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Background: A high Mandard score implies a non-response to chemotherapy in oesophageal adenocarcinoma. However, some patients exhibit tumour volume reduction and a nodal response despite a high score. This study examines survival and recurrence patterns in these patients.Methods: Clinicopathological factors were analysed using multivariable Cox regression assessing time to death and recurrence. Computed tomography-estimated tumour volume change was examined in a subgroup of consecutive patients.Results: Five hundred and fifty-five patients were included. Median survival was 55 months (Mandard 1-3) and 21 months (Mandard 4 and 5). In the Mandard 4 and 5 group (332 patients), comparison between complete nodal responders and persistent nodal disease showed improved survival (90 vs 18 months), recurrence rates (locoregional 14.75 vs 28.74%, systemic 24.59 vs 48.42%) and circumferential resection margin positivity (22.95 vs 68.11%). Complete nodal response independently predicted improved survival (hazard ratio 0.34 (0.16-0.74). Post-chemotherapy tumour volume reduction was greater in patients with a complete nodal response (-16.3 vs -7.7 cm3, p = 0.033) with no significant difference between Mandard groups.Conclusion: Patients with a complete nodal response to chemotherapy have significantly improved outcomes despite a poor Mandard score. High Mandard score does not correspond with a non-response to chemotherapy in all cases and patients with nodal downstaging may still benefit from adjuvant chemotherapy. [ABSTRACT FROM AUTHOR]

The interdisciplinary field of neurorobotics looks to neuroscience to overcome the limitations of modern robotics technology, to robotics to advance our understanding of the neural system's inner workings, and to information technology to develop tools that support those complementary endeavours. The development of these technologies is still at an early stage, which makes them an ideal candidate for proactive and anticipatory ethical reflection. This article explains the current state of neurorobotics development within the Human Brain Project, originating from a close collaboration between the scientific and technical experts who drive neurorobotics innovation, and the humanities and social sciences scholars who provide contextualising and reflective capabilities. This article discusses some of the ethical issues which can reasonably be expected. On this basis, the article explores possible gaps identified within this collaborative, ethical reflection that calls for attention to ensure that the development of neurorobotics is ethically sound and socially acceptable and desirable. [ABSTRACT FROM AUTHOR]

Traumatic spine injuries (TSIs) carry significantly high risks of morbidity, mortality, and exorbitant health care costs from associated medical needs following injury. For these reasons, TSI was chosen as an ENLS protocol. This article offers a comprehensive review on the management of spinal column injuries using the best available evidence. Though the review focuses primarily on cervical spinal column injuries, thoracolumbar injuries are briefly discussed as well. The initial emergency department (ED) clinical evaluation of possible spinal fractures and cord injuries, along with the definitive early management of confirmed injuries, are also covered. [ABSTRACT FROM AUTHOR]

Traumatic spine injuries (TSIs) carry significantly high risks of morbidity, mortality, and exorbitant health care costs from associated medical needs following injury. For these reasons, TSI was chosen as an ENLS protocol. This article offers a comprehensive review on the management of spinal column injuries using the best available evidence. Alhough the review focuses primarily on cervical spinal column injuries, thoracolumbar injuries are briefly discussed as well. The initial emergency department clinical evaluation of possible spinal fractures and cord injuries, along with the definitive early management of confirmed injuries, is also covered. [ABSTRACT FROM AUTHOR]

The study explored the factors that relate to the likelihood of institutional researchers (IRs) to plan to leave their jobs. Learning more about the effects on IR job turnover can serve to improve the employment experience of IR practitioners, the profession of IR, and, indirectly, higher education. 1,264 IRs responded to a national survey comprised of antecedents of intention to quit one’s job that had a high degree of construct validity within job turnover theories. Data were tested against a theoretical model developed from the Industrial-Organizational Psychology and IR literature. Perceived organizational support was the strongest predictor of intent to quit. Burnout, lack of advancement opportunities, lack of rewards and recognition, job embeddedness, and available job alternatives also affect IRs intention to quit. Suggestions for supporting IRs and elevating the role of IR on campuses are included. [ABSTRACT FROM AUTHOR]

A numerical model for the global tsunamis computation constructed by K owalik et al. (2005), is applied to the tsunami of 26 December, 2004 in the World Ocean from 80°S to 69°N with spatial resolution of one minute. Because the computational domain includes close to 200 million grid points, a parallel version of the code was developed and run on a Cray X1 supercomputer. An energy flux function is used to investigate energy transfer from the tsunami source to the Atlantic and Pacific Oceans. Although the first energy input into the Pacific Ocean was the primary (direct) wave, reflections from the Sri Lankan and eastern shores of Maldives were a larger source. The tsunami traveled from Indonesia, around New Zealand, and into the Pacific Ocean by various routes. The direct path through the deep ocean to North America carried miniscule energy, while the stronger signal traveled a considerably longer distance via South Pacific ridges as these bathymetric features amplified the energy flux vectors. Travel times for these amplified energy fluxes are much longer than the arrival of the first wave. These large fluxes are organized in the wave-like form when propagating between Australia and Antarctica. The sources for the larger fluxes are multiple reflections from the Seychelles, Maldives and a slower direct signal from the Bay of Bengal. The energy flux into the Atlantic Ocean shows a different pattern since the energy is pumped into this domain through the directional properties of the source function. The energy flow into the Pacific Ocean is approximately 75% of the total flow to the Atlantic Ocean. In many locations along the Pacific and Atlantic coasts, the first arriving signal, or forerunner, has lower amplitude than the main signal which often is much delayed. Understanding this temporal distribution is important for an application to tsunami warning and prediction. [ABSTRACT FROM AUTHOR]

An antiserum raised against the peptide, culetachykinin II, immunocytochemically detected a group of neurosecretory cells in the first flagellar segment of the antennae of both males and females of the mosquito, Culex salinarius. This is the first insect species in which neurosecretory cells have been found in the antennae. The ultrastructure of these antennal neurosecretory cells (ANC) is described, as well as their relationship to other neurons in the antennae and antennal lobe of the mosquito. These tachykinin-reactive cells contain relatively small (140–220 nm) elementary neurosecretory granules. Not only do the ANC have axons that terminate on specific glomeruli of the deutocerebrum, but these neurons also have collaterals that form neurohemal terminals in the receptor lymph channels of the dendrites of the sensory neurons. Thus, the ANC not only influence higher centers of the brain that interpret signals from the antennal sensillae, but also modulate the response of the sensory receptors. To our knowledge, this is the first report of neurosecretory cells directly affecting the signal reception of sensory neurons. [ABSTRACT FROM AUTHOR]

Terenzini (1993) approached the issue of institutional research effectiveness by articulating three tiers of organizational intelligence necessary for effective institutional researchers. Responses (n = 601) from a nationwide survey of AIR members provided for an empirical investigation based on this concept. The study examined the existence and acquisition of examples of institutional research knowledge and skills and how they relate to perceptions of effectiveness. Participants indicated that they were effective in their functions and reported that they possessed examples of the technical, issues, and (to a lesser extent) contextual knowledge and skills articulated by Terenzini. Multiple regression revealed the relationships between background characteristics, knowledge and skills in institutional research, and perceptions of effectiveness to be minimal, however. The authors conclude that an institutional researcher's effectiveness can perhaps only be adequately evaluated relative to institutional culture and expectations and leaders' personalities and orientation toward decision making. [ABSTRACT FROM AUTHOR]