellams, Nathan, Lannon, Kevin, Segura Delgado, Manuel Alejandro, Li, Wenzhao, Loukas, Nikitas, Marinelli, Nancy, Meng, Fanbo, Mueller, Charles, Musienko, Yuri, 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Roy, Nash, Kevin, Osherson, Marc, Saka, Halil, Salur, Sevil, Schnetzer, Steve, Sheffield, David, Somalwar, Sunil, Stone, Robert, Thomas, Scott, Starodumov, Andrei, Thomassen, Peter, Walker, Matthew, Delannoy, Andrés G, Heideman, Joseph, Riley, Grant, Rose, Keith, Spanier, Stefan, Thapa, Krishna, Bouhali, Othmane, Castaneda Hernandez, Alfredo, Susa, Tatjana, Celik, Ali, Dalchenko, Mykhailo, De Mattia, Marco, Delgado, Andrea, Dildick, Sven, Eusebi, Ricardo, Gilmore, Jason, Huang, Tao, Kamon, Teruki, Mueller, Ryan, Ather, Mohsan Waseem, Pakhotin, Yuriy, Patel, Rishi, Perloff, Alexx, Perniè, Luca, Rathjens, Denis, Safonov, Alexei, Tatarinov, Aysen, Akchurin, Nural, Damgov, Jordan, De Guio, Federico, Attikis, Alexandros, Dudero, Phillip Russell, Faulkner, James, Gurpinar, Emine, Kunori, Shuichi, Lamichhane, Kamal, Lee, Sung Won, Mengke, Tielige, Muthumuni, Samila, Peltola, Timo, Undleeb, Sonaina, Mavromanolakis, Georgios, Volobouev, Igor, Wang, Zhixing, Greene, Senta, Gurrola, Alfredo, 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Miroslav, Finger Jr, Michael, Carrera Jarrin, Edgar, Mahmoud, Mohammed, Mohamed, Amr, Salama, Elsayed, Bhowmik, Sandeep, Dewanjee, Ram Krishna, Kadastik, Mario, Schieck, Jochen, Perrini, Lucia, Raidal, Martti, Veelken, Christian, Eerola, Paula, Kirschenmann, Henning, Pekkanen, Juska, Voutilainen, Mikko, Havukainen, Joona, Heikkilä, Jaana Kristiina, Jarvinen, Terhi, Schöfbeck, Robert, Karimäki, Veikko, Kinnunen, Ritva, Lampén, Tapio, Lassila-Perini, Kati, Laurila, Santeri, Lehti, Sami, Lindén, Tomas, Luukka, Panja-Riina, Mäenpää, Teppo, Siikonen, Hannu, Spanring, Markus, Tuominen, Eija, Tuominiemi, Jorma, Tuuva, Tuure, Besancon, Marc, Couderc, Fabrice, Dejardin, Marc, Denegri, Daniel, Faure, Jean-Louis, Ferri, Federico, Ganjour, Serguei, Spitzbart, Daniel, Ghosh, Saranya, Givernaud, Alain, Gras, Philippe, Hamel de Monchenault, Gautier, Jarry, Patrick, Leloup, Clément, Locci, Elizabeth, Machet, Martina, Malcles, Julie, Negro, Giulia, Taurok, Anton, Rander, John, Rosowsky, André, Sahin, Mehmet Özgür, Titov, Maksym, Abdulsalam, Abdulla, Amendola, Chiara, Antropov, Iurii, Baffioni, Stephanie, Beaudette, Florian, Busson, Philippe, Waltenberger, Wolfgang, Cadamuro, Luca, Charlot, Claude, Granier de Cassagnac, Raphael, Jo, Mihee, Kucher, Inna, Lisniak, Stanislav, Lobanov, Artur, Martin Blanco, Javier, Nguyen, Matthew, Ochando, Christophe, Ambrogi, Federico, Wittmann, Johannes, Ortona, Giacomo, Paganini, Pascal, Pigard, Philipp, Salerno, Roberto, Sauvan, Jean-Baptiste, Sirois, Yves, Stahl Leiton, Andre Govinda, Yilmaz, Yetkin, Zabi, Alexandre, Zghiche, Amina, Wulz, Claudia-Elisabeth, Agram, Jean-Laurent, Andrea, Jeremy, Bloch, Daniel, Brom, Jean-Marie, Chabert, Eric Christian, Collard, Caroline, Conte, Eric, Coubez, Xavier, Drouhin, Frédéric, Fontaine, Jean-Charles, Zarucki, Mateusz, Gelé, Denis, Goerlach, Ulrich, Jansová, Markéta, Juillot, Pierre, Le Bihan, Anne-Catherine, Tonon, Nicolas, Van Hove, Pierre, Gadrat, Sébastien, Beauceron, Stephanie, Bernet, Colin, Chekhovsky, 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Luyando, Juan Manuel, Van Mechelen, Pierre, Grohsjean, Alexander, Gunnellini, Paolo, Guthoff, Moritz, Harb, Ali, Hauk, Johannes, Jung, Hannes, Kasemann, Matthias, Keaveney, James, Kleinwort, Claus, Knolle, Joscha, Van Remortel, Nick, Korol, Ievgen, Krücker, Dirk, Lange, Wolfgang, Lelek, Aleksandra, Lenz, Teresa, Lipka, Katerina, Lohmann, Wolfgang, Mankel, Rainer, Melzer-Pellmann, Isabell-Alissandra, Meyer, Andreas Bernhard, Abu Zeid, Shimaa, Meyer, Mareike, Missiroli, Marino, Mittag, Gregor, Mnich, Joachim, Mussgiller, Andreas, Pflitsch, Svenja Karen, Pitzl, Daniel, Raspereza, Alexei, Savitskyi, Mykola, Saxena, Pooja, Blekman, Freya, Schwanenberger, Christian, Shevchenko, Rostyslav, Singh, Akshansh, Stefaniuk, Nazar, Tholen, Heiner, Van Onsem, Gerrit Patrick, Walsh, Roberval, Wen, Yiwen, Wichmann, Katarzyna, Wissing, Christoph, D'Hondt, Jorgen, Zenaiev, Oleksandr, Aggleton, Robin, Bein, Samuel, Blobel, Volker, Centis Vignali, Matteo, Dreyer, Torben, Garbers, Christoph, Garutti, Erika, 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Stefan Michael, Husemann, Ulrich, Kassel, Florian, Lowette, Steven, Kudella, Simon, Mildner, Hannes, Mozer, Matthias Ulrich, Plagge, Michael, Quast, Gunter, Rabbertz, Klaus, Schröder, Matthias, Shvetsov, Ivan, Sieber, Georg, Marchesini, Ivan, Simonis, Hans-Jürgen, Ulrich, Ralf, Wayand, Stefan, Weber, Marc, Weiler, Thomas, Williamson, Shawn, Wöhrmann, Clemens, Wolf, Roger, Anagnostou, Georgios, Daskalakis, Georgios, Moortgat, Seth, Geralis, Theodoros, Kyriakis, Aristotelis, Loukas, Demetrios, Topsis-Giotis, Iasonas, Karathanasis, George, Kesisoglou, Stilianos, Panagiotou, Apostolos, Saoulidou, Niki, Tziaferi, Eirini, Kousouris, Konstantinos, Moreels, Lieselotte, Papakrivopoulos, Ioannis, Evangelou, Ioannis, Foudas, Costas, Gianneios, Paraskevas, Katsoulis, Panagiotis, Kokkas, Panagiotis, Mallios, Stavros, Manthos, Nikolaos, Papadopoulos, Ioannis, Paradas, Evangelos, Python, Quentin, Strologas, John, Triantis, Frixos A, Tsitsonis, Dimitrios, Csanad, Mate, Filipovic, Nicolas, Pasztor, Gabriella, Surányi, Olivér, Veres, Gabor Istvan, Bencze, Gyorgy, Hajdu, Csaba, Skovpen, Kirill, Horvath, Dezso, Hunyadi, Ádám, Sikler, Ferenc, Vámi, Tamás Álmos, Veszpremi, Viktor, Vesztergombi, Gyorgy, Beni, Noemi, Czellar, Sandor, Karancsi, János, Makovec, Alajos, Tavernier, Stefaan, Molnar, Jozsef, Szillasi, Zoltan, Bartók, Márton, Raics, Peter, Trocsanyi, Zoltan Laszlo, Ujvari, Balazs, Choudhury, Somnath, Komaragiri, Jyothsna Rani, Bahinipati, Seema, Mal, Prolay, Brandstetter, Johannes, Van Doninck, Walter, Mandal, Koushik, Nayak, Aruna, Sahoo, Deepak Kumar, Swain, Sanjay Kumar, Bansal, Sunil, Beri, Suman Bala, Bhatnagar, Vipin, Chauhan, Sushil, Chawla, Ridhi, Dhingra, Nitish, Van Mulders, Petra, Gupta, Rajat, Kaur, Anterpreet, Kaur, Manjit, Kaur, Sandeep, Kumar, Ramandeep, Kumari, Priyanka, Lohan, Manisha, Mehta, Ankita, Sharma, Sandeep, Singh, Jasbir, Van Parijs, Isis, Walia, Genius, Bhardwaj, Ashutosh, Choudhary, Brajesh C, Garg, Rocky Bala, Keshri, Sumit, Kumar, Ajay, Kumar, Ashok, Malhotra, Shivali, Naimuddin, Md, Ranjan, Kirti, Beghin, Diego, Shah, Aashaq, Sharma, Ramkrishna, Bhardwaj, Rishika, Bhattacharya, Rajarshi, Bhattacharya, Satyaki, Bhawandeep, Bhawandeep, Bhowmik, Debabrata, Dey, Sourav, Dutt, Suneel, Dutta, Suchandra, Bilin, Bugra, Ghosh, Shamik, Majumdar, Nayana, Mondal, Kuntal, Mukhopadhyay, Supratik, Nandan, Saswati, Purohit, Arnab, Rout, Prasant Kumar, Roy, Ashim, Roy Chowdhury, Suvankar, Sarkar, Subir, Brun, Hugues, Sharan, Manoj, Singh, Bipen, Thakur, Shalini, Behera, Prafulla Kumar, Chudasama, Ruchi, Dutta, Dipanwita, Jha, Vishwajeet, Kumar, Vineet, Mohanty, Ajit Kumar, Netrakanti, Pawan Kumar, Clerbaux, Barbara, Pant, Lalit Mohan, Shukla, Prashant, Topkar, Anita, Aziz, Tariq, Dugad, Shashikant, Mahakud, Bibhuprasad, Mitra, Soureek, Mohanty, Gagan Bihari, Sur, Nairit, Sutar, Bajrang, De Lentdecker, Gilles, Banerjee, Sudeshna, Bhattacharya, Soham, Chatterjee, Suman, Das, Pallabi, Guchait, Monoranjan, Jain, Sandhya, Kumar, Sanjeev, Maity, Manas, Majumder, Gobinda, Mazumdar, Kajari, Delannoy, Hugo, Sahoo, Niladribihari, Sarkar, Tanmay, Wickramage, Nadeesha, Chauhan, Shubhanshu, Dube, Sourabh, Hegde, Vinay, Kapoor, Anshul, Kothekar, Kunal, Pandey, Shubham, Rane, Aditee, Dorney, Brian, Sharma, Seema, Chenarani, Shirin, Eskandari Tadavani, Esmaeel, Etesami, Seyed Mohsen, Khakzad, Mohsen, Mohammadi Najafabadi, Mojtaba, Naseri, Mohsen, Paktinat Mehdiabadi, Saeid, Rezaei Hosseinabadi, Ferdos, Safarzadeh, Batool, Brondolin, Erica, Fasanella, Giuseppe, Zeinali, Maryam, Felcini, Marta, Grunewald, Martin, Abbrescia, Marcello, Calabria, Cesare, Colaleo, Anna, Creanza, Donato, Cristella, Leonardo, De Filippis, Nicola, De Palma, Mauro, Favart, Laurent, Di Florio, Adriano, Errico, Filippo, Fiore, Luigi, Gelmi, Andrea, Iaselli, Giuseppe, Lezki, Samet, Maggi, Giorgio, Maggi, Marcello, Marangelli, Bartolomeo, Miniello, Giorgia, Goldouzian, Reza, My, Salvatore, Nuzzo, Salvatore, Pompili, Alexis, Pugliese, Gabriella, Radogna, Raffaella, Ranieri, Antonio, Selvaggi, Giovanna, Silvestris, Lucia, Venditti, Rosamaria, Grebenyuk, Anastasia, Verwilligen, Piet, Zito, Giuseppe, Abbiendi, Giovanni, Battilana, Carlo, Bonacorsi, Daniele, Borgonovi, Lisa, Braibant-Giacomelli, Sylvie, Brigliadori, Luca, Campanini, Renato, Capiluppi, Paolo, Kalsi, Amandeep Kaur, Castro, Andrea, Cavallo, Francesca Romana, Chhibra, Simranjit Singh, Codispoti, Giuseppe, Cuffiani, Marco, Dallavalle, Gaetano-Marco, Fabbri, Fabrizio, Fanfani, Alessandra, Fasanella, Daniele, Giacomelli, Paolo, Lenzi, Thomas, Grandi, Claudio, Guiducci, Luigi, Iemmi, Fabio, Marcellini, Stefano, Masetti, Gianni, Montanari, Alessandro, Navarria, Francesco, Perrotta, Andrea, Rovelli, Tiziano, Siroli, Gian Piero, Luetic, Jelena, Tosi, Nicolò, Albergo, Sebastiano, Costa, Salvatore, Di Mattia, Alessandro, Giordano, Ferdinando, Potenza, Renato, Tricomi, Alessia, Tuve, Cristina, Barbagli, Giuseppe, Chatterjee, Kalyanmoy, Seva, Tomislav, Ciulli, Vitaliano, Civinini, Carlo, D'Alessandro, Raffaello, Focardi, Ettore, Latino, Giuseppe, Lenzi, Piergiulio, Meschini, Marco, Paoletti, Simone, Russo, Lorenzo, Sguazzoni, Giacomo, Starling, Elizabeth, Strom, Derek, Viliani, Lorenzo, Benussi, Luigi, Bianco, Stefano, Fabbri, Franco, Piccolo, Davide, Primavera, Federica, Calvelli, Valerio, Ferro, Fabrizio, Ravera, Fabio, Vander Velde, Catherine, Robutti, Enrico, Tosi, Silvano, Benaglia, Andrea, Beschi, Andrea, Brianza, Luca, Brivio, Francesco, Ciriolo, Vincenzo, Dinardo, Mauro Emanuele, Fiorendi, Sara, Gennai, Simone, Dragicevic, Marko, Vanlaer, Pascal, Ghezzi, Alessio, Govoni, Pietro, Malberti, Martina, Malvezzi, Sandra, Manzoni, Riccardo Andrea, Menasce, Dario, Moroni, Luigi, Paganoni, Marco, Pauwels, Kristof, Pedrini, Daniele, Vannerom, David, Pigazzini, Simone, Ragazzi, Stefano, Tabarelli de Fatis, Tommaso, Buontempo, Salvatore, Cavallo, Nicola, Di Guida, Salvatore, Fabozzi, Francesco, Fienga, Francesco, Galati, Giuliana, Iorio, Alberto Orso Maria, Yonamine, Ryo, Khan, Wajid Ali, Lista, Luca, Meola, Sabino, Paolucci, Pierluigi, Sciacca, Crisostomo, Thyssen, Filip, Voevodina, Elena, Azzi, Patrizia, Bacchetta, Nicola, Benato, Lisa, Cornelis, Tom, Bisello, Dario, Boletti, Alessio, Carlin, Roberto, Checchia, Paolo, Dall'Osso, Martino, De Castro Manzano, Pablo, Dorigo, Tommaso, Dosselli, Umberto, Gasparini, Fabrizio, Gasparini, Ugo, Dobur, Didar, Gozzelino, Andrea, Lacaprara, Stefano, Lujan, Paul, Margoni, Martino, Meneguzzo, Anna Teresa, Pozzobon, Nicola, Ronchese, Paolo, Rossin, Roberto, Simonetto, Franco, Tiko, Andres, Fagot, Alexis, Torassa, Ezio, Ventura, Sandro, Zanetti, Marco, Zotto, Pierluigi, Braghieri, Alessandro, Magnani, Alice, Montagna, Paolo, Ratti, Sergio P, Re, Valerio, Ressegotti, Martina, Gul, Muhammad, Riccardi, Cristina, Salvini, Paola, Vai, Ilaria, Vitulo, Paolo, Alunni Solestizi, Luisa, Biasini, Maurizio, Bilei, Gian Mario, Cecchi, Claudia, Ciangottini, Diego, Fanò, Livio, Khvastunov, Illia, Lariccia, Paolo, Leonardi, Roberto, Manoni, Elisa, Mantovani, Giancarlo, Mariani, Valentina, Menichelli, Mauro, Rossi, Alessandro, Santocchia, Attilio, Spiga, Daniele, Androsov, Konstantin, Poyraz, Deniz, Azzurri, Paolo, Bagliesi, Giuseppe, Bianchini, Lorenzo, Boccali, Tommaso, Borrello, Laura, Castaldi, Rino, Ciocci, Maria Agnese, Dell'Orso, Roberto, Fedi, Giacomo, Giannini, Leonardo, Roskas, Christos, Giassi, Alessandro, Grippo, Maria Teresa, Ligabue, Franco, Lomtadze, Teimuraz, Manca, Elisabetta, Mandorli, Giulio, Messineo, Alberto, Palla, Fabrizio, Rizzi, Andrea, Spagnolo, Paolo, Erö, Janos, Trocino, Daniele, Tenchini, Roberto, Tonelli, Guido, Venturi, Andrea, Verdini, Piero Giorgio, Barone, Luciano, Cavallari, Francesca, Cipriani, Marco, Daci, Nadir, Del Re, Daniele, Di Marco, Emanuele, Tytgat, Michael, Diemoz, Marcella, Gelli, Simone, Longo, Egidio, Marzocchi, Badder, Meridiani, Paolo, Organtini, Giovanni, Pandolfi, Francesco, Paramatti, Riccardo, Preiato, Federico, Rahatlou, Shahram, Verbeke, Willem, Rovelli, Chiara, Santanastasio, Francesco, Amapane, Nicola, Arcidiacono, Roberta, Argiro, Stefano, Arneodo, Michele, Bartosik, Nazar, Bellan, Riccardo, Biino, Cristina, Cartiglia, Nicolo, Vermassen, Basile, Castello, Roberto, Cenna, Francesca, Costa, Marco, Covarelli, Roberto, Degano, Alessandro, Demaria, Natale, Kiani, Bilal, Mariotti, Chiara, Maselli, Silvia, Migliore, Ernesto, Vit, Martina, Monaco, Vincenzo, Monteil, Ennio, Monteno, Marco, Obertino, Maria Margherita, Pacher, Luca, Pastrone, Nadia, Pelliccioni, Mario, Pinna Angioni, Gian Luca, Romero, Alessandra, Ruspa, Marta, Zaganidis, Nicolas, Sacchi, Roberto, Shchelina, Ksenia, Sola, Valentina, Solano, Ada, Staiano, Amedeo, Belforte, Stefano, Candelise, Vieri, Casarsa, Massimo, Cossutti, Fabio, Della Ricca, Giuseppe, Bakhshiansohi, Hamed, Vazzoler, Federico, Zanetti, Anna, Kim, Dong Hee, Kim, Gui Nyun, Kim, Min Suk, Lee, Jeongeun, Lee, Sangeun, Lee, Seh Wook, Moon, Chang-Seong, Oh, Young Do, Bondu, Olivier, Sekmen, Sezen, Son, Dong-Chul, 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D, Safonov, A, Tatarinov, A, Akchurin, N, Damgov, J, De Guio, F, Dudero, PR, Faulkner, J, Gurpinar, E, Kunori, S, Lamichhane, K, Mengke, T, Muthumuni, S, Peltola, T, Undleeb, S, Volobouev, I, Greene, S, Gurrola, A, Janjam, R, Johns, W, Maguire, C, Melo, A, Ni, H, Padeken, K, Alvarez, JDR, Sheldon, P, Tuo, S, Velkovska, J, Xu, Q, Arenton, MW, Barria, P, Cox, B, Hirosky, R, Joyce, M, Ledovskoy, A, Li, H, Neu, C, Sinthuprasith, T, Wolfe, E, Xia, F, Harr, R, Karchin, PE, Poudyal, N, Sturdy, J, Thapa, P, Zaleski, S, Brodski, M, Buchanan, J, Caillol, C, Carlsmith, D, Dasu, S, Dodd, L, Duric, S, Gomber, B, Grothe, M, Herndon, M, Herve, A, Hussain, U, Klabbers, P, Lanaro, A, Levine, A, Long, K, Loveless, R, Rekovic, V, Ruggles, T, Savin, A, Smith, N, Smith, WH, and Woods, N
Subjects: perturbation theory [quantum chromodynamics], p p: scattering, Q007TP, CERN Lab, Physics and Astronomy (miscellaneous), showers [parton], top: mass: measured, 13000 GeV-cms, final state: ((n)jet lepton), 0 [higher-order], pair production [top], parton: showers, scattering [p p], ddc:530, quantum chromodynamics: perturbation theory, Engineering (miscellaneous), hadronic decay [W], W: hadronic decay, higher-order: 0, CMS, Physics, perturbation theory: higher-order, higher-order: 1, calibration, higher-order [perturbation theory], mass [W], CERN LHC Coll, kinematics, W: mass, semileptonic decay [top], mass: measured [top], Erratum, colliding beams [p p], top: pair production, p p: colliding beams, 1 [higher-order], top: semileptonic decay, ((n)jet lepton) [final state], experimental results
Abstract: The European physical journal / C 82(4), 323 (2022). doi:10.1140/epjc/s10052-022-10277-1, In this article the author name Luigi Calligaris was incorrectly written as A. Calligaris. The original article has been corrected., Published by Springer, Heidelberg
Published: 2022

50. Correction: A consensus document on definition and diagnostic criteria for orthorexia nervosa.

Author: Donini, Lorenzo M., Barrada, Juan Ramón, Barthels, Friederike, Dunn, Thomas M., Babeau, Camille, Brytek-Matera, Anna, Cena, Hellas, Cerolini, Silvia, Cho, Hye-hyun, Coimbra, Maria, Cuzzolaro, Massimo, Ferreira, Claudia, Galfano, Valeria, Grammatikopoulou, Maria G., Hallit, Souheil, Håman, Linn, Hay, Phillipa, Jimbo, Masahito, Lasson, Clotilde, and Lindgren, Eva-Carin
Abstract: This correction notice is for an article titled "A consensus document on definition and diagnostic criteria for orthorexia nervosa" published in the journal Eating & Weight Disorders. The correction adds Rebecca C. Reynolds to the list of authors. The article provides a comprehensive overview of the authors who contributed to the document. The correction has been made by the publisher, Springer Nature. [Extracted from the article]
Published: 2023
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