Search

Chinese lunar landing mission Chang'E-4 reached the far side of the Moon in January 2019 and has been providing unprecedented Lunar Penetrating Radar data able to explore the lunar subsurface down to more than 40 m (with its more resolutive high frequency band). Data are periodically released to the scientific community in raw PDS4 format. Here we provide different versions of the radar dataset after editing (i.e. pre-processing), partial, and full processing in order to provide a complete ready-to-use dataset to end-users (data collected since 4th January 2019 until 27th March 2023) which can be directly exploited for analysis, interpretation, inversion, as well as integration with imagery or other information. In particular, we implemented an efficient and objective way to remove duplicated traces representing more than 90% of original data, as well as a processing flow able to retain all the original data information, while avoiding redundancies. The provided datasets can be implemented with future data releases and straightforwardly exploited for any future analysis. [ABSTRACT FROM AUTHOR]

One of the main functions of enzyme complexes that constitute electron transport (respiratory) chains of organisms is to maintain cellular redox homeostasis by oxidizing reducing equivalents, NADH and quinol. Cytochrome bd is a unique terminal oxidase of the chains of many bacteria including pathogenic species. This redox enzyme couples the oxidation of ubiquinol or menaquinol by molecular oxygen to the generation of proton motive force, a universal energy currency. The latter is used by the organism to produce ATP, another cellular energy currency, via oxidative phosphorylation. Escherichia coli contains two bd-type oxidases, bd-I and bd-II, encoded by the cydAB and appCB operons, respectively. Surprisingly, both bd enzymes make a further contribution to molecular mechanisms of maintaining the appropriate redox balance in the bacterial cell by means of elimination of reactive oxygen species, such as hydrogen peroxide. This review summarizes recent data on the redox-modulated H2O2-scavenging activities of cytochromes bd-I and bd-II from E. coli. The possibility of such antioxidant properties in cytochromes bd from other bacteria is also discussed. [ABSTRACT FROM AUTHOR]

We critically discuss both advantages and limitations of helicopter-borne GPR surveys in rugged mountainous areas by analyzing a pseudo 3D data set acquired over the Marmolada Glacier, which constitutes the largest ice body in the Dolomites (Eastern Alps) and contains several peculiar features both in terms of the internal structures and the surrounding topography. In this paper we analyze several possible issues that can be encountered when performing airborne surveys in mountain regions, related to both the local conditions in the particular survey areas, and the general performance of the data acquisition equipment, which includes the GPR device, the GPS system, and the helicopter itself. Based on our analyses and observations, we propose a few guidelines and optimization strategies in order to address several issues, including the choice of various data acquisition parameters, interpretation problems related to curvilinear or irregular flight paths, and trace positioning errors caused by GPS malfunctioning or oscillating antennas. Such results have general validity and can be used for helicopter-borne survey planning, as well as for data analysis and interpretation. [ABSTRACT FROM AUTHOR]

Cytochrome bd is a terminal quinol oxidase of the bacterial respiratory chain. This tri-heme integral membrane protein generates a proton motive force at lower efficiency than heme-copper oxidases. This notwithstanding, under unfavorable growth conditions bacteria often use cytochrome bd in place of heme-copper enzymes as the main terminal oxidase. This is the case for several pathogenic and opportunistic bacteria during host colonization. This review summarizes recent data on the contribution of cytochrome bd to bacterial resistance to hydrogen peroxide, nitric oxide, and peroxynitrite, harmful species produced by the host as part of the immune response to microbial infections. Growing evidence supports the hypothesis that bd-type oxidases contribute to bacterial virulence by promoting microbial survival under oxidative and nitrosative stress conditions. For these reasons, cytochrome bd represents a protein target for the development of next-generation antimicrobials. [ABSTRACT FROM AUTHOR]

We propose an integrated methodology to image the internal structure, evaluate the volume and estimate the densities of different units within ice bodies, useful for more precise mass estimation of very small glaciers. The procedure encompasses light detection and ranging (LiDAR) and ground penetrating radar (GPR) common offset data. The case study is the Canin Eastern Glacieret (CEG), a very small and maritime glacier in the Eastern Alps, and one of the lowermost glaciers of the European Alps. We calculate both volumetric and mass variations of the analysed ice body by integrating GPR measurements with LiDAR surveys acquired in different years (2006 and 2011). Between 2006 and 2011, the area of the glacieret increased from 8,510 to 17,530 m with a gain of 9,016 m. The observed volume increase has been estimated in 96,350 m (+97 %), which corresponds to a positive mass balance of 3.89 m w.e.. This quite unusual finding in the present global warming behaviour is mainly due to the above-average winter accumulation (c) in the considered period. Moreover, the winter season 2008-2009 represented an exceptional event with a c equal to 13.38 m, the highest of the available record. Thanks to density estimation, we infer the total mass of the CEG at the time of the geophysical surveys, comparing such results with the ones obtained with available empirical equations, observing an important mass gain in the 5 years considered. [ABSTRACT FROM AUTHOR]

Multimodal imaging probes can provide diagnostic information combining different imaging modalities. Nanoparticles (NPs) can contain two or more imaging tracers that allow several diagnostic techniques to be used simultaneously. In this work, a complex coacervation process to produce core-shell completely biocompatible polymeric nanoparticles (HyCoS) for multimodal imaging applications is described. Innovations on the traditional coacervation process are found in the control of the reaction temperature, allowing a speeding up of the reaction itself, and the production of a double-crosslinked system to improve the stability of the nanostructures in the presence of a clinically relevant contrast agent for MRI (Gd-DTPA). Through the control of the crosslinking behavior, an increase up to 6 times of the relaxometric properties of the Gd-DTPA is achieved. Furthermore, HyCoS can be loaded with a high amount of dye such as ATTO 633 or conjugated with a model dye such as FITC for in vivo optical imaging. The results show stable core-shell polymeric nanoparticles that can be used both for MRI and for optical applications allowing detection free from harmful radiation. Additionally, preliminary results about the possibility to trigger the release of a drug through a pH effect are reported. [ABSTRACT FROM AUTHOR]