1. Carbapenem-resistant and carbapenem-susceptible isogenic isolates of Klebsiella pneumoniae ST101 causing infection in a tertiary hospital
- Author
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Carmen Peña, Miquel Pujol, María Ángeles Domínguez, Carmen Ardanuy, Meritxell Cubero, Josefina Liñares, Guillermo Cuervo, Elena Sevillano, Fe Tubau, Lucía Gallego, Josefina Ayats, and Sara Martí
- Subjects
Male ,Carbapenem ,Imipenem ,Klebsiella pneumoniae ,medicine.medical_treatment ,efficacy ,Drug resistance ,OXA-48 carbapenemase ,molecular epidemiology ,Disease Outbreaks ,Tertiary Care Centers ,chemistry.chemical_compound ,polycyclic compounds ,Antibiòtics betalactàmics ,Medicaments antibacterians ,Aged, 80 and over ,Cross Infection ,biology ,Middle Aged ,Infeccions ,Hospitals ,Anti-Bacterial Agents ,Electrophoresis, Gel, Pulsed-Field ,Female ,escheria cpli ,spetrum beta-lactamases ,Ertapenem ,Beta lactam antibiotics ,Plasmids ,Research Article ,medicine.drug ,Adult ,Microbiology (medical) ,MICROBIOLOGY ,Genotype ,Microbial Sensitivity Tests ,Infections ,Microbiology ,Meropenem ,Genomic Instability ,beta-Lactam Resistance ,beta-Lactamases ,Bacterial Proteins ,medicine ,Humans ,Aged ,Retrospective Studies ,Resistència als medicaments ,outbreak ,criteria ,Outbreak ,biochemical phenomena, metabolism, and nutrition ,biology.organism_classification ,bacterial infections and mycoses ,Virology ,Klebsiella Infections ,Molecular Typing ,Antibacterial agents ,Carbapenems ,chemistry ,Spain ,Beta-lactamase ,bacteria ,enterobacteriaceae ,imipenem - Abstract
Background: In this study we describe the clinical and molecular characteristics of an outbreak due to carbapenem-resistant Klebsiella pneumoniae (CR-KP) producing CTX-M-15 and OXA-48 carbapenemase. Isogenic strains, carbapenem-susceptible K. pneumoniae (CS-KP) producing CTX-M-15, were also involved in the outbreak. Results: From October 2010 to December 2012 a total of 62 CR-KP and 23 CS-KP were isolated from clinical samples of 42 patients (22 had resistant isolates, 14 had susceptible isolates, and 6 had both CR and CS isolates). All patients had underlying diseases and 17 of them (14 patients with CR-KP and 3 with CS-KP) had received carbapenems previously. The range of carbapenem MICs for total isolates were: imipenem: 2 to >32 mu g/ml vs. 32 mu g/ml vs. 32 mu g/ml vs.
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