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The medicinal treatment of mental disorders during pregnancy and lactation requires special knowledge about possible effects of the psychopharmacotherapy on the intrauterine exposure of the embryo/fetus. Therefore, the first part of this 2‑part article focuses on the use of psychotropic drugs during pregnancy. In the second part, the use of psychotropic drugs during breastfeeding is addressed. Possible substance-specific risks as a consequence of the administration have to be assessed compared to the natural risk of pregnancy complications, birth complications and neonatal complications associated with the appropriate (untreated) mental disease. Pharmacokinetic changes during pregnancy require a special focus on the safety of drug treatment and treatment efficacy. Currently, neither the European Medicines Agency (EMA) nor the U. S. Food and Drug Administration (FDA) has approved any psychotropic drug for use during pregnancy or breastfeeding. A more detailed consideration of the risk profiles of all psychotropic drugs, prescribed off-label during this time, is important. Antidepressants, antipsychotics, and mood stabilizers are the main drugs used, despite their lack of approval. This first part of our 2‑part article provides an overview of the most frequently used substance groups during pregnancy and their special characteristics. Therapeutic drug monitoring (TDM) is presented as a clinical tool that can provide a supportive contribution to treatment safety and effectiveness during pregnancy and later also during breastfeeding, not only because of the changing pharmacokinetics. In this context, the measurement of concentrations of the active substance allows a better quantification of the intrauterine and postpartum exposure risk. Despite all clinical support possibilities, each therapeutic decision for the administration of a psychotropic drug remains an individual case decision. For those involved in the treatment, this means a careful balancing of the possible consequences of non-treatment and the possible sequelae of the use of psychopharmacotherapy. [ABSTRACT FROM AUTHOR]

The drug treatment of mental disorders during lactation requires special knowledge about the possible effects on the breastfed infant. The first part of this 2‑part article is devoted to the use of psychotropic drugs during pregnancy. This second part addresses the use of psychotropic drugs during breastfeeding. The uncertainty about whether maternal breastfeeding can be recommended during drug treatment is high and the clinical management of psychopharmacotherapy during breastfeeding is a major challenge. Due to sparse scientific evidence, the administration of psychotropic drugs must be evaluated individually; however, the risk of mental decompensation of the mother is a weighty factor that can have a very negative impact on the mother-child pair, in the worst case up to suicide or infanticide. Drug treatment during breastfeeding is always off-label and should therefore only be given after a careful risk assessment and comprehensive clarification. Every treatment decision is a case by case decision based on an assessment of the overall constellation. This includes the psychiatric history, the current complaints and a risk assessment for the infant, ideally with the involvement of a social support network in the environment. A multiprofessional support by psychiatrists, pediatricians, gynecologists and midwives should accompany drug treatment during breastfeeding under close monitoring. This second part of the 2‑part article provides an overview of the most frequently used drug classes during the breastfeeding period. Therapeutic drug monitoring (TDM) is a valuable tool for risk and exposure assessment during the breastfeeding period. [ABSTRACT FROM AUTHOR]

The highlights of the 24th International Exposition Glass World held in Moscow are briefly cited. About 100 companies from 12 countries of the world participated. New manufacturing and quality-control technologies of glass products and the main structural components of glass furnaces and methods of their high-quality production are demonstrated at the exposition. Examples of the most successful enterprises in the glass industry are given. [ABSTRACT FROM AUTHOR]

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Khibiny mountains are the largest alkaline-rock intrusion of the Kola Peninsula located at its central part and having a considerable impact on local geology. Reaching a height of 1200 m above sea level at its top (the highest point of Kola Peninsula), Khibiny is constructing the regional landscape for tens of kilometers around. Alpine character of the mountains area is unparalleled to any other territories on the Peninsula and is unique with its crags, rock bends, lofty precipices, boulders, crevices, and other landscape rock forms such as the leveling surface in the gable zone, denudation pavement, regoliths, outliers, and samples of physical weathering. In addition, there are numerous thresholds and bends filled with lakes and ponds, underground springs, crevice waterfalls, and other water sources. Such a landscape scenery makes the Khibiny mountain group a popular attraction for tourists and visitors of the region willing to get acquainted with the extraordinary local nature ranging from the taiga forests to the Arctic desert. The area also serves as a habitat for several fauna representatives, including brown bears and various Arctic birds species. The long-lasting human presence in the area manifests itself in the local toponymy of geographical names referring to the Saami language and culture. A particular interest lies in the history of the territory’s colonization and development as well as in numerous artifacts related to the Soviet and Russian imperial past (i.e., US steam engine from the early 1920s). Another option for possible tourist attraction might be found in the unusual substrate of alkaline rocks having a very rare type of mineralization containing eudialyte, lorenzenite, aenigmatite, or arfvedsonite with rare phases particular for only a few places in the world, as well as in a variety of locally discovered minerals that can be observed while hiking in the area. This uniqueness and significance have come to appreciate by establishing a local geological museum serving as a geocenter and by the area itself being acknowledged as a national park. All of this foregrounds the development and formalization of off-road hiking tourist routes. This article aims to meet this need by proposing a tourist trail in the area of western Khibiny while taking the reader on an excursion around this extraordinary area. [ABSTRACT FROM AUTHOR]

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Background: Alongside depression, anxiety disorders are the most frequent reason for consulting a psychotherapist. Objective: This article describes the recent progress in understanding basic learning processes in anxiety treatment, the resulting therapeutic procedures, the current state of knowledge on the efficacy of the various psychotherapeutic procedures and on the moderators of the success of treatment. Material and methods: The English and German language literature was reviewed and compiled, with an emphasis on the last 10 years. Results: Cognitive-behavioral therapy (CBT) achieves the best and broadest level of evidence across all anxiety disorders. Initial studies have also provided emerging evidence for the efficacy of manualized short-term psychodynamic treatment. The most discussed mechanism of action is that of inhibitory learning. Augmentation strategies and personalized treatment approaches are gaining in relevance. Conclusion: Current models of inhibitory learning are rooted in basic research and foster a deeper understanding of the underlying neurobiological mechanisms. In order to optimize success of exposure treatment in vulnerable subgroups of patients, many procedural, device-based and pharmacological augmentation strategies are currently under investigation, whereby the latter are mostly still in the stage of (pre)clinical testing. [ABSTRACT FROM AUTHOR]

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The objective of the survey was to assess evolutionary trends in the mountain-grassland soil processes and the environmental and anthropogenic impacts on soil degradation and land efficiency. Generalization of the previously studied materials in comparison with the data collected in route surveys carried out in the large river basins, including the Samur, Chirakhchai, Sulak, and other rivers, allowed for identifying the main factor affecting the evolutionary trends in the soil processes within the altitudinal zones in mountain regions in Dagestan. This is particularly the factor associated with both the climate and vegetation changes and the human economic activities. In addition, it has been proven that slope exposition and anthropogenic factors effect pedogenesis and soil degradation. Slopes of a southern exposition and the slopes of slightly different expositions from it are generally drier. Snow cover lasts for a long time, which is followed by rapid snowmelt. Therefore, the vegetation of such areas is poor, and, moreover, the occurred denudation processes are much stronger. According to the data collected on the basis of observations for the most recent 50 years, humus concentrations in the soils used in the economic circulation decreased by 0.5–1.2% and even by 1.5–2% in some of them. Annual soil washout comprises 12 million t on average. It involves approximately 50 thousand t of humus. Unregulated livestock grazing causes pothole formation, compaction by pathways, and sparse vegetation. Therefore, a 20–30% reduction in the projective vegetation land cover can induce a five- to sevenfold increase in the volume of eroded material in long-term erosion when compared to a 70–75% vegetation land cover. In addition, the current pedogenic processes are affected by global warming, differences in soil moisture and temperature regimes on slopes of different expositions in the altitudinal zonation system, and high erosion rates caused by natural and anthropogenic factors. Complex erosion-control measures, including amelioration by slitting once every 3–4 years, grazing regulation, and evenly distributed grazing with taking slope expositions into account, are required. [ABSTRACT FROM AUTHOR]

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Berufsbedingte Meniskusschäden wurden als sog. Bergmann-Meniskus 1952 in die Berufskrankheitenliste aufgenommen. Seit 1988 wurde die Berufskrankheit auf alle Berufe erweitert. Exposition und Meniskusschaden müssen vollbeweislich gesichert sein. Es müssen ein belastungskonformes Schadensbild und ein belastungskonformer Verlauf vorliegen. Bei konstant 1000 bis 1200 Verdachtsanzeigen pro Jahr wird etwa ein Fünftel der Fälle anerkannt. Die Höhe der Minderung der Erwerbsfähigkeit (MdE) richtet sich nach den Erfahrungswerten im Schrifttum. [ABSTRACT FROM AUTHOR]

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Surgeons routinely work in an environment with occupational risks and hazards about which they are often uninformed. Based on the currently available scientific literature this review article describes the various hazards in the operating theater and their effects on personnel, particularly from the surgical perspective. A further aim of this article is to describe the occupational safety measures to reduce the burdens and to maintain the long-term health of personnel. Ultimately, surgeons should be equipped with the necessary knowledge for implementing hazard assessments according to the German Occupational Health and Safety Act. Surgeons are exposed to increased risks and hazards by working in awkward positions with a high risk for musculoskeletal pain and injuries. They are also commonly exposed to inhalational anesthetics, surgical smoke, radiation, noise and infectious agents. Furthermore, the mental and emotional stress associated with these activities is also high. Meaningful occupational safety measures for reduction of burdens are from a technical aspect the installation of effective air extraction systems, measures to reduce exposure to radiation and noise and the use of safer instruments to prevent needle stick injuries. Furthermore, individual occupational safety measures, such as the use of personal protective equipment (e.g. radiation protective clothing and double gloves) must be observed. The consistent implementation and also adherence to these described occupational safety measures and regulations can reduce the burden on operating theater personnel and contribute to maintaining health. Furthermore, periodic preventive healthcare controls and health checks by the company medical officer and individually initiated additional prevention measures can be a sensible augmentation to these safety measures. [ABSTRACT FROM AUTHOR]

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This paper aims to single out and to highlight the fundamental tenets of Agricola's De inuentione dialectica. After the structure of the volume, its theoretical perspective and its educational concern are illustrated, Agricola's understanding of the fundamental notion of locus is expounded. In this relation his particular use of the medieval term habitudo and the exclusion of maxims, which had been the main concern of the Medieval doctrine of loci, show a certain distance from the Medieval tradition. Several innovative and constructive contributions of Agricola's work are stressed, in particular the elaboration of a new taxonomy of loci and the discovery of the relevant role played by loci not only in argumentation but also in exposition and in explanation. In this way, loci acquire the status of intentiones secundae, i.e. of meta-categorical concepts which govern the connections ensuring textual congruity. A reading of this text in the light of contemporary argumentation theory reveals a surprising topicality and richness of concrete contributions in some dialectical and rhetorical domains, like argument schemes, topical potential, and presentational techniques. [ABSTRACT FROM AUTHOR]

Chicago's Jackson Park witnessed intense and sustained tourism during the 1893 World's Columbian Exposition. Recent archaeological survey and excavation produced information about the tourist experience of the Fair in a somewhat familiar artifactural form. The dig drew local tourists whose appetites for the Exposition were whetted by a bestselling book. At the heart of these multiple touristic consumptions in, and of, Jackson Park lies the central issue-the way that tourists create themselves as modern subjects through the practice of tourism and how this process can be both helped and hindered by the presence of familiar objects. [ABSTRACT FROM AUTHOR]

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This essay is an attempt to analyze, classify and illustrate different scholarly approaches to the Sanskrit philosophical commentaries as reflected in some influential and especially thoughtful studies of Indian philosophy; at the same time it highlights some specific features involving commentary and annotation in general, drawing from results of studies on commentaries conducted in other disciplines and fields, such as Classical and Medieval Studies, Theology, and Early English Literature. In the field of South Asian Studies, philosophical commentaries may be assessed from various overlapping and not always exclusive points of view, such as preservation of otherwise lost historical information, historical authenticity and reliability, interpretational innovation, spiritual or experiential insight, philosophical creativity, intellectual liveliness, doxographic intent, degree of incidentality, expository breadth and explanatory depth. The essay provides numerous examples taken from classical to early modern philosophical literature in Sanskrit, especially of the Brahminical and Buddhist traditions, and also discusses their diverging perception by modern scholars and interpretators. [ABSTRACT FROM AUTHOR]

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From the perspective of a political philosophy of law, this essay explores the rich encounter of the thoughts of Jacques Derrida and Jean-Luc Nancy. This articulation discloses the opportunity for a new mode of thinking and writing the political that challenges current models of legal and political legitimacy. This opportunity and task of thought is called deliberation, as deconstruction of freedom, and deconstruction of deliberation. Furthermore, an account of radical freedom and reason is found in deliberation. Following Derrida's description of Nancy's approach to freedom, this essay undertakes a work of translations; from audaciousness into prudence…and back. It escapes from Nancy's audaciousness to fall onto Derrida's prudent world, and only then, perhaps, return to the shelter that comforts both, to the spacing that they share out. Deliberation and freedom are, however, scathed by such a lacerating sharing. Severed from the law—but exposed to the law of the law—they demand and yet persist in deliberation. [ABSTRACT FROM AUTHOR]

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Experimental data available in literature on changes in the carbon isotopic composition of biochemical fractions and metabolites isolated from plant biomass (Clusia minor) and photosynthesizing algae (Chlorella stigmatophora) under the action of environmental stress factors are reviewed and analyzed. Within the framework of previously suggested mechanism of carbon isotope fractionation in photosynthesis, all studied fractions and metabolites obtained from plants and photosynthesizing algae can be divided into two groups according to their carbon isotope composition. The first group includes the fractions and metabolite pools that contain carbon stored by cell during the carboxylase phase of Rubisco functioning. The second group consists of those formed primarily by the photorespiratory carbon flow, generated during the oxygenase phase of Rubisco functioning. The first group represents the “assimilatory” branch of photosynthesis and is enriched in 12C relative to carbon of biomass, whereas the second group represents the “photorespiratory” branch and is enriched in 13C. Under the action of environmental stress factors, such as incident light intensity, moisture availability, and salinity; the isotope composition of metabolites and fractions changes, which reflects variable contributions of the “assimilatory” and “photorespiratory” flows to the metabolite synthesis. These isotope shifts were used to study biochemical adaptation of plants to stress conditions and to elucidate the role of photorespiration in this adaptation. [ABSTRACT FROM AUTHOR]

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Volunteers were exposed in a controlled environment chamber at different concentrations of styrene in order to determine the quantity and percentage of the solvent absorbed and eliminated by the lungs. As a result of these experiments, it was found that the absorption rate of styrene is constant during the exposure at a level representing 88,7 ± 3,4 % of the inspired concentration. The proportion of solvent eliminated by the lungs was only of 2,62 ± 0,85 % of the absorbed dose, while the rate of decay of alveolar concentration curves with respect to time is independent of the steady inspired concentration during exposure. Accordingly, breath decay curves can be used as a method to monitor time weighted average exposure. [ABSTRACT FROM AUTHOR]

An impedance conversion technique was used to study the behaviour of Gammarus pulex (L.) exposed to acutely toxic concentrations of Pb (0.01, 0.05, 0.1 and 0.5 mg Pb l) and to field concentrations of Cu ( ≤ 0.05 mg Cu l). Initial stress responses were studied during short-term exposure (1 h) and sublethal toxic effects were monitored during 7 (Pb) and 35 days (Cu), respectively. Exposure to Pb caused 30 % mortality and resulted in a bioconcentration factor (BCF) of 2700 at 0.5 mg Pb l after 168 h. Exposure to Cu polluted stream water caused no mortality within 35 days and uptake was low (BCF 5.8). Gammarus pulex reacted with initial stress responses to metal exposure within 30 min. (Cu) or 1 h (Pb). The reactions consisted of increased ventilation and decreased locomotion. Sublethal concentrations of Pb and Cu caused toxic effects on the behaviour of G. pulex after several days of exposure, consisting of increased ventilation and decreased locomotion. Impedance conversion is an appropriate method for detecting stress responses to metals and can be used in 'early warning' biomonitoring systems as well as for acute and chronic behavioural toxicity testing. [ABSTRACT FROM AUTHOR]

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