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Weichteilsarkome sind mit weniger als 1 % aller Krebserkrankungen selten. In Deutschland wurden in den letzten Jahren zwischen 3500 und 3750 Neuerkrankungen pro Jahr registriert. Es lassen sich grob 2 Gruppen unterteilen: Entitäten mit einzelnen, gut definierten Treibermutationen und Sarkome mit einem komplexen Genotyp. Als Risikofaktoren gelten eine genetische Prädisposition wie die Neurofibromatose, radioaktive Strahlung, infektiöse Agenzien, Umweltgifte und chronische Entzündungen. Daneben können insbesondere fibroblastische Tumoren mit einem Trauma assoziiert sein. Die vorliegende Übersichtsarbeit basiert auf der mehrjährigen Erfahrung des Erstautors als Leiter des Referenzzentrums für Weichteiltumoren am Institut für Pathologie des Universitätsklinikums Jena und präsentiert aktuelle Daten zur Epidemiologie sowie zur pathologischen, genetischen und epigenetischen Klassifikation von Sarkomen. Darüber hinaus werden die technischen Entwicklungen der Sarkomdiagnostik mittels Methylom- und Genkopienzahlanalytik beleuchtet sowie die Möglichkeit illustriert, wie sich Sarkome anhand ihres Methylierungsmusters klassifizieren lassen. Diese Methodik wird voraussichtlich zusammen mit der massiven parallelen DNA-Sequenzierung Einzug in die Sarkomdiagnostik halten. Dem Pathologen wird zukünftig eine wichtige Rolle in der Interpretation dieser Daten im Kontext seiner konventionellen, auf histomorphologischen und immunhistologischen Befunden basierenden Klassifikation zukommen. Neben der Kenntnis der vielen Tumorentitäten bedarf es dabei eines Verständnisses der molekularen und zellulären Mechanismen im Sinne einer Pathway-Pathologie. Es ist zu hoffen, dass sich daraus neue translationale Ansätze bei der Behandlung dieser aktuell nur schwer medikamentös therapierbaren Tumoren ergeben werden. [ABSTRACT FROM AUTHOR]

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Since November 2009, the first European guidelines on perioperative cardiac care for non-cardiac surgery have been published by the European Society of Cardiology (ESC) and endorsed by the European Society of Anaesthesiology (ESA). The following article will describe the most important recommendations of these guidelines and discuss the clinically relevant differences to the corresponding recommendations of the current guidelines of the American College of Cardiology (ACC) and the American Heart Association (AHA). [ABSTRACT FROM AUTHOR]

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