1. Radiotherapy induces responsiveness of a resistant mammary carcinoma to PD-1 blockade
- Author
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Julie M. Diamond, Karsten A. Pilones, Ralph E. Vatner, Joseph Aryankalayil, Silvia C. Formenti, and Sandra Demaria
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Pharmacology ,Cancer Research ,business.industry ,medicine.medical_treatment ,Immunology ,Spleen ,Bioinformatics ,Mammary carcinoma ,Radiation therapy ,medicine.anatomical_structure ,Oncology ,Downregulation and upregulation ,Poster Presentation ,medicine ,Cancer research ,Molecular Medicine ,Immunology and Allergy ,Pd 1 blockade ,Delayed growth ,Tumor growth ,business ,CD8 - Abstract
ligands, PDL-1/2, were upregulated by RT on TSA cells and tumor-infiltrating myeloid cells, suggesting PD-1’s interaction with its ligands may limit RT-activated antitumor T-cell activity. Consistent with this hypothesis, RMP1-14 alone had no effect on tumor growth; RT delayed growth (p < 0.01), but only 1/6 mice showed tumor regression, whereas all mice receiving RT+RMP114 completely rejected tumors by day 25. In spleen, RMP1-14 had no effect on AH1-specific CD8 + T-cells
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