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The results of analyses of the major chemical constituents of Lobatostoma ringens are as follows: water, 71.6% fresh weight; ash, 4.6% dry weight; protein, 64.3% dry weight; glycogen, 4.7% ethanol-extracted dry weight; lipid, 6.4% fresh weight. Histochemical staining revealed glycogen mainly in the parenchyma and musculature, with smaller deposits in the vitelline cells and spermatozoa; neutral lipid was localized in the gastrodermis and excretory system; and the surfaces of the tegument and gastrodermis were reactive for acidic mucopolysaccharides. Protein synthesis was evident in the tegumental cells, gastrodermis, and vitellaria. [ABSTRACT FROM AUTHOR]

The article examines the results from the Myriad trials conducted to assess a disease modifying drug for the treatment of Alzheimer's disease (AD). It is noted that the phase 3 Myriad study provides useful information for trial design, including natural history data for mild patients and usage rates for concomitant medications for AD. The program is also said to introduce novel approaches to study design that may be helpful for developing disease modifying drugs. Information on the Phase 2 Myriad studies is also provided.