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SPECT/CT images have proved the capability of 99mTc-EDDA/HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu to detect prostate cancer tumors in patients. Considering that theranostics combines the potential of therapeutic and diagnostic radionuclides in the same molecular probe, this research aimed to prepare 177Lu-DOTA-HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu (177Lu-iPSMA) and evaluate the in vitro and in vivo radiotracer ability to target the PSMA protein overexpressed in prostate cancer cells (LNCaP). 177Lu-iPSMA, obtained with radiochemical purities of 99%, showed specific in vitro and in vivo recognition for PSMA in prostate cancer cells and high LNCaP-tumor uptake (11 ± 2% ID/g at 24 h). The results obtained warrant further studies to evaluate the therapeutic efficacy of 177Lu-iPSMA. [ABSTRACT FROM AUTHOR]

Lu-Tyr-octreotide and Lu-PSMA(inhibitor) radiopeptides were obtained with radiochemical purities of 98.7-100%, from lyophilized formulations after reconstitution with sterile solutions of LuCl (40 GBq/mL) without the need for further purification or sterilization processes. More than 50 radiochemical syntheses were performed with a failure rate of 0% and radiochemical yields of 94-97%. From one lyophilized kit of DOTA-Tyr-octreotide or DOTA-iPSMA, it was possible to obtain from 5 (7.4 GBq) to 10 (3.7 GBq) doses suitable for patients. Also, by using a sterile solution of LuCl approved as a radiopharmaceutical precursor for human use, it is possible to obtain GMP-compliant Lu-peptides from sterile freeze-dried formulations without the need of using commercially-available radiochemical synthesizers. [ABSTRACT FROM AUTHOR]

The goal of this paper is to introduce bounded rational behaviors in a competitive queuing system. Furthermore, we propose a realistic queuing model for two last-mile delivery services in which consumers are in competition. This work is derived from a real-world e-commerce application. We study the problem using a game theoretical point of view: the e-consumers are interacting through the last-mile delivery service system creating congestion for each other. Specifically, we focus our analysis on several equilibrium concepts from congestion/routing games: Wardrop and Logit equilibria. The difference in these equilibrium concepts is on the rationality level of players in the game. We are able to prove the existence and uniqueness of both equilibria. We compare them through a new metric called the Price of Rationality and we also compare each one to the social optimum solution through the Price of Anarchy. Some numerical results are presented in order to illustrate the theoretical results obtained. [ABSTRACT FROM AUTHOR]

Temporary overload situations in queues can be approximated by fluid queues. We strengthen earlier results on the comparison of multi-server tandem systems with their fluid limits. At the same time we give conditions under which economies of scale hold. We apply the results to call centers. [ABSTRACT FROM AUTHOR]