1. The validity and precision of the leicester cough questionnaire in COPD patients with chronic cough
- Author
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Farida F. Berkhof, Jan W.K. van den Berg, Huib A. M. Kerstjens, Nynke E Doornewaard Ten Hertog, Lisenka N. Boom, Steven M. Uil, and Groningen Research Institute for Asthma and COPD (GRIAC)
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Male ,BRONCHIECTASIS ,validity ,Intraclass correlation ,health status ,Azithromycin ,Pulmonary Disease, Chronic Obstructive ,Risk Factors ,QUALITY-OF-LIFE ,cough ,Surveys and Questionnaires ,Prospective Studies ,HEALTH SURVEY QUESTIONNAIRE ,VERSION ,COPD ,education.field_of_study ,Productive Cough ,Age Factors ,General Medicine ,Middle Aged ,Chronic cough ,Treatment Outcome ,LCQ ,lcsh:R858-859.7 ,Female ,medicine.symptom ,medicine.medical_specialty ,Population ,Concurrent validity ,SURVEY SF-36 ,AIR-FLOW LIMITATION ,lcsh:Computer applications to medicine. Medical informatics ,OBSTRUCTIVE PULMONARY-DISEASE ,Drug Administration Schedule ,VALIDATION ,Sex Factors ,Cronbach's alpha ,medicine ,Humans ,education ,Bronchiectasis ,Dose-Response Relationship, Drug ,business.industry ,Research ,Public Health, Environmental and Occupational Health ,Reproducibility of Results ,medicine.disease ,GEORGES RESPIRATORY QUESTIONNAIRE ,respiratory tract diseases ,EXACERBATIONS ,Chronic Disease ,Physical therapy ,business ,Follow-Up Studies - Abstract
Background A validated instrument to assess the effects of chronic cough on health status in patients with chronic obstructive pulmonary disease (COPD) is currently not available. The Leicester Cough Questionnaire (LCQ) is a cough-specific health status questionnaire which is originally validated for a population of general patients presenting with chronic cough. We examined the psychometric performance of the LCQ in patients with COPD and chronic productive cough. Methods Concurrent validity, internal consistency, reproducibility and responsiveness were determined. The St. George's Respiratory Questionnaire (SGRQ) and the Short Form-36 (SF-36) were used as external criteria. Questionnaires were completed at the start of the study. After 2 and 12 weeks the LCQ was repeated, together with a global rating of change. Results In total 54 patients were included. Concurrent validity analysis showed significant correlations between corresponding domains of the LCQ and the SGRQ (rs -0.31 to -0.60). Corresponding domains of the LCQ and the SF-36 showed weaker correlations (rs 0.04 to 0.41). Internal consistency was adequate for two of the three domains (Cronbach's α 0.74 - 0.86). Test-retest reliability in stable patients was high (intraclass correlation coefficients 0.79 - 0.93). The mean difference after two weeks was 0.73 (± 1.75). Responsiveness analysis indicated that the LCQ was able to detect changes after 12 weeks. Conclusion The LCQ is a valid, reliable, responsive instrument to measure health status in COPD patients with chronic productive cough. Trial Registration ClinicalTrials.gov: NCT01071161
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