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The status of the TAIGA experiment (Tunka Advanced Instrument for cosmic-ray physics and Gamma-ray Astronomy) located in the Tunka Valley is presented. The paper presents mainly the tasks, developed approaches for their solution, and first results on high-energy gamma-ray astronomy (10 TeV and higher) obtained from a two- to three-year exposure. The current tasks of gamma-ray astronomy and plans for development of the installation are discussed. [ABSTRACT FROM AUTHOR]

Deployment of the deep-sea neutrino telescope Baikal-GVD continues in Lake Baikal. By April 2022, ten telescope clusters, which include 2880 optical modules, were put into operation. One of the urgent tasks of the Baikal project is to study the possibility of increasing the detection efficiency of the detector based on the experience of its operation and the results obtained with other neutrino telescopes in recent years. In this paper, the authors consider a variant of optimizing the telescope configuration by installing an additional string of optical modules between the detector clusters (external string). An experimental version of the external garland was installed in Lake Baikal in April 2022. The paper presents the results from calculations of the efficiency of registration of neutrino events for a new setup configuration, the technical implementation of the system for recording and collecting data from the external garland, and the first results of its full-scale tests in Lake Baikal. [ABSTRACT FROM AUTHOR]

This paper presents the results of an analysis of observations of the Crab Nebula gamma-ray source with the first two atmospheric Cherenkov telescopes of the TAIGA (Tunka Advanced Instrument for cosmic ray physics and Gamma Astronomy) astrophysical complex in the stereo mode of observations. The article analyzed observational data from 2020 to 2021. Over 36 hours of observations, a signal was obtained at a statistical significance level of 5 and a spectrum of gamma rays was plotted in the energy range from 2 to 70 TeV. The paper describes a technique for gamma–hadron separation and reconstruction of detected gamma-rays energy. [ABSTRACT FROM AUTHOR]

The physical motivations and performance of the TAIGA (Tunka Advanced Instrument for cosmic ray physics and Gamma Astronomy) project are presented. The TAIGA observatory addresses ground-based gamma-ray astronomy at energies from a few TeV to several PeV, as well as cosmic ray physics from 100 TeV to several EeV and astroparticle physics. The pilot TAIGA-1 complex locates in the Tunka valley, km West from the southern tip of the lake Baikal. It includes integrated air Cherenkov TAIGA-HiSCORE array with 120 wide-angle optical stations distributed over on area 1.1 square kilometer about and three 4-m class Imaging Atmospheric Cherenkov Telescopes of the TAIGA-IACT array. The latter array has a shape of triangle with side lengths of about 300, 400 and 500 m. The integral sensitivity of the 1-km TAIGA-1 detector is about TeV cm s for detection of TeV gamma-rays in 300 hours of source observations. The combination of the wide-angle Cherenkov array and IACTs could offer a cost effective-way to build a large (up to 10 km ) array for very high energy gamma-ray astronomy. The reconstruction of a given EAS energy, incoming direction, and the core position, based on the TAIGA-HiSCORE data, allows one to increase the distance between the relatively expensive IACTs up to 600–800 m. These, together with the surface and underground electron/Muon detectors, will be used for selection of gamma-ray-induced EAS. Present status of the project, together with the current array description, the first experimental results and plans for the future are reported. [ABSTRACT FROM AUTHOR]

A scintillation experiment is a part of the TAIGA astrophysical complex located in the Tunka Valley, 50 km from Lake Baikal. It consists of the Tunka-Grande and TAIGA-Muon arrays. Its scientific program is devoted to the study of cosmic rays (CRs) and search for astrophysical gamma rays by detecting charged particles (electrons and muons) of extensive air showers (EASs). We present the current status of the scintillation experiment, methods of EAS and CR parameters' reconstruction, the main results obtained by the Tunka-Grande array and our scientific program for the future. [ABSTRACT FROM AUTHOR]

An analysis is performed of the spectrum of gamma rays from the Crab Nebula in the 4–100 TeV range of energies, obtained using data from two Atmospheric Cherenkov Telescopes that are part of the TAIGA complex. A way of selecting and restoring the energy of gamma rays is described that includes a procedure for restoring the energy spectrum. [ABSTRACT FROM AUTHOR]

Baikal-GVD is a 1 km3 scale neutrino telescope now under construction in Lake Baikal. The sensitive volume of the detector is currently around 0.5 km3. Muons form through the exchange of W-bosons in the interaction between muon- and partial tau-neutrinos near the telescope. The muons then propagate to great distances in the lake's water. Reconstructing their trajectory allows us to obtain the most accurate estimate of the direction of neutrinos at telescopes of this type. Angular resolution can be as good as 0.5° for fairly long muon tracks. The current state of affairs in analyzing track events at the Baikal-GVD is discussed. [ABSTRACT FROM AUTHOR]

The Tunka-Grande scintillation array is described. Scientific results obtained over the first five years of its operation are presented. Prospects for studying cosmic rays in the 1016–1018 eV range of energies are discussed. [ABSTRACT FROM AUTHOR]

The main goal of the Baikal-GVD deep-sea neutrino telescope is to detect high-energy neutrinos of astrophysical origin by reconstructing muon tracks or showers of particles generated in interactions of neutrino with water. Since 2020, Baikal-GVD has been monitoring IceCube telescope alerts about detecting neutrinos with energies of more than 100 TeV. This work presents results from searching for matches between Baikal-GVD events and IceCube neutrino alerts from September 2020 to April 2022. [ABSTRACT FROM AUTHOR]

The more correct recalculation from the measured Cherenkov light fluxes at distances of 200 (Q200) and 100 (Q100) m from the Extensive Air Shower (EAS) core to the energy of the primary particle has been developed using the results of M-C simulation by the CORSIKA code, assuming a light primary composition of cosmic rays. Using the new conversion expressions, a differential energy spectrum was obtained according to the data of the Tunka-133 array for 7 years of operation and the TAIGA-HiSCORE array for 2 years of operation. [ABSTRACT FROM AUTHOR]

Background: Surgery with radical intent is the only potentially curative option for entero-pancreatic neuroendocrine tumors (EP-NETs) but many patients develop recurrence even after many years. The subset of patients at high risk of disease recurrence has not been clearly defined to date. Objective: The aim of this retrospective study was to define, in a series of completely resected EP-NETs, the recurrence-free survival (RFS) rate and a risk score for disease recurrence. Patients and Methods: This was a multicenter retrospective analysis of sporadic pancreatic NETs (PanNETs) or small intestine NETs (SiNETs) [G1/G2] that underwent R0/R1 surgery (years 2000–2016) with at least a 24-month follow-up. Survival analysis was performed using the Kaplan–Meier method and risk factor analysis was performed using the Cox regression model. Results: Overall, 441 patients (224 PanNETs and 217 SiNETs) were included, with a median Ki67 of 2% in tumor tissue and 8.2% stage IV disease. Median RFS was 101 months (5-year rate 67.9%). The derived prognostic score defined by multivariable analysis included prognostic parameters, such as TNM stage, lymph node ratio, margin status, and grading. The score distinguished three risk categories with a significantly different RFS (p < 0.01). Conclusions: Approximately 30% of patients with EP-NETs recurred within 5 years after radical surgery. Risk factors for recurrence were disease stage, lymph node ratio, margin status, and grading. The definition of risk categories may help in selecting patients who might benefit from adjuvant treatments and more intensive follow-up programs. [ABSTRACT FROM AUTHOR]

High-energy cosmic-ray research via the detection of Cherenkov radiation from extensive air showers was begun in the Tunka valley (50 km to the west from the southern extremity of Lake Baikal) in the early 1990s. A series of large arrays combined into the TAIGA (Tunka Advanced Instrument for cosmic-ray physics and Gamma Astronomy) astrophysical facility and designed to study gamma rays and charged cosmic rays have been created in the elapsed time. Descriptions of the facility arrays and the main results obtained while investigating high-energy cosmic rays are presented. Plans for a further development of the astrophysical facility are discussed. [ABSTRACT FROM AUTHOR]

The differential energy spectrum of cosmic rays in the energy range of 3 × 1014–3 × 1018 eV and the corrected dependence of the mean depth of the maximum 〈Xmax〉 of an extensive air shower (EAS) inside the wide energy range of 1015–3 × 1017 eV have been obtained from the data of the Tunka-133 array for 7 years of operation (2009–2017) and the TAIGA-HiSCORE array for the 2019–2020 season of operation. At the extremely high energy, our results agree with the results of the Pierre Auger Observatory based on direct measurements of the maximum depth by the observation of fluorescent light from EAS. The recalculation from the 〈Xmax〉 to the parameter , which characterizes the average composition of the primary cosmic rays, is presented. [ABSTRACT FROM AUTHOR]

A wide-angle Cerenkov array TAIGA-HiSCORE (FOV 0.6 sr), was originally created as a part of TAIGA installation for high-energy gamma-ray astronomy and cosmic ray physics. Array now consist on nearly 100 optical stations on the area of 1 km . Due to high accuracy and stability ( 1 ns) of time synchronization of the optical stations the accuracy of EAS arrival direction reconstruction is reached 0.1 . It was proven that the array can also be used to search for nanosecond events of the optical range. The report discusses the method of searching for optical transients using the HiSCORE array and demonstrates its performance on a real example of detecting signals from an artificial Earth satellite. The search for this short flares in the HiSCORE data of the winter season 2018–2019 is carried out. One candidate for double repeater has been detected, but the estimated probability of random simulation of such a transient by background EAS events is not less than 10 , which does not allow us to say that the detected candidate corresponds to a real astrophysical transient. An upper bound on the frequency of optical spikes with flux density of more than and a duration of more than 5 ns is established as events/sr/h. [ABSTRACT FROM AUTHOR]

The Tunka Advanced Instrument for Gamma-ray and cosmic ray Astrophysics (TAIGA) is a hybrid experiment for the measurement of Extensive Air Showers (EAS) with good spectral resolution in the TeV to PeV energy range. In this domain, the long-sought Pevatrons can be detected. Currently the TAIGA detector complex combines a two wide angle shower front Cherenkov light sampling timing arrays (HiSCORE and Tunka-133), two 4 m class, 10 aperture Imaging Air Cherenkov Telescopes (IACTs) and 240 m surface and underground charged particle detector stations. Our goal is to introduce a new hybrid reconstruction technique, combining the good angular and shower core resolution of HiSCORE with the gamma-hadron separation power of imaging air Cherenkov telescopes. This approach allows to maximize the effective area and simultaneously to reach a good gamma-hadron separation at low energies (few teraelectronvolts). At higher energies, muon detectors are planned to enhance gamma-hadron separation. During the commissioning phase of the first and second IACT, several sources were observed. First detections of known sources with the first telescope show the functionality of the TAIGA IACTs. Here, the status of the TAIGA experiment will be presented, along with first results from the current configuration. [ABSTRACT FROM AUTHOR]

TAIGA (Tunka Advanced Instrument for cosmic ray physics and Gamma Astronomy) Astrophysical complex is being developed for studies of gamma rays and charged cosmic rays in the energy range of 10 –10 eV. The complex is located in the Tunka Valley, about 50 km from Lake Baikal. In this report we present the experiment status and plans for study of high-energy cosmic-ray physics as well as main results reached by wide-angle TAIGA-HiSCORE and Tunka-133 Cherenkov arrays of the Astrophysical complex. Plans to study cosmic rays by means of other arrays of the complex, namely scintillation array Tunka-Grande and new TAIGA-muons array and system of IACT telescopes, are discussed too. [ABSTRACT FROM AUTHOR]

The physics motivations and advantages of the hybrid detector complex TAIGA are presented. TAIGA aims to address gamma-ray astronomy at energies from a few TeV to several PeV units, as well as cosmic-ray physics from 100 TeV to several EeV units and astroparticle physics problems. In 2021 deployment and commissioning of the one square kilometer TAIGA setup in the Tunka valley 50 km West from Lake Baikal will be finished. The first experimental results with the TAIGA are presented. [ABSTRACT FROM AUTHOR]

The prototype of a small wide-angle telescope was installed within the astrophysical complex TAIGA in the Tunka Valley in September 2019. Data were collected on the prototype's performance during the last eight observation sessions. Operating regimes of the telescope's systems, the trigger system, and the system for synchronizing with the TAIGA complex were tested. The first results from analyzing data on the prototype telescope's performance are presented. [ABSTRACT FROM AUTHOR]

The TAIGA hybrid gamma-ray observatory is currently being developed in the Tunka Valley, 50 km from Lake Baikal, to study gamma radiation and charged cosmic ray fluxes in the 1013–1018 eV range. The first results are presented for detecting gamma rays from the Crab Nebula in 44 h of observation, and from the blazar Markarian 421 in 62 h of observation with a significance of around 5–6 σ by one of the TAIGA IACT telescopes. [ABSTRACT FROM AUTHOR]

The astrophysical complex TAIGA (Tunka Advanced Instrument for cosmic-ray physics and Gamma-ray Astronomy), whose first phase is being completed in the Tunka valley 50 km from Lake Baikal, is described. Its research program, first results, and development prospects are discussed. [ABSTRACT FROM AUTHOR]

The importance and advantages of the hybrid approach developed within the TAIGA project for studying the high-energy section of the spectrum of gamma radiation in the Universe are discussed. The pilot complex of the TAIGA gamma observatory with an area of 1 km is briefly described along with the lines of its development, and the first results obtained on this basis are given. [ABSTRACT FROM AUTHOR]

The Tunka-133 Cherenkov complex for recording extensive air showers (EAS) collected data over seven winters from 2009 to 2017. The differential energy spectra of all particles was acquired in the 6 × 1015–3 × 1018 eV range of energies over 2175 h. The TAIGA-HiSCORE complex is continually being expanded and upgraded. Data acquired by 30 first-line stations over 35 days during the period 2017–2018 is analyzed in this work. As at the Tunka-133 setup, the primary particle energies above 1015 eV are measured using the density of the Cherenkov light flux at a distance of 200 m from a shower's axis. Data on lower energies are collected by determining the energy of the light flux near a shower's axis. This results in a spectrum of 2 × 1014–1017 eV. The combined spectrum for the two systems covers a range of 2 × 1014–2 × 1018 eV. [ABSTRACT FROM AUTHOR]

Work is currently under way in the Tunka Valley, 50 km from Lake Baikal, to create the TAIGA gamma observatory for studying gamma radiation and cosmic ray fluxes in the 1013–1018 eV range of energies. To detect gamma rays with energies above tens of TeV, a hybrid method of detecting showers is implemented. It is based on data obtained by the TAIGA Imaging Atmospheric Cherenkov Telescope (IACT) and the wide-angle TAIGA-HiSCORE array. The preliminary results from processing the telescope's data for the low-energy region (>2–3 TeV) are presented. Joint events with energy more than 50 TeV are analyzed and compared to Monte Carlo calculations. [ABSTRACT FROM AUTHOR]

The TAIGA (Tunka Advanced Instrument for cosmic ray physics and Gamma-ray Astronomy) experiment aims at observing gamma-rays in the energy range from 1 TeV to several 100 TeV. The operation of the observatory is based on a new hybrid approach that combines imaging air Cherenkov telescopes (IACTs) and wide-angle Cherenkov detectors (TAIGA-HiSCORE) for measuring times of extensive air shower (EAS) light front arrival. Monte Carlo simulations are compared to real data to determine the performance of the detector setup. Dedicated software and algorithms are described, model parameters are given, and an overview of the current status of model-based performance studies is presented. [ABSTRACT FROM AUTHOR]

The relevance and benefits of the new TAIGA gamma observatory complex in the Tunka Valley (50 km from Lake Baikal) are discussed. The main aim of the TAIGA installation is to study high-energy gamma radiation and search for cosmic pevatrons. The first series of gamma stations was commissioned in 2019 and covers an area of 1 km2. Its expected integral gamma radiation sensitivity at an energy of 100 TeV over 300 h of source monitoring is (2–5) × 10−13 TeV cm−2 s−1. It is planned to expand the effective area of TAIGA gamma observation to 10 km2 in the future. [ABSTRACT FROM AUTHOR]

Copyright of Der Gastroenterologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Der Internist is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A corrected energy dependence of the depth of the maximum in the wide range of energies 1015 to 1018 eV is obtained using data collected at the Tunka-133 facility over 7 years of operation (2009–2017) and the TAIGA-HiSCORE facility in the 2019–2020 season. At the highest energies, our results match those of the Pierre Auger observatory. The results are converted to parameter ❬ln A❭, which characterizes the mean EAS composition. [ABSTRACT FROM AUTHOR]

A new knee-like approximation of the lateral distribution function (LDF) of EAS Cherenkov light in the 30-3000 TeV energy range was proposed and tested with simulated showers in our earlier studies. This approximation fits the LDFs of individual showers accurately for all types of primary particles gamma-rays, protons, and nuclei) and is suitable for reconstructing the shower core, determining the energy, and separating gamma-induced showers from hadron-induced ones. In the present study, the knee-like fitting function is used to determine the parameters of real showers detected by TAIGA-HiSCORE. It is demonstrated that this approximation characterizes properly all types of individual LDFs of experimental events in the 300-1000 TeV range. The accuracy of fit is governed by fluctuations intrinsic to the process of measurement of the Cherenkov photon density. The probability density function of these fluctuations was reconstructed and introduced into simulations. Certain useful methodical applications of the knee-like approximation are con-sidered, and the possibility of shower sorting into nuclei groups is examined. The extensive statistical coverage and detailed LDF measurement data of HiSCORE have provided the first opportunity to examine in depth the LDF of Cherenkov radiation in the 300-1000 TeV range. [ABSTRACT FROM AUTHOR]

Copyright of Der Gastroenterologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Der Internist is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Over the past few years, the TAIGA (Tunka Advanced Instrument for cosmic ray physics and Gamma-ray Astronomy) observatory has been being deployed in the Tunka Valley, Republic of Buryatia. It is designed for studying gamma rays of energy above 30 TeV and performing searches for sources of galactic cosmic rays with energies in the vicinity of 1 PeV, which is an energy region around the classic knee in the cosmic-ray energy spectrum. The first phase of the observatory will be situated at a distance of about 50 km from Lake Baikal at the site of the Tunka-133 array. The TAIGA gamma observatory will include a network of 500 wide-angle (0.6 sr) Cherenkov detectors (TAIGA-HiSCORE array) and up to 16 atmospheric Cherenkov telescopes (ACT) designed for analyzing the EAS images (imaging atmospheric Cherenkov telescopes, or IACT) and positioned within an area of 5 km2. The observatory will also include muon detectors of total area 2000 m2 distributed over an area of 1 km2. Within the next three years, it is planned to enhance the area of the TAIGA-HiSCORE array by a factor of four—from 0.25 km2 to 1 km2; to supplement the existing IACT with two new ones; and to deploy new muon detectors with a total coverage of 200 m2. The structure of the new observatory is described along with the data analysis techniques used. The most interesting physical results are presented, and the research program for the future is discussed. [ABSTRACT FROM AUTHOR]

We have analyzed the neutrino events recoded in the deep-water neutrino experiment NT200 in Lake Baikal in five years of observations toward dark dwarf spheroidal galaxies (dSphs) in the southern hemisphere and the Large Magellanic Cloud (LMC). This analysis completes the series of works based on NT200 data in the search for a dark matter annihilation signal in astrophysical objects. We have found no significant excess in the number of observed events relative to the expected background from atmospheric neutrinos in all tested directions, in 22 dSphs and the LMC. For a sample of five selected dwarf galaxies we have performed a joint analysis of the data by the maximum likelihood method. We have obtained a correspondence of the observational data to the null hypothesis about the presence of only background events and established 90% confidence-level upper limits for the annihilation cross sections of dark matter particles with a mass from 30 GeV to 10 TeV in several annihilation channels both in the joint analysis of the selected sample of galaxies and in the analysis toward the LMC. The strongest constraints at a level of 7 × 10 cm s have been obtained for the direction toward the LMC in the channel of annihilation into a pair of neutrinos. [ABSTRACT FROM AUTHOR]

The design for the TAIGA-HiSCORE array, a part of the TAIGA Gamma Ray Observatory, is considered. The observatory is being constructed in the Tunka Valley, 50 km from Lake Baikal. Preliminary results obtained using the first 28 optical stations of the array are presented. [ABSTRACT FROM AUTHOR]

The Tunka-Grande array is part of an experimental complex located in the Tunka Valley (Republic of Buryatia, Russia) about 50 km from Lake Baikal. This complex also contains the Tunka-133 and Tunka-Rex arrays. The aim of this complex is to study the primary cosmic ray energy spectrum and mass composition in the energy range of 1016–1018 eV, and to search for diffuse gamma rays in the energy range of 5 × 1016–5 × 1017 eV. The design of the Tunka-Grande array and the procedure for reconstructing the parameters of extensive air showers (EASes) are described, and preliminary results are presented from the search for diffuse gamma rays with energies of more than 5 × 1016 eV. [ABSTRACT FROM AUTHOR]

In April 2015, the first cluster of Baikal-GVD was deployed in Lake Baikal and put into operation. It comprises eight strings. Each string consists of 24 optical modules. An optical module is a detection element of Baikal-GVD; it includes a Hamamatsu R7081-100 photomultiplier tube with a high quantum sensitivity. We describe the design of the optical module, the front-end electronics, and the laboratory characterization and calibration. [ABSTRACT FROM AUTHOR]

We analyze sensitivity of the gigaton volume telescope Baikal-GVD for detection of neutrino signal from dark matter annihilations or decays in the Galactic Center. Expected bounds on dark matter annihilation cross section and its lifetime are found for several annihilation/decay channels. [ABSTRACT FROM AUTHOR]

The Tunka-HISCORE wide-angle Cherenkov array, one part of the planned TAIGA integrated gamma observatory intended for investigations in the field of high-energy (>30 TeV) gamma-ray astronomy and cosmic-ray physics, is deployed in the Tunka Valley (Buryat Republic). The first results from operating a prototype array composed of nine stations spread over an area of ∼0.1 square kilometers during the winter of 2013-2014 are presented. Data processing techniques are described, along with data on the accuracy of reconstructing the position of a shower's axis, energy, and angle of arrival. The differential spectrum of all cosmic-ray particles in a shower in the energy range of 2 × 10 to 2 × 10 eV is presented and compared to the available data. [ABSTRACT FROM AUTHOR]

Many solid cancers including pancreatic ductal adenocarcinoma (PDAC) are characterized by an extensive stromal reaction that is accompanied by infiltrating tumor-associated macrophages (TAMs). The role of TAMs in malignant tumors is only partially understood. Previously, we identified the transcription factor CUX1 as an important mediator of tumor progression in PDAC. Interestingly, we found that CUX1 is highly expressed not only in tumor cells but also in TAMs. On the basis of these data, we aimed to elucidate the effects of CUX1 in TAMs in vitro and in vivo. We analyzed the effects of CUX1 on cytokine expression using overexpression and knockdown strategies. The cytokine regulation by CUX1 was further assessed by reporter assays, DNA pulldown experiments and chromatin-immunoprecipitation. CUX1 expression in TAMs was analyzed in human pancreatic cancer tissues and in a genetic mouse model. Immunohistochemical analysis revealed strong expression levels of CUX1 in a distinct subset of TAMs in human PDAC tissues. Furthermore, its expression increased during tumor progression in a genetic mouse model of PDAC. Profiling experiments showed that CUX1 downregulates several NF-κB-regulated chemokines such as CXCL10, which have been associated with M1 polarization and inhibition of angiogenesis and tumor progression. We could demonstrate that CUX1 interacts with NF-κB p65, leading to reduced binding of NF-κB p65 to the chemokine promoters. In addition, CUX1 reduces acetylation of NF-κB p65 at K310 by recruiting HDAC1. Functionally, CUX1 expression in TAMs antagonizes T-cell attraction and enhances angiogenesis in vitro. We identified CUX1 as an important modulator of the TAMs phenotype and function by modulating NF-κB-dependent cytokines. [ABSTRACT FROM AUTHOR]

The Tunka-Grande scintillation array is described. The first results from its operation are presented. The prospects for studying primary cosmic rays in the energy range of 10 to 10 eV during simultaneous registration of the Cherenkov and charged particle components along with radio emissions from extensive air showers are discussed. [ABSTRACT FROM AUTHOR]

Background:Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies with an overall 5-year survival rate of <5%. Despite significant advances in treatment of the disease during the past decade, the median survival rate (∼6 months) has hardly improved, warranting the need to identify novel targets for therapeutic approaches.Methods:Quantitative real time PCR, western blot analyses and immunohistochemical staining of tissue microarrays were used to analyse the expression of TTK gene in primary PDAC tissues and cell lines. To inhibit TTK kinase expression in a variety of pancreatic cancer cell lines, RNA interference was used. Functional roles of this kinase in the context of PDAC were studied using cell proliferation, viability and anchorage-independent growth assays. Western blotting, fluorescence-activated cell sorting analyses and fluorescence microscopy were used to gain mechanistic insight into the functional effects.Conclusions:We show that the dual specificity kinase TTK (also known as Mps1), is strongly overexpressed in human PDAC. Functionally, cell proliferation was significantly attenuated following TTK knockdown, whereas apoptosis and necrosis rates were significantly increased. In addition, anchorage-independent growth, a hallmark of malignant transformation and metastatic potential, was strongly impaired in the absence of TTK gene function. Interestingly, immortalised normal pancreatic hTERT-HPNE cells were not affected by loss of TTK function. Mechanistically, these effects in cancer cells were associated with increased formation of micronuclei, suggesting that loss of TTK function in pancreatic cancer cells results in chromosomal instability and mitotic catastrophe. Taken together, our data show that TTK function is critical for growth and proliferation of pancreatic cancer cells, thus establishing this kinase as an interesting new target for novel therapeutic approaches in combating this malignancy. [ABSTRACT FROM AUTHOR]

In April of 2013, the first stage of the experimental cluster of the NT1000 deep-water neutrino telescope consisting of three strings with 24 optical modules in each was installed at Lake Baikal and switched on in the continuous exposure mode. The detection and data acquisition systems of this setup are described. [ABSTRACT FROM AUTHOR]

The NT1000 deep-water neutrino telescope with an effective volume of ∼2 km is currently being developed at Lake Baikal by the BAIKAL collaboration. The telescope will be composed of functionally independent setups-clusters of strings of optical modules based on photomultiplier tubes (with eight strings in each cluster). Since 2011, field tests of the basic elements and systems of the future telescope included in autonomous measuring complexes-prototypes of the NT1000 cluster-have been performed at Lake Baikal. The basic elements and the layout of one of the currently considered versions of the acoustic positioning system for the NT1000 telescope are described, and results of tests of the system prototype included as a component in the experimental cluster of the year 2012 are presented. [ABSTRACT FROM AUTHOR]

Most screening programs for familial pancreatic cancer are currently based on endoscopic ultrasonography and/or magnetic resonance imaging (MRI). Cystic lesions, especially those suspicious for small intraductal pancreatic mucinous neoplasms (IPMNs) of the branch ducts, can be visualized in up to 40 % of individuals at risk, but their pathological importance in the setting of FPC is yet not well established. Individuals at risk from a prospective screening program for familial pancreatic cancer with small 'imaging' IPMNs of the branch-duct type (BD-IPMN) who underwent pancreatic resection were analysed regarding clinico-pathological data and the locations of pancreatic lesions. Five of 125 individuals at risk who underwent screening had multiple small (size 2-10 mm) unicystic lesions and/or multicystic single lesions in the pancreatic body and tail suspicious for BD-IPMNs upon MRI imaging and decided to undergo surgical resection after interdisciplinary counselling, although none fulfilled the consensus criteria for IPMN resection. Histological examination revealed BD-IPMNs with low or moderate dysplasia of the gastric type in combination with multifocal PanIN2 and PanIN3 lesions in 4 individuals. The remaining patient had only tiny ductectasias in the pancreatic tail with multifocal PanIN 2 lesions in the entire gland and one PanIN3 lesion in the pancreatic head. Intriguingly, the location of the most dysplastic histological lesions (PanIN3) did not correspond to the preoperatively detected lesions and were not visible in preoperative imaging. In the setting of FPC, the presence of multiple small 'imaging' BD-IPMNs may indicate the presence of high-grade PanIN lesions elsewhere in the pancreas. [ABSTRACT FROM AUTHOR]

Copyright of Der Internist is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The currently running NT200 and NT200+ Baikal neutrino telescopes and the prospects for development of the Baikal Neutrino Project are briefly descr⇊ed. Preliminary results of the search for neutrino events correlated with cosmological gamma-ray bursts at the NT200 are presented. The feasibility of developing a method for acoustic detection of ultrahigh-energy neutrinos in the Baikal Neutrino Project is discussed. The calculation results for the energy spectrum and zenith-angle distributions of atmospheric neutrinos in the energy range from 10 to 10 GeV obtained within various high-energy hadron-nucleus interaction models are presented. [ABSTRACT FROM AUTHOR]

We present the results of our search for neutrino events coinciding in time and direction with gamma-ray bursts (GRBs) with the Baikal underwater neutrino telescope NT200. No events confirming a neutrino accompaniment of GRBs have been detected. Model-independent limits (Greens function) on the neutrino flux from GRBs have been obtained. For the Waxman-Bahcall neutrino spectrum, the limit on the neutrino flux from a GRB has been found to be EΦ ⩽ 1.1 × 10 GeV cm s sr. [ABSTRACT FROM AUTHOR]