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Demonstrates that clonal anergy in B lymphocytes is a reversible process, and that silenced self-reactive B cells can be reactivated under particular conditions to give rise to vigorous antibody responses. Methods; Results; Discussion.

Describes the use of a transgenic mouse model to follow the fate of self-reactive B cells when they encounter self-antigen only at the mature stage of development, in peripheral lymphoid organs. Low-lysozyme double-transgenic mice; Transfer of nontolerant B cells; Tolerance and IgM-down-regulation in transgenic mice; Discussion.