Search

Sustained or chronic inflammation in the placenta can result in placental insufficiency, leading to adverse reproductive outcomes such as pregnancy loss. Branched-chain amino acid transaminase 1 (BCAT1) expresses in the placenta and is involved in the pathological inflammatory response, but its role in recurrent miscarriage (RM) has not been fully investigated. In the present study, we delved into the effects of BCAT1 on trophoblast inflammation induced by lipopolysaccharide (LPS) and a mouse model of pregnancy loss induced by LPS. In vitro, after the HTR-8/SVneo cells were treated with LPS and BCATc inhibitor 2 (a selective BCAT inhibitor), the cell apoptosis was verified by TUNEL assay, and the activity of caspase-3 and caspase-9 was detected. Real-time PCR, enzyme-linked immunosorbent assay (ELISA), and immunofluorescence (IF) were used to determine the expression of inflammatory cytokines (TNF-α, IL-6, and IL-1β) and inflammasomes (NLRP3 and ASC) in LPS-treated trophoblast cells. Western blot analysis was performed to verify the expression of phospho-IκBα (p-IκBα) in cells and NF-κB p65 in the nuclei. IF staining was used to detect the nuclear translocation of NF-κB p65. The DNA binding activity of NF-κB was detected by an electrophoretic mobility shift assay (EMSA). The results demonstrated that inhibition of BCAT1 reduced trophoblast apoptosis, suppressed the release of proinflammatory cytokines, and prevented NLRP3 inflammasome activation in response to LPS. Additionally, BCAT1 inhibition blocked the activation of the NF-κB pathway in trophoblasts. This study highlights the potential therapeutic role of targeting BCAT1 in preventing adverse reproductive outcomes associated with chronic placental inflammation. [ABSTRACT FROM AUTHOR]

In recent years, the development of various hydrogel types has aimed to address concerns regarding the inefficient utilization of water and nutrients in agricultural settings. However, conflicting outcomes have emerged regarding the effectiveness of hydrogel application in agriculture and its potential negative environmental consequences. Therefore, this comprehensive review seeks to evaluate the functionality of hydrogels as water and nutrient reservoirs, while identifying potential solutions to mitigate their environmental impacts based on previous research. By synthesizing data from prior studies, this review analyzes how the performance of hydrogels may be influenced by soil pH, ionic strength, and other solution chemistry factors in the environment. Notably, this review encompasses a comprehensive assessment of the impact of the environmental matrix on hydrogel performance, which fills an important knowledge gap and provides valuable insights for future research directions and practical applications in agricultural lands. Considering sustainability concerns associated with conventional hydrogel applications, it is recommended to explore biodegradable hydrogels derived from natural materials like cellulose. These biodegradable options offer minimal negative impacts on the environment. Although studies on the economic analysis of hydrogel usage are limited, they play a significant role in identifying current obstacles and promoting the adoption of biodegradable hydrogels. Conventional hydrogels have shown greater commercial benefits, but the increasing focus on environmental concerns has driven the development of nature-based hydrogels (e.g., starch) in recent years. However, the trade-off between the relatively high cost of biodegradable hydrogels and their low environmental impacts necessitates more pilot-scale experiments and political efforts in this field. In summary, this review demonstrates that incorporating sustainable hydrogels into soils can effectively improve water and nutrient retention, ultimately enhancing crop production. These findings suggest a promising and sustainable future for hydrogel applications in agriculture, while emphasizing the need for further research, pilot studies, and concerted efforts to strike a balance between economic viability and environmental considerations. [ABSTRACT FROM AUTHOR]

Human beings exhibit varying risk-taking behaviors in response to different risk levels. Despite numerous studies on risk-taking in decision-making, the neural mechanisms of decision-making regarding risk levels remains unclear. To investigate the neural correlates of individual differences in risk-taking under different risk-levels, we analyzed behavioral data of the Balloon Analogue Risk Task (BART) and resting-state functional Magnetic Resonance Imaging (rs-fMRI) data of healthy participants (22–39 years, N = 93) from the University of California, Los Angeles Consortium for Neuropsychiatric Phenomics dataset. In the BART, the participants decided to pump for more points or stop pumping to avoid explosion of the balloons, where the risk level was manipulated by the explosion likelihood which was distinguished by the balloon color (blue for low-, red for high- risk condition). Compared with low-risk condition, the participants pumped less number, exploded more balloons, and showed more variability in pump numbers in high-risk condition, demonstrating the effective manipulation of the risky level. Next, resting state features and functional connectivity (rsFC) strength were associated with behavioral measures in low- and high-risk conditions. We found that the explosion number of balloons were correlated with the low frequency fluctuations (ALFF) in the left dorsolateral prefrontal cortex (L. DLPFC), the rsFC strength between L. DLPFC and the left anterior orbital gyrus in the low-risk condition. In the high-risk condition, we found variability in pump numbers was correlated with the ALFF in the left middle/superior frontal gyrus, the fractional ALFF (fALFF) in the medial segment of precentral gyrus (M. PrG), and the rsFC strength between the M. PrG and bilateral precentral gyrus. Our results highlighted significance of the L. DLPFC in lower risky decision making and the precentral gyrus in higher risky decision making, suggesting that distinctive neural correlates underlie the individual differences of decision-making under different risk level. [ABSTRACT FROM AUTHOR]

Purpose of Review: We summarise the physiological changes and risk factors for hypertension in females, potential sex-specific management approaches, and long-term prognosis. Key Findings: Pregnancy and menopause are two key phases of the life cycle where females undergo significant biological and physical changes, making them more prone to developing hypertension. Gestational hypertension occurs from changes in maternal cardiac output, kidney function, metabolism, or placental vasculature, with one in ten experiencing pregnancy complications such as intrauterine growth restriction and delivery complications such as premature birth. Post-menopausal hypertension occurs as the protective effects of oestrogen are reduced and the sympathetic nervous system becomes over-activated with ageing. Increasing evidence suggests that post-menopausal females with high blood pressure (BP) experience greater risk of cardiovascular events at lower BP thresholds, and greater vulnerability to treatment-related adverse effects. Summary: Hypertension is a key risk factor for cardiovascular disease in females. Current BP treatment guidelines and recommendations are similar for both sexes, without addressing sex-specific factors. Future investigations into ideal diagnostic thresholds, BP control targets and treatment regimens in females are needed. [ABSTRACT FROM AUTHOR]

Subjective well-being is an important indicator of adolescents' positive development. Although the general developmental trends of subjective well-being in adolescents have been investigated, the longitudinal differences in the developmental trajectory of subjective well-being in early adolescents remain unclear. This study aimed to explore the developmental trajectory of subjective well-being and examine the predictive roles of gender and parental involvement in this developmental trajectory among Chinese early adolescents. A longitudinal design was used with 2,483 middle students who were followed up across three time points (T1, T2 and T3). The growth mixture model (GMM) analysis showed three subgroups within the developmental trajectory of the subjective well-being of Chinese early adolescents: high-rising (53.3%), moderate-decline (39.7%) and low-decline (7.0%). Furthermore, group membership was predicted by gender, parental academic involvement and parental academic pressure. These findings suggest that it is necessary to implement normative and effective interventions for the different development trajectories of the subjective well-being of early adolescents. [ABSTRACT FROM AUTHOR]

Alismatis rhizoma is an essential medicine in clinical practice. Asian water plantain (Alisma orientale (Sam.) Juzep) is one of the original plants of Alismatis rhizoma. Previous studies have identified the optimal light intensity range for the growth and development of A. orientale, but the mechanism by which light intensity affects the accumulation of secondary metabolites of A. orientale is unknown. The aim of this study was to investigate the effect of light intensity on the accumulation of triterpenoids in A. orientale saplings and its potential molecular mechanism. The dry weight and contents of total triterpenes and indicative components (alisol B 23-acetate and alisol C 23-acetate) as well as the expression of key enzyme genes in the triterpene biosynthesis pathway under different light intensities (50–600 μmol m−2·s−1) were determined. The results showed that the accumulation of dry matter and the contents of total triterpenes, alisol B 23-acetate, and alisol C 23-acetate increase first and then decrease with increasing light intensity, with the maximum values of 31.65 g, 18.35 mg·g−1, 1.91 mg·g−1, and 0.13 mg·g−1 recorded at light intensities of 400, 200, and both of 300 μmol m−2·s−1, respectively. Light intensities of 200–400 μmol m−2·s−1 promote the expressions of key enzyme genes and the accumulation of total triterpenes significantly. Correlation analysis showed that the expression levels of key enzyme genes are significantly correlated with total triterpene and indicative component contents, and these correlations are strongest under moderate light intensities. Overall, our results reveal that a moderate light intensity of 200–400 μmol m−2·s−1 is beneficial for the growth and synthesis of protostane triterpenes in A. orientale seedlings, and that its probable mechanism involves the upregulated expression of enzymes that are key in the synthesis of triterpenoid ingredients. This study clarified the suitable light intensity range for the synthesis and accumulation of protostane triterpenes of A. orientale, which provided scientific basis for the production of high-quality superior forms of A. orientale. [ABSTRACT FROM AUTHOR]

Although loneliness and depressive symptoms are particularly prominent among migrant children and often occur simultaneously, little is known about the co-occurring and transitional nature of loneliness and depressive symptoms among migrant children, and the role of bullying victimization on their profiles and transitions. This study examined the profiles and transitions of loneliness and depressive symptoms among migrant children using latent profile analysis and latent transition analysis, as well as how bullying victimization predicted their profile memberships and transitions. A total of 692 migrant children (55.3% males, Mage = 9.41, SD = 0.55, range = 8 to 12 years old at T1) participated in both two waves of the study over six months. The results indicated that low profile (59.2%), moderate profile (22.0%), moderately high profile (14.3%), and high profile (4.5%) were identified at Time 1; low profile (69.4%), predominantly loneliness profile (16.8%), predominantly depressive symptoms profile (6.5%), and high profile (7.3%) were identified at Time 2. Migrant children in at-risk profiles displayed varying degrees of transition. Migrant children experiencing more bullying victimization were more likely to belong or transition to at-risk profiles. The findings highlight the importance of subgroup differences considerations in understanding the co-occurring and transitional nature of loneliness and depressive symptoms, as well as the predictive role of bullying victimization, informing effective strategies for prevention and intervention. [ABSTRACT FROM AUTHOR]

The reorganization of the global production network and the increased mobility of urban-rural elements have accelerated the differentiation of rural spaces, resulting in a trend towards specialization in rural areas. This paper focuses on the concept of specialization, and takes a renowned bonsai specialized village in Guangzhou City, China as a typical case to explore its transformation and development process, action logic and coupling mechanism with the social governance. The results show that: 1) the development of rural specialization in Ruiling Village is shaped by several key actors, such as local governments, grassroots organizations, villagers, social organizations, policies, markets and infrastructure. The transfer of these key actors and the reconstruction of actor-networks in different stages have an important influence on the transformation and realization of rural development goals. 2) Through subjects-driven, organization management and resource connection, social governance supports the specialization of rural industrial organization, operation, technology and mode. The governance structure shifts from decentralization to networking, refinement and integration. A coupling community of social governance and specialization is created by the social governance system of 'local government-grassroots organizations-economic cooperatives-villagers', which links industries, industrial chains and cooperatives. 3) Social governance integrates into the value chain extension process of rural specialized development with a central, multi-level organizational structure. It promotes the construction of the whole value chain through organizational planning, resource integration and image shaping, thus realizing the value, branding and organization of the industry, as well as the integration of rural sustainable development and governance mechanism. Social governance has a profound impact on the development of rural specialization in terms of subject, structure and mode, and participates in the construction of the whole value chain of rural areas. This paper provides a new perspective for understanding the coupling effect of social governance in the rural development transformation, and promotes the rural sustainable development and governance. [ABSTRACT FROM AUTHOR]

Private supplementary tutoring (PT) has expanded significantly and attracted widespread public interest in China in recent years. It deserves systematic empirical research and reflection, given its crucial theoretical and practical implications. Based on the data of a large-scale survey and testing project, this study examined its effects on the students' academic achievements in mathematics. The results revealed that PT in the current semester did not have any significant positive effect on the students' academic achievement in mathematics. This suggested that households' huge financial investment in PT failed to achieve the desired result. Accordingly, these findings imply that parents should carefully select private tutoring for their children, and the government should provide more comprehensive professional guidelines to regulate the private tutoring industry. [ABSTRACT FROM AUTHOR]

The beginning of secondary school is a critical time point of adolescents' development as they entered a new peer context in which social status was re-established. As the key indicators of social status, likability and popularity co-occur but also display distinct developmental trajectories over time. Nevertheless, little is known about the joint developmental trajectories of likability and popularity among adolescents and how identified trajectories are associated with important social behavior. The current study examined the joint developmental trajectories of likability and popularity among Chinese adolescents and their associations with social behavior (prosocial behavior, aggression, and peer victimization) over time. A total of 1509 Chinese 7th grade students (53.6% male, Mage = 13.1, SD = 0.67) participated in self-report and peer nomination assessments on three occasions at 6-month intervals. Parallel process latent growth mixture models revealed four distinct trajectories of likability and popularity: social status decreasing, average, high social status, and social status increasing. The high social status group showed the highest levels of prosocial behavior, the lowest levels of peer victimization, and higher aggression than the average group. The social status decreasing group and social status increasing group exhibited the lower prosocial behavior as well as the higher aggression and peer victimization compared to the average group over time. The findings highlight the co-occurrence but diversity of developmental patterns of likability and popularity in adolescence. [ABSTRACT FROM AUTHOR]

Fluoride-contaminated water is a major problem worldwide, and modified biochar is a promising low-cost adsorbent for fluoride removal. In this study, synthesis, optimization, and performance of Al-Fe co-modified rice-straw biochar (Fe-Al-RSBC) for fluoride removal were investigated. The Fe-Al-RSBC, containing amorphous Fe and Al oxides, efficiently adsorbed fluoride from liquid phase. The fluoride adsorption on Fe-Al-RSBC was a spontaneous process and was better fitted by the pseudo-second-order kinetic model than the first-order kinetic model. The Freundlich isotherm model better described the characteristic of fluoride adsorption than the Langmuir isotherm model. Fourier transform infrared spectra analysis showed that fluoride adsorption on Fe-Al-RSBC was mainly driven by electrostatic attraction and ion exchange. The maximum fluoride adsorption capacity of Fe-Al-RSBC reached 6.85 mg/g with a C-Fe-Al molar ratio of 1:0.25:0.75 at pH 7.0. Higher initial fluoride concentrations induced higher adsorption capacities of Fe-Al-RSBC, while the increasing pH from 6.0 to 9.0 decreased its adsorption capacity. The coexisting anions decreased fluoride adsorption capacities of the Fe-Al-RSBC following the order: PO43- > HCO3- > Cl- > SO42-. The current results suggest that Fe-Al co-modified rice straw biochar can be a promising fluoride adsorbent for remediation of the fluoride contamination in the aquatic systems. [ABSTRACT FROM AUTHOR]

Alkaline pretreatment (APT) is the promising disintegration pretreatment for the anaerobic digestion (AD) of sewage sludge (SS) to improve digestion efficiency and methane yields. In this study, the heavy metals (HMs) were observed to be leached from SS in the APT process, which could lower the HMs secondary pollution risk of the residual biosolids after AD in land application. The sequential chemical extraction (SCE) experiment was performed to determine the variation in HMs' distribution prior to and after the APT. The alkaline extracts were characterized in order to elucidate the HMs' release mechanism. The APT could cause significant release of Zn and Cu with a maximum release efficiency of 96.6% ± 4.6% and 62.7% ± 8.4% under the condition of 1.5 mol/L NaOH and 25 ℃, respectively. The release efficiency of Zn and Cu was reduced by 63.0% and 21.7%, respectively, due to the extra addition of 0.25 mol/L NaCl at a NaOH concentration of 1.25 mol/L in the APT process. The release of Zn and Cu may be attributed to a complex process including disruption of microbial cells in SS, solubilization of organic matters bounded with metals, and the chemical leaching reaction of minerals. This study demonstrates the possibility to remove the Zn and Cu from the SS in the APT process before the AD disposal. [ABSTRACT FROM AUTHOR]

The high strain rate dynamic behavior of additively manufactured (AM) 316L stainless steel (SS) is investigated, and a dynamic deformation-induced microstructural evolution is examined in this study. First, the as-built microstructure feature is characterized. The grain morphology is revealed to be location-dependent and driven by the solidification process. A steep rise in the point-to-origin misorientation profile traversing a melt pool boundary is observed, quantitatively describing the influence of process-induced interface on the initial grain orientation state. The static and dynamic mechanical properties are then examined. Compared with conventional wrought 316L SS, AM 316L SS demonstrates an enhanced mechanical strength under quasi-static compression (with a ∼ 95 % increase in yield strength). Under dynamic shearing, strain rate-induced strength enhancement is observed in wrought 316L SS (with a ∼ 47 % increase in dynamic flow stress); AM 316L SS nevertheless demonstrates nearly rate-insensitive responses in its yield stress (with a ∼ 5 % increase in dynamic flow stress). Localized deformation in the form of an adiabatic shear band and the associated structural evolution are analyzed. Radical changes in crystallographic and structural features induced by high strain rate deformation are observed. Grain deformation and rotation lead to a remarkable difference in the grain orientation and spatial direction from the starting state driven by the solidification process. Upon dynamic shearing, the transmission of localized plastic deformation across melt pools is revealed, and the indication in grain rotations is discussed. The change in the geometrically necessary dislocation density is examined, hinting at the competition of the dislocation multiplication and annihilation under localized deformation. The current work enriches the understanding of the dynamic mechanical properties of AM materials at high strain rates. [ABSTRACT FROM AUTHOR]

The presence of contaminants of emerging concern (CECs) in wastewater treatment plant effluents is a significant underlying health risk and environmental concern. CECs consist of a wide variety of contaminants, including pharmaceuticals and personal care products, hormones, steroids, alkyl-phenols, flame retardants and pesticides. Their impact is of particular relevance to agricultural settings due to CEC uptake and accumulation in food crops and consequent diffusion into the food-chain. Meanwhile, marijuana reform is accelerating in the US, based on the scope and pace of legalization efforts and on wider acceptance in polls of voters. In this review, the effectiveness of industrial hemp (Cannabis sativa L.) in phytoremediation and hyperaccumulation of organic contaminants (e.g., benzo(a)pyrene, Naphthalene, and Chrysene) and heavy metal (e.g., Selenium and Cobalt) from either aqueous solutions or contaminated soils has been reviewed. The potential of industrial hemp as a renewable resource to biodegrade and/or decontaminate CECs is explored. Disposal strategies of this new phytoremediation crop that promote circular economy are also discussed. According to this current review, we believe the use of industrial hemp for phytoremediation is promising to have a sustainable, environmentally friendly and economically viable future. [ABSTRACT FROM AUTHOR]

With rapid globalization, industrial parks are playing an increasingly important role in the national and regional development. Since the Belt and Road Initiative (BRI) was put forward, national-level overseas industrial parks of China have emerged with new development features and trends. It is of great importance to carry out a comparative study on domestic and overseas industrial parks of China. Based on the perspective of spatiotemporal evolution, this paper compares and analyzes national-level overseas industrial parks along the Belt and Road (B&R) and domestic industrial parks of China. In time, China's industrial parks have experienced four stages with distinctive state-led characteristic. There are different development paths and modes for overseas industrial parks along the B&R and domestic industrial parks. In space, the national-level overseas industrial parks are invested and constructed by Chinese enterprises (mostly from the coastal developed cities), and mainly distributed in the countries along the B&R. Through typical cases comparison of Thai-Chinese Rayong Industrial Zone and Tianjin Economic-Technological Development Area, the paper finds that national-level overseas industrial parks are basically market-driven and concentrated in traditional advantageous industries, while domestic industrial parks are mainly government-led high-tech industries. Localization of overseas industrial parks and remote coupling with domestic industrial parks become very important. [ABSTRACT FROM AUTHOR]

The increasing food demand and deteriorating climate change require improvement in current strategies for enhancing nitrogen (N) retention and mitigating nitrous oxide (N2O) emission in agricultural soils. This paper has discussed and compared the mechanisms, effects and affecting factors of major contemporary strategies, including soil amendment with biochar, biological nitrification inhibition (BNI) and applications of synthetic nitrification inhibitor (NI), urease inhibitor (UI), hydrogel and slow-/controlled-release fertilizer (SRF/CRF). Among these strategies, soil amendment with biochar seems to be the most promising, considering its demonstrated effectiveness and sustainable nature. Despite the large number of biochar-relevant studies in the recent years, the data have not been systematically utilized. A database model has been proposed in this review to link the production, properties and performance of biochar and delve into the valuable information scattered in current and future biochar studies. At the same time, the other strategies should also be continuously studied for improvement. NIs and UIs need to be more stable and lasting; hydrogels and SRFs/CRFs have to be more environmentally friendly and economically sound; BNI deserves broader investigations and its future applications can be more widespread. Future studies may also explore strategic combinations of two or more contemporary strategies. More long-term studies should be conducted to improve the evaluation of benefits and flaws of these strategies. [ABSTRACT FROM AUTHOR]

Genetically modified agricultural products have been introduced to increase food supply by enhancing their resistance to pests and diseases, along with easily adapting to environmental conditions. Due to the modification of DNA, public objections are prevalent, including concerns on the impact on the ecosystem. In this research, adsorption and transport of Cry1Ab, a toxin exuded by the transgenic Bt maize in alumino-silica clays, were evaluated in laboratory columns under steady-state flow conditions. Since Cry1Ab fate and transport were very responsive to animal waste field applications, during which humic acids were released, Cry1Ab adsorption and transport in humic acid-coated alumino-silica clays were also investigated. Cry1Ab breakthrough curves were simulated using the convection-dispersion transport models. It was discovered that the humic acid coating increased Cry1Ab deposition during the transport. Based on analysis of the breakthrough curves, adsorption isotherms of Cry1Ab in alumino-silica clays were obtained and compared with those of batch experiments. The humic acid coating changed the bonding energy between Cry1Ab and the adsorption receptor sites on alumino-silica clay surfaces, thereby changing Cry1Ab partition between the aqueous phase and the solid phase. [ABSTRACT FROM AUTHOR]