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Background: Chronic migraine (CM) is a significant neurological condition affecting a substantial portion of the global population. The economic burden of CM includes both direct healthcare costs and indirect costs resulting from productivity losses and intangible impacts on patients' quality of life. However, there is limited research that comprehensively evaluates all cost components associated with CM, highlighting the need for a systematic review. Methods: We conducted a systematic literature search in databases including MEDLINE, Embase, and CINAHL to identify studies estimating the cost of illness of chronic migraines. The search was restricted to English language articles published from inception to October 2021, and only findings from Organisation for Economic Co-operation and Development (OECD) countries were included. Methodology features and key findings were extracted from the studies, and reported costs were converted to GBP for cross-country comparisons. Results: Thirteen cost-of-illness studies on CM from various OECD countries were included in this review. The studies demonstrated substantial variations in monetary estimates, but consistently highlighted the considerable economic burden of CM. Direct costs, particularly hospitalisation and medication expenses, were identified as the highest contributors. However, indirect costs, such as productivity losses due to absenteeism and presenteeism, were often underexplored in the reviewed studies. Additionally, intangible costs related to emotional and social impacts on patients were largely overlooked. Conclusion: Chronic migraine imposes a significant economic burden on individuals, healthcare systems, and society. Policymakers and healthcare stakeholders should consider both direct and indirect cost components, as well as intangible costs, in developing targeted strategies for effective CM management and resource allocation. Further research focusing on comprehensive cost assessments and sensitivity analyses is needed to enhance the understanding of CM's economic implications and inform evidence-based healthcare policy decisions. Addressing these research gaps can alleviate the economic burden of CM and improve patient outcomes. [ABSTRACT FROM AUTHOR]

Background: Previous literature documents the direct and indirect economic costs of obesity, yet none has attempted to quantify the intangible costs of obesity. This study focuses on quantifying the intangible costs of one unit body mass index (BMI) increase and being overweight and obese in Germany. Methods: By applying a life satisfaction-based compensation value analysis to 2002–2018 German Socio-Economic Panel Survey data for adults aged 18–65, the intangible costs of overweight and obesity are estimated. We apply individual income as a reference for estimating the value of the loss of subjective well-being due to overweight and obesity. Results: The intangible costs of overweight and obesity in 2018 amount to 42,450 and 13,853 euros, respectively. A one unit increase in BMI induced a 2553 euros annual well-being loss in the overweight and obese relative to those of normal weight. When extrapolated to the entire country, this figure represents approximately 4.3 billion euros, an intangible cost of obesity similar in magnitude to the direct and indirect costs documented in other studies for Germany. These losses, our analysis reveals, have remained remarkably stable since 2002. Conclusions: Our results underscore how existing research into obesity's economic toll may underestimate its true costs, and they strongly imply that if obesity interventions took the intangible costs of obesity into account, the economic benefits would be considerably larger. [ABSTRACT FROM AUTHOR]

This paper proposes a first monetary measure of the private costs of celiac disease, including intangible costs (physical symptoms, logistical constraints, etc.) in Switzerland. This auto-immune disease damages the intestine when patients ingest gluten. The only treatment currently available is a gluten-free diet, which implies great nutritional constraints. To get a monetary equivalent of the costs borne by celiac patients, we used a contingent valuation. The scenario suggested to celiac patients a treatment in form of a daily pill, which would allow them to eat normally and avoid any physical pain from celiac disease. Mean Willingness To Pay (WTP) for the treatment is found to be around CHF 87 (approx. USD 87) per month. WTP is positively influenced by direct and indirect costs of the disease. Oppositely, individuals, who find the gluten-free diet healthier are willing to pay less. Finally, unlike symptoms before diagnostic, the current presence or intensity of physical symptoms are found to be insignificant. The latter result can be explained by the fact that, individuals facing stronger symptoms are more likely to adhere strictly to the GFD and hence to reduce their frequency. [ABSTRACT FROM AUTHOR]

The flood risk is a function of the flood hazard, the exposed values, and their vulnerability. In addition to extreme hydrological events, different anthropogenic activities such as extensive urbanization and land use play an important role in producing catastrophic floods. Considerations of both physical and social dimensions are therefore equally important in flood risk assessment. However, very often the risk assessment studies focus either on physical or social dimensions. In addition, the available studies often focus on economic valuation of only direct tangible costs. In this study, we provide an integrated flood risk assessment approach that goes beyond the valuation of direct tangible costs, through incorporating physical dimensions in hazard and exposure and social dimensions in vulnerability. The method has been implemented in the Dhaka City, Bangladesh, an area internationally recognized as hot spot for flood risk. In this study, flood hazards for different return periods are calculated in spatial environment using a hydrologic model, HEC-RAS. Vulnerability is assessed through aggregation of various social dimensions, i.e., coping and adaptive capacities, and susceptibility. We assess vulnerability for both baseline and improved scenarios. In the baseline scenario, current early warning for study area is considered. In the alternative scenario, the warning system is expected to improve. Aggregating hazard, exposure and vulnerability, risk maps (in terms of both tangible and intangible costs) of several return period floods are produced for both baseline and improved scenarios. Compared to traditional assessments, the integrated assessment approach used in this study generates more information about the flood risk. Consequently, the results are useful in evaluating policy alternatives and minimizing property loss in the study area. [ABSTRACT FROM AUTHOR]

Traditional economic evaluation techniques are often used to rank the technology alternatives for adoption purposes. However, the results of such evaluations are somewhat misleading since these techniques ignore the intangibles. Intangibles are factors that cannot be quantified for inclusions in the economic evaluation techniques but have great impact on the evaluation and adoption process. The current research addresses this issue by first identifying the intangible costs or risks of adopting a new technology and then developing a mechanism for their inclusion in the evaluation process. Taguchi loss functions are used as a tool for quantifying the intangible costs. The loss functions are developed based on the risks' specification limits set by the decision maker. These loss functions are used to calculate a loss score for each technology candidate. The technology alternatives are then ranked based on their loss scores, and the technology with the lowest loss score is selected for adoption. The proposed methodology offers a powerful tool for evaluation of alternative technologies by complementing the traditional economic evaluation techniques. [ABSTRACT FROM AUTHOR]