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For underground deep mines, mining activities often cause mining disasters such as rock burst, roof fall and water inrush. Especially for underwater mines in the fault zone, surrounding rock instability and water inrush are the main threats to mining safely and efficiently. This paper briefly reviews the research progress and development trend of deformation law and failure mechanism of jointed rock mass specimens, multi-field coupling numerical simulation method of rock mass with faults, prevention of water inrush. Geological tectonic movement and rock mass excavation destroy the integrity and continuity of rock, break the in-situ stress field of rock mass, and lead to weak structural planes such as joints, cracks, and faults. The stress and strain properties of rock mass reflects the mechanical effects of rock mass and joints comprehensively. The physical, chemical, and stress environments of rock masses in deep mines are more complex. The mechanism of rock failure and water inrush disaster under the coupling effect of THMC multiple fields is worth further research. By combining CT scanning technology, digital core construction, and 3D printing technology, a digital core model and repeatable rock specimens can be constructed to study the mechanical properties and permeability evolution mechanism of jointed rock masses. According to the development of 5G technology and artificial intelligence technology, 5G technology is integrated into the monitoring, early warning, and emergency disposal of water inrush disaster. [ABSTRACT FROM AUTHOR]

Vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are the most common lower genital tract infections in reproductive women. In recent years, the research on its pathogenesis mainly focuses on vaginal local immunity and IL-17 as key factors in adaptive immunity, attracting much attention. However, the role of IL-17 in local immunity in VVC and RVVC is poorly understood. At the same time, neutrophils are considered the most effective way to control and eliminate candidal infection and have a controversial role in VVC and RVVC. In this study, we built a mouse RVVC model. After analyzing the vaginal lavage solution of RVVC mice with an inflammatory factor antibody chip and ELISA, we found that IL-17 may play a protective role in RVVC. The experiment of constructing RVVC mice with different concentrations of IL-17 using halofuginone and comparing the vaginal fungi load and vaginal epithelial damage verified that IL-17 had a protective effect in RVVC. In addition, in vitro and in vivo studies found that IL-17 can promote neutrophil apoptosis and recruit neutrophils in the vagina. The neutrophils in the vagina can secrete IL-17 in an autocrine manner. These two may be why IL-17 plays a protective role in RVVC. In summary, the study suggests that IL-17-mediated regulation of neutrophil function is involved in host immune response to RVVC, which helps us to further understand the potential mechanism of IL-17 in RVVC. [ABSTRACT FROM AUTHOR]