1. Regulation of apoptosis by protein S-nitrosylation.
- Author
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J. B. Mannick
- Subjects
- *
APOPTOSIS , *CELL death , *PROTEIN S , *CIRCULATING anticoagulants - Abstract
Summary. S-nitrosylation/denitrosylation of critical cysteine residues on proteins serves as a redox switch that regulates the function of a wide array of proteins. A key signaling pathway that is regulated by S-nitrosylation is apoptotic cell death. Here we will review the proteins in apoptotic pathways that are known to be S-nitrosylated by endogenous NO production. The targets and functional consequences of S-nitrosylation during apoptosis are multifaceted, allowing cells to fine tune their response to apoptotic signals. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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