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This document is a letter published in the Archives of Dermatological Research. The letter discusses the spatiotemporal changes and functional alterations of T-cell substates gene expression during the progression of mycosis fungoides (MF), a type of cutaneous T-cell lymphoma (CTCL). The authors conducted a mass cytometry experiment comparing the proportion difference of T-cell substates in MF patients' skin and lymphatic tissues and peripheral blood. They found that CD8+ T-cell exhaustion and CD4+ T helper cell type-1 (Th1) were significantly higher in skin tissues compared to lymphatic tissues and peripheral blood. The authors also analyzed publicly available single-cell RNA-seq datasets to identify landmark genes affecting the dynamic changes of T-cell substates during the progression of MF. They concluded that this study expands our understanding of MF disease and provides potential biomarkers for future immunotherapy. [Extracted from the article]

After treatment with moxifloxacin, linezolid, and vancomycin, the patient still had recurrent fever, multiple swollen LNs, and skin lesions. Considering the rare reports of NTM infections in immunocompetent patients, we further detected the genetic susceptibility to mycobacterial diseases and immunological condition of the patient. The patient described here had pulmonary infections for a long time before having skin lesions and multiple swollen LNs. Susceptibility testing is desirable to adjust the treatment according to patients' conditions and realize personalized treatment [[1], [3]]. [Extracted from the article]