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3. Physische Belastungen bei Beschäftigten in der Personenbeförderung – Ergebnisse einer Online-Befragung.

Author

Griemsmann, Stephanie, Ecke, Christian, Koch, Matthias, Winter, Gabriele, Koch, Ulrich, Derakshani, Manigée, and Schiefer, Christoph

Subjects
ACCIDENT insurance, EMPLOYEE reviews, WORK environment, PHYSIOLOGICAL stress, PHYSICAL mobility
Abstract

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Published
2023
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6. Ultrasound in the diagnosis and differential diagnosis of enoral and plunging ranula: a detailed and comparative analysis.

Author

Koch, Michael, Mantsopoulos, Konstantinos, Leibl, Victoria, Müller, Sarina, Iro, Heinrich, and Sievert, Matti

Abstract

Purpose: To develop sonographic criteria for ranula that to allow rapid and precise diagnosis, differentiation between enoral (ER) and plunging ranula (PR), and differential diagnosis from other competing pathologies in this region. Methods: Patients who presented with or were referred with ranula between 2002 and 2022 were assessed in a retrospective study. After clinical investigation, ultrasound examinations were performed in all cases. Several sonographic parameters describing the echotexture, shape and size of ranulas, their relationship to important surrounding anatomical landmarks and the characteristic spreading pattern of ERs and PRs were elaborated and evaluated. Results: 207 ranulas were included (82.12% ERs and 17.87% PRs). The ranulas were all in close anatomical relationship to the sublingual gland (SLG) and mylohyoid muscle (MM). The echo texture was hypoechoic to anechoic in 97.6% of the lesions. In comparison with ERs, PRs were larger and irregular in shape significantly more often (P = 0.0001). There were significant differences between ERs and PRs in their exact location relative to the SLG (superficial, deep, anterior, each P = 0.0001; posterior, P = 0.03) and level of the MM (above, below, above and below, P = 0.0001 each). The exact extent and plunging pattern were depicted in all PRs, but naturally in none of the ERs. Conclusions: The ultrasound criteria developed in this study, confirming previously published results, indicate that ultrasound is an excellent diagnostic tool for diagnosing ranula and differentiating between ERs and PRs. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Tagesschläfrigkeit bei Pflegepersonal: Eine Querschnittanalyse der Daten der Hamburg City Health Study (HCHS).

Author

Koch, Peter, Damerau, Lukas, Kersten, Jan Felix, Harth, Volker, Augustin, Matthias, Nienhaus, Albert, and Terschüren, Claudia

Subjects
RESEARCH, CONFIDENCE intervals, CROSS-sectional method, SLEEP disorders, RISK assessment, SEX distribution, CHRONOTYPE, COMPARATIVE studies, HOSPITAL nursing staff, ODDS ratio, DROWSINESS, DISEASE risk factors
Abstract

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Published
2023
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9. Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial.

Author

Gasparyan, Samvel B., Buenconsejo, Joan, Kowalewski, Elaine K., Oscarsson, Jan, Bengtsson, Olof F., Esterline, Russell, Koch, Gary G., Berwanger, Otavio, and Kosiborod, Mikhail N.

Subjects
EXPERIMENTAL design, STATISTICS, VIRAL pneumonia, CARDIOVASCULAR diseases risk factors, DRUG efficacy, LENGTH of stay in hospitals, STATISTICAL power analysis, COVID-19, SAMPLE size (Statistics), RANDOMIZED controlled trials, TREATMENT effectiveness, CONCEPTUAL structures, COMPARATIVE studies, DATA analysis, DISCHARGE planning, EVALUATION
Abstract

Background/Aim: DARE-19 (NCT04350593) was a randomized trial studying the effects of dapagliflozin, an SGLT2 inhibitor, in hospitalized patients with COVID-19 pneumonia and cardiometabolic risk factors. The conduct of DARE-19 offered the opportunity to define an innovative and clinically meaningful endpoint in a new disease that would best reflect the known profile of dapagliflozin, accompanied by the statistical challenges of analysis and interpretation of such a novel endpoint. Methods: Hierarchical composite endpoints (HCEs) are based on clinical outcomes which, unlike traditional composite endpoints incorporate ranking of components according to clinical importance. Design of an HCE requires the clinical considerations specific to the therapeutic area under study and the mechanism of action of the investigational treatment. Statistical aspects for the clinical endpoints include the proper definition of the estimand as suggested by ICH E9(R1) for the precise specification of the treatment effect measured by an HCE. Results: We describe the estimand of the DARE-19 trial, where an HCE was constructed to capture the treatment effect of dapagliflozin in hospitalized patients with COVID-19, and was analyzed using a win odds. Practical aspects of designing new studies based on an HCE are described. These include sample size, power, and minimal detectable effect calculations for an HCE based on the win odds analysis, as well as handling of missing data and the clinical interpretability of the win odds in relation to the estimand. Conclusions: HCEs are flexible endpoints that can be adapted for use in different therapeutic areas, with win odds as the analysis method. DARE-19 is an example of a COVID-19 trial with an HCE as one of the primary endpoints for estimating a clinically interpretable treatment effect in the COVID-19 setting. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Arbeitsschutzwissen und Gesundheitskompetenz: Querschnittsbefragung unter Auszubildenden.

Author

Koch, Peter and Nienhaus, Albert

Abstract

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Published
2022
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11. Pollen columns and a wax canopy in a first nest description of Bombus (Cullumanobombus) morrisoni (Apidae)

Author

Koch, Jonathan Berenguer Uhuad and Cane, James H.

Abstract

In this study, we describe the first reported nest of Bombus morrisoni, a species with an extensive range in the arid Intermountain Region of the Nearctic. The mature, naturally terminated nest consisted of 424 nest cells (cocoons), with 328 non-gyne cells and 94 gyne cells. The nest also had two kinds of understudied structures associated with bumble bee nests: pollen columns and a wax canopy. We found five pollen columns rising amid the cocoons. A 0.3-mm-thick wax canopy spanned over the entire nest. An estimated 40 million pollen grains were incorporated into the 19 g wax canopy, demonstrating that B. morrisoni devotes a significant amount of pollen to this non-dietary purpose. Bombus morrisoni is a species of conservation concern due to an observed reduction in their historic distribution. The data generated in our study contributes to the much-needed comparative accounts of bumble bee nesting biology and has consequential implications in supporting management and conservation decisions. [ABSTRACT FROM AUTHOR]

Published
2022
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12. Application of Meta-analysis to Evaluate Relationships Among ARIA-E Rate, Amyloid Reduction Rate, and Clinical Cognitive Response in Amyloid Therapeutic Clinical Trials for Early Alzheimer's Disease.

Author

Wang, Deli, Kowalewski, Elaine Kearney, and Koch, Gary

Subjects
THERAPEUTIC use of monoclonal antibodies, DRUG efficacy, STATISTICS, ALZHEIMER'S disease, META-analysis, MONOCLONAL antibodies, AMYLOID beta-protein precursor, DESCRIPTIVE statistics, STATISTICAL models, LOGISTIC regression analysis, DATA analysis, DATA analysis software
Abstract

Background: Removal of the extracellular Aβ plaques in the brain is one of the mechanisms to treat Alzheimer's disease (AD). Separate clinical trials for several therapeutic compounds that target amyloid plaque reduction have shown noteworthy correlations among plaque removal, the Amyloid-Related Imaging Abnormalities (ARIA) rate, and clinical efficacy of the treatment. The relationships among therapeutic dose levels, the rate of amyloid removal, and the clinical efficacy deserve further investigation across therapeutic agents, particularly for clinical trials to provide insights for strategies to develop amyloid therapies in Alzheimer's disease. Methods: Published data summaries from clinical trials with amyloid therapies of aducanumab, donanemab, lecanemab, and gantenerumab are evaluated with meta-analyses. Linear mixed models for repeated measurements for visits and random study effects are applied to analyze amyloid centiloid value reduction from baseline and clinical cognition change from baseline for treatment groups according to doses and compounds for the clinical trials. Logistic regression analysis is applied to evaluate the relationship between the amyloid removal rate and the ARIA-Edema (ARIA-E) rate across different dose groups and clinical trials. Results: The extent of amyloid removal varies among therapeutic agents and their dose levels. Across treatment groups and clinical trials, amyloid centiloid value reductions at Weeks 26 and 52 are strongly correlated with both ARIA-E rate over 78 weeks and the clinical efficacy response in the Clinical Dementia-Rating Scale Sum of Boxes (CDR-SB) score change from baseline at Week 78; and the Spearman rank correlations for amyloid reduction at Week 52 are stronger as − 0.79 with the ARIA-E rate over 78 weeks and 0.73 with the Week 78 CDR-SB score change from baseline. Conclusion: Aβ plaques removal in the brain due to amyloid therapy is strongly correlated with a better clinical response in patients with early Alzheimer's disease and a higher ARIA-E rate for the treatment groups and clinical trials in this meta-analysis. These relationships suggest that the balance between the clinical efficacy response and safety in ARIA-E rate is relevant for the choice of doses for amyloid therapies in confirmatory clinical trials. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Diagnosing acetabular labral tears with hip traction sonography: a case series.

Author

Billham, Jessica, Cornelson, Stacey M., Koch, Amy, Nunez Jr., Mero, Estrada, Patricia, and Kettner, Norman

Abstract

Purpose: Three cases of acetabular labral tear (ALT) diagnosed with sonography (US) are reported. We aim to show utility for US with the addition of manual hip traction as an adjunctive modality to the current diagnostic imaging of choice, magnetic resonance arthrography (MRA), for diagnosing ALT. Methods: Three cases of young athletic patients with similar clinical presentations are reported. All received US examination of the hip with attention to the labrum that included a novel long-axis hip traction technique which assisted in diagnosing ALT. Results: In the first and second cases, MRA and orthopedic consult were obtained for confirmation of the diagnosis. Arthroscopy was performed to correct the ALT. The third patient declined an MRA. Conservative management consisted of McKenzie method active care, resulting in return to sport in the third case. Conclusion: These three cases demonstrate the clinical and sonographic presentation of ALT. The dynamic long-axis hip traction protocol facilitated the use of US as an adjunctive modality for diagnosing ALT by increasing the visualization of the defect. [ABSTRACT FROM AUTHOR]

Published
2021
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15. Auswirkungen von alternativen Hilfsmitteln auf die körperlichen Belastungen beim Patiententransport im Rettungsdienst.

Author

Schiefer, Christoph, Griemsmann, Stephanie, Hermanns, Ingo, Derakshani, Manigée, Göbel, Friedhelm, Jäger, Matthias, Koch, Ulrich, Ditchen, Dirk, and Ellegast, Rolf

Subjects
TRANSPORTATION of patients, STAIRCASES, ERGONOMICS
Abstract

Copyright of Zeitschrift für Arbeitswissenschaft is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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16. Wissen über berufsbedingte inhalative Noxen bei Beschäftigten im Gesundheitsdienst und der Wohlfahrtspflege.

Author

Koch, Peter, Halsen, Gabriele, Damerau, Lukas, Nienhaus, Albert, Harth, Volker, Augustin, Matthias, and Terschüren, Claudia

Subjects
STATISTICS, PROFESSIONS, INDUSTRIAL safety, SOCIAL workers, OCCUPATIONAL exposure, INHALATION injuries, RULES, QUESTIONNAIRES, DESCRIPTIVE statistics, INDUSTRIAL hygiene
Abstract

Copyright of Zentralblatt fuer Arbeitsmedizin, Arbeitsschutz und Ergonomie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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17. Prävalenz kardiovaskulärer Risikofaktoren bei Polizeivollzugsbeamten in Ausbildung: Ergebnisse einer Querschnittsstudie in Thüringen.

Author

Koch, S., Werdecker, L., and Esch, T.

Subjects
CARDIOVASCULAR diseases risk factors, SEDENTARY lifestyles, BLOOD pressure, HYPERTENSION, OBESITY, JOB stress, CROSS-sectional method, ACTIVITIES of daily living, DISEASE prevalence, HEART beat, WAIST circumference, QUESTIONNAIRES, DESCRIPTIVE statistics, BODY mass index, SMOKING, POLICE
Abstract

Copyright of Zentralblatt fuer Arbeitsmedizin, Arbeitsschutz und Ergonomie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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18. Design and Analysis of a Biosimilar Bridging Study with a Prediction Interval-Based Consistency Test.

Author

Pan, Zhiying, Huang, Wenying, Pan, Jianhong, and Koch, Gary

Subjects
DRUG efficacy, STATISTICS, CLINICAL trials, RESEARCH evaluation, SAMPLE size (Statistics), BIOSIMILARS, HEALTH outcome assessment, STATISTICAL hypothesis testing, STATISTICAL models, DATA analysis, MEDICAL practice, MEDICAL research
Abstract

The development of biosimilars has substantially increased in recent years. A biosimilar is a biological product which is highly similar to a licensed biological product (reference product), with no clinically meaningful differences between the proposed biosimilar and the reference product. A bridging study is a viable strategy to bring an approved biosimilar product from the original region(s) to new regions or countries. While the bridging concept and the principles of conducting bridging studies for innovative products outlined in ICH E5 guidance are informative for biosimilar development, existing statistical strategies for designing and analyzing a bridging study may not be directly applicable when the biosimilar global study compares the biosimilar product to a reference product as control. In this paper, we present a novel and practical statistical methodology for designing and analyzing a biosimilar bridging study based on a prediction interval-based consistency test for assessing consistency between the bridging study and the biosimilar global study. We prove analytically that the method has the desired statistical properties (i.e., high power when the two studies are perfectly consistent or nearly consistent in efficacy and type I error control when the two studies are clearly inconsistent in efficacy). We present a numerical example to illustrate that the implementation of the method is straightforward in practice. We also discuss the application of the method to various endpoints and metrics. [ABSTRACT FROM AUTHOR]

Published
2021
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19. Attitudes to dental visits in a child population attending public dental health care in Jönköping, Sweden—trends over 40 years.

Author

Nydell Helkimo, A., Rolander, B., and Koch, G.

Subjects
DENTAL care utilization, DENTAL care, MEDICAL care, ATTITUDE (Psychology), DENTAL students, PRESCHOOL children, DENTISTS
Abstract

Purpose: To study attitudes to dental visits in a child population attending public dental health care between 1973 and 2013. Methods: Random samples of individuals aged 3, 5, 10, 15 and 20 years took part in cross-sectional studies based on clinical parameters and a questionnaire, all repeated every 10 years using the same study design. One question related to dental attitude; "What do you feel at the prospect of an appointment with a dentist?". The affirmative answers were full of expectation, unaffected, ill at ease, frightened and sick, representing positive, neutral and negative attitudes. During the same 40-year period, a dental health care system based on prevention and regular dental appointments was reinforced. Results: In preschool children, the most pronounced change was an increase in the number of children reporting full of expectation during the study period. In 10-, 15- and 20-year-olds, there was an increase in unaffected and a decrease in ill at ease over time. A reduction in frightened was only seen in the 20-year-olds. Conclusions: Despite a simultaneous dramatic decline in caries and a reduced need for operative dental treatment, the dental attitudes were fairly constant during the 40-year period. The moderate shifts to more positive or neutral dental attitudes were merely seen during the first 10 or 20 years. After this, the changes in answers were limited. This leads to the assumption that factors other than dental treatment experiences have an impact on dental attitudes in children. [ABSTRACT FROM AUTHOR]

Published
2021
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21. A Behavioral Approach to Increasing Perceptions of Capability Toward People With Disabilities.

Author

Catrone, Rocco Giovanni and Koch, D. Shane

Abstract

Many of the roughly 1,000,000,000 people around the world who have some form of a disability diagnosis (World Health Organization, 2018) also experience barriers to education (DasGupta, 2015), barriers to health care access Dodds et al. in, Social Work, 63(3), 261-264, (2018), and legal discrimination (Ziegler in, Boston Law Review, 61, 1183-1221, 2020). Much of this has been attributed to perceptions of stigma, microaggressions, and misunderstanding toward people with disabilities (PWDs; Smart in Journal of Rehabilitation, 75(2), 3-11, 2009, 2015; Ziegler in Boston Law Review, 61, 1183-1221, 2020), which exacerbate these barriers. Previous research has suggested that relational frame theory can be a method to alter these hurtful frames of stigma (Florez et al. in Journal of Contextual Behavioral Science, 12, 1-6, 2019; Kohlenberg et al. in Journal of the Experimental Analysis of Behavior, 56(3), 505-518, 1991). The current study extends the work of Dixon et al. in The Behavior Analyst Today, 7(3), 275-289 (2006) and Dixon et al. in The Behavior Analyst Today, 10(2), 295-318. (2009) by applying a computer-based conditional-discrimination training paradigm to increase the research participants' perceptions of capability toward PWDs. Results indicated an increase in psychological flexibility, a decrease in the perception of stigma, and an increase in the overall perception of capability toward PWDs. A discussion of these results is followed by limitations of the current paradigm, ethical considerations, and future research to further analyze the relational frame families involved in stigma formation and, ultimately, reduction. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Combined-Indications Significance Level of Multiple Related Indications Developed Simultaneously.

Author

Yuan, Jiacheng, Zhu, Ray, Jia, Daniel, Palm, Ulo, and Koch, Gary

Subjects
MARKETING, DRUG approval
Abstract

Background: Typically, regulatory requirements include 2 confirmatory studies, each at a 1-sided.025 significance level, for a medicine to be approved for a specific indication. When the same medicine has been approved in related indications, 1 confirmatory study at a 1-sided.025 significance level could constitute adequate evidence of efficacy for a new indication. Methods: This article does not contain any studies with human or animal subjects performed by any of the authors. For multiple related indications developed simultaneously to constitute sufficient evidence of clinical efficacy, the combined-studies significance level can be set at the same level as if those indications are developed sequentially. Results: This article establishes possible strategies to develop a few related indications at the same time for marketing registration approval, maintaining a desired combined-studies significance level; for example, 1-sided.0000156 for 2 indications, with 1 option having each indication assessed with 1 confirmatory study at.00395 significance level. Conclusion: It is possible to develop a few indications at the same time for marketing registration approval, where the combinedstudies significance level is less stringent than that of the usual paradigm with 2 confirmatory studies each at 1-sided.025 significance level for every indication. [ABSTRACT FROM AUTHOR]

Published
2020
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24. Robust Model Predictive Controller Applied to Three-Phase Grid-Connected LCL Filters.

Author

Maccari Jr., L. A., Lima, D. M., Koch, G. G., and Montagner, V. F.

Subjects
PREDICTION models, RENEWABLE energy sources, LINEAR matrix inequalities, ROBUST control, PREDICTIVE control systems, FILTERS & filtration, CLOSED loop systems
Abstract

Grid-connected inverters play an important role in renewable energy system nowadays, serving as an interface between the renewable energy source and the grid. However, the PWM modulation used to control the converters produces harmonic content that must be filtered properly. In this paper, an active damping strategy is used with a three-phase power converter with an LCL filter to achieve harmonic rejection. The control strategy which will be used is a continuous control set model predictive control (CCS-MPC) based on a state-space model of the system. This controller must ensure that the injected grid currents track sinusoidal references and reject harmonic disturbances from the grid voltage. This is achieved by using an augmented model of the system that contains resonant controllers. Following the unconstrained CCS-MPC methodology, a fixed gain controller that can be implemented similarly to a classical state-space feedback controller is obtained. An analysis of the impact of the CCS-MPC tuning parameters on the closed-loop response is made. Also, an a posteriori linear matrix inequality approach is used to show that the resulting closed-loop system is robust in regard to grid inductance uncertainties and variations. Simulation and experimental test results show that the proposed controller yields good results, complying with the IEEE 1547 Standard grid currents harmonic limits. [ABSTRACT FROM AUTHOR]

Published
2020
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25. Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA

Author

Abbott, B. P., Abbott, R., Abbott, T. D., Abernathy, M. R., Acernese, F., Ackley, K., Adams, C., Adams, T., Addesso, P., Adhikari, R. X., Adya, V. B., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., Allen, B., Allocca, A., Altin, P. A., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Appert, S., Arai, K., Araya, A., Araya, M. C., Areeda, J. S., Arnaud, N., Arun, K. G., Asada, H., Ascenzi, S., Ashton, G., Aso, Y., Ast, M., Aston, S. M., Astone, P., Atsuta, S., Aufmuth, P., Aulbert, C., Avila-Alvarez, A., Awai, K., Babak, S., Bacon, P., Bader, M. K. M., Baiotti, L., Baker, P. T., Baldaccini, F., Ballardin, G., Ballmer, S. W., Barayoga, J. C., Barclay, S. E., Barish, B. C., Barker, D., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Batch, J. C., Baune, C., Bavigadda, V., Bazzan, M., Bécsy, B., Beer, C., Bejger, M., Belahcene, I., Belgin, M., Bell, A. S., Berger, B. K., Bergmann, G., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhagwat, S., Bhandare, R., Bilenko, I. A., Billingsley, G., Billman, C. R., Birch, J., Birney, R., Birnholtz, O., Biscans, S., Bisht, A., Bitossi, M., Biwer, C., Bizouard, M. A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bloemen, S., Bock, O., Boer, M., Bogaert, G., Bohe, A., Bondu, F., Bonnand, R., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Braginsky, V. B., Branchesi, M., Brau, J. E., Briant, T., Brillet, A., Brinkmann, M., Brisson, V., Brockill, P., Broida, J. E., Brooks, A. F., Brown, D. A., Brown, D. D., Brown, N. M., Brunett, S., Buchanan, C. C., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buskulic, D., Buy, C., Byer, R. L., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Calderón Bustillo, J., Callister, T. A., Calloni, E., Camp, J. B., Cannon, K. C., Cao, H., Cao, J., Capano, C. D., Capocasa, E., Carbognani, F., Caride, S., Casanueva Diaz, J., Casentini, C., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cepeda, C. B., Cerboni Baiardi, L., Cerretani, G., Cesarini, E., Chamberlin, S. J., Chan, M., Chao, S., Charlton, P., Chassande-Mottin, E., Cheeseboro, B. D., Chen, H. Y., Chen, Y., Cheng, H.-P., Chincarini, A., Chiummo, A., Chmiel, T., Cho, H. S., Cho, M., Chow, J. H., Christensen, N., Chu, Q., Chua, A. J. K., Chua, S., Chung, S., Ciani, G., Clara, F., Clark, J. A., Cleva, F., Cocchieri, C., Coccia, E., Cohadon, P.-F., Colla, A., Collette, C. G., Cominsky, L., Constancio, M., Conti, L., Cooper, S. J., Corbitt, T. R., Cornish, N., Corsi, A., Cortese, S., Costa, C. A., Coughlin, M. W., Coughlin, S. B., Coulon, J.-P., Countryman, S. T., Couvares, P., Covas, P. B., Cowan, E. E., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Cripe, J., Crowder, S. G., Cullen, T. J., Cumming, A., Cunningham, L., Cuoco, E., Canton, T. Dal, Danilishin, S. L., D’Antonio, S., Danzmann, K., Dasgupta, A., Da Silva Costa, C. F., Dattilo, V., Dave, I., Davier, M., Davies, G. S., Davis, D., Daw, E. J., Day, B., Day, R., De, S., DeBra, D., Debreczeni, G., Degallaix, J., De Laurentis, M., Deléglise, S., Del Pozzo, W., Denker, T., Dent, T., Dergachev, V., De Rosa, R., DeRosa, R. T., DeSalvo, R., Devine, R. C., Dhurandhar, S., Díaz, M. C., Fiore, L. Di, Giovanni, M. Di, Girolamo, T. Di, Lieto, A. Di, Pace, S. Di, Palma, I. Di, Virgilio, A. Di, Doctor, Z., Doi, K., Dolique, V., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Douglas, R., Dovale Álvarez, M., Downes, T. P., Drago, M., Drever, R. W. P., Driggers, J. C., Du, Z., Ducrot, M., Dwyer, S. E., Eda, K., Edo, T. B., Edwards, M. C., Effler, A., Eggenstein, H.-B., Ehrens, P., Eichholz, J., Eikenberry, S. S., Eisenstein, R. A., Essick, R. C., Etienne, Z., Etzel, T., Evans, M., Evans, T. M., Everett, R., Factourovich, M., Fafone, V., Fair, H., Fairhurst, S., Fan, X., Farinon, S., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favata, M., Fays, M., Fehrmann, H., Fejer, M. M., Fernández Galiana, A., Ferrante, I., Ferreira, E. C., Ferrini, F., Fidecaro, F., Fiori, I., Fiorucci, D., Fisher, R. P., Flaminio, R., Fletcher, M., Fong, H., Forsyth, S. S., Fournier, J.-D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fries, E. M., Fritschel, P., Frolov, V. V., Fujii, Y., Fujimoto, M.-K., Fulda, P., Fyffe, M., Gabbard, H., Gadre, B. U., Gaebel, S. M., Gair, J. R., Gammaitoni, L., Gaonkar, S. G., Garufi, F., Gaur, G., Gayathri, V., Gehrels, N., Gemme, G., Genin, E., Gennai, A., George, J., Gergely, L., Germain, V., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, S., Giaime, J. A., Giardina, K. 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S., Fournier, J.-D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fries, E. M., Fritschel, P., Frolov, V. V., Fujii, Y., Fujimoto, M.-K., Fulda, P., Fyffe, M., Gabbard, H., Gadre, B. U., Gaebel, S. M., Gair, J. R., Gammaitoni, L., Gaonkar, S. G., Garufi, F., Gaur, G., Gayathri, V., Gehrels, N., Gemme, G., Genin, E., Gennai, A., George, J., Gergely, L., Germain, V., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, S., Giaime, J. A., Giardina, K. D., Giazotto, A., Gill, K., Glaefke, A., Goetz, E., Goetz, R., Gondan, L., González, G., Gonzalez Castro, J. M., Gopakumar, A., Gorodetsky, M. L., Gossan, S. E., Gosselin, M., Gouaty, R., Grado, A., Graef, C., Granata, M., Grant, A., Gras, S., Gray, C., Greco, G., Green, A. C., Groot, P., Grote, H., Grunewald, S., Guidi, G. M., Guo, X., Gupta, A., Gupta, M. K., Gushwa, K. E., Gustafson, E. K., Gustafson, R., Hacker, J. J., Hagiwara, A., Hall, B. R., Hall, E. D., Hammond, G., Haney, M., Hanke, M. 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B., Karki, S., Karvinen, K. S., Kasprzack, M., Kataoka, Y., Katsavounidis, E., Katzman, W., Kaufer, S., Kaur, T., Kawabe, K., Kawai, N., Kawamura, S., Kéfélian, F., Keitel, D., Kelley, D. B., Kennedy, R., Key, J. S., Khalili, F. Y., Khan, I., Khan, S., Khan, Z., Khazanov, E. A., Kijbunchoo, N., Kim, C., Kim, H., Kim, J. C., Kim, J., Kim, W., Kim, Y.-M., Kimbrell, S. J., Kimura, N., King, E. J., King, P. J., Kirchhoff, R., Kissel, J. S., Klein, B., Kleybolte, L., Klimenko, S., Koch, P., Koehlenbeck, S. M., Kojima, Y., Kokeyama, K., Koley, S., Komori, K., Kondrashov, V., Kontos, A., Korobko, M., Korth, W. Z., Kotake, K., Kowalska, I., Kozak, D. B., Krämer, C., Kringel, V., Krishnan, B., Królak, A., Kuehn, G., Kumar, P., Kumar, Rahul, Kumar, Rakesh, Kuo, L., Kuroda, K., Kutynia, A., Kuwahara, Y., Lackey, B. D., Landry, M., Lang, R. N., Lange, J., Lantz, B., Lanza, R. K., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lebigot, E. O., Lee, C. H., Lee, H. K., Lee, H. M., Lee, H. W., Lee, K., Lehmann, J., Lenon, A., Leonardi, M., Leong, J. R., Leroy, N., Letendre, N., Levin, Y., Li, T. G. F., Libson, A., Littenberg, T. B., Liu, J., Lockerbie, N. A., Lombardi, A. L., London, L. T., Lord, J. E., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. D., Lousto, C. O., Lovelace, G., Lück, H., Lundgren, A. P., Lynch, R., Ma, Y., Macfoy, S., Machenschalk, B., MacInnis, M., Macleod, D. M., Magaña-Sandoval, F., Majorana, E., Maksimovic, I., Malvezzi, V., Man, N., Mandic, V., Mangano, V., Mano, S., Mansell, G. L., Manske, M., Mantovani, M., Marchesoni, F., Marchio, M., Marion, F., Márka, S., Márka, Z., Markosyan, A. S., Maros, E., Martelli, F., Martellini, L., Martin, I. W., Martynov, D. V., Mason, K., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matichard, F., Matone, L., Matsumoto, N., Matsushima, F., Mavalvala, N., Mazumder, N., McCarthy, R., McClelland, D. E., McCormick, S., McGrath, C., McGuire, S. C., McIntyre, G., McIver, J., McManus, D. J., McRae, T., McWilliams, S. T., Meacher, D., Meadors, G. D., Meidam, J., Melatos, A., Mendell, G., Mendoza-Gandara, D., Mercer, R. A., Merilh, E. L., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P. M., Mezzani, F., Miao, H., Michel, C., Michimura, Y., Middleton, H., Mikhailov, E. E., Milano, L., Miller, A. L., Miller, A., Miller, B. B., Miller, J., Millhouse, M., Minenkov, Y., Ming, J., Mirshekari, S., Mishra, C., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Miyamoto, A., Miyamoto, T., Miyoki, S., Moggi, A., Mohan, M., Mohapatra, S. R. P., Montani, M., Moore, B. C., Moore, C. J., Moraru, D., Moreno, G., Morii, W., Morisaki, S., Moriwaki, Y., Morriss, S. R., Mours, B., Mow-Lowry, C. M., Mueller, G., Muir, A. W., Mukherjee, Arunava, Mukherjee, D., Mukherjee, S., Mukund, N., Mullavey, A., Munch, J., Muniz, E. A. M., Murray, P. G., Mytidis, A., Nagano, S., Nakamura, K., Nakamura, T., Nakano, H., Nakano, Masaya, Nakano, Masayuki, Nakao, K., Napier, K., Nardecchia, I., Narikawa, T., Naticchioni, L., Nelemans, G., Nelson, T. J. N., Neri, M., Nery, M., Neunzert, A., Newport, J. M., Newton, G., Nguyen, T. T., Ni, W.-T., Nielsen, A. B., Nissanke, S., Nitz, A., Noack, A., Nocera, F., Nolting, D., Normandin, M. E. N., Nuttall, L. K., Oberling, J., Ochsner, E., Oelker, E., Ogin, G. H., Oh, J. J., Oh, S. H., Ohashi, M., Ohishi, N., Ohkawa, M., Ohme, F., Okutomi, K., Oliver, M., Ono, K., Ono, Y., Oohara, K., Oppermann, P., Oram, Richard J., O’Reilly, B., O’Shaughnessy, R., Ottaway, D. J., Overmier, H., Owen, B. J., Pace, A. E., Page, J., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pal-Singh, A., Pan, H., Pankow, C., Pannarale, F., Pant, B. C., Paoletti, F., Paoli, A., Papa, M. A., Paris, H. R., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patricelli, B., Pearlstone, B. L., Pedraza, M., Pedurand, R., Pekowsky, L., Pele, A., Peña Arellano, F. E., Penn, S., Perez, C. J., Perreca, A., Perri, L. M., Pfeiffer, H. P., Phelps, M., Piccinni, O. J., Pichot, M., Piergiovanni, F., Pierro, V., Pillant, G., Pinard, L., Pinto, I. M., Pitkin, M., Poe, M., Poggiani, R., Popolizio, P., Post, A., Powell, J., Prasad, J., Pratt, J. W. W., Predoi, V., Prestegard, T., Prijatelj, M., Principe, M., Privitera, S., Prodi, G. A., Prokhorov, L. G., Puncken, O., Punturo, M., Puppo, P., Pürrer, M., Qi, H., Qin, J., Qiu, S., Quetschke, V., Quintero, E. A., Quitzow-James, R., Raab, F. J., Rabeling, D. S., Radkins, H., Raffai, P., Raja, S., Rajan, C., Rakhmanov, M., Rapagnani, P., Raymond, V., Razzano, M., Re, V., Read, J., Regimbau, T., Rei, L., Reid, S., Reitze, D. H., Rew, H., Reyes, S. D., Rhoades, E., Ricci, F., Riles, K., Rizzo, M., Robertson, N. A., Robie, R., Robinet, F., Rocchi, A., Rolland, L., Rollins, J. G., Roma, V. J., Romano, R., Romie, J. H., Rosińska, D., Rowan, S., Rüdiger, A., Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadeghian, L., Sago, N., Saijo, M., Saito, Y., Sakai, K., Sakellariadou, M., Salconi, L., Saleem, M., Salemi, F., Samajdar, A., Sammut, L., Sampson, L. M., Sanchez, E. J., Sandberg, V., Sanders, J. R., Sasaki, Y., Sassolas, B., Sathyaprakash, B. S., Sato, S., Sato, T., Saulson, P. R., Sauter, O., Savage, R. L., Sawadsky, A., Schale, P., Scheuer, J., Schmidt, E., Schmidt, J., Schmidt, P., Schnabel, R., Schofield, R. M. S., Schönbeck, A., Schreiber, E., Schuette, D., Schutz, B. F., Schwalbe, S. G., Scott, J., Scott, S. M., Sekiguchi, T., Sekiguchi, Y., Sellers, D., Sengupta, A. S., Sentenac, D., Sequino, V., Sergeev, A., Setyawati, Y., Shaddock, D. A., Shaffer, T. J., Shahriar, M. S., Shapiro, B., Shawhan, P., Sheperd, A., Shibata, M., Shikano, Y., Shimoda, T., Shoda, A., Shoemaker, D. H., Shoemaker, D. M., Siellez, K., Siemens, X., Sieniawska, M., Sigg, D., Silva, A. D., Singer, A., Singer, L. P., Singh, A., Singh, R., Singhal, A., Sintes, A. M., Slagmolen, B. J. J., Smith, B., Smith, J. R., Smith, R. J. E., Somiya, K., Son, E. J., Sorazu, B., Sorrentino, F., Souradeep, T., Spencer, A. P., Srivastava, A. K., Staley, A., Steinke, M., Steinlechner, J., Steinlechner, S., Steinmeyer, D., Stephens, B. C., Stevenson, S. P., Stone, R., Strain, K. A., Straniero, N., Stratta, G., Strigin, S. E., Sturani, R., Stuver, A. L., Sugimoto, Y., Summerscales, T. Z., Sun, L., Sunil, S., Sutton, P. J., Suzuki, T., Swinkels, B. L., Szczepańczyk, M. J., Tacca, M., Tagoshi, H., Takada, S., Takahashi, H., Takahashi, R., Takamori, A., Talukder, D., Tanaka, H., Tanaka, K., Tanaka, T., Tanner, D. B., Tápai, M., Taracchini, A., Tatsumi, D., Taylor, R., Telada, S., Theeg, T., Thomas, E. G., Thomas, M., Thomas, P., Thorne, K. A., Thrane, E., Tippens, T., Tiwari, S., Tiwari, V., Tokmakov, K. V., Toland, K., Tomaru, T., Tomlinson, C., Tonelli, M., Tornasi, Z., Torrie, C. I., Töyrä, D., Travasso, F., Traylor, G., Trifirò, D., Trinastic, J., Tringali, M. C., Trozzo, L., Tse, M., Tso, R., Tsubono, K., Tsuzuki, T., Turconi, M., Tuyenbayev, D., Uchiyama, T., Uehara, T., Ueki, S., Ueno, K., Ugolini, D., Unnikrishnan, C. S., Urban, A. L., Ushiba, T., Usman, S. A., Vahlbruch, H., Vajente, G., Valdes, G., van Bakel, N., van Beuzekom, M., van den Brand, J. F. J., Van Den Broeck, C., Vander-Hyde, D. C., van der Schaaf, L., van Heijningen, J. V., van Putten, M. H. P. M., van Veggel, A. A., Vardaro, M., Varma, V., Vass, S., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Venugopalan, G., Verkindt, D., Vetrano, F., Viceré, A., Viets, A. D., Vinciguerra, S., Vine, D. J., Vinet, J.-Y., Vitale, S., Vo, T., Vocca, H., Vorvick, C., Voss, D. V., Vousden, W. D., Vyatchanin, S. P., Wade, A. R., Wade, L. E., Wade, M., Wakamatsu, T., Walker, M., Wallace, L., Walsh, S., Wang, G., Wang, H., Wang, M., Wang, Y., Ward, R. L., Warner, J., Was, M., Watchi, J., Weaver, B., Wei, L.-W., Weinert, M., Weinstein, A. J., Weiss, R., Wen, L., Weßels, P., Westphal, T., Wette, K., Whelan, J. T., Whiting, B. F., Whittle, C., Williams, D., Williams, R. D., Williamson, A. R., Willis, J. L., Willke, B., Wimmer, M. H., Winkler, W., Wipf, C. C., Wittel, H., Woan, G., Woehler, J., Worden, J., Wright, J. L., Wu, D. S., Wu, G., Yam, W., Yamamoto, H., Yamamoto, K., Yamamoto, T., Yancey, C. C., Yano, K., Yap, M. J., Yokoyama, J., Yokozawa, T., Yoon, T. H., Yu, Hang, Yu, Haocun, Yuzurihara, H., Yvert, M., Zadrożny, A., Zangrando, L., Zanolin, M., Zeidler, S., Zendri, J.-P., Zevin, M., Zhang, L., Zhang, M., Zhang, T., Zhang, Y., Zhao, C., Zhou, M., Zhou, Z., Zhu, S. J., Zhu, X. J., Zucker, M. E., and Zweizig, J.

Abstract

We present possible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next decade, with the intention of providing information to the astronomy community to facilitate planning for multi-messenger astronomy with gravitational waves. We estimate the sensitivity of the network to transient gravitational-wave signals, and study the capability of the network to determine the sky location of the source. We report our findings for gravitational-wave transients, with particular focus on gravitational-wave signals from the inspiral of binary neutron star systems, which are the most promising targets for multi-messenger astronomy. The ability to localize the sources of the detected signals depends on the geographical distribution of the detectors and their relative sensitivity, and 90% credible regions can be as large as thousands of square degrees when only two sensitive detectors are operational. Determining the sky position of a significant fraction of detected signals to areas of 5-20 deg² requires at least three detectors of sensitivity within a factor of ∼2 of each other and with a broad frequency bandwidth. When all detectors, including KAGRA and the third LIGO detector in India, reach design sensitivity, a significant fraction of gravitational-wave signals will be localized to a few square degrees by gravitational-wave observations alone.

Published
2018

26. Linear Matrix Inequalities for Digital Redesign Under Delay Suitable for PI Controllers with Application to PMSMs.

Author

Gabbi, Thieli S., Koch, Gustavo G., Vieira, Rodrigo P., Montagner, Vinícius F., Tognetti, Eduardo S., Borges, Renato A., Maccari, Luiz A., and Oliveira, Ricardo C. L. F.

Subjects
LINEAR matrix inequalities, MATRIX inequalities, PERMANENT magnet motors, CLOSED loop systems, SPEED limits, ELECTRONIC paper
Abstract

This paper investigates the digital redesign of proportional integral (PI) controllers implemented under a delay of one sampling period. The usual digital redesign based on state matching cannot be directly applied here. The digital control gains are obtained by means of linear matrix inequalities that minimize the H ∞ norm associated with an error signal defined as the difference between the closed-loop system with continuous-time controller and the closed-loop system with the discrete-time controller implemented under the delay. Three synthesis conditions are given, exploring extra matrix variables and suitable matrix structures to provide more efficient redesigns that can deal even with large control delays in the implementation of the redesigned controller. As a contribution, the proposed conditions provide a theoretical guarantee that digital PIs, operating under delay, will perform very close to originally designed continuous-time PIs. A numerical example illustrates the efficiency of the proposed conditions, and a practical application for permanent magnet synchronous motor speed regulation shows good experimental results, illustrating the viability of the proposal. [ABSTRACT FROM AUTHOR]

Published
2019
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28. Clinical Study Design to Assess Both Short- and Long-term Efficacy in Addition to Group Sequential Test on Safety.

Author

Yuan, Jiacheng, Mesenbrink, Peter, Zhou, Jihao, Liu, Jeen, Zhu, Ray, and Koch, Gary

Subjects
SAFETY, DRUG approval
Abstract

In clinical studies for disorders such as rheumatoid arthritis, type 2 diabetes mellitus, multiple sclerosis, osteoporosis, etc, sometimes the developers need to address safety concerns (eg, cardiovascular risk) in the phase III development, so that a large long-term safety study is needed before registration. This article does not contain any studies with human or animal subjects performed by any of the authors. Aiming for potential regulatory approval with a single confirmatory study, the authors suggest a design that assesses short-term efficacy (eg, signs or symptoms) and long-term efficacy (eg, structure or imaging), as well as safety (eg, major adverse cardiac events), for which a group sequential test is performed applying an alpha spending function. A graphical testing procedure is suggested for the data analysis. The testing procedure controls the family-wise type I error rate. The study may reach all or part of short-term efficacy, long-term efficacy, and/or safety objectives. It is possible to get market approval with a single confirmatory study that assesses short-term efficacy, long-term efficacy, and safety. [ABSTRACT FROM AUTHOR]

Published
2018
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30. Incidence of dental traumatic injuries in children 0-4 years of age: a prospective study based on parental reporting.

Author

Odersjö, M. L., Robertson, A., and Koch, G.

Subjects
TEETH injuries, DENTAL pathology, PEDIATRIC dentistry
Abstract

Aim: To collect prospective information reported by parents regarding dental traumas occurring in children 6 months to 4 years of age, furthermore, to collect data on complications from the dental records.Methods: The staff from the child health services distributed a questionnaire at the regular health check-up reviews for a number of age groups, i.e., 6, 12, 18, 24, 30, 36, and 42 months of age. The parents were to observe and register factors around dental trauma for the following 6-month period. The questionnaires (138) were returned, irrespective of any trauma having occurred or not. If a child was seeing a dentist (emergency visit), the diagnosis of trauma and later complications were collected from the dental records.Results: There were 35 of 138 children experienced trauma (6-47 months of age). The half-year incidence of trauma in children 6 months to 4.0 years of age was between 12 and 48%. A total of 41 traumatic dental injuries (TDIs) were reported. Of these 24 occurred indoors. The most common reason for trauma was falling accidents. In 24 out of the 41 reported TDIs the children were not seen by a dentist in connection with the trauma. The reason was that the parents thought the trauma did not matter.Conclusions: The high incidence of TDIs reported in toddlers in this study indicates that there is an under-reporting of TDIs in previously reported studies. The research design used in the present study has an advantage and should be tested in further studies. [ABSTRACT FROM AUTHOR]

Published
2018
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31. Determination of Alveolar Geometry by Optical Coherence Tomography to Develop a Numerical Model of the Fluid Dynamics in the Pulmonary Acinus.

Author

Buzug, Thorsten M., Holz, Dietrich, Bongartz, Jens, Kohl-Bareis, Matthias, Hartmann, Ulrich, Weber, Simone, Meißner, Sven, Krüger, Alexander, Wendel, Martina, Knels, Lilla, Heller, Axel, Koch, Thea, and Koch, Edmund

Abstract

In this feasibility study a Fourier domain optical coherence tomography (FDOCT) system was used for 3D imaging of sub pleural lung parenchyma in the ventilated and perfused isolated rabbit lung. A series of 3D OCT images during a stepwise increase of pulmonary airway pressure was acquired. Refocusing and repositioning of the OCT scanner head allowed follow the volume changes of a single partial acinus of the lung. [ABSTRACT FROM AUTHOR]

Published
2007
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32. Simulationsgestützte Entwicklung eines Wasserstoffmotors: für einen emissionsfreien Verkehr.

Author

Koch, Daniel, Zeilinga, Stephan Christian, Rottengruber, Hermann, and Sousa, Alvaro

Abstract

Copyright of MTZ: Motortechnische Zeitschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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33. The role of transient receptor potential vanilloid 2 channel in cardiac aging.

Author

Jones, Shannon, Mann, Adrien, Worley, Mariah, Fulford, Logan, Hall, David, Karani, Rajiv, Jiang, Min, Robbins, Nathan, Rubinstein, Jack, and Koch, Sheryl

Abstract

Background: The aging heart is characterized by cellular and molecular changes leading to a decline in physiologic function and cardiac remodeling, specifically the development of myocyte hypertrophy and fibrosis. Transient receptor potential vanilloid 2 (TRPV2), a stretch-mediated channel and regulator of calcium homeostasis, plays a key role in the function and structure of the heart. TRPV2 also plays an important role in the adaptive and maladaptive compensatory mechanisms of the heart in response to pathologic and exercise-induced stress. Our current study seeks to elucidate the potential role of TRPV2 channels in the regulation of cardiac function in aging. Methods: Wild-type (WT) and TRPV2 functional knockout (FKO) mice were aged out to various time points, and their cardiac function was measured using advanced echocardiography. Furthermore, we histologically analyzed the heart morphology to determine myocyte hypertrophy, the development of fibrosis and the relative expression of TRPV2. Results: Our results demonstrate that even though TRPV2-FKO mice have impaired function at baseline, their cardiac function as measured via standard and advanced echocardiographic parameters (ejection fraction, cardiac output and circumferential strain) decreased less with aging in comparison with the WT group. Furthermore, there was less fibrosis and hypertrophy in the TRPV2-FKO group with aging in comparison with the WT. The expression of TRPV2 in the WT group did not significantly change with aging. Conclusions: TRPV2 functional deletion is compatible with aging and associated with a decreased development of myocyte hypertrophy and fibrosis. It may be an important target for prevention of age-induced cardiac remodeling. [ABSTRACT FROM AUTHOR]

Published
2017
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34. Caries prevalence and distribution in individuals aged 3-20 years in Jönköping, Sweden: trends over 40 years.

Author

Koch, G., Helkimo, A., and Ullbro, C.

Subjects
DENTAL caries in children, DISEASE prevalence, EPIDEMIOLOGY, THERAPEUTICS
Abstract

Aim: To present and analyse changes in caries prevalence and caries distribution in child population sample groups in the city of Jönköping, Sweden, based on investigations performed in 1973, 1978, 1983, 1993, 2003, and 2013. Methods: At each investigation, the study population included about 500 randomly sampled individuals, divided into age groups of 3, 5, 10, 15, and 20 years. The oral health status of all individuals was clinically and radiographically examined by trained paediatric dentists. Results: 35% of the 3-year-olds were caries-free in 1973, compared to 79% 40 years later. Decayed and filled primary (dfs) and permanent (DFS) tooth surfaces were reduced by 67-90% between 1973 and 2013. Adolescents aged 10 and 15 years exhibited the most pronounced reduction in DFS on the occlusal surfaces. By 2013, more than 90% of the proximal caries lesions in 15-year-olds were initial lesions. About 85% of 15-year-olds had a DFS of ≤ 5, whilst 1% exhibited a DFS of ≥ 26. The corresponding figures for 1973 were 0 and 45% respectively. The DFS score for the 20-year-olds was 35.1 in 1973 and 5.8 in 2013. Caries-free 20-year-olds were not seen until 1993 and reached 19% in 2013. Conclusions: Despite the dramatic decline in the prevalence of caries, caries still remains a health problem in a limited group of children, particularly those of pre-school ages. Repeated epidemiological studies are recommended to follow changes in oral health over time in order to evaluate existing preventive measures. [ABSTRACT FROM AUTHOR]

Published
2017
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37. Betrachtung des dermatochirurgischen Patientenkollektivs an einem Hauttumorzentrum in Deutschland.

Author

Lobeck, A., Weiss, C., Orouji, A., Koch, P.-S., Heck, M., Utikal, J., Koenen, W., Faulhaber, J., Klemke, C.-D., and Felcht, M.

Abstract

Copyright of Der Hautarzt is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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38. Organ and Metabolic Complications: β2-Microglobulin Amyloidosis.

Author

Jacobs, C., Kjellstrand, C. M., Koch, K. M., Winchester, J. F., Schaeffer, Juergen, and Koch, Karl-Martin

Abstract

Five years after the initial publication on carpal tunnel syndrome in hemodialysis patients (1), Assenat et al. (2) were the first to point out an association of this syndrome with a local deposition of amyloid. In 1984, Charra et al. (3) reported a correlation of the shoulder pain syndrome in hemodialysis patients with amyloid-positive histology from carpal tunnel surgery, and described the presence of amyloid in synovial tissue. Bardin et al. (4) established amyloidosis as a prominent cause of carpal tunnel syndrome, finger flexor synovitis, and cystic bone radiolucencies, and coined the phrase ‘dialysis amyloidosis'. The existence of a new form of amyloidosis peculiar to long-term hemodialysis patients underlying the amyloid arthropathy was suggested in 1985 (5), but the etiology and biochemical precursor were still unknown (6, 7). [ABSTRACT FROM AUTHOR]

Published
1996
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39. Replacement of Renal Function by Dialysis.

Author

Jacobs, C., Kjellstrand, C. M., Koch, K. M., Winchester, J. F., Lonnemann, Gerhard, and Koch, Karl M.

Abstract

In this review we will discuss the importance of bacterial contamination of dialysate fluid and the associated risk of pyrogenic reactions for patients on hemodialysis therapy. The degree of bacterial contamination of dialysate, relevant bacterial species and pyrogenic substances released from these microorganisms will be described. In addition, information about bacteriological methods to determine bacterial growth as well as assays to measure the pyrogenic activity of bacteria-derived substances will be given. Furthermore, we will describe in vitro studies testing the permeability of dialyzer membranes to pyrogenic substances derived from dialysate-born bacteria. We will discuss recent investigations suggesting that bacterial contamination of dialysate may cause repeated stimulation of immuno-competent cells including monocytes, lymphocytes and neutrophils, resulting in increased production of inflammatory mediators in end-stage renal disease (ESRD) patients. Finally, we will describe an effective approach to reduce the bacterial contamination of dialysis and the associated risk of pyrogenic reactions during hemodialysis [ABSTRACT FROM AUTHOR]

Published
1996
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44. Deutsche Industrieverbände: Studie zur Heterogenität der Verbandswirklichkeit.

Author

Kohler-Koch, Beate

Abstract

Copyright of Zeitschrift für Politikwissenschaft is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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45. Biomonitoring von Weichmachern.

Author

Koch, H.

Abstract

Copyright of Zentralblatt fuer Arbeitsmedizin, Arbeitsschutz und Ergonomie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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46. Die Auswirkung künftiger Geräuschgrenzwerte auf die Gestaltung von Abgasanlagen.

Author

Krüger, Jan, Buganza, Federico, and Koch, Viktor

Abstract

Copyright of ATZ: Automobiltechnische Zeitschrift is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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47. Design and Fabrication of TES Detector Modules for the TIME-Pilot [CII] Intensity Mapping Experiment.

Author

Hunacek, J., Bock, J., Bradford, C., Bumble, B., Chang, T.-C., Cheng, Y.-T., Cooray, A., Crites, A., Hailey-Dunsheath, S., Gong, Y., Kenyon, M., Koch, P., Li, C.-T., O'Brient, R., Shirokoff, E., Shiu, C., Staniszewski, Z., Uzgil, B., and Zemcov, M.

Subjects
PARTICLE detectors, WAVELENGTHS, SPECTROMETERS, REDSHIFT, POLARIZATION (Nuclear physics), FLUCTUATIONS (Physics)
Abstract

We are developing a series of close-packed modular detector arrays for TIME-Pilot, a new mm-wavelength grating spectrometer array that will map the intensity fluctuations of the redshifted 157.7 $$\upmu $$ m emission line of singly ionized carbon ([CII]) from redshift $$z \sim 5$$ to 9. TIME-Pilot's two banks of 16 parallel-plate waveguide spectrometers (one bank per polarization) will have a spectral range of 183-326 GHz and a resolving power of $$R \sim 100$$ . The spectrometers use a curved diffraction grating to disperse and focus the light on a series of output arcs, each sampled by 60 transition edge sensor (TES) bolometers with gold micro-mesh absorbers. These low-noise detectors will be operated from a 250 mK base temperature and are designed to have a background-limited NEP of $${\sim }10^{-17}~ \mathrm {W}/\mathrm {Hz}^{1/2}$$ . This proceeding presents an overview of the detector design in the context of the TIME-Pilot instrument. Additionally, a prototype detector module produced at the Microdevices Laboratory at JPL is shown. [ABSTRACT FROM AUTHOR]

Published
2016
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