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About a fifth of the ascorbic acid is readily lost from intestinal tissue during handling procedures such as washing with saline and blotting. Further losses occur during incubation in Krebs-phosphate saline; after 10 min strips of intestine retained 80% of their original ascorbic acid content and chopped tissue only 50%. This suggests that some of the intestinal ascorbic acid is very loosely held in the tissue. The small intestine is capable of accumulating double the normal amount of ascorbic acid when animals are dosed intramuscularly and retains some ascorbic acid (0.7 to 5 µ/mg DNA) even when the animals" body stores are depleted. [ABSTRACT FROM AUTHOR]

Discusses the study on alteration in lipid metabolism produced by ethyl trichloracetate. Investigation on functions of ethyl trichloracetate in enhancing synthesis of secretion of low and very low density lipoproteins; Adverse events of ethyl trichloracetate administration; Factors affecting lipotropic action of ethyl trichloracetate.

Female rats on a diet adequate, except for pyridoxine, did not give rise to pyridoxine deficiency in their young, when extra thiamine or extra thiamine and calcium was included in the diet. A hypothesis correlating this result to the finding of Richards Is advanced. [ABSTRACT FROM AUTHOR]

In acute thiamine deficiency the increased excretion of ribofiavin occurs at the same time as loss of body weight. Animals receiving adequate amounts of thiamine, but which were losing weight through an insufficient food intake, had increased excretions of riboflavin similar to the deficient animals. In chronic thiamine deficiency there was a 25 p.c. increase in riboflavin excretion by the deficient animals when compared to litter mate controls. No significant differences could be shown in the riboflavin content of the liver from thiamine deficient animals and those receiving thiamine. [ABSTRACT FROM AUTHOR]

Cites a study conducted by researchers in Australia which examines the changes in levels of tissue nucleotides and glutathione after hyperbaric oxygen treatment. Destruction of tissue constituents by autoxidation; Factors that influenced the changes in glutathione and pyridine nucleotides; Detection of the small amounts of lipid peroxide in the erythrocytes of mice.

The results presented indicate that subcutaneous injections of ethyl trichloracetate in appropriate doses will cause a statistically significant fall in liver lipid values and statistically significant increases in liver phospholipids, of choline deficient animals. The extra phospholipids found in the liver had a similar choline content to that found in the choline deficient control livers. Assessment of the histological changes in such livers does not indicate any toxic effect of ethyl trichloracetate, nor any effect on the changes due to the amino acid imbalance of the diet used. The reduction in liver lipid found by biochemical analysis appears related to a decrease in centrolobular fat. [ABSTRACT FROM AUTHOR]