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Injection moulding has been a pivotal technology in the mass production of polymer optics for many years. The surface quality of the moulding inserts exerts a significant influence on the quality of the optics produced. In the production of micro-structured polymer optics, such as Fresnel lenses, conventional isothermal injection moulding is unable to achieve the requisite surface accuracy. Variothermal injection moulding allows for improved surface accuracy and reduced residual stresses, but increases technical effort and cycle times. To reduce the cycle time and residual stresses of variothermal injection moulding, the potential of additive manufacturing of Al-40Si for the fabrication of moulding inserts is investigated. In order to achieve these objectives, the offered design freedom of additive manufacturing is investigated with a view to developing optimised conformal cooling channels. Numerical methods will be used for thermal and structural analyses. The performance of the newly developed moulding insert is evaluated experimentally by thermographic measurements and the measurement of stress birefringence on replicated PMMA samples. [ABSTRACT FROM AUTHOR]

The median age of the patients was 56 years, and 15 patients suffered from SAH, 2 patients from postoperative hydrocephalus, and 1 patient each from intracerebral hemorrhage, subdural empyema, and traumatic brain injury. For this reason, we also examined CSF samples with blood, as they are typically present in intracranial hemorrhage CSF specimens. Given that red blood cells also contain large amounts of NSE hemolysis may cause a marked increase of NSE in CSF samples. We therefore assume that CSF-repellant properties of the CSF filter system that are supposed to prevent ascending infections do cause an inconsistent downstream drainage of cells into the overflow system. [Extracted from the article]

The Cryogenic Rare Event Search with Superconducting Thermometers (CRESST) experiment aims at the direct detection of dark matter particles via their elastic scattering off nuclei in a scintillating CaWO 4 target crystal. The CaWO 4 crystal is operated together with a light detector at mK temperature and read out by a Transition Edge Sensor. For many years, CaWO 4 crystals have successfully been produced in-house at Technical University of Munich (TUM) with a focus on high radiopurity which is crucial to reduce background originating from radioactive contamination. In order to further improve the CaWO 4 crystals, an extensive chemical purification of the raw materials and the synthesised CaWO 4 powder has been performed. In addition, a temperature gradient simulation of the growth process and subsequently an optimisation of the growth furnace with the goal to reduce the intrinsic stress was carried out. We present results on the intrinsic stress in the CaWO 4 crystals and on the CaWO 4 powder radiopurity. A crystal grown from the purified material was installed in the current CRESST set-up. The detector is equipped with an instrumented holder which is used to measure the alpha decay rate of the crystal. We present a preliminary analysis showing a significantly reduced intrinsic background from natural decay chains. [ABSTRACT FROM AUTHOR]

Coherent neutrino-nucleus scattering is a promising new tool in the toolbox of electroweak precision measurements at low q-transfer. It will enable precise measurements of standard model (SM) physics like the running of the Weinberg angle but also the search for new physics beyond the SM like sterile neutrinos. The Nucleus experiment aims at the first detection of fully coherent neutrino-nucleus scattering at the Chooz power plant in France, using its two 4GWth reactor cores as high-intensity source for anti-neutrinos. For this endeavour a new experimental site, the Very Near Site (VNS), with a shallow rock overburden of ≈ 3 m w.e. is under development. To be competitive in this challenging environment, Nucleus developed the novel concept of fiducialised cryogenic bolometers based on CaWO 4 monocrystals operated at O (10 mK). The signature of a coherent neutrino-nucleus scattering is a nuclear recoil at the 10 eV-scale. Currently, Nucleus is preparing its first phase with 10 g of target mass at the VNS. In this contribution, we will first introduce Nucleus, report its current state and give an outlook to its future. [ABSTRACT FROM AUTHOR]

The NUCLEUS experiment aims for the detection of coherent elastic neutrino-nucleus scattering at a nuclear power reactor with gram-scale, ultra-low-threshold cryogenic detectors. This technology leads to a miniaturization of neutrino detectors and allows to probe physics beyond the Standard Model of particle physics. A 0.5 g NUCLEUS prototype detector, operated above ground in 2017, reached an energy threshold for nuclear recoils of below 20 eV. This sensitivity is achieved with tungsten transition edge sensors which are operating at temperatures of 15 mK and are mainly sensitive to non-thermal phonons. These small recoil energies become accessible for the first time with this technology, which allows collecting large-statistics neutrino event samples with a moderate detector mass. A first-phase cryogenic detector array with a total mass of 10 g enables a 5-sigma observation of coherent scattering within several weeks. We identified a suitable experimental site at the Chooz Nuclear Power Plant and performed muon and neutron background measurements there. The operation of a NUCLEUS cryogenic detector array at such a site requires highly efficient background suppression. NUCLEUS plans to use an innovative technique consisting of separate cryogenic anticoincidence detectors against surface backgrounds and penetrating (gamma, neutron) radiation. We present first results from prototypes of these veto detectors and their operation in coincidence with a NUCLEUS target detector. [ABSTRACT FROM AUTHOR]

Coherent elastic neutrino–nucleus scattering ( CE ν NS ) offers a unique way to study neutrino properties and to search for new physics beyond the Standard Model. Nuclear reactors are promising sources to explore this process at low energies since they deliver large fluxes of anti-neutrinos with typical energies of a few MeV. In this paper, a new-generation experiment to study CE ν NS is described. The NUCLEUS experiment will use cryogenic detectors which feature an unprecedentedly low-energy threshold and a time response fast enough to be operated under above-ground conditions. Both sensitivity to low-energy nuclear recoils and a high event rate tolerance are stringent requirements to measuring CE ν NS of reactor anti-neutrinos. A new experimental site, the Very-Near-Site (VNS), at the Chooz nuclear power plant in France is described. The VNS is located between the two 4.25 GW th reactor cores and matches the requirements of NUCLEUS. First results of on-site measurements of neutron and muon backgrounds, the expected dominant background contributions, are given. In this paper a preliminary experimental set-up with dedicated active and passive background reduction techniques and first background estimations are presented. Furthermore, the feasibility to operate the detectors in coincidence with an active muon veto at shallow overburden is studied. The paper concludes with a sensitivity study pointing out the physics potential of NUCLEUS at the Chooz nuclear power plant. [ABSTRACT FROM AUTHOR]

For ground- and spaced-based applications, Ag-coated reflectors are indispensable because of their high reflectivity. The transport, assembly, and storage of these reflectors take places over a long period before they are finally commissioned for application. To endure this period without a decrease of reflectivity, protective coatings with a final layer, which offers a high resistance to aqueous solutions, and a low mechanical stress should be used. These criteria were taken into account for the selection of a final layer for a protected Ag coating, which was applied for reflectors utilized in the CRIRES+-instrument (an IR spectrograph used at the VLT). Reactively sputtered Al2O3, SiO2 and Si3N4 layers were investigated with regard to these criteria. In aqueous (alkaline) solutions, the investigated Si3N4 layers are more stable than the SiO2 layers and the SiO2 layers more stable than the Al2O3 layers. This shows the influence of the intrinsic material properties. The mechanical stress of the sputtered layers depends on the deposition conditions and thus on the selected parameters. A Si3N4 layer with a high resistance to aqueous (alkaline) solutions also offers low and stable mechanical stress. Therefore, the deposition parameters used for this layer were applied for sputtering the final layer of the protected Ag coating for the reflectors. [ABSTRACT FROM AUTHOR]

The Physics Department of the Technical University of Munich operates a shallow underground detector laboratory in Garching, Germany. It provides ∼160m2 of laboratory space which is shielded from cosmic radiation by ∼6m of gravel and soil, corresponding to a shielding of ∼15m.w.e.. The laboratory also houses a cleanroom equipped with work- and wetbenches, a chemical fumehood as well as a spin-coater and a mask-aligner for photolithographic processing of semiconductor detectors. Furthermore, the shallow underground laboratory runs two high-purity germanium detector screening stations, a liquid argon cryostat and a 3He-4He dilution refrigerator with a base temperature of ≤12-14mK. The infrastructure provided by the shallow laboratory is particularly relevant for the characterization of CaWO4 target crystals for the CRESST-III experiment, detector fabrication and assembly for rare event searches. Future applications of the laboratory include detector development in the framework of coherent neutrino nucleus scattering experiments (ν-cleus) and studying its potential as a site to search for MeV-scale dark matter with gram-scale cryogenic detectors. [ABSTRACT FROM AUTHOR]

Growing numbers of translational genomics studies are based on the highly efficient and versatile zebrafish ( Danio rerio) vertebrate model. The increasing types of zebrafish models have improved our understanding of inherited kidney diseases, since they not only display pathophysiological changes but also give us the opportunity to develop and test novel treatment options in a high-throughput manner. New paradigms in inherited kidney diseases have been developed on the basis of the distinct genome conservation of approximately 70 % between zebrafish and humans in terms of existing gene orthologs. Several options are available to determine the functional role of a specific gene or gene sets. Permanent genome editing can be induced via complete gene knockout by using the CRISPR/Cas-system, among others, or via transient modification by using various morpholino techniques. Cross-species rescues succeeding knockdown techniques are employed to determine the functional significance of a target gene or a specific mutation. This article summarizes the current techniques and discusses their perspectives. [ABSTRACT FROM AUTHOR]

A new model for patchy landscapes in drylands is introduced. The model captures the dynamics of biogenic soil crusts and their mutual interactions with vegetation growth. The model is used to identify spatially uniform and spatially periodic solutions that represent different vegetation-crust states, and map them along the rainfall gradient. The results are consistent extensions of the vegetation states found in earlier models. A significant difference between the current and earlier models of patchy landscapes is found in the bistability range of vegetated and unvegetated states; the incorporation of crust dynamics shifts the onset of vegetation patterns to a higher precipitation value and increases the biomass amplitude. These results can shed new light on the involvement of biogenic crusts in desertification processes that involve vegetation loss. [ABSTRACT FROM AUTHOR]

Site-specific weed management can allow more efficient weed control from both an environmental and an economic perspective. Spectral differences between plant species may lead to the ability to separate wheat from weeds. The study used ground-level image spectroscopy data, with high spectral and spatial resolutions, for detecting annual grasses and broadleaf weeds in wheat fields. The image pixels were used to cross-validate partial least squares discriminant analysis classification models. The best model was chosen by comparing the cross-validation confusion matrices in terms of their variances and Cohen's Kappa values. This best model used four classes: broadleaf, grass weeds, soil and wheat and resulted in Kappa of 0.79 and total accuracy of 85 %. Each of the classes contains both sunlit and shaded data. The variable importance in projection method was applied in order to locate the most important spectral regions for each of the classes. It was found that the red-edge is the most important region for the vegetation classes. Ground truth pixels were randomly selected and their confusion matrix resulted in a Kappa of 0.63 and total accuracy of 72 %. The results obtained were reasonable although the model used wheat and weeds from different growth stages, acquisition dates and fields. It was concluded that high spectral and spatial resolutions can provide separation between wheat and weeds based on their spectral data. The results show feasibility for up-scaling the spectral methods to air or spaceborne sensors as well as developing ground-level application. [ABSTRACT FROM AUTHOR]

Hypoxanthine phosphoribosyl transferase (HPRT) deficiency results in Lesch-Nyhan disease (LND). The link between the HPRT defect and the self-injurious behavior in LND is still unknown. HPRT-deficient rat B103 neuroblastoma cells serve as a model system for LND. In B103 cell membranes, HPRT deficiency is associated with a decrease of basal and guanosine triphosphate-stimulated adenylyl cyclase (AC) activity (Pinto and Seifert, J Neurochem 96:454-459, ). Since recombinant AC2 possesses a high basal activity, we tested the hypothesis that AC2 function and expression is impaired in HPRT deficiency. We examined AC regulation in B103 cell membranes, cAMP accumulation in intact B103 cells, AC isoform expression, and performed morphological studies. As most important pharmacological tool, we used 4,4-difluoro-4-bora-3a,4a-diaza- s-indacene forskolin (BODIPY-FS) that inhibits recombinant AC2 but activates ACs 1 and 5 (Erdorf et al., Biochem Pharmacol 82:1673-1681, ). In B103 control membranes, BODIPY-FS reduced catalysis, but in HPRT membranes, BODIPY-FS was rather stimulatory. 2′(3′)- O-( N-methylanthraniloyl) (MANT)-nucleoside 5′-[γ-thio]triphosphates inhibit recombinant ACs 1 and 5 more potently than AC2. In B103 control membranes, MANT-guanosine 5′-[γ-thio]triphosphate inhibited catalysis in control membranes less potently than in HPRT membranes. Quantitative real-time PCR revealed that in HPRT deficiency, AC2 was virtually absent. In contrast, AC5 was up-regulated. Forskolin (FS) and BODIPY-FS induced cell clustering and rounding and neurite extension in B103 cells. The effects of FS and BODIPY-FS were much more prominent in control than in HPRT cells, indicative for a differentiation defect in HPRT deficiency. Neither FS nor BODIPY-FS significantly changed cAMP concentrations in intact B103 cells. Collectively, our data show that HPRT deficiency in B103 cells is associated with impaired AC2 function and expression and reduced sensitivity to differentiation induced by FS and BODIPY-FS. We discuss the pathophysiological implications of our data for LND. [ABSTRACT FROM AUTHOR]

Magnetic and structural properties of Heusler PdMnSn with x = 0.05, 0.10, 0.17, 0.20 and 0.25, have been studied by magnetisation and X-ray diffraction measurements at room and low temperatures. The crystal structure at room temperature is L2 cubic phase for x = 0.17, 0.20, 0.25 and B2 cubic phase for x = 0.10. Martensite structure 10M, was observed at room temperature for x = 0.05. X-ray measurements at low temperatures revealed a structural transformation from B2 to 14 M for the x = 0.10 case. The lattice parameter of the L2 phase decreases linearly with the concentration, x. A ferromagnetic behaviour has been detected for L2 compounds, but the ferromagnetic exchange characteristic of each composition is of different strength. This gives rise to different Curie temperatures. [ABSTRACT FROM AUTHOR]

Abstract   We use all-optical methods to produce a highly-degenerate Fermi gas of spin-1/2 6Li atoms. A magnetic field tunes the gas near a collisional (Feshbach) resonance, producing strong interactions between spin-up and spin-down atoms. We have measured properties of a breathing mode over a wide range of temperatures. As the temperature is increased from below the superfluid transition to above, the frequency of the mode is always close to the hydrodynamic value, while the damping rate increases. A complete explanation of both the frequency and the damping rate in the normal collisional regime has not been achieved. Our measurements of the damping rate as a function of the energy of the gas are used to estimate an upper bound on the viscosity. Using our new measurements of the entropy of the gas, we estimate the ratio of the shear viscosity to the entropy density and compare the result with a recent string theory conjecture for the minimum viscosity of a perfect quantum fluid. [ABSTRACT FROM AUTHOR]

Evaluates the impact of ascorbic acid doses during luteal phase in infertility treatment. Differences in clinical pregnancy rate and implantation rate of ascorbic acid; Details on the statistical logistic regression analysis between intake groups; Value of intake of vitamin C during luteal phase in infertility treatment.

Copyright of Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopadie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopadie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopadie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopadie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopadie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopadie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopadie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Conventional interlocking nails for the femur use an inclined proximal interlocking screw; the AO/ASIF universal interlocking nail utilizes a transverse interlocking screw which is anchored in cortical bone. The transverse position of the screw allows one to employ the nail for either the right or left side. The yield strength of the thinner diameter transverse screw, (thread 4.5 mm. core 3.0 mm) was compared with that of the Grosse-Kempf nail oblique screw (thread 6.3 mm, core 4.5 mm) by testing in cadaver femora to evaluate the risk of fatigue failure. The test, performed using slow loading rates (50 N/s), simulated either a diaphyseal or a subtrochanteric fracture situation. The test rig applied a load corresponding to body weight and pull at the trochanter. Taking the highest load without plastic deformation as a criterion, the mechanical strength of the two screws was evaluated for each fracture situation. The thinner but shorter transverse interlocking screw demonstrated higher strength (4500 N vs. 3000 N; P less than or equal to 0.02) than the thicker inclined screw in the diaphyseal and the subtrochanteric fracture situation (2300 N vs. 1100 N; P less than or equal to 0.06). The biomechanical test showed the transverse screw to have sufficient and superior strength. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopadie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Orofacial Orthopedics/Fortschritte der Kieferorthopadie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Since 2003 bread and fine bakery products must not contain more than 350 μg Deoxynivalenol (DON). As a prerequisite for the label “Geprüfte Qualität”—Thüringen [proved quality Thuringia] and since coming into force of the respective evaluation prescription a total of 25 breads and 41 fine bakery products was investigated by ELISA with regard of this compound. In the 66 samples of the year 2003 no DON concentrations above the limit were detected and in the preparation period 2001/2002 only one sample exceeded the maximum. In several samples, most narrow to the maximum limit, an additional determination by HPLC was performed which resulted in lower DON-concentrations as compared to the values analyzed by ELISA. [ABSTRACT FROM AUTHOR]

PHA-activated lymphocytes release colony-stimulating activity (CSA) for macrophage-granulocyte precursor cells (colony forming units, CFU) in the culture medium. Somatostatin, known to interfer with ribosomal protein synthesis, was demonstrated to reduce the release of CSA from PHA-treated mouse spleen lymphocytes. [ABSTRACT FROM AUTHOR]

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In this work, we want to highlight the potential of lithium as a target for spin-dependent dark matter search in cryogenic experiments, with a special focus on the low-mass region of the parameter space. We operated a prototype detector module based on a Li 2 MoO 4 target crystal in an above-ground laboratory. Despite the high background environment, the detector sets a competitive limit on spin-dependent interactions of dark matter particles with protons and neutrons for masses between 0.8 GeV/c 2 and 1.5 GeV/c 2 . [ABSTRACT FROM AUTHOR]

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Copyright of Langenbecks Archiv fuer Chirurgie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Langenbecks Archiv fuer Chirurgie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)