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The UK Met Office decadal prediction system DePreSys4 shows skill in predicting the number of tropical cyclones (TCs) and TC track density over the eastern Pacific and tropical Atlantic Ocean on the decadal timescale (up to ACC = 0.93 and ACC = 0.83, respectively, as measured by the anomaly correlation coefficient—ACC). The high skill in predicting the number of TCs is related to the simulation of the externally forced response, with internal climate variability also allowing the improvement in prediction skill. The Skill is due to the model's ability to predict the temporal evolution of surface temperature and vertical wind shear over the eastern Pacific and tropical Atlantic Ocean. We apply a signal-to-noise calibration framework and show that DePreSys4 predicts an increase in the number of TCs over the eastern Pacific and the tropical Atlantic Ocean in the next decade (2023–2030), potentially leading to high economic losses. [ABSTRACT FROM AUTHOR]

There is a knowledge gap in tracing and analyzing historical records (e.g., annual or bi-annual) of educational technology, particularly, exploring emerging technology trends and their uptake in education. This study addresses this gap by reviewing technology adoption in education, based on bibliometric and content analyses of EDUCAUSE Horizon reports over 20 years, hence identifying the trends of educational technologies over this period, the driving factors of their adoption, and the associated challenges. The findings revealed that technological and social trends were the most frequently cited, such as ubiquitous learning, augmented reality (AR), virtual reality (VR), and mobile learning. The challenges encountered throughout the years have been related to the resistance to digital transformation, maintaining sustainable teaching practices, and personalized learning. The results offer guidance for future research aimed to provide a better understanding of how to increase the use and effectiveness of educational technology to transform teaching and learning. [ABSTRACT FROM AUTHOR]

This study assesses the performance of the latest phase of Coupled Model Intercomparison Project (CMIP6) models in simulating easterly wave disturbances (EWD) over the tropical South Atlantic (TSA) impacting northeast Brazil (NEB). Initially, we evaluate simulated precipitation from 17 historical CMIP, 16 AMIP, 7 hist-1950, and 10 highresSST-present models against the Global Precipitation Climatology Project (GPCP) dataset to identify models that accurately reproduce the spatial and temporal precipitation patterns in the study region. The ensemble's spatial analysis demonstrates their capability in reproducing annual and seasonal precipitation climatology. However, models underestimate precipitation intensity along NEB's coast while overestimating it in TSA and NEB's north. Model uncertainties tend to be greater with higher latitudes. The models represented the annual cycle in all subareas within the study region, particularly from July to October, albeit with a greater spread in the first half of the year, especially over the Intertropical Convergence Zone (ITCZ). Based on it, three top-performing models from each ensemble were selected for EWD evaluation. The automatic tracking algorithm for EWDs showed the model's ability to represent mean values of EWD lifetime (~ 6 days) and phase speed (~ 7 m s−1) as found in ERA5 reanalysis. However, they failed to capture EWD's interannual variability or climatological mean frequency. Despite CMIP6 model weaknesses, they accurately identified two primary EWD genesis regions: one over the TSA and another near the West African coast. Overall, CMIP6 models, particularly atmospheric and high-resolution models (HighResMIP), effectively captured precipitation climatology and EWD characteristics over NEB and the adjacent TSA. [ABSTRACT FROM AUTHOR]

Oxacillin (bactericidal) and tetracycline (bacteriostatic) are clinically relevant antibiotics that are routinely prescribed to treat Staphylococcus aureus infections but not conventionally used in combination. There is an urgent need for treatment regimens that can act upon biofilms during infection, associated with chronic infections on indwelling devices, as well as acute planktonic (systemic) infection. Here we show that in an in vitro model oxacillin and tetracycline act synergistically against S. aureus UAMS-1 biofilms, reducing the concentration of both antibiotics necessary to eradicate an established biofilm. Using an in vivo zebrafish larval infection model with S.aureus NewHG, they display improved bacterial clearance compared to each drug alone and can counteract a loss of host phagocytes, an important innate defence against S. aureus. In these cases, the bacteriostatic nature of tetracycline enhances rather than dampens the bactericidal action of oxacillin, although an exact mechanism remains to be elucidated. We suggest a dual therapy could be of clinical use against biofilm-forming S. aureus and has a potential use in patients with a compromised immune system. [ABSTRACT FROM AUTHOR]

Background: While enrolled in Hospital at Home (HaH) programs, patients rely on their social network to provide supportive behaviors that are routinely provided by hospital staff in the inpatient setting. Objective: This study investigated how social connectedness is associated with patient outcomes in a HaH program. Design: The explanatory iterative sequential mixed methods design included an electronic health record review to collect quantitative measures to describe the severity of patient illness and healthcare utilization and then qualitative interviews to explain quantitative findings. Participants: The quantitative phase included 100 patients (18 years or older) admitted to the hospital who were subsequently enrolled in the HaH program. In the qualitative phase, 33 of the 100 patients participated in semi-structured interviews. Analysis: Qualitative data was analyzed using the Sort & Sift, Think & Shift method. Integrated analysis included merged data displays of healthcare utilization data and patient descriptions of their care and genogram-type illustrations to enable variable-oriented analysis of structural support. We then examined patient narratives by two variables: life course and care elevation, to understand differences in the trajectories of six subsets of patients as identified by the quantitative data. Key Results: Three factors prompted patients to enroll in HaH: low attention from hospital staff during hospital stay; loneliness and isolation during hospital stay; and family encouragement to enroll. After discharge, social support within the home structure facilitated recovery during HaH. Conversely, HaH patients with limited support within the home were more likely to be readmitted. Conclusions: Structural social connectedness facilitates patient recovery in HaH. Before enrolling patients in HaH, clinicians should take an in-depth social history, including questions about social/familial roles, household responsibilities, and technology acceptance. Clinicians should engage formal and informal caregivers in these conversations early and communicate a clear picture of what caregivers should do to support the patient through recovery. [ABSTRACT FROM AUTHOR]

Fast radio bursts (FRBs) are millisecond-duration events detected from beyond the Milky Way. FRB emission characteristics favour highly magnetized neutron stars, or magnetars, as the sources1, as evidenced by FRB-like bursts from a galactic magnetar2,3, and the star-forming nature of FRB host galaxies4,5. However, the processes that produce FRB sources remain unknown6. Although galactic magnetars are often linked to core-collapse supernovae (CCSNe)7, it is uncertain what determines which supernovae result in magnetars. The galactic environments of FRB sources can be used to investigate their progenitors. Here, we present the stellar population properties of 30 FRB host galaxies discovered by the Deep Synoptic Array (DSA-110). Our analysis shows a marked deficit of low-mass FRB hosts compared with the occurrence of star formation in the Universe, implying that FRBs are a biased tracer of star formation, preferentially selecting massive star-forming galaxies. This bias may be driven by galaxy metallicity, which is positively correlated with stellar mass8. Metal-rich environments may favour the formation of magnetar progenitors through stellar mergers9,10, as higher-metallicity stars are less compact and more likely to fill their Roche lobes, leading to unstable mass transfer. Although massive stars do not have convective interiors to generate strong magnetic fields by dynamo11, merger remnants are thought to have the requisite internal magnetic-field strengths to result in magnetars11,12. The preferential occurrence of FRBs in massive star-forming galaxies suggests that a core-collapse supernova of merger remnants preferentially forms magnetars.Analysis of the stellar population properties of 30 host galaxies of fast radio bursts (FRBs) suggests an abundance of FRBs in massive star-forming galaxies, and implies that the formation of FRB sources—magnetars—is linked to core-collapse supernovae of stellar merger remnants. [ABSTRACT FROM AUTHOR]

In the field of educational technology and instructional design, research methods are emerging that aim to curate different forms of knowledge and insights beyond traditional research studies, or what Reigeluth and An (in Reigeluth and Carr-Chellman (eds) Instructional-design theories and models: Building a common knowledge base, Lawrence Erlbaum Associates, Mahwah, 2009) refer to as "research to prove." As a result of evolving efforts in this area, editors of research journals in the field are receiving increased submissions employing these methods but have detected some persistent confusion among authors surrounding them. This has resulted in authors submitting articles with muddled methodologies and to outlets that may not be a fit for the work an author seeks to share. It can even be unclear whether authors intentionally employed a specific design-related method prior to reporting. In this piece, we will cover four methods—instructional design cases, case studies, design-based research, and formative evaluation of designs/products—to provide clarity for both graduate students and researchers. For each of these, we will provide definitions, discuss exemplars and features of exemplars, summarize key features that should be present in such a study and its reporting, and provide guidance on front-end intentional design and planning for research studies that employ these methodologies. Additional clarity on these methods can better support scholars and emerging scholars in their roles as researchers, authors, and reviewers. [ABSTRACT FROM AUTHOR]

Background: Bariatric surgery has been proven safe in end-stage kidney disease (ESKD); however, few studies have evaluated whether a history of bariatric surgery impacts transplant-specific outcomes. We hypothesize that a history of bariatric surgery at the time of transplant does not adversely impact transplant-specific outcomes. Methods: The IBM MarketScan Commercial Claims and Encounters database was queried for patients with a history of kidney transplant between 2000 and 2021. Patients were stratified into three groups based on bariatric surgery status and body mass index (BMI) at the time of transplant: patients with obesity (O), patients without obesity (NO), and patients with a history of bariatric surgery (BS). Inverse probability of treatment weighting was used to control for confounding. Adjusted hazard ratios (aHRs) describing the risk of transplant-specific and postoperative outcomes were estimated using weighted Kaplan–Meier curves. Primary outcomes included 30-day and 1-year risk of transplant-specific outcomes. Secondary outcomes included 30-day and 1-year postoperative complications and 30-day and 1-year risk of wound-related complications. Results: We identified 14,806 patients; 128 in the BS group, 1572 in the O group, and 13,106 in the NO group. There was no difference in 30-day or 1-year risk of transplant-specific complications between the BS and NO group or the O and NO group. Patients with obesity (O) were more likely to experience wound infection (aHR 1.49, 95% CI 1.12–1.99), wound dehiscence (aHR 2.2, 95% CI 1.5–3.2), and minor reoperation (aHR 1.52, 95% CI 1.23–1.89) at 1 year. BS patients had increased risk of wound infection at 1 year (aHR 2.79, 95% CI 1.26–6.16), but were without increase in risk of minor or major reoperation. Conclusion: A history of bariatric surgery does not adversely affect transplant-specific outcomes after kidney transplant. Bariatric surgery can be safely utilized to improve the transplant candidacy of patients with obesity with CKD and ESKD. [ABSTRACT FROM AUTHOR]

Ibogaine and its main metabolite noribogaine provide important molecular prototypes for markedly different treatment of substance use disorders and co-morbid mental health illnesses. However, these compounds present a cardiac safety risk and a highly complex molecular mechanism. We introduce a class of iboga alkaloids – termed oxa-iboga – defined as benzofuran-containing iboga analogs and created via structural editing of the iboga skeleton. The oxa-iboga compounds lack the proarrhythmic adverse effects of ibogaine and noribogaine in primary human cardiomyocytes and show superior efficacy in animal models of opioid use disorder in male rats. They act as potent kappa opioid receptor agonists in vitro and in vivo, but exhibit atypical behavioral features compared to standard kappa opioid agonists. Oxa-noribogaine induces long-lasting suppression of morphine, heroin, and fentanyl intake after a single dose or a short treatment regimen, reversal of persistent opioid-induced hyperalgesia, and suppression of opioid drug seeking in rodent relapse models. As such, oxa-iboga compounds represent mechanistically distinct iboga analogs with therapeutic potential. Ibogaine is a natural substance that interrupts opioid addiction but has cardiac risks. This article introduces novel ibogaine analogs that show reduced cardiac risk and enhanced neuroplasticity and therapeutic-like effects in models of opioid use disorder. [ABSTRACT FROM AUTHOR]

In this paper, we discuss a variety of ways in which practising motor actions by means of motor imagery (MI) can be enhanced via synchronous action observation (AO), that is, by AO + MI. We review the available research on the (mostly facilitatory) behavioural effects of AO + MI practice in the early stages of skill acquisition, discuss possible theoretical explanations, and consider several issues related to the choice and presentation schedules of suitable models. We then discuss considerations related to AO + MI practice at advanced skill levels, including expertise effects, practical recommendations such as focussing attention on specific aspects of the observed action, using just-ahead models, and possible effects of the perspective in which the observed action is presented. In section "Coordinative AO + MI", we consider scenarios where the observer imagines performing an action that complements or responds to the observed action, as a promising and yet under-researched application of AO + MI training. In section "The dual action simulation hypothesis of AO + MI", we review the neurocognitive hypothesis that AO + MI practice involves two parallel action simulations, and we consider opportunities for future research based on recent neuroimaging work on parallel motor representations. In section "AO + MI training in motor rehabilitation", we review applications of AO, MI, and AO + MI training in the field of neurorehabilitation. Taken together, this evidence-based, exploratory review opens a variety of avenues for future research and applications of AO + MI practice, highlighting several clear advantages over the approaches of purely AO- or MI-based practice. [ABSTRACT FROM AUTHOR]

High-quality partnerships between families and schools can bring enormous benefits to the development, learning, and wellbeing of children. Decades of research has identified parenting self-efficacy as a key factor influencing parents’ contributions toward effective home-school partnerships. However, the strength of this association has varied significantly across studies with the aggregated strength remaining unclear. This meta-analysis aimed to investigate the associations between parenting self-efficacy and various aspects of parents’ contribution to the home-school partnership, namely home-based involvement, school-based involvement, home-school communication and relationships, as well as parental expectations and aspirations among parents of primary school students. Moderator effects were also examined. Through systematically searching six databases and screening papers, we included 50 independent studies involving 185 effect sizes (N = 20,043 children). Results showed a small to medium correlation between parenting self-efficacy and the multidimensional construct of home-school partnership outcomes (r =.189). The associations were stronger for education-focused parenting self-efficacy (r =.183) than general parenting self-efficacy (r =.114) and were stronger still for home-based participation (r =.248) and parental expectations and aspirations (r =.248) than school-based participation (r =.124) and parent-teacher communication/relationship (r =.090). We detected limited moderating effects of child gender, parent gender, ethnicity, sample type (general or targeted), and socio-economic status and publication bias. Overall, this meta-analysis provides evidence to support the positive relationship between parenting self-efficacy and parents’ contributions to the strength of the home-school partnership. Implications and suggestions for future research are discussed. [ABSTRACT FROM AUTHOR]

Background: Sleeve gastrectomy (SG) increased in popularity after 2010 but recent data suggest it has concerning rates of gastroesophageal reflux and need for conversions. This study aims to evaluate recent trends in the utilization of bariatric procedures, associated complications, and conversions using an administrative claims database in the United States. Methods: We included adults who had bariatric procedures from 2000 to 2020 with continuous enrollment for at least 6 months in the MarketScan Commercial Claims and Encounters database. Index bariatric procedures and subsequent revisions or conversions were identified using CPT codes. Baseline comorbidities and postoperative complications were identified with ICD-9-CM and ICD-10 codes. Cumulative incidences of complications were estimated at 30-days, 6-months, and 1-year and compared with stabilized inverse probability of treatment weighted Kaplan–Meier analysis. Results: We identified 349,411 bariatric procedures and 5521 conversions or revisions. The sampled SG volume appeared to begin declining in 2018 while Roux-en-Y gastric bypass (RYGB) remained steady. Compared to RYGB, SG was associated with lower 1-year incidence [aHR, (95% CIs)] for 30-days readmission [0.65, (0.64–0.68)], dehydration [0.75, (0.73–0.78)], nausea or vomiting [0.70, (0.69–0.72)], dysphagia [0.55, (0.53–0.57)], and gastrointestinal hemorrhage [0.43, (0.40–0.46)]. Compared to RYGB, SG was associated with higher 1-year incidence [aHR, (95% CIs)] of esophagogastroduodenoscopy [1.13, (1.11–1.15)], heartburn [1.38, (1.28–1.49)], gastritis [4.28, (4.14–4.44)], portal vein thrombosis [3.93, (2.82–5.48)], and hernias of all types [1.36, (1.34–1.39)]. There were more conversions from SG to RYGB than re-sleeving procedures. SG had a significantly lower 1-year incidence of other non-revisional surgical interventions when compared to RYGB. Conclusions: The overall volume of bariatric procedures within the claims database appeared to be declining over the last 10 years. The decreasing proportion of SG and the increasing proportion of RYGB suggest the specific complications of SG may be driving this trend. Clearly, RYGB should remain an important tool in the bariatric surgeon's armamentarium. [ABSTRACT FROM AUTHOR]

Young diagrams are fundamental combinatorial objects in representation theory and algebraic geometry. Many constructions that rely on these objects depend on variations of a straightening process that expresses a filling of a Young diagram as a sum of semistandard tableaux subject to certain relations. This paper solves the long standing open problem of giving a non-iterative formula for straightening a filling. We apply our formula to give a complete generalization of a theorem of Gonciulea and Lakshmibai. [ABSTRACT FROM AUTHOR]

Endangered species recovery requires knowledge of species abundance, distribution, habitat preferences, and threats. Endangered beach mouse populations (Peromyscus polionotus subspp.) occur on barrier islands in Florida and Alabama. Camera traps may supplement current methods and strengthen inferences of animal activity. Between November 2020-February 2022, we conducted 140 camera surveys across 86 track tubes on Tyndall Air Force Base, Florida. We used generalized linear models to explore the relationships between beach mouse detections and environmental factors. We detected beach mice on 6,397 occasions across all tubes. Detections ranged from 0 to 147 observations/survey. Our top model suggested that beach mouse detection was related to cover type with positive associations with grassland and dune compared to scrub. Detections further varied depending on islands, were negatively associated with predator detections, and increased in winter months. Our results suggest that cameras can supplement inference about vegetation associations at broader scales to complement monthly track tube surveys since detection counts are more informative than presence/absence data alone. Given that all tubes exhibited at least one observation, the camera trap network may provide a less frequent and more robust survey method relative to monthly track tube surveys. Adopting such a multifaceted approach may reduce effort and strengthen inference to inform recovery objectives and adaptive management range-wide for all listed beach mouse subspecies. [ABSTRACT FROM AUTHOR]

In 2022, Defant and Kravitz introduced extended promotion (denoted ∂ ), a map that acts on the set of labelings of a poset. Extended promotion is a generalization of Schützenberger's promotion operator, a well-studied map that permutes the set of linear extensions of a poset. It is known that if L is a labeling of an n-element poset P, then ∂ n - 1 (L) is a linear extension. This allows us to regard ∂ as a sorting operator on the set of all labelings of P, where we think of the linear extensions of P as the labelings which have been sorted. The labelings requiring n - 1 applications of ∂ to be sorted are called tangled; the labelings requiring n - 2 applications are called quasi-tangled. We count the quasi-tangled labelings of a relatively large class of posets called inflated rooted trees with deflated leaves. Given an n-element poset with a unique minimal element with the property that the minimal element has exactly one parent, it follows from the aforementioned enumeration that this poset has 2 (n - 1) ! - (n - 2) ! quasi-tangled labelings. Using similar methods, we outline an algorithmic approach to enumerating the labelings requiring n - k - 1 applications to be sorted for any fixed k ∈ { 1 , ... , n - 2 } . We also make partial progress towards proving a conjecture of Defant and Kravitz on the maximum possible number of tangled labelings of an n-element poset. [ABSTRACT FROM AUTHOR]

Purpose: Sitting balance on an unstable surface requires coordinated out-of-phase lumbar spine and provides sufficient challenge to expose quality of spine control. We investigated whether the quality of spine coordination to maintain balance in acute low back pain (LBP) predicts recovery at 6 months. Methods: Participants in an acute LBP episode (n = 94) underwent assessment of sitting balance on an unstable surface. Seat, hip and spine (lower lumbar, lumbar, upper lumbar, thoracic) angular motion and force plate data were recorded. Coordination between the seat and hip/spine segments to maintain balance was quantified in the frequency domain to evaluate coordination (coherence) and relative timing (phase angle: in-phase [segments move together]; out-of-phase [segments move opposite]). Center of pressure (CoP) and upper thorax motion assessed overall balance performance. Hip and spine coordination with the seat were compared between those who did not recover (increased/unchanged pain/disability), partially recovered (reduced pain/disability) or recovered (no pain and disability) at 6 months. Results: In both planes, coherence between the seat and lower lumbar spine was lower (and in-phase—unhelpful for balance) at baseline in those who did not recover than those who recovered. Coherence between the seat and hip was higher in partially recovered in both planes, suggesting compensation by the hip. LBP groups had equal overall balance performance (CoP, upper thorax motion), but non-recovery groups used a less optimal strategy that might have consequences for long-term spine health. Conclusion: These longitudinal data revealed that individuals with compromised contribution of the lumbar spine to the balance during unstable sitting during acute LBP are less likely to recover. [ABSTRACT FROM AUTHOR]

Purpose: Aerobic exercise produces beneficial outcomes in patients with low back pain and partially attenuates the fibrotic changes to the multifidus in a model of intervertebral disc (IVD) degeneration. More targeted exercise might be required to fully attenuate these fibrotic alterations. This study aimed to investigate whether activation of the multifidus induced by neurostimulation could reduce fibrosis of the multifidus in a model of IVD degeneration in sheep. Methods: IVD degeneration was induced in 18 merino sheep via a partial thickness unilateral annulus fibrosus lesion to the L1/2 and L3/4 IVDs. All sheep received an implantable neurostimulation device that provides stimulation of the L2 medial branch of the dorsal ramus. Three months after surgery, the animals were assigned to Injury or Activated groups. Activated animals received neurostimulation and the Injury group received no stimulation. Six months after surgery, the multifidus was harvested at L2 and L4. Van Gieson's, Sirius Red and immunofluorescence staining for Collagen-I and -III and quantitative PCR was used to examine fibrosis. Muscle harvested from a previous study without IVD injury was used as a control. Results: Neurostimulation of the multifidus attenuated IVD degeneration dependent increases in the connective tissue, including Collagen-I but not Collagen-III, compared to the Injury group at L4. No measures of the multifidus muscle at L2, which received no stimulation, differed between the Injury and Activated groups. Conclusions: These data reveal that targeted activation of the multifidus muscle attenuates IVD degeneration dependent fibrotic alterations to the multifidus. [ABSTRACT FROM AUTHOR]

Electroencephalogram (EEG) can be used to assess depth of consciousness, but interpreting EEG can be challenging, especially in neonates whose EEG undergo rapid changes during the perinatal course. EEG can be processed into quantitative EEG (QEEG), but limited data exist on the range of QEEG for normal term neonates during wakefulness and sleep, baseline information that would be useful to determine changes during sedation or anesthesia. We aimed to determine the range of QEEG in neonates during awake, active sleep and quiet sleep states, and identified the ones best at discriminating between the three states. Normal neonatal EEG from 37 to 46 weeks were analyzed and classified as awake, quiet sleep, or active sleep. After processing and artifact removal, total power, power ratio, coherence, entropy, and spectral edge frequency (SEF) 50 and 90 were calculated. Descriptive statistics were used to summarize the QEEG in each of the three states. Receiver operating characteristic (ROC) curves were used to assess discriminatory ability of QEEG. 30 neonates were analyzed. QEEG were different between awake vs asleep states, but similar between active vs quiet sleep states. Entropy beta, delta2 power %, coherence delta2, and SEF50 were best at discriminating awake vs active sleep. Entropy beta had the highest AUC-ROC ≥ 0.84. Entropy beta, entropy delta1, theta power %, and SEF50 were best at discriminating awake vs quiet sleep. All had AUC-ROC ≥ 0.78. In active sleep vs quiet sleep, theta power % had highest AUC-ROC > 0.69, lower than the other comparisons. We determined the QEEG range in healthy neonates in different states of consciousness. Entropy beta and SEF50 were best at discriminating between awake and sleep states. QEEG were not as good at discriminating between quiet and active sleep. In the future, QEEG with high discriminatory power can be combined to further improve ability to differentiate between states of consciousness. [ABSTRACT FROM AUTHOR]

The mating effort questionnaire (MEQ) is a multi-dimensional self-report instrument that captures factors reflecting individual effort in upgrading from a current partner, investment in a current partner, and mate seeking when not romantically paired. In the current studies, we sought to revise the MEQ so that it distinguishes among two facets of mate seeking—mate locating and mate attracting—to enable a more nuanced measurement and understanding of individual mating effort. Moreover, we developed additional items to better measure partner investment. In total, the number of items was increased from 12 to 26. In Study 1, exploratory factor analysis revealed that a four-factor solution, reflecting partner upgrading, mate locating, mate attracting, and partner investment, yielded the best fit. In Study 2, this structure was replicated using confirmatory factor analysis in an independent sample. Based on extant studies documenting the relationships between psychopathy, short-term mating effort, and sexual risk taking, a structural equation model (SEM) indicated that trait psychopathy positively predicted mate locating, mate attracting, and partner upgrading and negatively predicted partner investment. A separate SEM showed that partner upgrading positively predicted risky sexual behaviors, while partner upgrading and mate locating positively predicted acceptance of cosmetic surgery. [ABSTRACT FROM AUTHOR]

Background: This investigation evaluated the state of ultrasound imaging (USI) education in entry-level Doctor of Physical Therapy (DPT) program curricula in the USA, including faculty perceptions and qualifications regarding USI and identification of potential barriers to inclusion or expansion of USI education. A review of published literature reveals that the inclusion of USI education in entry-level DPT program curricula has not been systematically investigated and is largely unknown. Methods: Investigators created an online survey developed in QualtricsXM and distributed through email an electronic link to the program chair/director at all 258 accredited entry-level DPT programs in the USA with instructions to complete and or share with faculty. Results: The overall response rate was 24% (65/269) and represented 54 programs from 28 of the 50 states; 70% reported including USI education in their program's curriculum, with 91% spending < 10 h on instruction throughout their curriculum; 44% reported plans to expand USI education in their curriculum, with 85% citing expanding scope of practice and curriculum as primary reasons; 79% cited the lack of qualified instructors, lack of knowledge/training, and equipment cost as the largest barriers to the inclusion of USI education in their program's curriculum. Whether USI is an entry-level skill was evenly split among respondents. Conclusions: Respondents from a representative sample of entry-level DPT programs across the USA provided survey responses. Despite most respondents being knowledgeable about USI, most do not use this point-of-care imaging modality in clinical practice. Based on the results of this survey, overcoming perceived barriers is necessary to expand USI education in entry-level DPT program curricula, namely, lack of qualified instructors, lack of knowledge/training, and cost of equipment. This national survey provides original data that may stimulate discussion about innovative ways to include USI education in entry-level DPT program curricula to meet the emerging needs of our profession. [ABSTRACT FROM AUTHOR]

This qualitative phenomenological study utilized structured interviews with 23 preschool administrators to explore their beliefs about preschool inclusion and needed resources for providing high-quality preschool inclusion. Themes emerged regarding administrators' beliefs about inclusion, including divergent understandings of inclusion as something that is either for all or for some children. Administrators placed a high value on families' preferences regarding preschool inclusion and at times focused their descriptions of inclusion on logistical aspects of placements and funding. Administrators said they needed additional money and personnel resources to provide high-quality preschool inclusion. Study findings are discussed in the context of the paucity of research on administrator perspectives regarding inclusion and implications for supporting administrators who play a key role in implementing preschool inclusion. [ABSTRACT FROM AUTHOR]

SMARCB1 loss has long been observed in many solid tumors. However, there is a need to elucidate targetable pathways driving growth and metastasis in SMARCB1-deficient tumors. Here, we demonstrate that SMARCB1 deficiency, defined as genomic SMARCB1 copy number loss associated with reduced mRNA, drives disease progression in patients with bladder cancer by engaging STAT3. SMARCB1 loss increases the chromatin accessibility of the STAT3 locus in vitro. Orthotopically implanted SMARCB1 knockout (KO) cell lines exhibit increased tumor growth and metastasis. SMARCB1-deficient tumors show an increased IL6/JAK/STAT3 signaling axis in in vivo models and patients. Furthermore, a pSTAT3 selective inhibitor, TTI-101, reduces tumor growth in SMARCB1 KO orthotopic cell line-derived xenografts and a SMARCB1-deficient patient derived xenograft model. We have identified a gene signature generated from SMARCB1 KO tumors that predicts SMARCB1 deficiency in patients. Overall, these findings support the clinical evaluation of STAT3 inhibitors for the treatment of SMARCB1-deficient bladder cancer. SMARCB1 is frequently lost in solid cancer and reported to support tumourigenesis through STAT3 activation. Here, the authors show in several preclinical models that targeting IL6/JAK/STAT3 molecular pathway is a potential therapeutic approach for SMARCB1-deficient bladder cancer. [ABSTRACT FROM AUTHOR]

Background: Co-use of cannabis is increasing in nicotine users and presents additional challenges in addressing nicotine dependence. This study examined the links between regular co-use of cannabis and nicotine with biobehavioral and affective changes in response to stress during nicotine withdrawal and ad libitum use. Methods: Participants (N = 79) who regularly used nicotine-only, cannabis-only, both substances, or neither substance were invited to attend two laboratory stress assessment sessions. For nicotine users, one session occurred during ad libitum nicotine use and one occurred after abstinence from nicotine. During the stress sessions, participants provided saliva samples for cortisol assay and completed measures of subjective states. Cardiovascular measures were collected during resting baseline, exposure to acute stressors, and a recovery rest period. Results: Nicotine-only users had higher average cortisol levels in the second lab session (nicotine withdrawal) relative to the first lab session (ad libitum nicotine use). Compared to nicotine non-users, nicotine users reported less positive affect and exhibited attenuated cortisol and systolic blood pressure (BP) stress responses. Cannabis users exhibited exaggerated diastolic BP responses to stress compared to cannabis non-users, and co-users of nicotine and cannabis had higher levels of cannabis craving than cannabis-only users (p <.01). Conclusions: This study partially replicated earlier findings on the effects of chronic nicotine use and provided novel results regarding the influence of cannabis co-use on physiological and affective responses to stress in nicotine users during nicotine withdrawal. [ABSTRACT FROM AUTHOR]

The long-term changes of ocean surface waves associated with tropical cyclones (TCs) are poorly observed and understood. Here, we present the global trend analysis of TC waves for 1979–2022 based on the ERA5 wave reanalysis. The maximum height and the area of the TC wave footprint in the six h reanalysis have increased globally by about 3%/decade and 6%/decade, respectively. The TC wave energy transferred at the interface from the atmosphere to the ocean has increased globally by about 9%/decade, which is three times larger than that reported for all waves. The global energy changes are mostly driven by the growing area of the wave footprint. Our study shows that the TC-associated wave hazard has increased significantly and these changes are larger than those of the TC maximum wind speed. This suggests that the wave hazard should be a concern in the future. Ocean waves caused by tropical cyclones show a significant global increase of energy and area over the last 44 years, leading to critical emerging wave hazard. [ABSTRACT FROM AUTHOR]

The article discusses the impact of Generative Artificial Intelligence (GenAI) tools, such as ChatGPT, on education. While some believe that GenAI will solve all educational problems, others fear that it will destroy education as we know it. GenAI's ability to generate human-like text poses challenges for education, particularly in areas like plagiarism detection. The article suggests various strategies for educators to adapt to the presence of GenAI, including emphasizing process over product, incorporating oral assessments, using AI detection tools, modifying assignment design, encouraging critical thinking and creativity, and developing digital literacy and ethics curriculum. The article concludes that disabling or banning GenAI tools is not feasible or productive, and instead, the focus should be on designing instruction to ensure that students actually learn. [Extracted from the article]

Dementia with Lewy bodies (DLB) is a common form of dementia in the elderly population. We performed genome-wide DNA methylation mapping of cerebellar tissue from pathologically confirmed DLB cases and controls to study the epigenetic profile of this understudied disease. After quality control filtering, 728,197 CpG-sites in 278 cases and 172 controls were available for the analysis. We undertook an epigenome-wide association study, which found a differential methylation signature in DLB cases. Our analysis identified seven differentially methylated probes and three regions associated with DLB. The most significant CpGs were located in ARSB (cg16086807), LINC00173 (cg18800161), and MGRN1 (cg16250093). Functional enrichment evaluations found widespread epigenetic dysregulation in genes associated with neuron-to-neuron synapse, postsynaptic specialization, postsynaptic density, and CTCF-mediated synaptic plasticity. In conclusion, our study highlights the potential importance of epigenetic alterations in the pathogenesis of DLB and provides insights into the modified genes, regions and pathways that may guide therapeutic developments. An epigenome-wide association study of dementia with Lewy bodies discovers differentially methylated probes, genomic regions and pathways associated with this disease. [ABSTRACT FROM AUTHOR]

Our study investigates the global impact of midlatitude cyclones on extreme wind speed events in both hemispheres under a warmer climate. Using the latest version of the high-resolution ≈ 50 km grid-spacing atmospheric climate model AM4, developed by the Geophysical Fluid Dynamics Laboratory, we conducted simulations covering the 71-years period 1949–2019 for both the present-day climate and an idealised future global warming climate scenario with a homogeneous Sea Surface Temperature (SST) increase by 2 K. Our findings reveal that extreme near-surface wind speeds increase by up to 3% K−1 towards the poles while decrease by a similar amount in the lower midlatitudes. When considering only extreme wind speed events objectively attributed to midlatitude cyclones, we observe a migration by the same amount towards higher latitudes both in percentage per degree SST warming and absolute value. The total number of midlatitude cyclones decreases by roughly 4%, but the proportion of cyclone-associated extreme wind speed events increases by 10% in a warmer climate. Finally, Northwestern Europe, the British Isles, and the West Coast of North America are identified as hot spots with the greatest socio-economic impacts from increased cyclone-associated extreme winds. [ABSTRACT FROM AUTHOR]

Background: The physiological effects of renin-angiotensin system modulation in acute respiratory distress syndrome (ARDS) remain controversial and have not been investigated in randomized trials. We sought to determine whether angiotensin-II treatment is associated with improved oxygenation in shock-associated ARDS. Methods: Post-hoc subgroup analysis of the Angiotensin Therapy for High Output Shock (ATHOS-3) trial. We studied patients who met modified Berlin ARDS criteria at enrollment. The primary outcome was PaO2/FiO2-ratio (P:F) at 48-h adjusted for baseline P:F. Secondary outcomes included oxygenation index, ventilatory ratio, PEEP, minute-ventilation, hemodynamic measures, patients alive and ventilator-free by day-7, and mortality. Results: Of 81 ARDS patients, 34 (42%) and 47 (58%) were randomized to angiotensin-II or placebo, respectively. In angiotensin-II patients, mean P:F increased from 155 mmHg (SD: 69) at baseline to 265 mmHg (SD: 160) at hour-48 compared with no change with placebo (148 mmHg (SD: 63) at baseline versus 164 mmHg (SD: 74) at hour-48)(baseline-adjusted difference: + 98.4 mmHg [95%CI 35.2–161.5], p = 0.0028). Similarly, oxygenation index decreased by − 6.0 cmH2O/mmHg at hour-48 with angiotensin-II versus − 0.4 cmH2O/mmHg with placebo (baseline-adjusted difference: -4.8 cmH2O/mmHg, [95%CI − 8.6 to − 1.1], p = 0.0273). There was no difference in PEEP, minute ventilation, or ventilatory ratio. Twenty-two (64.7%) angiotensin-II patients had sustained hemodynamic response to treatment at hour-3 versus 17 (36.2%) placebo patients (absolute risk-difference: 28.5% [95%CI 6.5–47.0%], p = 0.0120). At day-7, 7/34 (20.6%) angiotensin-II patients were alive and ventilator-free versus 5/47(10.6%) placebo patients. Day-28 mortality was 55.9% in the angiotensin-II group versus 68.1% in the placebo group. Conclusions: In post-hoc analysis of the ATHOS-3 trial, angiotensin-II was associated with improved oxygenation versus placebo among patients with ARDS and catecholamine-refractory vasodilatory shock. These findings provide a physiologic rationale for trials of angiotensin-II as treatment for ARDS with vasodilatory shock. Trial Registration: ClinicalTrials.Gov Identifier: NCT02338843 (Registered January 14th 2015). [ABSTRACT FROM AUTHOR]

Actions in social settings are often adapted based on co-actors. This adaptation can occur because one actor "co-represents" the actions and plans of another. Co-representation can result in motor contagion errors, whereby another's actions unintentionally interfere with (negatively impact) the actor. In sports, practice often takes place simultaneously or alternating with a partner. Co-representation of another's task could either harm or benefit skill retention and transfer, with benefits due to variable experiences and effortful processes in practice. Here, dyad groups that either alternated or simultaneously practiced golf putting to different (near vs. far) targets were compared to alone groups (n = 30/group). We focused on errors in distance from the target and expected overshooting for near-target partners paired with far-target partners (and undershooting for far-target partners paired with near-target partners), when compared to alone groups. There was evidence of co-representation for near-target partners paired with far-target partners. We also saw trial-to-trial error-based adjustments based on a partner's outcome in alternating dyads. Despite differences in practice between dyad and alone groups, these did not lead to costs or benefits at retention or transfer. We conclude that the social-context of motor learning impacts behaviours of co-actors, but not to the detriment of overall learning. [ABSTRACT FROM AUTHOR]

Over the last decade, applications of ion mobility-mass spectrometry (IM-MS) have exploded due primarily to the widespread commercialization of robust instrumentation from several vendors. Unfortunately, the modest resolving power of many of these platforms (~40–60) has precluded routine separation of constitutional and stereochemical isomers. While instrumentation advances have pushed resolving power to >150 in some cases, chemical approaches offer an alternative for increasing resolution with existing IM-MS instrumentation. Herein we explore the utility of two reactions, derivatization by Girard's reagents and 1,1-carbonyldiimidazole (CDI), for improving IM separation of steroid hormone isomers. These reactions are fast (≤30 min), simple (requiring only basic lab equipment/expertise), and low-cost. Notably, these reactions are structurally selective in that they target carbonyl and hydroxyl groups, respectively, which are found in all naturally occurring steroids. Many steroid hormone isomers differ only in the number, location, and/or stereochemistry of these functional groups, allowing these reactions to "amplify" subtle structural differences and improve IM resolution. Our results show that resolution was significantly improved amongst CDI-derivatized isomer groups of hydroxyprogesterone (two-peak resolution of Rpp = 1.10 between 21-OHP and 11B-OHP), deoxycortisone (Rpp = 1.47 between 11-DHC and 21-DOC), and desoximetasone (Rpp = 1.98 between desoximetasone and fluocortolone). Moreover, characteristic collision cross section (DTCCSN2) measurements can be used to increase confidence in the identification of these compounds in complex biological mixtures. To demonstrate the feasibility of analyzing the derivatized steroids in complex biological matrixes, the reactions were performed following steroid extraction from urine and yielded similar results. Additionally, we applied a software-based approach (high-resolution demultiplexing) that further improved the resolving power (>150). Overall, our results suggest that targeted derivatization reactions coupled with IM-MS can significantly improve the resolution of challenging isomer groups, allowing for more accurate and efficient analysis of complex mixtures. [ABSTRACT FROM AUTHOR]

Approximately 10% of Cystic Fibrosis (CF) patients, particularly those with CF transmembrane conductance regulator (CFTR) gene nonsense mutations, lack effective treatments. The potential of gene correction therapy through delivery of the CRISPR/Cas system to CF-relevant organs/cells is hindered by the lack of efficient genome editor delivery carriers. Herein, we report improved Lung Selective Organ Targeting Lipid Nanoparticles (SORT LNPs) for efficient delivery of Cas9 mRNA, sgRNA, and donor ssDNA templates, enabling precise homology-directed repair-mediated gene correction in CF models. Optimized Lung SORT LNPs deliver mRNA to lung basal cells in Ai9 reporter mice. SORT LNP treatment successfully corrected the CFTR mutations in homozygous G542X mice and in patient-derived human bronchial epithelial cells with homozygous F508del mutations, leading to the restoration of CFTR protein expression and chloride transport function. This proof-of-concept study will contribute to accelerating the clinical development of mRNA LNPs for CF treatment through CRISPR/Cas gene correction. Roughly 10% of Cystic Fibrosis (CF) patients still have no effective medicine to take. Lung Selective Organ Targeting (SORT) Lipid Nanoparticles can efficiently deliver Cas9 mRNA, sgRNA, and donor ssDNA templates for precise homology-directed repair-mediated gene correction in ex vivo and in vivo CF models. [ABSTRACT FROM AUTHOR]

Although motor learning can occur from observing others perform a motor skill (action observation; AO), observers' confidence in their own ability to perform the skill can be falsely increased compared to their actual ability. This illusion of motor competence (i.e., 'over-confidence') may arise because the learner does not gain access to sensory feedback about their own performance—a source of information that can help individuals understand their veridical motor capabilities. Unlike AO, motor imagery (MI; the mental rehearsal of a motor skill) is thought to be linked to an understanding of movement consequences and kinaesthetic information. MI may thus provide the learner with movement-related diagnostic information, leading to greater accuracy in assessing ability. The present study was designed to evaluate the effects of MI when paired with AO in assessments of one's own motor capabilities in an online observation task. Two groups rated their confidence in performing a juggling task following repeated observations of the action without MI (OBS group; n = 45) or with MI following observation (OBS+MI; n = 39). As predicted, confidence increased with repeated observation for both groups, yet increased to a greater extent in the OBS relative to the OBS+MI group. The addition of MI appeared to reduce confidence that resulted from repeated AO alone. Data support the hypothesis that AO and MI are separable and that MI allows better access to sensory information than AO. However, further research is required to assess changes in confidence that result from MI alone and motor execution. [ABSTRACT FROM AUTHOR]

In the United States, state-funded preschool is a critical component of both K-12 public education and the early childhood education and care system. In 2021, 44 states and the District of Columbia operated 63 school/center-based preschool programs serving over 1.3 million children. The vast majority of state-funded preschool programs require two adults in each classroom: typically, a lead teacher and an assistant teacher, with an expectation for team teaching. This paper examines the trends and variations in state policies that address the qualifications requirements, compensation, and professional development supports for preschool lead and assistant teachers in state-funded preschool programs that provide a foundation for supporting a culture of collective success and potential quality of the classroom. [ABSTRACT FROM AUTHOR]

Using six HighResMIP multi-ensemble GCMs (both the atmosphere-only and coupled versions) at 25 km resolution, the Tropical Cyclone (TC) activity over the Bay of Bengal (BoB) is examined in the present (1950–2014) climate. We use the Genesis Potential Index (GPI) to study the large-scale environmental conditions associated with the TC frequency in the models. Although the models struggle to reproduce the observed frequency and intensity of TCs, most models can capture the bimodal characteristics of the seasonal cycle of cyclones over the BoB (with fewer TCs during the pre-monsoon [April–May] than the post-monsoon [October–November] season). We find that GPI can capture the seasonal variation of the TC frequency over the BoB in both the observations and models. After calibrating the maximum sustained windspeeds in the models with IBTrACS, we find that like the observations the proportion of strong cyclones is also higher in the pre-monsoon than the post-monsoon. However, the inter-seasonal contrast of the proportion of strong cyclones between the pre-monsoon and post-monsoon seasons is reduced in almost all the models compared to the observations. The windshear term in GPI contributes the most to the model biases in all models during the post-monsoon season. This bias is caused by weakening of upper-level (200 hPa) easterlies in analysed models. During the pre-monsoon season, the environmental term in GPI dominating the model biases varies from model to model. When comparing the atmosphere-only and coupled versions of the models, a reduction of 0.5 °C in the sea surface temperature (SST) and a lowering of TC frequency occur in almost all the coupled models compared to their atmosphere-only counterparts. [ABSTRACT FROM AUTHOR]

The potential changes in the characteristics and damage potential of three of the most damaging tropical cyclone (TC) events (Haiyan 2013, Bopha 2012, Mangkhut 2018) in the Philippines have been simulated using the pseudo global warming (PGW) technique. Simulations were performed using the Weather Research and Forecasting model at 5 km resolution with cumulus parameterization (5 kmCU) and 3 km without cumulus parameterization (3 kmNoCU), with PGW deltas derived from a selection of the CMIP6 models. We found that re-forecasting the three TCs under future warming leads to more intense TCs, with changes in maximum wind of 4%, 3%, and 14% for the 5 kmCU runs, and 14%, 4%, and 12% for the 3 kmNoCU runs of Typhoon Haiyan, Bopha, and Mangkhut, respectively. The changes in track, translation speed, and size are relatively small. The TC cases have a higher impact potential in the future, as expressed by the cyclone damage potential index, ranging from ~ 1% to up to 37% under the SSP5-8.5 scenario. Based on the pre-industrial runs, climate change has had, so far, only a weak influence on TC intensity and not much influence on track, translation speed, and size. Simulations without convective parameterization show similar changes in the sign of the projected TC intensity response, but different signals of change in translation speed and size. [ABSTRACT FROM AUTHOR]

This research explored identity conflict among aspiring professionals, and the association between this conflict and anticipated difficulty in managing parent and career roles. Women (n = 281) and men (n = 300) enrolled in advanced degree programs in the United States completed implicit (session 1) and explicit (session 2) measures of work and parent identity strength. Women identified more strongly with the parent role on the implicit measure, but with the career role on the explicit measure. The degree to which their identities shifted across measures predicted how much conflict they anticipated in navigating parent and professional roles. Anticipated conflict in turn predicted poorer outcomes on an aggregate measure of health and well-being and accounted for (mediated) the gender difference on this outcome. Having a mother who worked, and perceiving greater equality in gender roles, were associated with lower levels of expected role-conflict for women students. The findings speak to the role cultural stereotypes continue to play in generating greater identity conflict for women, but also to avenues for combatting inequality through the normalization of women in professional roles and men in parenting roles. [ABSTRACT FROM AUTHOR]

Researcher degrees of freedom can affect the results of hypothesis tests and consequently, the conclusions drawn from the data. Previous research has documented variability in accuracy, speed, and documentation of output across various statistical software packages. In the current investigation, we conducted Pearson's chi-square test of independence, Spearman's rank-ordered correlation, Kruskal–Wallis one-way analysis of variance, Wilcoxon Mann–Whitney U rank-sum tests, and Wilcoxon signed-rank tests, along with estimates of skewness and kurtosis, on large, medium, and small samples of real and simulated data in SPSS, SAS, Stata, and R and compared the results with those obtained through hand calculation using the raw computational formulas. Multiple inconsistencies were found in the results produced between statistical packages due to algorithmic variation, computational error, and statistical output. The most notable inconsistencies were due to algorithmic variations in the computation of Pearson's chi-square test conducted on 2 × 2 tables, where differences in p-values reported by different software packages ranged from.005 to.162, largely as a function of sample size. We discuss how such inconsistencies may influence the conclusions drawn from the results of statistical analyses depending on the statistical software used, and we urge researchers to analyze their data across multiple packages to check for inconsistencies and report details regarding the statistical procedure used for data analysis. [ABSTRACT FROM AUTHOR]

A Schubert variety in the complete flag manifold G L n / B is Levi-spherical if the action of a Borel subgroup in a Levi subgroup of a standard parabolic has an open dense orbit. We give a combinatorial classification of these Schubert varieties. This establishes a conjecture of the latter two authors, and a new formulation in terms of standard Coxeter elements. Our proof uses and contributes to the theory of key polynomials (type A Demazure module characters). [ABSTRACT FROM AUTHOR]

Purpose: Redundancy of the musculoskeletal system implies multiple strategies are theoretically available to coordinate back extensor muscles. This study investigated whether coordination between back muscles during a tightly constrained isometric trunk extension task varies within and between individuals, and whether this changes following brief exposure to activation feedback of a muscle. Methods: Nine healthy participants performed three blocks of two repetitions of ramped isometric trunk extension in side-lying against resistance from 0–30% of maximum voluntary contraction over 30 s (force feedback). Between blocks, participants repeated contractions with visual feedback of electromyography (EMG) from either superficial (SM) or deep multifidus (DM), in two conditions; 'After SM' and 'After DM'. Intramuscular EMG was recorded from SM, DM, and longissimus (LG) simultaneously with shear wave elastography (SWE) from SM or DM. Results: In the 'Natural' condition (force feedback only), group data showed incremental increases in EMG with force, with minor changes in distribution of activation between muscles as force increased. SM was the most active muscle during the 'Natural' condition, but with DM most active in some participants. Individual data showed that coordination between muscles differed substantially between repetitions and individuals. Brief exposure to EMG feedback altered coordination. SWE showed individual variation, but findings differed from EMG. Conclusion: This study revealed substantial variation in coordination between back extensor muscles within and between participants, and after exposure to feedback, in a tightly constrained task. Shear modulus revealed similar variation, but with an inconsistent relationship to EMG. These data highlight highly flexible control of back muscles. [ABSTRACT FROM AUTHOR]

The Hot Universe Baryon Surveyor (HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view, the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, diffuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. [ABSTRACT FROM AUTHOR]

Abstract Changes in the intracellular levels of the essential micronutrient zinc have been implicated in multiple diseases including pancreatic cancer; however, the molecular mechanism is poorly understood. Here, we report a novel mechanism where increased zinc mediated by the zinc importer ZIP4 transcriptionally induces miR‐373 in pancreatic cancer to promote tumour growth. Reporter, expression and chromatin immunoprecipitation assays demonstrate that ZIP4 activates the zinc‐dependent transcription factor CREB and requires this transcription factor to increase miR‐373 expression through the regulation of its promoter. miR‐373 induction is necessary for efficient ZIP4‐dependent enhancement of cell proliferation, invasion, and tumour growth. Further analysis of miR‐373 in vivo oncogenic function reveals that it is mediated through its negative regulation of TP53INP1, LATS2 and CD44. These results define a novel ZIP4‐CREB‐miR‐373 signalling axis promoting pancreatic cancer growth, providing mechanistic insights explaining in part how a zinc transporter functions in cancer cells and may have broader implications as inappropriate regulation of intracellular zinc levels plays an important role in many other diseases.

Background: It is widely believed that small rectal tumors are more likely to have a good response to neoadjuvant treatment, which may influence the selection of patients for a 'watch and wait' strategy. Objective: The aim of this study was to investigate whether there is a relationship between baseline tumor length on magnetic resonance imaging (MRI) and response to chemoradiotherapy. Method: The 96 patients with locally advanced rectal cancer randomised (2:1–intervention:control) in the TRIGGER feasibility study where eligible. Baseline tumor length was defined as the maximal cranio-caudal length on baseline MRI (mm) and was recorded prospectively at study registration. Magnetic resonance tumor regression grade (mrTRG) assessment was performed on the post-chemoradiotherapy (CRT) MRI 4–6 weeks (no later than 10 weeks) post completion of CRT. This was routinely reported for patients in the intervention (mrTRG-directed management) arm and reported for the purposes of this study by the central radiologist in the control arm patients. Those with an mrTRG I/II response were defined as 'good responders' and those with an mrTRG III–V response were defined as 'poor responders'. Results: Overall, 94 patients had a post-CRT MRI performed and were included. Forty-three (46%) patients had a good response (mrTRG I/II) and 51 (54%) patients had a poor response (mrTRG III/IV). The median tumor length of good responders was 43 mm versus 50 mm (p < 0.001), with considerable overlap in tumor lengths between groups. Conclusion: Baseline tumor length on MRI is not a clinically useful biomarker to predict mrTRG tumor response to CRT and therefore patient suitability for a deferral of surgery trial. [ABSTRACT FROM AUTHOR]

Purpose: Rooted in a trans-territorial framework, the present study was designed to provide new evidence regarding the patterns of communication among Hurricane Maria survivors who migrated to the U.S. in the aftermath of the storm. Methods: A total of 319 Hurricane Maria survivor adults ages 18 and older were recruited into the Adelante Boricua study between August 2020 and October 2021. Most participants had relocated to the U.S. between 2017 and 2018. We used latent profile analysis and multinomial regression to examine the relationship of technology-based communication with depressive symptoms, well-being, cultural connection, and migration stress. Results: We identified a five-class solution, consisting of (1) moderate communication (32%), (2) disengaged (24%), (3) no social media (18%), (4) daily with family in Puerto Rico (6%), and (5) daily trans-territorial (13%) typologies. Participants in the disengaged class were more likely to report elevated depressive symptoms and limited English proficiency, lower prosocial behaviors, lower levels of religiosity, lower attendance at religious services in the U.S., and less engagement in social activities, compared to participants in the Moderate Communication class. Conclusion: Roughly one in four individuals in our sample reported very limited technology-based communication with friends/family in their sending and new-receiving communities. As technology and smartphones continue to become integrated into 21st-century life, it is vital that researchers explore how the tremendous potential for connectedness relates to trans-territorial crisis migrants' well-being and adaptation. [ABSTRACT FROM AUTHOR]