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The purpose of this study was to investigate the relationship between the pneumatization of mastoid air cells and PNS using three-dimensional (3D) reconstruction of computed tomography (CT) scans of the PNS. A retrospective review of PNS CT scans from 60 cases was performed. Patients with evidence of sinusitis or mastoiditis, or a history of head trauma, were excluded from the study. Volumes were measured using 3D reconstruction based on axial images of 1 mm thickness. Volumes of the mastoid air cells (right and left), frontal sinus, sphenoid sinus, and maxillary sinuses (right and left) were obtained and compared using statistical analysis. The volume of mastoid air cells and sinuses did change with age, but the volumes of male subjects were larger than those of females. There was a positive correlation between the pneumatization of mastoid air cells and that of the sphenoid sinus; however, no relationship was observed between the volume of mastoid air cells and that of the maxillary sinuses. This study examined whether a similarity in pneumatization exists between the mastoid air cells and PNS of individuals; these results may be useful in understanding the normal and pathological conditions of both structures. [ABSTRACT FROM AUTHOR]

Postoperative ventilation tube (VT) blockage is relatively common with a reported incidence of 0.0–13.1%. The purpose of this study was to evaluate the factors that contribute to postoperative VT blockage. A retrospective chart review was carried out to compare rates of VT blockage within 2 weeks postsurgery. Analyzed factors included: otic drop, nature, and amount of middle ear (ME) effusion, presence of ME mucosa edema or granulation, bleeding during surgery, number of prior VT insertion, and the status of the tympanic membrane (TM). One hundred and twenty-eight ears from 79 patients were enrolled in this study. Eleven VTs (8.6%) were obstructed within 2 weeks postsurgery. Ears using ciprobay and tarivid otic drops showed a significantly higher rate of tube blockage (14.1%) compared to ears that were not exposed to otic drops (1.8%). Glue effusion caused the highest rates (14.8%) of tube blockage compared to mucoid (9.6%) and serous (3.0%) effusions. The amount of effusion, the presence of mucosal edema or granulation, bleeding during surgery, number of prior VT insertions and the status of the TM were not associated with postoperative VT blockage. The results of this study suggest that the routine use of antibiotic-containing otic drops after the insertion of VT may not be useful. Viscosity of the effusion appears to have an effect on the postoperative VT blockage. Thus, more attention should be focused on the ears with glue or mucoid effusions after surgery. [ABSTRACT FROM AUTHOR]

Testosterones have beneficial effects not only on the modulation of expression of autoimmunity of B/W mice, but on other unrelated models such as autoimmune thyroiditis as well. This study was performed to evaluate the effect of testosterone in the treatment of immune-mediated sensorineural hearing loss (IMSNHL). To induce IMSNHL, 29 female Wistar rats were sensitized with bovine inner ear antigen three times weekly. Fourteen of 29 rats were injected subcutaneously three times a week with 250 μg of testosterone propionate from 1 week prior to the first sensitization to 1 week following the second booster sensitization. An auditory brain-stem response (ABR) test was performed prior to each antigen challenge and at 1, 2, 3, 4, 6 and 8 weeks following sensitization. On ABR testing, the testosterone-treated animals showed better results than the control animals with IMSNHL in the degree of hearing loss (10 to 20 dB vs. 10 to 40 dB) and incidence of hearing loss over 20 dB (25.0% vs. 53.3%). None of testosterone-treated animals showed a hearing loss over 20 dB, whereas 40% of the control animals with IMSNHL revealed hearing loss over 20 dB. These results suggest that testosterone propionate may be effective in the prevention of and early recovery from IMSNHL and may be used in the future as a one treatment modality for IMSNHL. [ABSTRACT FROM AUTHOR]