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3 results on '"Hisashi Matsubara"'

1. Inducible nitric oxide synthase mediates retinal DNA damage in Goto-Kakizaki rat retina.

Author

Izumi Yuasa, Ning Ma, Hisashi Matsubara, Yoshihiro Fukui, and Yukitaka Uji

Subjects
THERAPEUTIC use of enzymes, RETINAL (Visual pigment), DNA damage, LABORATORY rats, HYDROXY acids, DIABETES, IMMUNOHISTOCHEMISTRY, NEUROTOXICOLOGY
Abstract

Abstract Purpose  To examine the nitrosative and oxidative DNA damage induced by 8-nitroguanine and 8-hydroxy-2-deoxy guanosine (8-OHdG), and to determine the role played by inducible nitric oxide synthase (iNOS) in damage to DNA in the retina of the Goto-Kakizaki (GK) rat. Methods  Experiments were performed on GK rats, an animal model of spontaneous type 2 diabetes without obesity or visible diabetic vascular lesions. Immunohistochemistry was used to determine the retinal distribution of 8-nitroguanine, 8-OHdG, and iNOS in GK rats and control rats. The change in the expression of 8-nitroguanine and 8-OHdG in GK rats was also determined following an intravitreal injection of 1400W, an inhibitor of iNOS activity. Results  Immunohistochemical analysis showed that 8-nitroguanine and 8-OHdG were expressed strongly in the inner nuclear layer of GK retinas but only weakly in control retinas. This expression was correlated with an increase in the expression of iNOS in GK retinas, which was confirmed by the inhibition of iNOS activity by 1400W. Conclusion  These findings demonstrate that iNOS plays a crucial role in nitrosative and oxidative DNA damage in GK rats, suggesting a retinal neurotoxic role of nitric oxide and superoxide in diabetic retinas. [ABSTRACT FROM AUTHOR]

Published
2008
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2. Exposure of haptic of posterior chamber intraocular lens after sutureless intrascleral fixation

Author

Hisashi Matsubara, Mineo Kondo, Tsukasa Hanemoto, and Yoshitsugu Matsui

Subjects
Male, Reoperation, medicine.medical_specialty, Visual acuity, genetic structures, medicine.medical_treatment, Visual Acuity, Intraocular lens, Case Report, Fixation (surgical), Lens Implantation, Intraocular, Ophthalmology, medicine, Humans, Haptic technology, Aged, Lenses, Intraocular, business.industry, Suture Techniques, General Medicine, equipment and supplies, eye diseases, Surgery, Sclera, Prosthesis Failure, Posterior chamber intraocular lens, medicine.anatomical_structure, sense organs, medicine.symptom, business
Abstract

Background A technique of sutureless intrascleral fixation of an intraocular lens (IOL) in an eye that lacks a posterior capsular support has been reported. The advantage of this technique was that the suture-related complications did not develop. However, the long-term complications of a sutureless IOL implantation have not been reported. Case presentation A 75-years-old man had a sutureless intrascleral fixation (Y-fixation) of an IOL 4 months before our examination. The nasal haptic became exposed and the temporal haptic was seen in the subconjunctiva. The tilted IOL was removed and replaced by a posterior chamber IOL that was sutured to the sclera. At the 6 months examination, the eye was quiet and the IOL was stable. Conclusion We suggest that the exposure of the nasal haptic of an IOL that was implanted by sutureless intrascleral fixation (Y-fixation) was due to poor surgical technique and/or the erosion of a fragile sclera. Thus, eyes should be carefully and frequently monitored after sutureless intrascleral posterior chamber IOL implantation.

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