Search

In order to reveal the effect of purging water during the startup process of fuel cells and optimize the purging strategy, a three-dimensional model and a one-dimensional model for the startup process of proton exchange membrane fuel cells (PEMFCs) were established. The influence of hydrogen flow rate and initial oxygen content was explored. The results show that at the beginning, the anode is filled with oxygen, but when hydrogen gas is introduced, the air is expelled along with the movement of the hydrogen-air interface. Once the anode is filled with hydrogen gas, the hydrogen-air interface disappears. As the flow rate increases, the residual oxygen content decreases more rapidly, and the time required to remove oxygen completely becomes significantly shorter. The higher the initial oxygen content, the longer the purging process takes and the more time is required for purging. As purging progresses, the rate of oxygen removal gradually decreases until it reaches zero. Using a high flow rate followed by a low flow rate for purging yields better purging efficiency, shorter purging time, and lower consumption compared to using a low flow rate followed by a high flow rate for purging. Implementing a stepwise or linear load increase during startup is beneficial for improving the voltage dynamic response and enhancing gas distribution in fuel cells. [ABSTRACT FROM AUTHOR]

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder with high morbidity and mortality. The current study aims to explore the role of Cullin-associated and neddylation-dissociated protein 1 (CAND1) in the development of NAFLD and the underlying mechanisms. CAND1 is reduced in the liver of NAFLD male patients and high fat diet (HFD)-fed male mice. CAND1 alleviates palmitate (PA) induced lipid accumulation in vitro. Hepatocyte-specific knockout of CAND1 exacerbates HFD-induced liver injury in HFD-fed male mice, while hepatocyte-specific knockin of CAND1 ameliorates these pathological changes. Mechanistically, deficiency of CAND1 enhances the assembly of Cullin1, F-box only protein 42 (FBXO42) and acetyl-CoA acyltransferase 2 (ACAA2) complexes, and thus promotes the ubiquitinated degradation of ACAA2. ACAA2 overexpression abolishes the exacerbated effects of CAND1 deficiency on NAFLD. Additionally, androgen receptor binds to the −187 to −2000 promoter region of CAND1. Collectively, CAND1 mitigates NAFLD by inhibiting Cullin1/FBXO42 mediated ACAA2 degradation. Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder with high morbidity and mortality, and there is no specific drug to treat it. Here, the authors show that the AR-CAND1-ACAA2 axis regulates the development of NAFLD, and enhancing the function of CAND1 is a promising strategy for the development of a therapeutic agent for NAFLD. [ABSTRACT FROM AUTHOR]

The energy management strategy (EMS) can efficiently split the power among different sources for a fuel cell electric vehicle (FCEV). This paper puts forward how to cooperate with a proton exchange membrane fuel cell as the primary energy source, and a ultracapacitor as the auxiliary energy storage. Firstly, the test bench of fuel cell is built and the characteristic of fuel cell is tested. A model of vehicle is built in AMESim software based on the real parameters of vehicle especially the characteristic of fuel cell. Secondly, the traditional power following strategy is introduced and an optimal energy management strategy is proposed. The demand power is decomposed by quadratic utility function (QUF) and Karush-Kuhn-Tucker (KKT) condition. In order to balance the vehicle economy and durability of fuel cell, the multi-objective artificial bee colony algorithm (MOABC) and pareto solution set are used to solve the optimal balance coefficient in the algorithm. The simulation results show that compared with the traditional strategy under one WLTP driving cycle, the novel strategy can reduce the fuel cell degradation by 25.08 %, and the equivalent hydrogen consumption can be also reduced. [ABSTRACT FROM AUTHOR]

The ridgetail white prawn Exopalaemon carinicauda is one of the major commercial mariculture species in eastern China. However, only limited molecular markers are currently available due to the lack of genome information, which hinders its genetic and breeding studies. In this study, we identified new simple sequence repeats from transcriptome sequences by Illumina Hiseq 2500 platform. A total of 14273 SSR loci were identified from 130,082 assembled transcripts, with 6590 pairs of PCR primers designed. A total of 12,155 sequences containing SSR were predicted; and 2764 (22.74%) transcripts had significant matches to the NCBI non redundant protein (Nr) database. 11,563 transcripts were assigned into gene ontology (GO) categories. A set of 200 primers selected randomly were synthesized, of which 152 (76.0%) were successfully amplified. Further test with 60 pairs of polymorphic SSR primers to evaluate the genetic diversity of 30 wild populations and 43 loci were polymorphic, which had a polymorphic information content between 0.204 and 0.911. The results enriched genomic resources of E. carinicauda and provided powerful information for future conservation and breeding researches. [ABSTRACT FROM AUTHOR]