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1. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.

Author

Kong, Young-Yun, Yoshida, Hiroki, Sarosi, Ildiko, Hong-Lin Tan, Timms, Emma, Capparelli, Casey, Morony, Sean, Oliveira-dos-Santos, Antonio J., Van, Gwyneth, Itie, Annick, Khoo, Wilson, Wakeham, Andrew, Dunstan, Colin R., Lacey, David L., Mak, Tak W., Boyle, William J., and Penninger, Josef M.

Subjects
TUMOR necrosis factors, OSTEOCLASTS, T cells, OSTEOPETROSIS, LYMPH nodes
Abstract

Presents research on the tumor-necrosis-factor-family molecule osteoprotegerin ligand, or OPGL. Identification of OPGL as a potential osteoclast differentiation factor and regulator of interaction between T cells and dendritic cells in vitro; Severity of osteopetrosis and a defect in tooth eruption of mice; Lack of osteoclasts as a result of an inability of osteoblasts to support osteoclastogenesis; Implication of OPGL as a regulator of lymph-node organogenesis and lymphocyte development.

Published
1999
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