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Rapid growth in the construction sector significantly influences the natural resource demands, waste assimilation, as well as its also responsible for environmental pollution. The combination of life cycle assessment (LCA) approach with Ecological Footprint (EF) analysis gives an opportunity to measure an environmental imprint of a building on the planet. The life cycle ecological footprint (EFT) methodology has been developed for a low-rise residential building located in the Indian tropical climatic zone. The EFT of the low-rise residential buildings is 74.02 gha (i.e. 0.49 gha/m2 per floor area of the building). The Ecological Footprint of building construction is about 15.41% of the total EFT of the low-rise building. The Ecological Footprint of the operational phase of the low-rise building is the highest (83.67%) among all the life cycle phases. The EFT of the building can be reduced in the range of 1.51–4.33% by replacing the fired clay brick (FCB) with proposed low environment impact bricks/blocks in the brickwork of the building. For achieving Sustainable Development Goals, the EF assessment of all proposed and existing buildings should be examined and policymakers try to promote low EF materials for construction. [ABSTRACT FROM AUTHOR]

Angiogenesis is regulated by highly coordinated function of various proteins with pro- and anti-angiogenic functions. Among the many cytoplasmic signaling proteins that are activated by VEGFR-2, activation of PLCγ1 is considered to have a pivotal role in angiogenic signaling. In previous study we have identified c-Cbl as a negative regulator of PLCγ1 in endothelial cells, the biochemical and biological significance of c-Cbl, however, in angiogenesis in vivo and molecular mechanisms involved were remained elusive. In this study, we report that genetic inactivation of c-Cbl in mice results in enhanced tumor angiogenesis and retinal neovascularization. Endothelial cells derived from c-Cbl null mice displayed elevated cell proliferation and tube formation in response to VEGF stimulation. Loss of c-Cbl also resulted in robust activation of PLCγ1 and increased intracellular calcium release. c-Cbl-dependent ubiquitination selectively inhibited tyrosine phosphorylation of PLCγ1 and mostly refrained from ubiquitin-mediated degradation. Hence, we propose c-Cbl as an angiogenic suppressor protein where upon activation it uniquely modulates PLCγ1 activation by ubiquitination and subsequently inhibits VEGF-driven angiogenesis. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 45-year-old Haitian woman with a one week history of severe vision loss in the left eye. Results of her eye examination were showed. This case reports the high-definition spectral domain (HD-OCT) features of an eye with diffuse unilateral subacute neuroretinitis (DUSN). It also describes the use of this imaging modality to possibly localize the worm and follow it after laser treatment.