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6 results on '"Kawamura, Naoshi"'

1. Personalized Cancer Immunotherapy: Immune Biomarkers and Combination Immunotherapy.

Author

Kawakami, Yutaka, Popivanova, Boryana, Nuchsupha, Sunthamala, Hayakawa, Taeko, Nakamura, Kenta, Nagumo, Haruna, Katano, Ikumi, Kinoshita, Tomonari, Tsubota, Kinya, Kamijuku, Hajime, Kawamura, Naoshi, Miyazaki, Junichiro, Satomi, Ryosuke, Sugiyama, Juri, Nishio, Hiroshi, Noji, Shinobu, Kudo-Saito, Chie, Tsukamoto, Nobuo, Sakurai, Toshiharu, and Fujita, Tomonobu

Published
2016
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2. Development of Personalized Combination Cancer Immunotherapy Based on the Patients' Immune Status.

Author

Kawakami, Yutaka, Qian, Li, Kawamura, Naoshi, Miyazaki, Junichiro, Nagumo, Haruna, Tsubota, Kinya, Kinoshita, Tomonari, Nakamua, Kenta, Ohmura, Gaku, Satomi, Ryosuke, Sugiyama, Juri, Nishio, Hiroshi, Hayakawa, Taeko, Popivanova, Boryana, Nuchsupha, Sunthamala, Liu, Tracy Hsin-ju, Kamijuku, Hajime, Kudo-Saito, Chie, Tsukamoto, Nobuo, and Sakurai, Toshiharu

Published
2015
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3. Cancer Induced Immunosuppression and Its Modulation by Signal Inhibitors.

Author

Kawakami, Yutaka, Qian, Li, Kawamura, Naoshi, Miyazaki, Junichiro, Tsubota, Kinya, Kinoshita, Tomonari, Nakamura, Kenta, Ohmura, Gaku, Satomi, Ryosuke, Sugiyama, Juri, Nishio, Hiroshi, Hayakawa, Taeko, Popivanova, Boryana, Nuchsupha, Sunthamala, Liu, Tracy Hsin-ju, Kamijuku, Hajime, Kudo-Saito, Chie, Tsukamoto, Nobuo, Sakurai, Toshiharu, and Fujita, Tomonobu

Published
2015
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4. Intratumoral Injection of BCG-CWS-Pretreated Dendritic Cells Following Tumor Cryoablation.

Author

Kawamura, Naoshi, Udagawa, Masaru, Fujita, Tomonobu, Sakurai, Toshiharu, Yaguchi, Tomonori, and Kawakami, Yutaka

Abstract

Intratumoral administration of dendritic cells (DC) following cryoablation of tumor is one of the personalized cancer immunotherapies which is able to induce immune responses to multiple endogenous tumor antigens, including shared and unique antigens. Here we describe protocols of cryoablation of tumors, generation of cultured DC, pretreatment of DC with a Toll-like receptor (TLR)-stimulating purified component of Bacillus Calmette-Guerin cell wall fraction (BCG-CWS) and highly immunogenic keyhole limpet hemocyanin (KLH) antigen, and combined use of tumor cryoablation and intratumoral administration of BCG-CWS-pretreated DC in both a murine model and cancer patients. [ABSTRACT FROM AUTHOR]

Published
2014
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6. The mechanisms of cancer immunoescape and development of overcoming strategies.

Author

Yaguchi, Tomonori, Sumimoto, Hidetoshi, Kudo-Saito, Chie, Tsukamoto, Nobuo, Ueda, Ryo, Iwata-Kajihara, Tomoko, Nishio, Hiroshi, Kawamura, Naoshi, and Kawakami, Yutaka

Abstract

Cancer-induced immunosuppression is a major problem as it reduces the anti-tumor effects of immunotherapies. In cancer tissues, cancer cells, immune cells, and other stromal cells interact and create an immunosuppressive microenvironment through a variety of immunosuppressive factors. Some cancer subpopulations such as cancer cells undergoing epithelial-mesenchymal transition and cancer stem-like cells have immunosuppressive and immunoresistant properties. The production of immunosuppressive factors by cancer cells is mechanistically attributed to oncogenic signals frequently activated in cancer cells, including the STAT3, MAPK, NF-κB, and Wnt/β-catenin signals, which are upstream events leading to immunosuppressive cascades. Moreover, some of these signals are also activated in immunosuppressive immune cells stimulated by cancer-derived factors and contribute to their immunosuppressive activities. Therefore, targeting these signals both in cancer cells and immunosuppressive immune cells may result in the restoration of immunocompetence in cancer patients and improve current immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2011
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