1. IL-10-producing CD4+ T cells negatively regulate fucosylation of epithelial cells in the gut.
- Author
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Goto, Yoshiyuki, Lamichhane, Aayam, Kamioka, Mariko, Sato, Shintaro, Honda, Kenya, Kunisawa, Jun, and Kiyono, Hiroshi
- Subjects
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T cells , *GLYCOSYLATION , *FUCOSYLATION , *EPITHELIAL cells , *REGENERATION (Biology) - Abstract
Fucosylated glycans on the surface of epithelial cells (ECs) regulate intestinal homeostasis by serving as attachment receptors and a nutrient source for some species of bacteria. We show here that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing CD4+ T cells. The number of fucosylated ECs was increased in the ileum of mice lacking T cells, especially those expressing αβ T cell receptor (TCR), CD4, and IL-10. No such effect was observed in mice lacking B cells. Adoptive transfer of αβTCR+ CD4+ T cells from normal mice, but not IL-10-deficient mice, normalized fucosylation of ECs. These findings suggest that IL-10-producing CD4+ T cells contribute to the maintenance of the function of ECs by regulating their fucosylation. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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