11 results on '"Giavoli, C"'
Search Results
2. Influence of biochemical diagnosis of growth hormone deficiency on replacement therapy response and retesting results at adult height.
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Rodari, Giulia, Profka, E., Giacchetti, F., Cavenaghi, I., Arosio, M., and Giavoli, C.
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PITUITARY dwarfism ,HORMONE therapy ,NEUROSECRETION ,HYPOTHALAMUS ,CHILDREN'S health - Abstract
Isolated growth hormone deficiency (IGHD) is the most frequent endocrinological disorder in children with short stature, however the diagnosis is still controversial due to the scarcity of reliable diagnostic criteria and pre-treatment predictive factors of long term-response. To evaluate recombinant growth hormone (rGH) long-term response and retesting results in three different groups of children divided in accordance with the biochemical criteria of initial diagnosis. Height gain (∆HT) at adult height (AH) and retesting results were evaluated in 57 rGH treated children (M = 34, 59.6%) divided into 3 groups according to initial diagnosis: Group A (n = 25) with max GH peak at stimulation test < 8 µg/L, Group B (n = 19) between 8 and 10 µg/L and Group C (n = 13) with mean overnight GH < 3 µg/L (neurosecretory dysfunction, NSD). Retesting was carried out in all patients after at least one month off therapy upon reaching the AH. 40/57 (70.2%) patients were pre-pubertal at diagnosis and showed ∆HT of 1.37 ± 1.00 SDS, with no significant differences between groups (P = 0.08). Nonetheless, 46% patients in Group B showed ∆HT < 1SDS (vs 13% and 12% in Group A and C, respectively) and 25% children failed to reach mid-parental height (vs 6% and 0% in Group A and C, respectively). At AH attainment, IGHD was reconfirmed in 28% (7/25) and 10% (2/19) in Group A and B, respectively. A reduction of diagnostic cut-off at GH stimulation tests could better discriminate between "good" and "poor responders" and predict the persistence of IGHD through transition. Group C response and the predictive value of baseline IGF-I SDS bring back to light NSD: should we consider an underlying hypothalamic derangement when the clinical presentation is strongly consistent with IGHD but pharmacological stimulation test is normal? [ABSTRACT FROM AUTHOR]
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- 2021
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3. Safety and effectiveness of a somatropin biosimilar in children requiring growth hormone treatment: second analysis of the PATRO Children study Italian cohort.
- Author
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Iughetti, L., Antoniazzi, F., Giavoli, C., Bona, G., Aversa, T., Greggio, N. A., Guazzarotti, L., Minelli, R., Perrone, L., Persani, L., Pozzobon, G., Ragusa, L., Stagi, S., Tornese, G., Zecchino, C., Gallinari, P., Zouater, H., Fedeli, P., and Zucchini, S.
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- 2021
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4. Safety and effectiveness of Omnitrope® in patients with growth hormone deficiency: snapshot analysis of PATRO Adults study in the Italian population.
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Arosio, M., Arnaldi, G., Gasco, V., Giavoli, C., Puxeddu, E., Vettor, R., Ambrosio, M. R., Gallinari, P., Zouater, H., Fedeli, P., and Ferone, D.
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- 2021
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5. Determinants of outcome of transsphenoidal surgery for Cushing disease in a single-centre series.
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Serban, A. L., Del Sindaco, G., Sala, E., Carosi, G., Indirli, R., Rodari, G., Giavoli, C., Locatelli, M., Carrabba, G., Bertani, G., Marfia, G., Mantovani, G., Arosio, M., and Ferrante, E.
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- 2020
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6. A 2019 update on TSH-secreting pituitary adenomas.
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Beck-Peccoz, P., Giavoli, C., and Lania, A.
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- 2019
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7. Birmingham epidermolysis severity score and vitamin D status are associated with low BMD in children with epidermolysis bullosa.
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Rodari, G., Guez, S., Manzoni, F., Chalouhi, K., Profka, E., Bergamaschi, S., Salera, S., Tadini, G., Ulivieri, F., Spada, A., Giavoli, C., and Esposito, S.
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HAND radiography ,WRIST radiography ,BONE diseases ,ANALYSIS of bones ,C-reactive protein ,EPIDERMOLYSIS bullosa ,LUMBAR vertebrae ,SCIENTIFIC observation ,PROBABILITY theory ,SODIUM ,SOMATOMEDIN ,VITAMIN D ,X-rays ,BONE density ,SEVERITY of illness index ,DESCRIPTIVE statistics ,PHOTON absorptiometry ,DISEASE complications ,DISEASE risk factors - Abstract
Summary: Bone status impairment represents a complication of generalized forms of epidermolysis bullosa (EB); however, the prevalence and the main determinants of this event in localized forms remain poorly defined. Birmingham epidermolysis bullosa severity (BEBS) score and 25-hydroxyvitamin D levels are strongly associated with low bone mass, suggesting that vitamin D may play a potential beneficial role in bone health. Further longitudinal studies are needed in order to confirm this hypothesis. Introduction: Bone status impairment represents a complication of generalized forms of EB; thus, we aimed to estimate the prevalence of low bone mass, to examine mineralization differences in various EB subtypes and to identify the most important determinants of bone impairment in children with either generalized or localized EB. Methods: An observational study of 20 children (11 males; mean age ± standard deviation, 11.7 ± 3.9 years) with EB was performed. Clinical history, physical examination, laboratory studies, X-ray of the left hand and wrist for bone age, and dual energy X-ray absorptiometry scans of the lumbar spine were obtained. Areal bone mineral density (aBMD Z-scores) and bone mineral apparent density were related to the BEBS score. Results: Areal BMD Z-score (mean −1.82 ± 2.33, range, −7.6-1.7) was reduced (<−2 SD) in 8 patients (40%), whereas aBMD Z-score adjusted for bone age was low in 7 patients (35%). BEBS score and 25-hydroxyvitamin D serum levels were the most important elements associated with aBMD ( P = 0.0001 and P = 0.016, respectively). A significant correlation between the aBMD Z-score and area of skin damage, insulin-like growth factor-1, C-reactive protein, and sodium serum levels was also found. Conclusions: Low aBMD can be considered a systemic complication of EB, primarily associated with BEBS score and 25-hydroxyvitamin D levels. Therefore, longitudinal evaluation of bone status is ongoing in these patients to define whether vitamin D supplementation would prevent, or at least reduce, bone status impairment. [ABSTRACT FROM AUTHOR]
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- 2017
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8. Obesity: impact of infections and response to vaccines.
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Tagliabue, C., Principi, N., Giavoli, C., and Esposito, S.
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OBESITY ,DISEASE risk factors ,VACCINE research ,IMMUNE response ,IMMUNE system - Abstract
Obesity is a common condition that has rapidly increased in both the industrialised and developing world in recent decades. Obese individuals show increased risk factors for severe infections and significant immune system dysregulation that may impair the immune response to vaccines. The main aim of this paper was to review the current knowledge regarding the association between obesity and the risk and outcome of infections as well as immune response to vaccines. The results showed that obesity is a highly complex clinical condition in which the functions of several organ and body systems, including the immune system, are modified. However, only a small minority of the biological mechanisms that lead to reduced host defences have been elucidated. Relevant efforts for future research should focus on obese children, as the available data on this population are scarce compared with the adult population. Even if most vaccines are given in the first months of life when obesity is rare, some vaccines require booster doses at preschool age, and other vaccines, such as the influenza vaccine, are recommended yearly in the obese population, but it is not known whether response to vaccines of obese patients is impaired. The reduced immune response of obese patients to vaccination can be deleterious not only for the patient but also for the community. [ABSTRACT FROM AUTHOR]
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- 2016
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9. Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma.
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Profka, E., Giavoli, C., Bergamaschi, S., Ferrante, E., Malchiodi, E., Sala, E., Verrua, E., Rodari, G., Filopanti, M., Beck-Peccoz, P., and Spada, A.
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- 2015
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10. Progressive bone impairment with age and pubertal development in neurofibromatosis type I.
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Rodari, Giulia, Scuvera, G., Ulivieri, F. M., Profka, E., Menni, F., Saletti, V., Esposito, S., Bergamaschi, S., Ferrante, E., Eller-Vainicher, C., Arosio, M., and Giavoli, C.
- Abstract
Summary: Bone density impairment represents an established complication in adults with neurofibromatosis type 1, while few data exist in the pediatric population. Age- and gender-adjusted bone mass decreases with age and pubertal development, identifying childhood as the best time frame to introduce prevention strategies aiming at peak bone mass achievement.Purpose: The present study aims at evaluating bone mineral density (BMD) in a population of children with neurofibromatosis type I (NF-1), with particular focus on changes occurring during growth and pubertal development.Methods: Bone metabolic markers and bone status [by dual-energy X-ray absorptiometry scans (DXA) of the total body and lumbar spine with morphometric analysis] were assessed in 50 children (33 males; mean age ± SD, 11.6 ± 4 years). Bone mineral apparent density (BMAD), trabecular bone score (TBS), and bone strain (BS) of the lumbar spine (LS) DXA were also obtained.Results: In our cohort areal BMD (aBMD) Z-score was below the mean in 88% of the patients at LS (70% after correction for bone size) and in 86% considering total body (TB) DXA. However, aBMD Z-score was < − 2 in 12% after correction for bone size at LS and TB, respectively. Lumbar spine aBMD Z-score (r = − 0.54, P < 0.0001), LS BMAD Z-score (r = − 0.53, P < 0.0001), and TB Z-score (r = − 0.39, P = 0.005) showed a negative correlation with growth and pubertal development (P = 0.007, P = 0.02, P = 0.01, respectively), suggesting that patients failed to gain as much as expected for age.Conclusion: Bone density impairment becomes more evident with growth and pubertal development in NF-1 patients, thus identifying childhood as the best time frame to introduce prevention strategies aiming at peak bone mass achievement. TBS and BS, providing bone DXA qualitative information, could be useful during longitudinal follow-up for better characterizing bone impairment in these patients. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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11. Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study
- Author
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Cappa, M., Iughetti, L., Loche, S., Maghnie, M., Vottero, A, GeNeSIS National Board on behalf of the GeNeSIS Italian Investigators, Franco, Antoniazzi, Luciano, Beccaria, Sergio, Bernasconi, Domenico, Caggiano, Manuela, Caruso-Nicoletti, Alessandra, Catucci, Francesco, Chiarelli, Stefano, Cianfarani, Annarita, Colucci, Francesca De Rienzo, Raffaele Di Pumpo, Alessandra Di Stasio, Giovanni, Farello, Leonardo, Felici, Pasquale, Femiano, Luigi, Garagantini, Claudia, Giavoli, Nellaaugusta, Greggio, Laura, Guazzarotti, Daniela, Larizza, Mariarosaria, Licenziati, Antonella, Lonero, Mariacristina, Maggio, Alberto, Marsciani, Patrizia, Matarazzo, Laura, Mazzanti, Beatrice, Messini, Flavia, Napoli, Annamaria, Pasquino, Laura, Perrone, Sabrina, Pilia, Alba, Pilotta, Marzia, Piran, Gabriella, Pozzobon, Predieri, Barbara, Michele, Sacco, Mariacarolina, Salerno, Antonina, Tirendi, Graziamaria, Ubertini, Silvia, Vannelli, Malgorzata, Wasniewska, Maria, Zampolli, Martina, Zanotti, Gianvincenzo, Zuccotti, Cappa, M., Iughetti, L., Loche, S., Maghnie, M., Vottero, A, Salerno, Mariacarolina, Vottero, A.* Antoniazzi F, Beccaria L, Bernasconi S, Caggiano D, Caruso-Nicoletti M, Catucci A, Chiarelli F, Cianfarani S, Colucci AR, De Rienzo F, Di Pumpo R, Di Stasio A, Farello G, Felici L, Femiano P, Garagantini L, Giavoli C, Greggio NA, Guazzarotti L, Larizza D, Licenziati MR, Lonero A, Maggio MC, Marsciani A, Matarazzo P, Mazzanti L, Messini B, Napoli F, Pasquino AM, Perrone L, Pilia S, Pilotta A, Piran M, Pozzobon G, Predieri B, Sacco M, Salerno M, Tirendi A, Ubertini G, Vannelli S, Wasniewska M, Zampolli M, Zanotti M, Zuccotti G, Vottero, A., and Perrone, Laura
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Male ,Pediatrics ,Endocrinology, Diabetes and Metabolism ,Turner Syndrome ,Pediatric GH treatment ,Growth ,Clinical study ,0302 clinical medicine ,Endocrinology ,Turner syndrome ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Child ,Final height ,Safety ,Short stature ,Human Growth Hormone ,Diabetes and Metabolism ,Growth hormone treatment ,Treatment Outcome ,Italy ,Child, Preschool ,Cohort ,Original Article ,Female ,Patient Safety ,medicine.symptom ,Human ,medicine.medical_specialty ,Adolescent ,030209 endocrinology & metabolism ,Dwarfism ,Neuroendocrinology ,Body Height ,Dwarfism, Pituitary ,Humans ,03 medical and health sciences ,medicine ,Preschool ,business.industry ,medicine.disease ,Prospective Studie ,Pituitary ,Observational study ,Final height, Growth, Pediatric GH treatment, Safety, Short stature, Endocrinology, Diabetes and Metabolism, Endocrinology ,business - Abstract
Purpose: We examined auxological changes in growth hormone (GH)-treated children in Italy using data from the Italian cohort of the multinational observational Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) of pediatric patients requiring GH treatment. Methods: We studied 711 children (median baseline age 9.6 years). Diagnosis associated with short stature was as determined by the investigator. Height standard deviation score (SDS) was evaluated yearly until final or near-final height (n = 78). Adverse events were assessed in all GH-treated patients. Results: The diagnosis resulting in GH treatment was GH deficiency (GHD) in 85.5 % of patients, followed by Turner syndrome (TS 6.6 %). Median starting GH dose was higher in patients with TS (0.30 mg/kg/week) than patients with GHD (0.23 mg/kg/week). Median (interquartile range) GH treatment duration was 2.6 (0.6â3.7) years. Mean (95 % confidence interval) final height SDS gain was 2.00 (1.27â2.73) for patients with organic GHD (n = 18) and 1.19 (0.97â1.40) for patients with idiopathic GHD (n = 41), but lower for patients with TS, 0.37 (â0.03 to 0.77, n = 13). Final height SDS was >â2 for 94 % of organic GHD, 88 % of idiopathic GHD and 62 % of TS patients. Mean age at GH start was lower for organic GHD patients, and treatment duration was longer than for other groups, resulting in greater mean final height gain. GH-related adverse events occurred mainly in patients diagnosed with idiopathic GHD. Conclusions: Data from the Italian cohort of GeNeSIS showed auxological changes and safety of GH therapy consistent with results from international surveillance databases.
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