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We aimed to evaluate the ratio of bilateral breast cancer (BBC) to breast cancer and to compare the clinicopathological characteristics, treatment, and results of synchronous bilateral breast cancer (sBBC) and metachronous bilateral breast cancer (mBBC) with long-term follow-up. Patients with breast cancer (BC) who were treated consecutively between 2009 and 2019, included on accrual records, were examined. We determined the time interval for the development of two tumors to be detected within 6 months for the definition of synchronous tumors. In total, of the 2198 patients diagnosed with BC, 76 had BBC. Our BBC rate was 3.4%. The median age of tumor detection was 56 for sBBC and 51 for mBBC. As a result of the 5-year disease-free survival (DFS) analysis, the mean survival times of sBBC and mBBC were found to be 41 months and 60 months, respectively (p = 0.006). As a result of the 5-year overall survival (OS) analysis, the OS in sBBC and mBBC was 44 months and 60 months, respectively, and the difference in mean survival times between the groups was statistically significant (p = 0.001). The difference between the sBBC and mBBC groups was statistically significant for both DFS and OS, based on 10-year survival (p = 0.004 and p = 0.001, respectively). In this study conducted at a single center, disease-free survival and overall survival were worse in sBBC than in mBBC. [ABSTRACT FROM AUTHOR]

Our aim is to present the results of early-stage clinicopathological occult breast cancer cases in a tertiary centre for breast diseases. There were 17 cases (T0/TxN 1,2,3 M0/M1) that were classified as clinicoradiological occult breast cancer (crOBC) from 01 January 2006 to 01 January 2018. By re-evaluating the postoperative histopathological and immunohistochemical results, the patients were divided into three groups; early-stage clinicopathological occult breast cancer [ecpOBC (T0/TxN1,2,3M0)], metastatic clinicopathological occult breast cancer [(mcpOBC (T0/TXN + M1)], and non-occult breast cancer (nOBC). Patients with ecpOBC (n = 11) were included in the study. The frequency of operable ecpOBC was 0.46% (11/2342) and the frequency of non-operable mcpOBC was 0.08% (2/2342). While modified radical mastectomy (MRM) was performed on 27.3 (3/11) of the patients, 72.7% (8/11) had axillary lymph node dissection (ALND). The operated MRM and ALND groups were followed up for at least 3 years after receiving chemotherapy (CTX) and radiotherapy (RT). The 3-year disease-free survival (DFS) rates of the groups were respectively 100% and 87.5%, and there was no significant difference between the groups regarding DFS (p = 0.540). Considering the concern for cosmesis in ecpOBC patients, ALND seems to be as an appropriate surgical approach. [ABSTRACT FROM AUTHOR]

In this study, we aimed to investigate the prognostic factors and survival in unifocal borderline luminal B human epidermal growth factor 2-negative breast cancers (UBLHNBC) and unifocal triple-negative breast cancers (UTNBC). For the study, 480 consecutive patients whose postoperative treatments were completed between 1 January 2010 and 1 January 2015 were analysed. After analysis, 62 women meeting the inclusion criteria were enrolled in the study, divided into two groups as UTNBC (n:47) and UBLHNBC (n:15), and historical patient records were analysed. The UTNBC and UBLHNBC groups did not significantly differ in terms of disease-free survival (DFS) (p = 0.771) and overall survival (OS) (p = 0.973). In the multivariate analysis, pathological nodal stage was the independent risk factor for DFS [(hazard ratio (HR): 1.901) (95% CI: 1.029–3.513) (p = 0.040)], whereas perineural invasion was the only common independent risk factor for DFS [(HR: 0.143) (95% CI: 0.023–0.902) (p = 0.038)] and OS [(HR: 0.138) (95% CI: 0.027–0.703) (p = 0.017)]. Unifocal borderline luminal B human epidermal growth factor 2-negative breast cancers and unifocal triple-negative breast cancers yielded similar survival outcomes. Pathological nodal stage is the independent risk factor for disease-free survival, while perineural invasion is the independent risk factor for both disease-free survival and overall survival. For effective endocrine treatment, it is necessary to determine appropriate oestrogen receptor/progesterone receptor threshold values for both immunohistochemical subgroups. [ABSTRACT FROM AUTHOR]

Background: Appendiceal diverticular disease (ADD) is a rare pathology which is associated with an increased mortality risk due to rapid perforation and high rates of neoplasm. In our study, we aimed to evaluate the clinical and histopathological characteristics of ADD with differences from acute appendicitis (AA) diagnosis and to determine the association with neoformative processes. Methods: The 4279 patients who underwent appendectomy were evaluated retrospectively. ADD patients histopathologically classified into four groups. Patients' demographic characteristics, imaging and preoperative laboratory findings, additionally postoperative histopathology results were compared between groups. Results: The prevalence of ADD was 2.29% (n = 98). In addition, the male/female ratio was 2.37 in ADD patients who were found to be significantly older than those with AA patients. Type III was the most frequently (62.2%) identified sub-group of ADD. The incidence of neoplasms, plastrone, and Littre's hernia was found statistically higher in ADD group than AA group. Mucinous adenomas (10.2%) was the most common neoplasm while the carcinoid tumor (1%) and precancerous serrated adenomas (4.1%) were also reported. Conclusions: As a result, high neoplasm in ADD patients can be shown with incidence of perforation and plastron, and in order to avoid possible neoplasm or major complications, it is necessary to carry out new studies for the right diagnosis of ADD whether the diagnosis is done preoperatively or ıntraoperatively. We recommend surgical resection of the ADD, which may even be incidentally detected during any surgical procedure, due to its high risk of neoplasm and rapid perforation. [ABSTRACT FROM AUTHOR]