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The current paper examines whether resilience-promoting interventions lead to increased self-reported resilience relative to a control group. The literature search was conducted using terms "resilience intervention" OR "promoting resilience" OR "promoting resiliency" OR "resilience-based intervention". A total of 83 studies were included in the meta-analysis and systematic review. The quality of studies was evaluated based on sample size, appropriateness of statistical analyses, and protocol for intervention adoption. Moderation models examined effects of study characteristics (study rigour), delivery characteristics (mode of intervention [e.g., self-guided], mode of delivery [e.g., in-person] and format [e.g., group-based]), and resilience characteristics (type of resilience [e.g., coping] and resilience process) on outcomes. Findings indicated that resilience-promoting interventions significantly improved resilience relative to controls, Hedges' g = 0.72 (SE = 0.07, 95% CI = [0.59, 0.85], Z = 10.61, p <.001). These effects were heterogeneous, Q(102) = 1232.57, p <.001. Mode of intervention, resilience type, and resilience process emerged as important moderators. Results of the current meta-analysis support the effectiveness of resilience interventions, while positing considerations for intervention design and implementation. Clinical and research implications are discussed. [ABSTRACT FROM AUTHOR]

Mental illness stigma has detrimental effects on health and wellbeing. Approaches to address stigma in racialized populations in Western nations need to emphasize inclusivity, social justice, and sociocultural intersectionality of determinants of health. The current paper evaluates three intervention approaches to reduce stigma of mental illness among Asian men in Toronto, Canada. Participants received one of four group interventions: psychoeducation, Acceptance and Commitment Therapy (ACT), Contact-based Empowerment Education (CEE), and a combination of ACT+CEE. Self-report measures on stigma (CAMI, ISMI) and social change (SJS) were administered before and after the intervention. A total of 535 Asian men completed the interventions. Overall analyses found that all intervention approaches were successful in reducing stigma and promoting social change. Subscale differences suggest that CEE may be more broadly effective in reducing mental illness stigmatizing attitudes while ACT may be more specifically effective in reducing internalized stigma. More work needs to be done to elucidate mechanisms that contribute to socioculturally-informed mental illness stigma interventions for racialized communities and traditionally marginalized populations. [ABSTRACT FROM AUTHOR]

Background: Coronavirus disease 2019 (COVID-19) disproportionately affects older people. Observational studies suggest indolent cardiovascular involvement after recovery from acute COVID-19. However, these findings may reflect pre-existing cardiac phenotypes. Aims: We tested the association of baseline cardiovascular magnetic resonance (CMR) phenotypes with incident COVID-19. Methods: We studied UK Biobank participants with CMR imaging and COVID-19 testing. We considered left and right ventricular (LV, RV) volumes, ejection fractions, and stroke volumes, LV mass, LV strain, native T1, aortic distensibility, and arterial stiffness index. COVID-19 test results were obtained from Public Health England. Co-morbidities were ascertained from self-report and hospital episode statistics (HES). Critical care admission and death were from HES and death register records. We investigated the association of each cardiovascular measure with COVID-19 test result in multivariable logistic regression models adjusting for age, sex, ethnicity, deprivation, body mass index, smoking, diabetes, hypertension, high cholesterol, and prior myocardial infarction. Results: We studied 310 participants (n = 70 positive). Median age was 63.8 [57.5, 72.1] years; 51.0% (n = 158) were male. 78.7% (n = 244) were tested in hospital, 3.5% (n = 11) required critical care admission, and 6.1% (n = 19) died. In fully adjusted models, smaller LV/RV end-diastolic volumes, smaller LV stroke volume, and poorer global longitudinal strain were associated with significantly higher odds of COVID-19 positivity. Discussion: We demonstrate association of pre-existing adverse CMR phenotypes with greater odds of COVID-19 positivity independent of classical cardiovascular risk factors. Conclusions: Observational reports of cardiovascular involvement after COVID-19 may, at least partly, reflect pre-existing cardiac status rather than COVID-19 induced alterations. [ABSTRACT FROM AUTHOR]

Few studies have examined interventions or therapeutic processes that may help parents of children with Autism Spectrum Disorder (ASD) manage their stress. This study examines the impact of a brief Acceptance and Commitment Therapy (ACT) group intervention, led by parents, among a cohort of 33 mothers of children with ASD. Changes in ACT process measures (psychological flexibility, cognitive fusion, values) were evaluated at pre, post, and 3 months following the intervention. Mothers reported significant improvement post-intervention in psychological flexibility, cognitive fusion, and value-consistent activities in multiple life domains, including parenting, relationships, and self-care. These improvements were maintained at follow-up. The results provide preliminary evidence that improvements observed in depression and stress may be mediated by cognitive fusion and action-values consistency. [ABSTRACT FROM AUTHOR]

Mothers of children with autism spectrum disorder (ASD) often face high levels of stress. While there have been interventions for parents of children with ASD targeting their parenting skills, there have been fewer studies that aim to target the psychological or physical well-being of the mothers themselves. This study included mothers of children with ASD to cofacilitate acceptance and commitment therapy (ACT) to other mothers of children with ASD. The intervention consisted of one evening session and a full-day workshop, followed by a refresher session 1 month later. Of the 33 mothers that enrolled in the study, 29 attended all three sessions and completed the outcome measures. Significant changes were observed over time in terms of depression, stress, social isolation and physical health scores. Post hoc analyses showed reductions in stress and depression and improvements in physical health which were maintained at follow-up. Results suggest that a brief parent-facilitated ACT group intervention may be effective in improving the mental and physical health of mothers of children with ASD. [ABSTRACT FROM AUTHOR]

UK Biobank, a large cohort study, plans to acquire 100,000 cardiac MRI studies by 2020. Although fully-automated left ventricular (LV) analysis was performed in the original acquisition, this was not designed for unsupervised incorporation into epidemiological studies. We sought to evaluate automated LV mass and volume (Siemens syngo InlineVF versions D13A and E11C), against manual analysis in a substantial sub-cohort of UK Biobank participants. Eight readers from two centers, trained to give consistent results, manually analyzed 4874 UK Biobank cases for LV end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF) and LV mass (LVM). Agreement between manual and InlineVF automated analyses were evaluated using Bland-Altman analysis and the intra-class correlation coefficient (ICC). Tenfold cross-validation was used to establish a linear regression calibration between manual and InlineVF results. InlineVF D13A returned results in 4423 cases, whereas InlineVF E11C returned results in 4775 cases and also reported LVM. Rapid visual assessment of the E11C results found 178 cases (3.7%) with grossly misplaced contours or landmarks. In the remaining 4597 cases, LV function showed good agreement: ESV -6.4 ± 9.0 ml, 0.853 (mean ± SD of the differences, ICC) EDV -3.0 ± 11.6 ml, 0.937; SV 3.4 ± 9.8 ml, 0.855; and EF 3.5 ± 5.1%, 0.586. Although LV mass was consistently overestimated (29.9 ± 17.0 g, 0.534) due to larger epicardial contours on all slices, linear regression could be used to correct the bias and improve accuracy. Automated InlineVF results can be used for case-control studies in UK Biobank, provided visual quality control and linear bias correction are performed. Improvements between InlineVF D13A and InlineVF E11C show the field is rapidly advancing, with further improvements expected in the near future. [ABSTRACT FROM AUTHOR]

To provide effective psychotherapy in cross-cultural situations, cultural issues need to be adequately addressed. We describe core concepts of cultural competence relevant for psychotherapists to consider. A contextualized approach to conducting cultural competent assessment and formulation is recommended, including the use of DSM-5 Outline for Cultural Formulation and Cultural Formulation Interview. We introduce a cultural competent framework to help therapists become more mindful of culturally relevant interactions in therapy. Finally, a three-tier system is proposed for the examination of psychotherapy models through a cultural lens. The concepts and framework described can be flexibly and pragmatically integrated into a therapist's regular clinical work, increasing the therapy's effectiveness across diverse populations. [ABSTRACT FROM AUTHOR]

Extended Gaussian image (EGI) and complex EGI (CEGI) have been widely used as the representation of 3D shapes for shape recognition and pose estimation. In this work, we extend the representations and present a new representation named enriched complex extended Gaussian image (EC-EGI). The representation follows the same framework of EGI and CEGI, which is to represent each surface patch of the target 3D shape as a weight at the associated spot on the surface of the Gaussian sphere. However, while the original CEGI uses a single complex number as the weight, the new representation uses three complex numbers, which are related to the centroid position of the surface patch in 3D. With the inclusion of more information in the new representation, not only could object pose be determined more accurately, but also some key ambiguities of shape representation that CEGI and EGI have also removed. The translation parameters in the pose estimation application could also be determined in a simpler and more accurate way. In addition, the Gaussian sphere partition problem of CEGI is no longer present. Experimental results on synthetic and real image data are shown to illustrate the performance of the proposed representation in pose estimation. [ABSTRACT FROM AUTHOR]

Clinically, dorzolamide (Trusopt®; Merck & Co Inc, West Point, PA, USA) is often used twice daily (b.i.d.) or three times daily (t.i.d.) as adjunctive therapy with prostaglandins. Our purpose was to determine the effect of dorzolamide on intraocular pressure (IOP) when added to latanoprost (Xalatan®; Pfizer Inc, New York, NY, USA) baseline treatment, and to evaluate potential efficacy differences between b.i.d. and t.i.d. dosing of dorzolamide. This was a prospective, randomised, two-period crossover trial in ocular hypertensive or primary open-angle glaucoma patients (29 eyes in 15 patients) with an IOP of > 20 mmHg on latanoprost baseline treatment. Patients were randomly assigned to b.i.d. (08.00 and 20.00) or t.i.d. (08.00, 16.00 and 20.00) dosing of dorzolamide, treated in both eyes for 4 weeks, washed out for 3 weeks, then switched to the opposite dosing frequency for 4 weeks. Diurnal IOP measurements (every 2 hours from 08.00 to 20.00) were performed at baseline and at the end of treatment periods. The mean baseline IOP was 20.9±0.6 mmHg. After b.i.d. and t.i.d. dosing, the mean IOP was 17.7±0.6 mmHg (13.5% reduction) and 17.8±0.8 mmHg (16.5% reduction), respectively (both P<0.001 compared with baseline IOP). Diurnal IOP control was similar in the two groups, although mean IOP reduction was significantly lower at 18.00 on the t.i.d. regimen (4.7±3.3 mmHg) than with the b.i.d. regimen (2.3±2.7 mmHg, P=0.038). At other time points, no significant differences between the groups were observed. Dorzolamide 2% added to latanoprost 0.005% baseline treatment caused a significant decrease in IOP. The b.i.d. versus t.i.d. dosing of dorzolamide did not significantly affect a change in IOP except at one afternoon time point. [ABSTRACT FROM AUTHOR]

Arterial stiffness index (ASI) is a non-invasive measure of arterial stiffness using infra-red finger sensors (photoplethysmography). It is a well-suited measure for large populations as it is relatively inexpensive to perform, and data can be acquired within seconds. These features raise interest in using ASI as a tool to estimate cardiovascular disease risk as prior work demonstrates increased arterial stiffness is associated with elevated systolic blood pressure, and ASI is predictive of cardiovascular disease and mortality. We conducted genome-wide association studies (GWASs) for ASI in 127,121 UK Biobank participants of European-ancestry. Our primary analyses identified variants at four loci reaching genome-wide significance (P < 5 × 10−8): TEX41 (rs1006923; P = 5.3 × 10−12), FOXO1 (rs7331212; P = 2.2 × 10−11), C1orf21 (rs1930290, P = 1.1 × 10−8) and MRVI1 (rs10840457, P = 3.4 × 10−8). Gene-based testing revealed three significant genes, the most significant gene was COL4A2 (P = 1.41 × 10−8) encoding type IV collagen. Other candidate genes at associated loci were also involved in smooth muscle tone regulation. Our findings provide new information for understanding the development of arterial stiffness. [ABSTRACT FROM AUTHOR]