12 results on '"García, María Ángeles"'
Search Results
2. Mosaic attenuation in non-fibrotic areas as a predictor of non-usual interstitial pneumonia pathologic diagnosis.
- Author
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Gayá García-Manso, Ignacio, Arenas-Jiménez, Juan, García-Sevila, Raquel, Ruiz-Alcaraz, Sandra, Sirera-Matilla, Marina, García-Garrigós, Elena, Martínez-García, María Ángeles, and Hernández-Blasco, Luis
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PULMONARY fibrosis ,IDIOPATHIC pulmonary fibrosis ,INTERSTITIAL lung diseases ,HYPERSENSITIVITY pneumonitis ,SURGICAL indications - Abstract
The new radiological diagnostic criteria for diagnosing idiopathic pulmonary fibrosis (IPF) seek to optimize the indications for surgical lung biopsy (SLB). We applied the new criteria to a retrospective series of patients with interstitial lung disease (ILD) who underwent SLB in order to analyse the correlation between the radiological findings suggestive of another diagnosis (especially mosaic attenuation and its location with respect to fibrotic areas) and the usual interstitial pneumonia (UIP) pathologic diagnosis. Two thoracic radiologists reviewed the HRCT images of 83 patients with ILD and SLB, describing the radiological findings and patterns based on the new criteria. The association of each radiological finding with radiological patterns and histology was analysed. Mosaic attenuation is highly prevalent in both the UIP and non-UIP pathologic diagnosis and with similar frequency (80.0% vs. 78.6%). However, the presence of significant mosaic attenuation (≥ 3 lobes) only in non-fibrotic areas was observed in 60.7% of non-UIP pathologic diagnosis compared to 20.0% in UIP. This finding was associated with other diagnoses different from IPF, mostly connective tissue disease-associated interstitial lung disease (CTD-ILD) and hypersensitivity pneumonitis (HP). In our series of pathologically confirmed ILD, mosaic attenuation in non-fibrotic areas was a predictor of non-UIP pathologic diagnosis, and was associated with other diagnoses different from UIP, mostly CTD-ILD and HP. If confirmed in larger series, this finding could constitute a valuable tool for improving the interpretation of radiological. [ABSTRACT FROM AUTHOR]
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- 2022
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3. Essential oils-based repellents for the management of Myzus persicae and Macrosiphum euphorbiae.
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Cantó-Tejero, Manuel, Casas, José Luis, Marcos-García, María Ángeles, Pascual-Villalobos, María Jesús, Florencio-Ortiz, Victoria, and Guirao, Pedro
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GREEN peach aphid ,REPELLENTS ,BIOPESTICIDES ,AGRICULTURAL pests ,PEST control ,ESSENTIAL oils ,INTEGRATED pest control - Abstract
Aphids are one of the major agricultural pests in the world. Their pest management in pepper greenhouses is based on integrated control with release of natural enemies and pesticide treatments used in specific conditions. Essential oils may be used as an eco-friendly alternative for the control of this pest. In this work, we study the repellent effect of essential oils and pure compounds against aphids by two-choice bioassays. (E)-anethole, geraniol, farnesol, and (Z)-jasmone were the most repellent compounds for Myzus persicae and Macrosiphum euphorbiae (RD
50 = 0.011 − 0.086 µl/cm2 ). Farnesol at dose of 10 µL attracts natural enemies of aphids, Aphidius colemani adults and Sphaerophoria rueppellii larvae, in y-tube olfactometer bioassays. A residual toxicity bioassay, using a computer-controlled spraying apparatus, showed a slight toxicity (< 20% mortality) against larvae of S. rueppellii when exposed to treatments of (E)-anethole, farnesol, or (Z)-jasmone individually. The foliar application of farnesol+(E)–anethole (1:1) nanoemulsions on plants infested with aphids resulted in a reduction of the population growth ratio of M. persicae (ri = − 0.78) and M. euphorbiae (ri = − 3.85). Among the tested compounds, farnesol is a promising compound to be introduced in aphid management for its potential as a repellent and aphicide, as well as an attractant of some natural enemies of this pest. [ABSTRACT FROM AUTHOR]- Published
- 2022
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4. Natural radioactivity and total K content in wild-growing or cultivated edible mushrooms and soils from Galicia (NW, Spain).
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Melgar, María Julia and García, María Ángeles
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EDIBLE mushrooms ,NATURAL radioactivity ,CULTIVATED mushroom ,RADIOISOTOPES ,SOILS - Abstract
The radioactive isotope,
40 K, of naturally occurring potassium (0.012%) is present in the Earth's crust in a low percentage of all potassium, leading to its presence in almost all foodstuffs. The impact of40 K activity concentrations was assessed in wild and cultivated edible mushrooms and in growing substrates. Samples were analysed by gamma spectroscopy. In the wild mushroom species, the average activity concentration of40 K was 1291 Bq kg−1 dry weight (dw), approximately 140 Bq kg−1 fresh weight (fw), with a range of average values per species from 748 in Lactarius deliciosus to 1848 Bq kg−1 dw in Tricholoma portentosum. The cultivated species presented an average value of 1086 Bq kg-1 dw; and the soils, compost of cultivation and wood of substrate are 876, 510 and 59.4 Bq kg−1 dw, respectively. The total K content reached a maximum of 59,935 mg kg−1 dw in T. portentosum. The transfer factors (TF > 1) suggested that mushrooms preferentially bioconcentrated40 K. Cantharellus cibarius, Craterellus tubaeformis, Hydnum repandum and T. portentosum by most TF could be considered as bioindicators of40 K. Taking into account that the annual radiation dose of40 K due to the average consumption of mushrooms analysed (0.15 μSv/year) is very low, it can be concluded that the consumption of these mushrooms does not represent a toxicological risk for human health. Finally, according to the total K content, from the nutritional point of view, these mushrooms could be considered as a potential source of potassium for the human diet. [ABSTRACT FROM AUTHOR]- Published
- 2021
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5. The adhesio interthalamica as a neuroanatomical marker of structural differences in healthy adult population.
- Author
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Miró-Padilla, Anna, Adrián-Ventura, Jesús, Costumero, Víctor, Palomar-García, María-Ángeles, Villar-Rodríguez, Esteban, Marin-Marin, Lidón, Aguirre, Naiara, and Bueichekú, Elisenda
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ADULTS ,PREMOTOR cortex ,GRAY matter (Nerve tissue) ,ARTIFICIAL intelligence - Abstract
The adhesio interthalamica (AI) is a small midline brain structure that connects the left and right thalamus. According to in vivo data, between 2.3 and 22.3% of the general population lack the AI, and the question of whether this absence is more prevalent in males than in females is a matter of debate. Despite the existence of these demographic figures, it remains unclear how this distinctive feature affects healthy people, or what specific anatomic profile is related to the presence or absence of the AI. The aim of this study was to investigate whole-brain gray matter (GM) volumetric differences depending on the presence or absence of the AI. A total of 240 healthy adult volunteers completed one MRI scanning session. After the AI assessment, the data from 110 participants were included in the final sample, of which 12.9% of the participants (n = 31) presented complete AI absence vs. 32.9% of participants (n = 79) who presented complete AI presence. Then, whole-brain group comparison analysis revealed that the absent AI brain, compared to the present AI brain, was associated with lower GM volume in the premotor cortex, inferior frontal gyrus, and anterior temporal cortex. Interestingly, neuroscience research has linked emotional and cognitive control brain processing to the latter two regions. The importance of these findings lies in providing a neuroanatomical profile for the absent AI brain in healthy human adults. [ABSTRACT FROM AUTHOR]
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- 2021
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6. The manifestation of individual differences in sensitivity to punishment during resting state is modulated by eye state.
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Costumero, Víctor, Adrián-Ventura, Jesús, Bueichekú, Elisenda, Miró-Padilla, Anna, Palomar-García, María-Ángeles, Marin-Marin, Lidón, Villar-Rodríguez, Esteban, Aguirre, Naiara, Barrós-Loscertales, Alfonso, and Ávila, César
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INDIVIDUAL differences ,FUNCTIONAL connectivity ,PUNISHMENT ,REWARD (Psychology) ,AMYGDALOID body - Abstract
Structural and functional neuroimaging studies have shown that brain areas associated with fear and anxiety (defensive system areas) are modulated by individual differences in sensitivity to punishment (SP). However, little is known about how SP is related to brain functional connectivity and the factors that modulate this relationship. In this study, we investigated whether a simple methodological manipulation, such as performing a resting state with eyes open or eyes closed, can modulate the manifestation of individual differences in SP. To this end, we performed an exploratory fMRI resting state study in which a group of participants (n = 88) performed a resting state with eyes closed and another group (n = 56) performed a resting state with eyes open. All participants completed the Sensitivity to Punishment and Sensitivity to Reward Questionnaire. Seed-based functional connectivity analyses were performed in the amygdala, hippocampus, and periaqueductal gray (PAG). Our results showed that the relationship between SP and left amygdala-precuneus and left hippocampus-precuneus functional connectivity was modulated by eye state. Moreover, in the eyes open group, SP was negatively related to the functional connectivity between the PAG and amygdala and between the PAG and left hippocampus, and it was positively related to the functional connectivity between the amygdala and hippocampus. Together, our results may suggest underlying differences in the connectivity between anxiety-related areas based on eye state, which in turn would affect the manifestation of individual differences in SP. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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7. The ever-evolving role of pathologists in the management of breast cancer with neoadjuvant treatment: recommendations based on the Spanish clinical experience
- Author
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Roche, Burgués, O., López-García, María Ángeles, Pérez-Míes, Belén, Santiago, P., Vieites, Begoña, García, José Francisco, Peg, Vicente, Roche, Burgués, O., López-García, María Ángeles, Pérez-Míes, Belén, Santiago, P., Vieites, Begoña, García, José Francisco, and Peg, Vicente
- Abstract
[Purpose] To compare the current international standards for neoadjuvant systemic therapy (NAST) protocols, and establish consensus recommendations by Spanish breast pathologists; and to look into the Spanish reality of defining pathological complete response in daily practice., [Materials and methods] A modified Delphi technique was used to gain consensus among a panel of 46 experts with regard to important issues about NAST specimens, with the objective of standardize handling and analysis of these breast cancer specimens. In addition, a survey was conducted among 174 pathologists to explore the Spanish reality of post-NAST breast cancer specimens handling., [Results] Our survey shows that pathologists in Spain follow the same guidelines as their international colleagues and face the same problems and controversies. Among the experts, 94.1% agreed on the recommendation for a pre-treatment evaluation with a core needle biopsy, and 100% of experts agreed on the need of having properly indicated information for the post-NAST surgical specimens. However, only 82.7% of them receive properly labelled specimens and even less receive specimens where markers are identified and the degree of clinical/radiological response is mentioned. Among participants 59.9% were familiar with the residual cancer burden system for post-NAST response quantification, but only 16.1% used it regularly., [Conclusions] Active participation on breast cancer multidisciplinary teams, optimal usage of core needle biopsy for timely and standardized procedures for the diagnostic analysis, and accurate diagnosis of pathological complete response and complete evaluation of the response to NAST need to become the standard practice when handling breast cancer specimens in Spain.
- Published
- 2018
8. Auditory and frontal anatomic correlates of pitch discrimination in musicians, non-musicians, and children without musical training.
- Author
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Palomar-García, María-Ángeles, Hernández, Mireia, Olcina, Gustau, Adrián-Ventura, Jesús, Costumero, Víctor, Miró-Padilla, Anna, Villar-Rodríguez, Esteban, and Ávila, César
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ABSOLUTE pitch , *GRAY matter (Nerve tissue) , *MUSICIANS , *INDIVIDUAL differences , *ADULTS , *CHILDREN - Abstract
Individual differences in pitch discrimination have been associated with the volume of both the bilateral Heschl's gyrus and the right inferior frontal gyrus (IFG). However, most of these studies used samples composed of individuals with different amounts of musical training. Here, we investigated the relationship between pitch discrimination and individual differences in the gray matter (GM) volume of these brain structures in 32 adult musicians, 28 adult non-musicians, and 32 children without musical training. The results showed that (i) the individuals without musical training (whether children or adults) who were better at pitch discrimination had greater volume of auditory regions, whereas (ii) musicians with better pitch discrimination had greater volume of the IFG. These results suggest that the relationship between pitch discrimination and the volume of auditory regions is innately established early in life, and that musical training modulates the volume of the IFG, probably improving audio-motor connectivity. This is the first study to detect a relationship between pitch discrimination ability and GM volume before beginning any musical training in children and adults. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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9. Genetics of Endometrial Carcinoma
- Author
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López-García, María Ángeles, Vieites, Begoña, Castilla, María Ángeles, Romero-Pérez, Laura, Díaz-Martín, J., Biscuola, Michele, Palacios Calvo, José, López-García, María Ángeles, Vieites, Begoña, Castilla, María Ángeles, Romero-Pérez, Laura, Díaz-Martín, J., Biscuola, Michele, and Palacios Calvo, José
- Abstract
Endometrial cancer (EC) is the most common gynaecological malignancy in the western world and it comprises a heterogeneous group of tumours with distinct risk factors, clinical presentation, and histopathological features. Two main groups of EC exist, endometrioid endometrial carcinomas (EECs or type I) and non endometrioid endometrial carcinoma (NEECs or type II), which evolve via distinct molecular pathways. The most common molecular alterations associated with EECs affect the phosphoinositide 3-kinase (PI3K)/Akt pathway due to mutations in PTEN or PI3KCA. Other pathways, such as the RAS-RAF-MEK-ERK, FGF and WNT signalling pathways are also frequently affected by gene mutations or epigenetic changes. In addition, a group of sporadic EECs are characterized by microsatellite instability due to DNA mismatch repair (MMR) deficiency secondary to promoter hypermethylation of MLH1. In addition, EC is the second most frequent malignancy in hereditary Lynch syndrome. MMR deficiency in these patients is secondary to germline mutations in MLH1, MSH2 or MSH6. Finally, ARID1A mutations have been recently described in a subset of EECs. Endometrial serous carcinoma is the most frequent histological type of NEEC and is characterized by alterations in TP53 with secondary chromosomal instability, which leads to multiple chromosomal gains and losses, including amplification of oncogenes and loss of important tumour suppressor genes. By contrast, the molecular alterations in clear cell carcinomas, another histological type of NEEC, are poorly defined. Differences in genetic and epigenetic alterations between EEC and NEEC tumours are reflected in distinct gene expression profiles observed amongst different EC types. In the near future, careful molecular characterization of ECs must be necessary in order to implement new directed targeted therapies. Endometrial carcinoma (EC) is a primary malignant epithelial tumour that arises in the endometrium and that can invade the myometrium in o
- Published
- 2013
10. Monadic Formal Concept Analysis.
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Eklund, Patrik, Galán García, María Ángeles, Kortelainen, Jari, and Ojeda-Aciego, Manuel
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- 2014
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11. Author Correction: Mosaic attenuation in non-fibrotic areas as a predictor of non-usual interstitial pneumonia pathologic diagnosis.
- Author
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García‑Manso, Ignacio Gayá, Arenas‑Jiménez, Juan, García‑Sevila, Raquel, Ruiz‑Alcaraz, Sandra, Sirera‑Matilla, Marina, García‑Garrigós, Elena, Martínez‑García, María Ángeles, and Hernández‑Blasco, Luis
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PULMONARY fibrosis ,DIAGNOSIS ,INTERNET publishing - Abstract
Correction to: I Scientific Reports i https://doi.org/10.1038/s41598-022-10750-7, published online 04 May 2022 The original version of this Article contained an error in the Abstract. The original article can be found online at https://doi.org/10.1038/s41598-022-10750-7. [Extracted from the article]
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- 2022
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12. Correction to: Auditory and frontal anatomic correlates of pitch discrimination in musicians, non‑musicians, and children without musical training.
- Author
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Palomar-García, María-Ángeles, Hernández, Mireia, Olcina, Gustau, Adrián-Ventura, Jesús, Costumero, Víctor, Miró-Padilla, Anna, Villar-Rodríguez, Esteban, and Ávila, César
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ABSOLUTE pitch , *MUSICIANS - Abstract
In the original version of the article, the abstract section was missed to be added, and the abstract should read as below. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
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