Search

Research demonstrates that stigma and resilience influence transgender peoples' healthcare use. Less is known about transgender Latinas in the U.S. South who face multilevel barriers to healthcare access. We used baseline data from the ChiCAS intervention study. Using logistic regression, we examined how stigma (perceived discrimination related to gender identity, race/ethnicity, sexual behavior and perceived documentation status and internalized transphobia), and resilience (ethnic group pride and social support) are associated with two healthcare outcomes (use of routine medical care and medically supervised gender-affirming hormones). We also explored barriers to accessing both types of care. After removing 13 participants with missing data, our sample size was 131 transgender Latinas in the U.S. South. Most participants (74.8%, n = 98) received routine medical care in the past year and 57.3% (n = 75) had ever received medically supervised gender-affirming hormones. Reports of discrimination were highest for gender identity and documentation status. Race/ethnicity-based discrimination was positively associated with accessing routine medical care in the past year (OR = 1.94, p = 0.048). Having more social support was positively associated with care (routine care: OR = 3.48, p = 0.002 and gender-affirming hormones: OR = 2.33, p = 0.003). The most commonly reported barriers to accessing both types of care included cost, insurance, and not knowing where to go. Findings highlight the importance of social support for healthcare use among transgender Latinas. Social support may be especially important when considering the unique experiences of discrimination faced by transgender Latinas in the U.S. South. [ABSTRACT FROM AUTHOR]

Sexual dysfunction (SD) has been associated with worse quality of life and higher disease activity in patients with rheumatic diseases, yet it is still not regularly addressed during routine rheumatologic evaluations. This study aimed to determine the prevalence of sexual dysfunction in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and evaluate their perception of their sexual health. We performed a retrospective study in an outpatient rheumatology clinic to evaluate patients over 18 years old with a diagnosis of RA or SLE through the Spanish version of the Arizona Sexual Experiences Scale (ASEX) and the Sexual Health Perception Survey (SHEPS), a questionnaire of 6 items designed in our clinic. Additionally, we applied the Functional Assessment of Chronic Illness Therapy – Fatigue (FACIT-F version 4) and the Hospital Anxiety and Depression Scale (HADS). A total of 567 patients were evaluated with SHEPS, most of whom were women with a median age of 50 years (IQR: 34) and a median disease duration of 5 years (IQR: 9). Through the ASEX, we found that 67% of the patients with RA and 60% of the patients with SLE experienced SD. Patients reported the level of sex drive, arousal, and the ability to achieve orgasms as the areas with the most difficulties. Most patients did not know their disease could affect their sexuality and had never addressed these issues with their rheumatologists, but almost all of them were willing to. Our findings highlight the importance of addressing sexual health issues regularly during rheumatologic evaluations. [ABSTRACT FROM AUTHOR]

School reopening is essential for restoring normalcy after a period of disruption. However, executing this endeavor during a pandemic requires a comprehensive strategy to ensure success. Consulting stakeholders is consequently crucial for informed and inclusive policies. Prior works recruited public officials, health authorities, teachers, and parents. Unfortunately, students were often not involved in such consultations. The present study addressed this gap by uncovering the sentiments and concerns on school reopening among higher education students. A total of 223 students enrolled in public and private universities from rural and urban areas participated in the study. Based on their reflective essays, students have mixed sentiments about returning to school during the pandemic and highlight safety, academic, health, and financial concerns as major areas requiring attention. It is now incumbent upon governments, schools, policymakers, and education leaders to carefully analyze and incorporate the findings of this study into their back-to-school guidelines and strategies. With informed decision-making and evidenced-based policy, we can build back a stronger and more resilient education system that equitably serves all students in the post-pandemic world. [ABSTRACT FROM AUTHOR]

Viruses play an important role in the marine ecosystem. However, our comprehension of viruses inhabiting the dark ocean, and in particular, under the Antarctic Ice Shelves, remains limited. Here, we mine single-cell genomic, transcriptomic, and metagenomic data to uncover the viral diversity, biogeography, activity, and their role as metabolic facilitators of microbes beneath the Ross Ice Shelf. This is the largest Antarctic ice shelf with a major impact on global carbon cycle. The viral community found in the cavity under the ice shelf mainly comprises endemic viruses adapted to polar and mesopelagic environments. The low abundance of genes related to lysogenic lifestyle (<3%) does not support a predominance of the Piggyback-the-Winner hypothesis, consistent with a low-productivity habitat. Our results indicate a viral community actively infecting key ammonium and sulfur-oxidizing chemolithoautotrophs (e.g. Nitrosopumilus spp, Thioglobus spp.), supporting a "kill-the-winner" dynamic. Based on genome analysis, these viruses carry specific auxiliary metabolic genes potentially involved in nitrogen, sulfur, and phosphorus acquisition. Altogether, the viruses under Antarctic ice shelves are putatively involved in programming the metabolism of ecologically relevant microbes that maintain primary production in these chemosynthetically-driven ecosystems, which have a major role in global nutrient cycles. The diversity and impact of viruses in remote marine environments are less well understood. In this study, the authors analyse an -omics dataset to gain insights into the genomics and potential role of endemic viruses infecting ecologically important microbes inhabiting the ocean cavity beneath the Ross Ice Shelf. [ABSTRACT FROM AUTHOR]

Economic historians have used GDP and its backwards projections to quantify economic growth and the process of early globalisation from year 1 CE to the present day. This has generated a lively debate concerning which methodologies are the most accurate for quantitative history and which data are most reliable. In addition, whilst an overwhelming amount of scholarship has emerged on the supply side, the demand side and family economic changes have been less popular in economic history. In this article, I present a concrete case study to analyse consumer behaviour: the circulation of Chinese goods in western Mediterranean markets during the eighteenth century. In so doing, I test the "trickle-down" theory with new archival data using GECEM Project Database, and apply the OLS and SNA to measure the social distribution of these goods through trade networks' intermediation. The main result is that the agency of middle social groups—mainly merchants—was changing consumers' behaviour in western Mediterranean markets, and not local oligarchies and nobility as the "trickle-down" theory has conventionally assessed. [ABSTRACT FROM AUTHOR]

Despite originating in the tech industry, hackathons have now been adopted in a variety of domains. However, little is known about the status of hackathon literature within educational research. As the number of studies grows, it is essential to develop an understanding of the current state and identify prevalent topics and trends shaping the literature. Toward this goal, this study conducted a bibliometric analysis and scoping review on hackathon research in the field of education. A total of 249 documents written by 1,309 authors and published in 180 unique sources for the period 2014–2022 were identified. Collectively, the dataset amassed 1,312 citations with an average of 6.69 citations per document. The most prevalent subject areas were computer science, social sciences, engineering, medicine, and business. Word frequency analysis showed that "innovation" was the most occurring word, which represents the fundamental objective of hackathon events. The most influential work was the analysis of hackathons as an informal learning platform. Engineering education was the most trending topic while healthcare is an emerging research cluster. Overall, this study provides a better understanding of the hackathon literature and its research landscape in an educational setting. [ABSTRACT FROM AUTHOR]

Intraoperative hypotension (IOH) is associated with increased morbidity and mortality. Hypotension Prediction Index (HPI) is a machine learning derived algorithm that predicts IOH shortly before it occurs. We tested the hypothesis that the application of the HPI in combination with a pre-defined Goal Directed Therapy (GDT) hemodynamic protocol reduces IOH during major gynaecologic oncologic surgery. We enrolled women scheduled for major gynaecologic oncologic surgery under general anesthesia with invasive arterial pressure monitoring. Patients were randomized to a GDT protocol aimed at optimizing stroke volume index (SVI) or hemodynamic management based on HPI guidance in addition to GDT. The primary outcome was the amount of IOH, defined as the timeweighted average (TWA) mean arterial pressure (MAP) < 65 mmHg. Secondary outcome was the TWA-MAP < 65 mmHg during the first 20 min after induction of GA. After exclusion of 10 patients the final analysis included 60 patients (30 in each group). The median (25–75th IQR) TWA-MAP < 65 mmHg was 0.14 (0.04–0.66) mmHg in HPI group versus 0.77 (0.36–1.30) mmHg in Control group, P < 0.001. During the first 20 min after induction of GA, the median TWA-MAP < 65 mmHg was 0.53 (0.06–1.8) mmHg in the HPI group and 2.15 (0.65–4.2) mmHg in the Control group, P = 0.001. Compared to a GDT protocol aimed to SVI optimization, a machine learning-derived algorithm for prediction of IOH combined with a GDT hemodynamic protocol, reduced IOH and hypotension after induction of general anesthesia in patients undergoing major gynaecologic oncologic surgery. Trial registration number: NCT04547491. Date of registration: 10/09/2020. [ABSTRACT FROM AUTHOR]

This letter highlights an escalating concern regarding predatory conference speaker invitations that are currently plaguing academia. Such invitations are frequently issued to individuals outside their areas of expertise, for instance, non-healthcare professionals being invited to health-related conferences. This issue poses a substantial threat as it compromises the integrity of legitimate academic discourse and carries the risk of propagating unchecked and potentially detrimental information. To avoid becoming ensnared by these predatory practices, it is paramount to undertake thorough due diligence. Consequently, this letter also outlines the characteristics of predatory speaker invitations. These guidelines underscore the necessity for the academic community to remain vigilant and judicious, thereby recognizing these overtures for what they truly represent: a deceptive temptation that leads away from authentic scholarly engagement toward a facade of recognition and prestige. [ABSTRACT FROM AUTHOR]

The Hypotension Prediction Index (HPI) is a validated algorithm developed by applying machine learning for predicting intraoperative arterial hypotension (IOH). We evaluated whether the HPI, combined with a personalized treatment protocol, helps to reduce IOH (depth and duration) and perioperative events in real practice. This was a single-center retrospective study including 104 consecutive adults undergoing urgent or elective non-cardiac surgery with moderate-to-high risk of bleeding, requiring invasive blood pressure and continuous cardiac output monitoring. Depending on the sensor, two comparable groups were identified: patients managed following the institutional protocol of personalized goal-directed fluid therapy (GDFT, n = 52), or this GDFT supported by the HPI (HPI, n = 52). The time-weighted average of hypotension for a mean arterial pressure < 65 mmHg (TWAMAP<65), postoperative complications and length of hospital stay (LOS) were automatically downloaded from medical records and revised by clinicians blinded to the management received by patients. Differences in preoperative variables (i.e. physical status -ASA class-, acute kidney Injury-AKI- risk) and outcomes were analyzed using non-parametric tests with Hodges-Lehmann estimator for the median of differences. ASA class and AKI risk were similar (p = 0.749 and p = 0.837, respectively). Blood loss was also comparable (p = 0.279). HPI patients had a lower TWAMAP<65 [0.09 mmHg (0–0.48 mmHg)] vs [0.23 mmHg (0.01 to 0.97 mmHg)], p = 0.037. Postoperative complications were less prevalent in the HPI patients (0.46 ± 0.98 vs. 0.88 ± 1.20), p = 0.035. Finally, LOS was significantly shorter among HPI patients with a median difference of 2 days (p = 0.019). The HPI combined with a GDFT protocol may help to minimize the severity of IOH during non-cardiac surgery. [ABSTRACT FROM AUTHOR]

Field trips are steadily declining due to limited funding, time constraints, safety concerns, and other logistical issues. Many schools are resorting to a virtual field trip (VFT), especially when education is disrupted due to public health concerns, natural disasters, or other unforeseen significant events. Virtual reality as a common form of VFT is likely not an option for many schools due to cost and other barriers. The purpose of our study was to explore the potential of going in a VFT using 360-degree (360°) videos as an alternative to a physical field trip in primary education. We recruited third-grade pupils (aged 8–9) from two private elementary schools to experience VFTs using 360° videos (360V) and regular videos (REGV). Using a switching-replications experimental design, we compared their content recall (assessment tests) and VFT experience (attitude, perceived usefulness, involvement, inquiry, video engagement, and virtual guide) across four-time points. Our results show that the increase in content recall scores of 360V groups after VFTs was consistently higher compared to REGV groups at all time points, although it was only significant in one quarter. We also found pupils' video engagement, involvement, and attitude as significant factors in their VFT experience. These results call attention to a possible implementation of VFTs and continue the long-standing tradition that has been acknowledged as a student-centered, interactive instructional method. [ABSTRACT FROM AUTHOR]

Several limitations regarding pulse pressure variation (PPV) use have been reported. Our aim was to describe changes in the PPV operative performance as a predictor of fluid responsiveness during the development of a swine endotoxin shock model and to assess hemodynamic variables associated with PPV changes. A swine porcine endotoxin shock model was established (Escherichia Coli 055:B5 endotoxin) in 7 pigs, and 3 pigs were included in the control group. The endotoxin was infused until the mean arterial pressure (MAP) dropped below 50 mmHg (TH0); then, the model animal was reanimated with fluids and vasopressors. We performed fluid challenges every hour for 6 h. ROC curve analysis and a linear mixed model were performed. The area under the curve of PPV decreased from 0.95 (0.81–1.00) to 0.60 (0.17–1.00) at TH0. Its cutoff increased from 10.5 to 22.00% at TH0. PPV showed an inverse relationship with stroke volume, mean systemic filling pressure, MAP, and systemic vascular resistance (SVR) (p < 0.001, AIC = 111.85). The PPV operative performance as a predictor of fluid responsiveness decreased with the progression of shock. This could lead to an inverse association between PPV and the following variables: MAP and SVR. [ABSTRACT FROM AUTHOR]

This letter highlights a pressing issue regarding the absence of established editorial policies for the utilization of AI tools (e.g., ChatGPT) in the peer review process. The increasing adoption of AI tools in academic publishing necessitates the formulation of standardized guidelines to ensure fairness, transparency, and accountability. Without clear editorial policies, there is a threat of compromising the integrity of the peer review process and undermining the credibility of academic publications. Urgent attention is needed to address this gap and establish robust protocols that govern the use of AI tools in peer review. [ABSTRACT FROM AUTHOR]

Immunoglobulin A (IgA) is the dominant antibody found in our mucosal secretions and has long been recognized to play an important role in protecting our epithelium from pathogens. Recently, IgA has been shown to be involved in gut homeostatic regulation by 'recognizing' and shaping our commensal microbes. Paradoxically, yet selective IgA-deficiency is often described as asymptomatic and there is a paucity of studies only focused on the mice and human gut microbiome context fully ignoring other niches of our body and our commensal viruses. Here, we used as a model the human oral cavity and employed a holistic view and studied the impact of IgA deficiency and also common variable IgA and IgM immunodeficiencies (CVID), on both the human virome and microbiome. Unexpectedly, metagenomic and experimental data in human IgA deficiency and CVID indicate minimal-moderate changes in microbiome and virome composition compared to healthy control group and point out to a rather functional, resilient oral commensal viruses and microbes. However, a significant depletion (two fold) of bacterial cells (p-value < 0.01) and viruses was observed in IgA-deficiency. Our results demonstrate that, within the limits of our cohort, IgA role is not critical for maintaining a rather functional salivary microbiome and suggest that IgA is not a major influence on the composition of abundant commensal microbes. [ABSTRACT FROM AUTHOR]

Computer programming education is often delivered using individual learning strategies leaving group learning techniques as an under-researched pedagogy. This pose a research gap since novice programmers tend to form their own group discussions after lecture meetings and laboratory activities, and often rely on peers when a topic or activity is difficult. Thus, this study intends to evaluate the impact of cooperative learning using jigsaw technique when teaching computer programming to novice programmers. A quasi-experimental research using a nonequivalent control group pretest-posttest design was adopted to examine the impact of jigsaw teaching strategy. After a 14-week programming course, pre- and post-test results revealed a significant increase in terms of attitude and self-efficacy, and the experimental group demonstrated significantly higher scores than in the control group. Therefore, it was concluded that cooperative learning using Jigsaw technique is a valid and effective teaching strategy when handling novice programmers in an introductory programming course. [ABSTRACT FROM AUTHOR]

The Protective Behavioral Strategies for Marijuana scale (PBSM) was initially developed using samples of university students in USA. A community sample of Spanish young adults was recruited to provide the Spanish full-length and short versions of the Protective Behavioral Strategies for Cannabis use (S-PBSC; S-PBSC-SF). We followed a rigorous item-selection process to select the most relevant items from the original 50-item pool developed by Pedersen et al. (2016), on the basis of evidence of reliability, evidence of validity according to the internal structure (factor loadings, invariance across genders and university status, and differential item functioning [DIF]), and evidence of validity based on the relationships between S-PBSC scores and cannabis outcomes. Our findings support a 31-item unidimensional measure and a 13-item short form with excellent fit and internal consistency, invariant across genders and college status and free of DIF. Both the S-PBSC and S-PBSC-SF scores were associated with reduced cannabis use and consequences. [ABSTRACT FROM AUTHOR]

The human Alzheimer's disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis is started near Aß plaques in both AD mouse models and human AD samples. However, endothelial cells express the molecular signature of non-productive angiogenesis (NPA) and accumulate, around Aß plaques, a tip cell marker and IB4 reactive vascular anomalies with reduced NOTCH activity. Notably, NPA induction by endothelial loss of presenilin, whose mutations cause familial AD and which activity has been shown to decrease with age, produced a similar vascular phenotype in the absence of Aß pathology. We also show that Aß plaque-associated NPA locally disassembles blood vessels, leaving behind vascular scars, and that microglial phagocytosis contributes to the local loss of endothelial cells. These results define the role of NPA and microglia in local blood vessel disassembly and highlight the vascular component of presenilin loss of function in AD. Aß are extracellular deposits relevant in Alzheimer's disease (AD). This study shows that Aß plaques are hubs of endothelial disassembly that induce non-productive angiogenesis. This process is aided by the microglia and unchained by reduced presenilin function, a trait of AD, in endothelial cells. [ABSTRACT FROM AUTHOR]

The gut microbiome is known to influence the pathogenesis and progression of neurodegenerative diseases. However, there has been relatively little focus upon the implications of the gut microbiome in retinal diseases such as retinitis pigmentosa (RP). Here, we investigated changes in gut microbiome composition linked to RP, by assessing both retinal degeneration and gut microbiome in the rd10 mouse model of RP as compared to control C57BL/6J mice. In rd10 mice, retinal responsiveness to flashlight stimuli and visual acuity were deteriorated with respect to observed in age-matched control mice. This functional decline in dystrophic animals was accompanied by photoreceptor loss, morphologic anomalies in photoreceptor cells and retinal reactive gliosis. Furthermore, 16S rRNA gene amplicon sequencing data showed a microbial gut dysbiosis with differences in alpha and beta diversity at the genera, species and amplicon sequence variants (ASV) levels between dystrophic and control mice. Remarkably, four fairly common ASV in healthy gut microbiome belonging to Rikenella spp., Muribaculaceace spp., Prevotellaceae UCG-001 spp., and Bacilli spp. were absent in the gut microbiome of retinal disease mice, while Bacteroides caecimuris was significantly enriched in mice with RP. The results indicate that retinal degenerative changes in RP are linked to relevant gut microbiome changes. The findings suggest that microbiome shifting could be considered as potential biomarker and therapeutic target for retinal degenerative diseases. [ABSTRACT FROM AUTHOR]

Copyright of AIDS & Behavior is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: In Argentina, health insurances demand a 24-month duration preoperative weight loss program (POWLP) before bariatric surgery. It is unknown whether it enhances weight loss before or after surgery, or even if it is related to comorbidity remission. The main objective of this study was to determine its effectiveness and reliability. Methods: An observational, longitudinal, retrospective study was carried out from June 2009 to December 2016, enrolling patients who underwent bariatric surgery in Sanatorio Allende Hospital of Cordoba, Argentina. Patients were divided into three groups according time-to-surgery from preoperative assessment initiation (A = before the 6th month, B = from 6th to 24th month, and C = over 24th month; all related to the first visit as previously mentioned). BMI, %EWL, comorbidity remission BMI, %EWL, comorbidity remission, and complications rate were assessed after surgery at 1, 3, 6, 12 months, and then annually until the 5th postoperative year. Revisional surgeries were excluded. Results: Three hundred seventy-six patients were recruited. There were no significant differences in the preoperative and postoperative weight loss, neither co-morbidities resolution between groups. Conclusions: Insurance-related delay in access to bariatric surgery is not associated to any benefit in comorbidity remission, as well as any improvement in weight loss in all groups studied. [ABSTRACT FROM AUTHOR]

Modern beam shaping techniques have enabled the generation of optical fields displaying a wealth of structural features, which include three-dimensional topologies such as Möbius, ribbon strips and knots. However, unlike simpler types of structured light, the topological properties of these optical fields have hitherto remained more of a fundamental curiosity as opposed to a feature that can be applied in modern technologies. Due to their robustness against external perturbations, topological invariants in physical systems are increasingly being considered as a means to encode information. Hence, structured light with topological properties could potentially be used for such purposes. Here, we introduce the experimental realization of structures known as framed knots within optical polarization fields. We further develop a protocol in which the topological properties of framed knots are used in conjunction with prime factorization to encode information. Beam shaping methods can generate optical fields with nontrivial topologies, which are invariant against perturbations and thus interesting for information encoding. Here, the authors introduce the realization of framed optical knots to encode programs with the conjoined use of prime factorization. [ABSTRACT FROM AUTHOR]

The compact form factor of nanosatellites or even smaller satellites makes them predestined for distributed systems such as formations, constellations or large swarms. However, when it comes to orbit insertion of multiple satellites, these ride share payloads have constrains in the deployment parameters such as sequence, direction, velocity and time interval. Especially for formation flight missions without propulsion, where the satellites should minimize their relative distance drift either passively or by atmospheric drag control, the initial ejection parameters must find a proper trade-off between collision probability and relative drift. Hence, this article covers short-term (first orbit) collision analysis, long-term (30 days) drift analysis and atmospheric drag control strategy for long-term distance control of multiple satellites. The collision analysis considers various orbit deployment parameters such as insertion direction and tolerance, orbital elements of insertion and time span. To cover the parameter space, a Monte Carlo simulation was conducted to identify the impact of these parameters. It showed that for collision probability the major factor is the time span between two ejections and the precision of the deployment vector. For long-term drift analysis, orbit perturbation such as atmosphere and J2 terms are considered. The result showed that for drift minimizing, minimizing the along-track variation is more substantial than reducing the time span between ejections. Additionally, a drag control strategy to reduce the relative drift of the satellites is described. The results have been applied on the S-NET mission, which consists of four nanosatellites with the task to keep their relative distance within 400 km to perform intersatellite communication experiments. The flight results for orbital drift show equal or better performance (0.1–0.7 km/day) compared to the worst-case simulation scenario, implying that orbit perturbation was chosen correctly and all orbit injection tolerances were within specified range. The drag control maneuver showed good matching to the flight results as well with a deviation for the maneuver time of approximately 10%. [ABSTRACT FROM AUTHOR]

The aim of this paper is to study the stability of an equilibrium for the second order ordinary differential equation q ¨ = F (q) , q ∈ R 2 , which are the equations of motion of a point of mass under the action of force F. The smooth force F is not supposed to be gradient. We consider two situations separately, the case of systems which have an indefinite quadratic first integral and the situation where the forces point inwards to circumferences with center at the equilibrium point. [ABSTRACT FROM AUTHOR]

To compare the effective arterial elastance (Ea) obtained from the arterial pressure with Ea calculated from left-ventricular (LV) pressure-volume analysis. Experimental study. LV pressure-volume data was obtained with a conductance catheter and arterial pressures were measured via a fluid-filled catheter placed in the proximal aorta, femoral and radial arteries. Ea was calculated as LV end-systolic pressure (ESP)/stroke volume (SV). Experimental protocol consisted sequentially changing afterload (phenylephrine/nitroprusside), preload (bleeding/fluid), and contractility (esmolol/dobutamine). 90% of systolic pressure (Eaao_SYS, Eafem_SYS, Earad_SYS), mean arterial pressure (Eaao_MAP, Eafem_MAP, Earad_MAP), and dicrotic notch pressure (Eaao_DIC, Eafem_DIC, Earad_DIC) were used as surrogates for LV ESP. SV was calculated from the LV pressure-volume data. When Ea was compared with estimations based on 90% SAP, the relationship was r2 = 0.95, 0.94 and 0.92; and the bias and limits of agreement (LOA): - 0.01 ± 0.12, - 0.09 ± 0.12, - 0.05 ± 0.15 mmHg ml-1, for Eaao_SYS, Eafem_SYS and Earad_SYS, respectively. For estimates using dicrotic notch, the relationship was r2 = 0.94, 0.95 and 0.94 for Eaao_DIC, Eafem_DIC and Earad_DIC, respectively; with a bias and LOA: 0.05 ± 0.11, 0.06 ± 0.12, 0.10 ± 0.12 mmHg ml-1, respectively. When Ea was compared with estimates using MAP, the relationship was r2 = 0.95, 0.96 and 0.95 for Eaao_MAP, Eafem_MAP and Earad_MAP, respectively; with a bias and LOA: 0.05 ± 0.11, 0.06 ± 0.11, 0.06 ± 0.11 mmHg ml-1, respectively. LV ESP can be estimated from the arterial pressure. Provided that the SV measurement is reliable, the ratio MAP/SV provides a robust Ea surrogate over a wide range of hemodynamic conditions and is interchangeably in any peripheral artery, so it should be recommended as an arterial estimate of Ea in further research. [ABSTRACT FROM AUTHOR]

Highlights from the article: These authors suggested that effective arterial elastance (Ea) using systolic arterial pressure (SAP) incorporates the oscillatory component of arterial load, whereas Ea using mean arterial pressure (MAP) does not. We used applanation tonometry-derived carotid pressure for estimating the central pressure and calculated Ea using dicrotic pressure from the carotid pressure and stroke volume from esophageal Doppler. We have estimated peripheral Ea from the invasive radial pressure using both MAP (Ea SB MAP sb ) and 90% of systolic arterial pressure (Ea SB 90%SAP sb ) as surrogates for Pes.

Introduction: Obesity is strongly associated with non-alcoholic fatty liver disease (NAFLD); 66-99% of the obese population could suffer some grade of NAFLD. It can progress into cirrhosis, which is associated to hepatocellular carcinoma, and a liver transplant could be indicated. NAFLD represents the third cause of liver transplant, and it is expected to be the first by 2025. Sleeve gastrectomy (SG) is the most common bariatric procedure over the world. There is scant literature regarding NAFLD after SG, and there are no prospective studies published up to date.Objective: To evaluate the evolution of NAFLD in patients with obesity after 1 year of SG.Methods: From January 2009 to December 2013, intraoperative liver biopsy was performed in 63 obese patients who underwent SG. Forty-three patients were again biopsied 1 year after surgery. Demographics, body mass index, percentage of excess weight loss, liver function test, lipid panel, glucose panel, and histological changes were prospectively analyzed.Results: One hundred percent of the patients reversed or reduced the stage of steatosis or steatohepatitis 12 months after surgery, obtaining a statistically significant difference for both steatosis and steatohepatitis. One patient presented complete cirrhosis regression in the pathology. Neither of the patients had worsened liver histology.Conclusions: NAFLD could be dealt with laparoscopic sleeve gastrectomy, preventing its progression into cirrhosis. SG can be performed in patients with obesity and metabolic syndrome, with NAFLD showing satisfactory results 12 months after surgery. NAFLD should be a formal indication for bariatric surgery. [ABSTRACT FROM AUTHOR]

In this work, a procedure for the determination of mercury and copper in canned tuna samples is presented, based on the extraction of their respective dithizone complexes and quantification by conventional MALDI-TOFMS with the aid of partial least square regression (PLS2). Methanolic dithizone solution (1 ml, 0.01% m/v) containing Ag(I) as internal standard was added to the calibration solutions and to the acid-digested samples (5 ml, pH 3); copper, mercury, and silver complexes were extracted to cyclohexane (1.5 ml), and after evaporation, the residues were re-constituted in acetone (100 μl). The samples were prepared by dried droplet crystallization with α-cyano-4-hydroxycinnamic acid. The experimental and MALDI-TOFMS instrument operating conditions were set up under criteria of as high as possible detectability and repeatability. When univariate calibration was carried out using the most intense ion of Cu or Hg complex normalized by internal standard, determination seemed feasible yet precision of the results was poor. Taking baseline-corrected spectra in m/z range 560-725, PLS2 model was constructed for the prediction of two elements with the method quantification limits 63 μg kg−1 for Cu and 75 μg kg−1 for Hg, respectively. For different brands of canned tuna, the results obtained by MALDI-TOFMS combined with PLS2 and by ICP-MS were in good agreement. The proposed procedure is an attractive alternative for the determination of trace metals in foods because of the procedural simplicity, micro-scale dimension, high speed of data acquisition/processing, and the cost of instrument operation lower as compared to any atomic spectrometry technique. [ABSTRACT FROM AUTHOR]

Attention deficit hyperactivity disorder (ADHD) begins in childhood and is characterized by attention deficits, hyperactivity, or impulsiveness that is inconsistent with a child's developmental level. The effects of ADHD are not limited to the child alone but can affect their familial context, particularly parenting styles. Using data from 68 parents of 6-11-year-old ADHD-diagnosed children, we attempted to identify the predictive variables of two parenting styles: criticism-rejection and permissiveness-indulgence. We analyzed two complex predictive models using structural equation modeling. We hypothesized that family impact variables would mediate the relation between the child's behavior and parenting. The data showed that the child's ADHD was only indirectly related to parenting styles, whereas child's behavior problems had a direct relationship. The results stressed the central role of the child's behavior on family social life, parents' marital relationship, and parents' feelings about their children. These variables mediated the relationship between the children's disorders and parenting styles. On the other hand, perceived social support had an inverse relationship with this negative family impact, and it even had relevant indirect effects on criticism and permissiveness. [ABSTRACT FROM AUTHOR]

This paper proposes a new methodology to evaluate the technical state of a Francis turbine installed in a hydroelectric plant by coupling computational fluid dynamics (CFD) and rotor-dynamic analysis. CFD simulations predicted the hydraulic performance of the turbine. The obtained field forces, due to the fluid-structure interaction over the blades of the runner, were used as boundary condition in the shaft rotor-dynamic numerical model, which accurately predicted the dynamic behavior of the turbine's shaft. Both numerical models were validated with in situ experimental measurements. The CFD model was validated measuring the pressure fluctuations near the rotor-stator interaction area and the torque and radial force in the shaft using strain gages. The rotor-dynamic model was validated using accelerometers installed over the bearings supporting the shaft. Results from both numerical models were in agreement with experimental measurements and provided a full diagnose of the dynamic working condition of the principal systems of the turbine. Implementation of this methodology can be applied to further identify potential failure and improve future designs. [ABSTRACT FROM AUTHOR]

The Moving Particle Semi-implicit (MPS) method is a Lagrangian particle method based on the prediction-correction calculation of the velocity field and the Helmhotz-Hodge decomposition. Initially the predicted velocity is calculated with the viscous and external forces terms and then corrected by the gradient of the pressure which is obtained by the solution of the Poisson Pressure's equation. The MPS was developed for non-compressible bodies and it is adequate for free surface problems. However, when used to simulate fluid structure interaction problems, like ship resistance, the original formulation of the method can not accurately compute the pressure distribution over the bodies. This paper proposes a modified MPS method for modelling immerse bodies in an free surface flow. It was found that small variations in the source term of the Poisson Pressure's equation can destabilise simulations. Therefore, a reformulation of the Poisson pressure equation was developed. The results show that the proposed variation produced numerical stabilisation. The free surface particles behave in a good agreement with experimental observations. Also, although pressure fluctuations were still present, satisfactory results were obtained when comparing the drag coefficient with those reported values in the literature. [ABSTRACT FROM AUTHOR]

We study the stability of an equilibrium point in a conservative Hamiltonian system in the case that equilibrium is not a minimum of the potential energy and this fact is shown by a jet of this function. Thanks to a modification of a result of Krasovskii, we prove that for a large class of systems under these conditions equilibrium is unstable and there is an asymptotic trajectory to that point. [ABSTRACT FROM AUTHOR]

Ladybeetles (Coleoptera: Coccinellidae) are ubiquitous predators which play an important role in suppressing pest insects. In North America, the coccinellid community is increasingly dominated by exotic species, and the abundance of some native species has declined dramatically since the 1980s. Several hypotheses have been proposed to describe the mechanism of invasion coupled with native species declines, e.g. vacant niche exploitation, intraguild predation, competitive exploitation and habitat compression. We analyze a 24-year dataset of coccinellid community structure in southwestern Michigan to elucidate the most likely mechanism(s) of native coccinellid decline and implications for their conservation. Correlation analyses indicated that impact of exotic species on native coccinellids varies with their degree of interaction. Although several native species were observed to be in numerical decline, only Adalia bipunctata and Coleomegilla maculata had declines that were statistically significant. The magnitude of decline in these two species varied with the degree of dietary overlap with invaders, thus their decline is most likely driven by competitive exploitation. Habitat use patterns by some native species ( A. bipunctata and Coccinella trifasciata) changed during years when the exotic Harmonia axyridis reached high numbers, lending support to the habitat compression hypothesis, where native species survive in ancestral (i.e. natural or semi-natural) habitats when invaders dominate cultivated habitats. Coccinellid communities occurring in semi-natural forested habitats were unique in both composition and variability from those occurring in cultivated habitats. Such semi-natural habitats can act as refuges for native coccinellids and may play a role in maintaining the functional resilience of coccinellid communities. [ABSTRACT FROM AUTHOR]

Heterotrophic protists are a highly diverse and biogeochemically significant component of marine ecosystems, yet little is known about their species-specific prey preferences and symbiotic interactions in situ. Here we demonstrate how these previously unresolved questions can be addressed by sequencing the eukaryote and bacterial SSU rRNA genes from individual, uncultured protist cells collected from their natural marine environment and sorted by flow cytometry. We detected Pelagibacter ubique in association with a MAST-4 protist, an actinobacterium in association with a chrysophyte and three bacteroidetes in association with diverse protist groups. The presence of identical phylotypes among the putative prey and the free bacterioplankton in the same sample provides evidence for predator-prey interactions. Our results also suggest a discovery of novel symbionts, distantly related to Rickettsiales and the candidate divisions ZB3 and TG2, associated with Cercozoa and Chrysophyta cells. This study demonstrates the power of single cell sequencing to untangle ecological interactions between uncultured protists and prokaryotes. [ABSTRACT FROM AUTHOR]

Recent discoveries suggest that photoheterotrophs (rhodopsin-containing bacteria (RBs) and aerobic anoxygenic phototrophs (AAPs)) and chemoautotrophs may be significant for marine and freshwater ecosystem productivity. However, their abundance and taxonomic identities remain largely unknown. We used a combination of single-cell and metagenomic DNA sequencing to study the predominant photoheterotrophs and chemoautotrophs inhabiting the euphotic zone of temperate, physicochemically diverse freshwater lakes. Multi-locus sequencing of 712 single amplified genomes, generated by fluorescence-activated cell sorting and whole genome multiple displacement amplification, showed that most of the cosmopolitan freshwater clusters contain photoheterotrophs. These comprised at least 10-23% of bacterioplankton, and RBs were the dominant fraction. Our data demonstrate that Actinobacteria, including clusters acI, Luna and acSTL, are the predominant freshwater RBs. We significantly broaden the known taxonomic range of freshwater RBs, to include Alpha-, Beta-, Gamma- and Deltaproteobacteria, Verrucomicrobia and Sphingobacteria. By sequencing single cells, we found evidence for inter-phyla horizontal gene transfer and recombination of rhodopsin genes and identified specific taxonomic groups involved in these evolutionary processes. Our data suggest that members of the ubiquitous betaproteobacteria Polynucleobacter spp. are the dominant AAPs in temperate freshwater lakes. Furthermore, the RuBisCO (ribulose 1,5-bisphosphate carboxylase/oxygenase) gene was found in several single cells of Betaproteobacteria, Bacteroidetes and Gammaproteobacteria, suggesting that chemoautotrophs may be more prevalent among aerobic bacterioplankton than previously thought. This study demonstrates the power of single-cell DNA sequencing addressing previously unresolved questions about the metabolic potential and evolutionary histories of uncultured microorganisms, which dominate most natural environments. [ABSTRACT FROM AUTHOR]

In this paper we discuss Kendall's problem on a sphere. In rather physical than mathematical terms, a sphere Σ of radius 1, which rolls without slipping and without twisting over a sphere M of radius R > 1, is considered, and a fixed orthonormal frame $${\mathcal {R}}$$ attached to Σ. Given two points p and q on M, not necessarily different, and two states of $${\mathcal {R}}$$ , $${\mathcal {R}_{p}}$$ and $${\mathcal {R}_{q}}$$ , also not necessarily different, it is supposed that Σ is on p with the frame $${\mathcal {R}}$$ in the position $${\mathcal {R}_{p}}$$ , and one wishes to move Σ by a sequence of displacements without slipping and without twisting over geodesics of M to the point q, where the frame $${\mathcal {R}}$$ must be in the state $${\mathcal {R}_{q}}$$ . We prove that it is possible to do this in a sequence of no more than four movements. [ABSTRACT FROM AUTHOR]

International trade is widely acknowledged as a conduit for movement of invasive species, but few studies have directly quantified the invasion risk confronting individual locations of interest. This study presents estimates of the likelihood of successful entry for alien forest insect species at more than 3,000 urban areas in the contiguous United States (US). To develop these location-specific estimates, we first utilized historical merchandise imports and insect incursions data to estimate an annual US rate of alien insect species establishment. Next, we used historical pest interception data to calculate the proportion of all insects arriving at US ports of entry that are associated with forest hosts. We then combined these results to estimate a nationwide establishment rate specifically for alien forest insects. Finally, we employed international and domestic commodity flow networks to allocate this nationwide rate to individual US urban areas. For 2010, we estimated the nationwide rate as 1.89 new alien forest insect species per year. While the establishment rates observed at most urban areas were low (<0.005 new species/year), for a few select areas the rates predict new alien forest insect species establishments every 5-15 years. This national-scale assessment provides a realistic depiction of human-assisted establishment potential in the US as well as functional inputs for quantitative models of invasion. Overall, these analyses support broad-scale biosecurity and management strategies. [ABSTRACT FROM AUTHOR]

The principle objective of this paper is to obtain trading rules with a low risk level which are also capable of obtaining high returns. To that purpose a methodology has been defined, based on the design of a genetic algorithm GAP and an incremental training technique adapted to the learning of series of stock market values. The GAP technique consists in a fusion of GP and GA. In GAP a chromosome is composed of a tree with language operators and a vector with numeric values. The GAP algorithm implements the automatic search for trading rules taking as objectives of the training both the optimization of the return obtained and the minimization of the assumed risk. In order to diminish high over-fitting, a technique of incremental training has been used. Applying the proposed methodology, rules have been obtained for a period of eight years of the S&P500 index. The achieved adjustment of the relation return-risk has generated rules with returns very superior in the testing period to those obtained applying habitual methodologies and even clearly superior to Buy&Hold. Insert your abstract here. Include keywords, PACS and mathematical subject classification numbers as needed. [ABSTRACT FROM AUTHOR]

The article finds the author John McDowell's minimal empiricism committed to the idea of a tribunal of experience where isolated contents are infused into the network of inferences. It proposes to retain McDowell's partial re-enchantment of nature without appealing to McDowell's Kantian conception of experience. It argues that it is sufficient to avoid the oscillation and to make sense of the objectivity of thought. It emphasized that minimal empiricism was not the most attractive element of McDowell's position.

Soil organic carbon (SOC) represents a significant pool of carbon within the biosphere. Climatic shifts in temperature and precipitation have a major influence on the decomposition and amount of SOC stored within an ecosystem. We have linked net primary production algorithms, which include the impact of enhanced atmospheric CO2 on plant growth, to the Soil Organic Carbon Resources And Transformations in EcoSystems (SOCRATES) model to develop a SOC map for the North Central Region of the United States between the years 1850 and 2100 in response to agricultural activity and climate conditions generated by the CSIRO Mk2 Global Circulation Model (GCM) and based on the Intergovernmental Panel for Climate Change (IPCC) IS92a emission scenario. We estimate that the current day (1990) stocks of SOC in the top 10 cm of the North Central Region to be 4692 Mt, and 8090 Mt in the top 20 cm of soil. This is 19% lower than the pre-settlement steady state value predicted by the SOCRATES model. By the year 2100, with temperature and precipitation increasing across the North Central Region by an average of 3.9°C and 8.1 cm, respectively, SOCRATES predicts SOC stores of the North Central Region to decline by 11.5 and 2% (in relation to 1990 values) for conventional and conservation tillage scenarios, respectively. [ABSTRACT FROM AUTHOR]