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Copyright of Öffentliche Experten is the property of Springer eBooks and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Öffentliche Experten is the property of Springer eBooks and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Öffentliche Experten is the property of Springer eBooks and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Öffentliche Experten is the property of Springer eBooks and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Öffentliche Experten is the property of Springer eBooks and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Öffentliche Experten is the property of Springer eBooks and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The main characteristic of a superantigen (SAg) is that it activates specific subsets of T cells that are composed of particular T-cell receptor (TCR) variable region β chain gene products (TCRBV). SAgs are thought to form a bridge between the TCRBV region on the T cell and the MHC class II molecule on the antigen-presenting cell (APC). This bridging transduces a strong signal to the T cell through the TCR, resulting in T-cell activation, which is manifested by upregulation of cell-surface markers associated with activation, T-cell proliferation, and cytokine release. In this chapter we shall outline two methods for assessing specific T-cell activation based on the preceding criteria: 1) detection of markers of activation in individual TCRBV subsets early after SAg stimulation; and 2) analysis of cytokine release from TCRBV specific T-cell hybridomas in response to SAg presentation. [ABSTRACT FROM AUTHOR]