1. The role of vitamin D receptor in predentin mineralization and dental repair after injury.
- Author
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Liu, Yudong, Wu, Yinlin, Hu, Xiaodong, Sun, Yu, Zeng, Guojin, Wang, Qinglong, Liu, Shanshan, and Sun, Meiqun
- Subjects
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VITAMIN D receptors , *MINERALIZATION , *DENTIN , *WOUNDS & injuries - Abstract
Dentin is a permeable and complex tubular composite formed by the mineralization of predentin that mineralization and repair are of considerable clinical interest during dentin homeostasis. The role of Vdr, a receptor of vitamin D, in dentin homeostasis remains unexplored. The aim of the present study was to assess the impact of Vdr on predentin mineralization and dental repair. Vdr-knockout (Vdr−/−) mice models were constructed; histology and immunohistochemistry analyses were conducted for both WT and Vdr−/− mice. The finding revealed a thicker predentin in Vdr−/− mice, characterized by higher expression of biglycan and decorin. A dental injury model was employed to observe tertiary dentin formation in Vdr−/− mice with dental injuries. Results showed that tertiary dentin was harder to form in Vdr−/− mice with dental injury. Over time, heightened pulp invasion was observed at the injury site in Vdr−/− mice. Expression of biglycan and decorin was reduced in the predentin at the injury site in the Vdr−/− mice by immunohistochemistry. Taken together, our results imply that Vdr plays a regulatory role in predentin mineralization and tertiary dentin formation during dentin homeostasis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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