1. Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11c]nnc-112
- Author
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Dara M. Cannon, Kristine Erickson, Summer A. Peck, Jacqueline M. Klaver, Denise Rallis-Voak, and Wayne C. Drevets
- Subjects
Male ,striatum ,Caudate nucleus ,Striatum ,g-protein-coupled receptor ,Basal Ganglia ,Functional Laterality ,Basal ganglia ,Radioligand ,Carbon Radioisotopes ,mood-disorders ,Sex Characteristics ,prefrontal cortex ,Putamen ,Dopaminergic ,serotonin transporter ,Middle Aged ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,anhedonia ,Dopamine receptor ,Female ,medicine.symptom ,Psychology ,Adult ,medicine.medical_specialty ,Adolescent ,d-1 receptor ,behavioral disciplines and activities ,Article ,Young Adult ,d1 receptors ,Internal medicine ,mental disorders ,medicine ,Humans ,human-brain ,caudate ,Benzofurans ,Pharmacology ,Depressive Disorder, Major ,Receptors, Dopamine D1 ,age-related-changes ,Anhedonia ,greater availability ,Benzazepines ,Endocrinology ,Positron-Emission Tomography ,g-protein coupled receptor ,parkinsons-disease ,striatal dopamine-d-2 ,Neuroscience - Abstract
Introduction The dopamine-type-1 receptor has been implicated in major depressive disorder (MDD) by clinical and preclinical evidence from neuroimaging, post-mortem and behavioral studies. To date, however, selective in vivo assessment of D1-receptors has been limited to the striatum in MDD-samples manifesting anger attacks. We employed the PET radioligand, [11C]NNC-112, to selectively assess D1-receptor binding in extrastriatal and striatal regions in a more generalized sample of MDD-subjects. Methods The [11C]NNC-112 nondisplaceable binding-potential (BPND) was assessed using PET in 18 unmedicated, currently-depressed subjects with MDD and 19 healthy controls, and compared between groups using MRI-based region-of-interest analysis. Results The mean D1-receptor BPND was reduced (14%) in the left middle caudate of the MDD group relative to control group (p
- Published
- 2008