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Functional coactivation between human brain regions is partly explained by white matter connections; however, how the structure-function relationship varies by function remains unclear. Here, we reference large data repositories to compute maps of structure-function correspondence across hundreds of specific functions and brain regions. We use natural language processing to accurately predict structure-function correspondence for specific functions and to identify macroscale gradients across the brain that correlate with structure-function correspondence as well as cortical thickness. Our findings suggest structure-function correspondence unfolds along a sensory-fugal organizational axis, with higher correspondence in primary sensory and motor cortex for perceptual and motor functions, and lower correspondence in association cortex for cognitive functions. Our study bridges neuroscience and natural language to describe how structure-function coupling varies by region and function in the brain, offering insight into the diversity and evolution of neural network properties. Collins et al. bridge neuroscience and natural language to describe how the structure-function relationship varies by specific region and function in the human brain, offering insight into the diversity and evolution of neural network properties. [ABSTRACT FROM AUTHOR]

This study aimed to examine the existing literature that investigated the effectiveness of optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A) as a biomarker for idiopathic intracranial hypertension (IIH). Our search was conducted on January 17th, 2024, and included the databases, Medline, Scopus, Embase, Cochrane, Latin American and Caribbean Health Sciences Literature (LILACS), International Standard Randomized Controlled Trial Number (ISRCTN) registry, and the International Clinical Trials Registry Platform (ICTRP). Our final review included 84 articles. In 74 studies, OCT was utilized as the primary ocular imaging method, while OCT-A was employed in two studies including eight studies that utilized both modalities. Overall, the results indicated that IIH patients exhibited significant increases in retinal nerve fiber layer (RNFL) thickness, total retinal and macular thickness, optic nerve head volume, and height, optic disc diameter and area, rim area, and thickness compared to controls. A significant correlation was observed between cerebrospinal fluid (CSF) pressure and OCT parameters including RNFL thickness, total retinal thickness, macular thickness, optic nerve head volume, and optic nerve head height. Interventions aimed at lowering CSF pressure were associated with a substantial improvement in these parameters. Nevertheless, studies comparing peripapillary vessel density using OCT-A between IIH patients and controls yielded conflicting results. Our systematic review supports OCT as a powerful tool to accurately monitor retinal axonal and optic nerve head changes in patients with IIH. Future research is required to determine the utility of OCT-A in IIH. [ABSTRACT FROM AUTHOR]

Gut microbiomes of mammals carry a complex symbiotic assemblage of microorganisms. Feeding newborn infants milk from the mammary gland allows vertical transmission of the parental milk microbiome to the offspring's gut microbiome. This has benefits, but also has hazards for the host population. Using mathematical models, we demonstrate that biparental vertical transmission enables deleterious microbial elements to invade host populations. In contrast, uniparental vertical transmission acts as a sieve, preventing these invasions. Moreover, we show that deleterious symbionts generate selection on host modifier genes that keep uniparental transmission in place. Since microbial transmission occurs during birth in placental mammals, subsequent transmission of the milk microbiome needs to be maternal to avoid the spread of deleterious elements. This paper therefore argues that viviparity and the hazards from biparental transmission of the milk microbiome, together generate selection against male lactation in placental mammals. Lactation allows vertical microbiome transmission from the parent to the offspring in mammals. Here, the authors create a mathematical model to argue that uniparental transmission prevents the invasion of deleterious microbes and suggest that this may generate selection against male lactation. [ABSTRACT FROM AUTHOR]

Optical coherence tomography (OCT) is a non-invasive imaging technique with extensive clinical applications in ophthalmology. OCT enables the visualization of the retinal layers, playing a vital role in the early detection and monitoring of retinal diseases. OCT uses the principle of light wave interference to create detailed images of the retinal microstructures, making it a valuable tool for diagnosing ocular conditions. This work presents an open-access OCT dataset (OCTDL) comprising over 2000 OCT images labeled according to disease group and retinal pathology. The dataset consists of OCT records of patients with Age-related Macular Degeneration (AMD), Diabetic Macular Edema (DME), Epiretinal Membrane (ERM), Retinal Artery Occlusion (RAO), Retinal Vein Occlusion (RVO), and Vitreomacular Interface Disease (VID). The images were acquired with an Optovue Avanti RTVue XR using raster scanning protocols with dynamic scan length and image resolution. Each retinal b-scan was acquired by centering on the fovea and interpreted and cataloged by an experienced retinal specialist. In this work, we applied Deep Learning classification techniques to this new open-access dataset. [ABSTRACT FROM AUTHOR]

A sub-terahertz holographic image of a two-dimensional 576-bit data code is produced using a diffractive phase-plate element. The phase plate was designed using a modified Gerchberg-Saxton iterative algorithm to encode a focused image of the data code into a phase modulation profile. The complex phase plate structure is fabricated from polylactic acid using fused deposition modeling, a common three-dimensional-printing technique. The design achieves a significantly simplified optical setup, consisting of a 0.14 THz diverging source, the holographic phase plate and a scanning detector, without the need for additional optical elements. The information stored in the data code is an example of a cryptographic private key. Specifically, the private key for a Bitcoin wallet address. Successful retrieval of the encoded information demonstrates a potential use case for terahertz holographic memory, using a storage medium that can be fabricated with consumer-level three-dimensional-printing techniques. [ABSTRACT FROM AUTHOR]

Eliminating conventional pulsed B0-gradient coils for magnetic resonance imaging (MRI) can significantly reduce the cost of and increase access to these devices. Phase shifts induced by the Bloch-Siegert shift effect have been proposed as a means for gradient-free, RF spatial encoding for low-field MR imaging. However, nonlinear phasor patterns like those generated from loop coils have not been systematically studied in the context of 2D spatial encoding. This work presents an optimization algorithm to select an efficient encoding trajectory among the nonlinear patterns achievable with a given hardware setup. Performance of encoding trajectories or projections was evaluated through simulated and experimental image reconstructions. Results show that the encodings schemes designed by this algorithm provide more efficient spatial encoding than comparison encoding sets, and the method produces images with the predicted spatial resolution and minimal artifacts. Overall, the work demonstrates the feasibility of performing 2D gradient-free, low-field imaging using the Bloch-Siegert shift which is an important step towards creating low-cost, point-of-care MR systems. [ABSTRACT FROM AUTHOR]

Large-scale functional networks have been characterized in both rodent and human brains, typically by analyzing fMRI-BOLD signals. However, the relationship between fMRI-BOLD and underlying neural activity is complex and incompletely understood, which poses challenges to interpreting network organization obtained using this technique. Additionally, most work has assumed a disjoint functional network organization (i.e., brain regions belong to one and only one network). Here, we employ wide-field Ca2+ imaging simultaneously with fMRI-BOLD in mice expressing GCaMP6f in excitatory neurons. We determine cortical networks discovered by each modality using a mixed-membership algorithm to test the hypothesis that functional networks exhibit overlapping organization. We find that there is considerable network overlap (both modalities) in addition to disjoint organization. Our results show that multiple BOLD networks are detected via Ca2+ signals, and networks determined by low-frequency Ca2+ signals are only modestly more similar to BOLD networks. In addition, the principal gradient of functional connectivity is nearly identical for BOLD and Ca2+ signals. Despite similarities, important differences are also detected across modalities, such as in measures of functional connectivity strength and diversity. In conclusion, Ca2+ imaging uncovers overlapping functional cortical organization in the mouse that reflects several, but not all, properties observed with fMRI-BOLD signals. The relationship between fMRI-BOLD and neural activity in the brain is not well understood. Here, the authors combine calcium imaging and fMRI in the mouse brain to compare network organization derived from these imaging modalities. [ABSTRACT FROM AUTHOR]

We consider a heterotic version of six-dimensional Kodaira-Spencer gravity derived from the heterotic superpotential. We compute the one-loop partition function and find it can be expressed as a product of holomorphic Ray-Singer torsions. We discuss its topological properties and potential gauge and gravitational anomalies. We show these anomalies can be cancelled using Green-Schwarz-like counter-terms. We also discuss the dependence on the background geometry, and in particular the choice of hermitian metric needed for quantisation. Given suitable topological constraints, this dependence may again be cancelled by the addition of purely background-dependent counter-terms. We also explain how our methods provide the one-loop partition functions of a large class of more general holomorphic field theories in terms of holomorphic Ray-Singer torsions. [ABSTRACT FROM AUTHOR]

The aim of this report was to analyze reaction times and accuracy in children with a vision impairment performing a feature-based visual search task using a multiverse statistical approach. The search task consisted of set sizes 4, 16, and 24, consisting of distractors (circle) and a target (ellipse) that were presented randomly to school-aged individuals with or without a vision impairment. Interactions and main effects of key variables relating to reaction times and accuracy were analyzed via a novel statistical method blending GAMLSS (generalized additive models for location, scale, and shape) and distributional regression trees. Reaction times for the target-present and target-absent conditions were significantly slower in the vision impairment group with increasing set sizes (p <.001). Female participants were significantly slower than were males for set sizes 16 and 24 in the target-absent condition (p <.001), with male participants being significantly slower than females in the target-present condition (p <.001). Accuracy was only significantly worse (p =.03) for participants less than 14 years of age for the target-absent condition with set sizes 16 and 24. There was a positive association between binocular visual acuity and search time (p <.001). The application of GAMLSS with distributional regression trees to the analysis of visual search data may provide further insights into underlying factors affecting search performance in case-control studies where psychological or physical differences may influence visual search outcomes. [ABSTRACT FROM AUTHOR]

In the western US, freshwater mussels (Order Unionida) contribute valuable ecosystem functions to riverine systems, yet have declined across their range following widespread degradation of freshwater habitat and parallel declines in salmonids, host fish for larval western pearlshell mussels (Margaritifera falcata). The status of M. falcata populations is of particular conservation interest in isolated coastal watersheds given unique freshwater mussel-host fish relationships. To understand M. falcata population ecology in Oregon's coastal watersheds, we analyzed stream survey data on presence/absence of mussels collected over a recent eleven-year period, explored co-varying habitat characteristics, and summarized mussel distribution and host fish co-occurrence. We also collected M. falcata and compared condition indices among eight locations. Naïve occupancy in surveyed areas was 12.3%, about half of predicted occupancy (ψ = 0.24, CI 0.19–0.31) based on modeling repeated visits over a ten year assumed closed period. Mussel occupancy was correlated with reach-scale habitat variables, and the probability of mussel observations was positively correlated with presence of coho (Oncorhynchus kisutch) salmon. Condition varied significantly among locations. Spatial relationships between existing mussel distribution, host species, and habitat variables answer questions about coastal freshwater mussel populations, as well as serve to identify priorities for further research and population assessment. [ABSTRACT FROM AUTHOR]

Background: Myocardial perfusion SPECT (MPS) images often suffer from artefacts caused by low-count statistics. Poor-quality images can lead to misinterpretations of perfusion defects. Deep learning (DL)-based methods have been proposed to overcome the noise artefacts. The aim of this study was to investigate the differences among several DL denoising models. Methods: Convolution neural network (CNN), residual neural network (RES), UNET and conditional generative adversarial neural network (cGAN) were generated and trained using ordered subsets expectation maximization (OSEM) reconstructed MPS studies acquired with full, half, three-eighths and quarter acquisition time. All DL methods were compared against each other and also against images without DL-based denoising. Comparisons were made using half and quarter time acquisition data. The methods were evaluated in terms of noise level (coefficient of variation of counts, CoV), structural similarity index measure (SSIM) in the myocardium of normal patients and receiver operating characteristic (ROC) analysis of realistic artificial perfusion defects inserted into normal MPS scans. Total perfusion deficit scores were used as observer rating for the presence of a perfusion defect. Results: All the DL denoising methods tested provided statistically significantly lower noise level than OSEM without DL-based denoising with the same acquisition time. CoV of the myocardium counts with the different DL noising methods was on average 7% (CNN), 8% (RES), 7% (UNET) and 14% (cGAN) lower than with OSEM. All DL methods also outperformed full time OSEM without DL-based denoising in terms of noise level with both half and quarter acquisition time, but this difference was not statistically significant. cGAN had the lowest CoV of the DL methods at all noise levels. Image quality and polar map uniformity of DL-denoised images were also better than reduced acquisition time OSEM's. SSIM of the reduced acquisition time OSEM was overall higher than with the DL methods. The defect detection performance of full time OSEM measured as area under the ROC curve (AUC) was on average 0.97. Half time OSEM, CNN, RES and UNET provided equal or nearly equal AUC. However, with quarter time data CNN, RES and UNET had an average AUC of 0.93, which was lower than full time OSEM's AUC, but equal to quarter acquisition time OSEM. cGAN did not achieve the defect detection performance of the other DL methods. Its average AUC with half time data was 0.94 and 0.91 with quarter time data. Conclusions: DL-based denoising effectively improved noise level with slightly lower perfusion defect detection performance than full time reconstruction. cGAN achieved the lowest noise level, but at the same time the poorest defect detection performance among the studied DL methods. [ABSTRACT FROM AUTHOR]

While head-mounted display (HMD) based gaming is often limited by cybersickness, research suggests that repeated exposure to virtual reality (VR) can reduce the severity of these symptoms. This study was therefore aimed at: (1) examining the exposure conditions required to reduce cybersickness during HMD VR; and (2) learning whether such reductions generalise from one HMD VR game to another. Our participants played two commercially-available HMD VR video games over two consecutive days. Their first exposure to HMD VR on both days was always to a 15-min virtual rollercoaster ride. On Day 1, half of our participants also played a virtual climbing game for 15-min, while the rest of them finished testing early. Participants in the latter group were only exposed to the climbing game late on Day 2. We found that sickness was significantly reduced for our participants on their second exposure to the virtual rollercoaster. However, sickness to the rollercoaster on Day 2 was unaffected by whether they had played the climbing game on Day 1. Sickness during virtual climbing was also unaffected by group differences in exposure to the virtual rollercoaster. This convergent evidence suggested that the reductions in cybersickness produced by repeated exposure to HMD VR were game-specific. While these benefits did not generalise to the second game, two 15-min exposures to the same HMD VR game was sufficient to significantly reduce cybersickness in this study. [ABSTRACT FROM AUTHOR]

Purpose: There is a higher prevalence of visual problems in children with Autistic Spectrum Disorder (ASD) compared with the neuro-typical population. Issues relating to visual perception can be evident as atypical visual behaviours (ViBes). The aim of the study was to compare findings of parents and eye health professionals using questionnaires to describe visual function in young children with ASD.Parents/Caregivers of patients diagnosed with ASD attending routine hospital eye clinics were invited to participate. A questionnaire to draw out presence of ViBes was completed by the parent prior to attending clinic. The clinician independently completed the same questionnaire and undertook a clinical ocular assessment.32 children were recruited (mean age 7 years, range 4–11). Most caregivers indicated they had noted at least one atypical ViBe (97%, median 5, range 0–8). Parental-reported ViBe8 scores were higher than clinician-reported scores (p = 0.04). The most commonly reported ViBes by both groups related to use of vision at the same time as other senses, and atypical fixation (e.g. looking away during speech or side viewing). There was weak correlation between visual acuity and parental ViBe8 score (rho = 0.364) and no correlation between refractive error and parental ViBe8 score (rho = 0.047).Clinicians were likely to under-report atypical visual function compared with parent. Refraction and visual acuity alone do not detect all visual problems in children with ASD. A Visual Behaviour (ViBe) questionnaire offers a structured approach and shared language to allow documentation of functional visual assessment for both parents, carers, and educational professionals. Use of the ViBe questionnaire may promote understanding between caregiver and professional and provide a baseline for visual behaviours.Materials and methods: There is a higher prevalence of visual problems in children with Autistic Spectrum Disorder (ASD) compared with the neuro-typical population. Issues relating to visual perception can be evident as atypical visual behaviours (ViBes). The aim of the study was to compare findings of parents and eye health professionals using questionnaires to describe visual function in young children with ASD.Parents/Caregivers of patients diagnosed with ASD attending routine hospital eye clinics were invited to participate. A questionnaire to draw out presence of ViBes was completed by the parent prior to attending clinic. The clinician independently completed the same questionnaire and undertook a clinical ocular assessment.32 children were recruited (mean age 7 years, range 4–11). Most caregivers indicated they had noted at least one atypical ViBe (97%, median 5, range 0–8). Parental-reported ViBe8 scores were higher than clinician-reported scores (p = 0.04). The most commonly reported ViBes by both groups related to use of vision at the same time as other senses, and atypical fixation (e.g. looking away during speech or side viewing). There was weak correlation between visual acuity and parental ViBe8 score (rho = 0.364) and no correlation between refractive error and parental ViBe8 score (rho = 0.047).Clinicians were likely to under-report atypical visual function compared with parent. Refraction and visual acuity alone do not detect all visual problems in children with ASD. A Visual Behaviour (ViBe) questionnaire offers a structured approach and shared language to allow documentation of functional visual assessment for both parents, carers, and educational professionals. Use of the ViBe questionnaire may promote understanding between caregiver and professional and provide a baseline for visual behaviours.Results: There is a higher prevalence of visual problems in children with Autistic Spectrum Disorder (ASD) compared with the neuro-typical population. Issues relating to visual perception can be evident as atypical visual behaviours (ViBes). The aim of the study was to compare findings of parents and eye health professionals using questionnaires to describe visual function in young children with ASD.Parents/Caregivers of patients diagnosed with ASD attending routine hospital eye clinics were invited to participate. A questionnaire to draw out presence of ViBes was completed by the parent prior to attending clinic. The clinician independently completed the same questionnaire and undertook a clinical ocular assessment.32 children were recruited (mean age 7 years, range 4–11). Most caregivers indicated they had noted at least one atypical ViBe (97%, median 5, range 0–8). Parental-reported ViBe8 scores were higher than clinician-reported scores (p = 0.04). The most commonly reported ViBes by both groups related to use of vision at the same time as other senses, and atypical fixation (e.g. looking away during speech or side viewing). There was weak correlation between visual acuity and parental ViBe8 score (rho = 0.364) and no correlation between refractive error and parental ViBe8 score (rho = 0.047).Clinicians were likely to under-report atypical visual function compared with parent. Refraction and visual acuity alone do not detect all visual problems in children with ASD. A Visual Behaviour (ViBe) questionnaire offers a structured approach and shared language to allow documentation of functional visual assessment for both parents, carers, and educational professionals. Use of the ViBe questionnaire may promote understanding between caregiver and professional and provide a baseline for visual behaviours.Conclusion: There is a higher prevalence of visual problems in children with Autistic Spectrum Disorder (ASD) compared with the neuro-typical population. Issues relating to visual perception can be evident as atypical visual behaviours (ViBes). The aim of the study was to compare findings of parents and eye health professionals using questionnaires to describe visual function in young children with ASD.Parents/Caregivers of patients diagnosed with ASD attending routine hospital eye clinics were invited to participate. A questionnaire to draw out presence of ViBes was completed by the parent prior to attending clinic. The clinician independently completed the same questionnaire and undertook a clinical ocular assessment.32 children were recruited (mean age 7 years, range 4–11). Most caregivers indicated they had noted at least one atypical ViBe (97%, median 5, range 0–8). Parental-reported ViBe8 scores were higher than clinician-reported scores (p = 0.04). The most commonly reported ViBes by both groups related to use of vision at the same time as other senses, and atypical fixation (e.g. looking away during speech or side viewing). There was weak correlation between visual acuity and parental ViBe8 score (rho = 0.364) and no correlation between refractive error and parental ViBe8 score (rho = 0.047).Clinicians were likely to under-report atypical visual function compared with parent. Refraction and visual acuity alone do not detect all visual problems in children with ASD. A Visual Behaviour (ViBe) questionnaire offers a structured approach and shared language to allow documentation of functional visual assessment for both parents, carers, and educational professionals. Use of the ViBe questionnaire may promote understanding between caregiver and professional and provide a baseline for visual behaviours. [ABSTRACT FROM AUTHOR]

Five grapevine viruses, including grapevine geminivirus A (GGVA), grapevine Syrah virus 1 (GSyV-1), grapevine Cabernet Sauvignon reovirus (GCSV), grapevine virus F (GVF) and grapevine Red Globe virus (GRGV) have been detected in four South Australian vineyards using metagenomic high throughput sequencing for the first time in Australia. Most of them were present in asymptomatic grapevines and some were present in grapevines with leafroll disease that were infected by several other viruses, including grapevine leafroll-associated viruses. Therefore, the association of GGVA, GSyV-1, GCSV, GVF and GRGV with disease in Australia is unknown. [ABSTRACT FROM AUTHOR]

Altered resting state functional connectivity (FC) involving the anterior insula (aINS), a key node in the salience network, has been reported consistently in autism. Here we examined, for the first time, FC between the aINS and the whole brain in a sample of full-term, postmenstrual age (PMA) matched neonates (mean 44.0 weeks, SD = 1.5) who due to family history have high likelihood (HL) for developing autism (n = 12) and in controls (n = 41) without family history of autism (low likelihood, LL). Behaviors associated with autism were evaluated between 12 and 18 months (M = 17.3 months, SD = 2.5) in a subsample (25/53) of participants using the First Year Inventory (FYI). Compared to LL controls, HL neonates showed hypoconnectivity between left aINS and left amygdala. Lower connectivity between the two nodes was associated with higher FYI risk scores in the social domain (r(25) = −0.561, p =.003) and this association remained robust when maternal mental health factors were considered. Considering that a subsample of LL participants (n = 14/41) underwent brain imaging during the fetal period at PMA 31 and 34 weeks, in an exploratory analysis, we evaluated prospectively development of the LaINS-Lamy connectivity and found that the two areas strongly coactivate throughout the third trimester of pregnancy. The study identifies left lateralized anterior insula—amygdala connectivity as a potential target of further investigation into neural circuitry that enhances likelihood of future onset of social behaviors associated with autism during neonatal and potentially prenatal periods. [ABSTRACT FROM AUTHOR]

Individual differences in brain functional organization track a range of traits, symptoms and behaviours1–12. So far, work modelling linear brain–phenotype relationships has assumed that a single such relationship generalizes across all individuals, but models do not work equally well in all participants13,14. A better understanding of in whom models fail and why is crucial to revealing robust, useful and unbiased brain–phenotype relationships. To this end, here we related brain activity to phenotype using predictive models—trained and tested on independent data to ensure generalizability15—and examined model failure. We applied this data-driven approach to a range of neurocognitive measures in a new, clinically and demographically heterogeneous dataset, with the results replicated in two independent, publicly available datasets16,17. Across all three datasets, we find that models reflect not unitary cognitive constructs, but rather neurocognitive scores intertwined with sociodemographic and clinical covariates; that is, models reflect stereotypical profiles, and fail when applied to individuals who defy them. Model failure is reliable, phenotype specific and generalizable across datasets. Together, these results highlight the pitfalls of a one-size-fits-all modelling approach and the effect of biased phenotypic measures18–20 on the interpretation and utility of resulting brain–phenotype models. We present a framework to address these issues so that such models may reveal the neural circuits that underlie specific phenotypes and ultimately identify individualized neural targets for clinical intervention.Predictive models that relate brain activity to phenotype reliably fail when applied to subgroups of participants who do not fit stereotypical profiles, showing that the utility of a one-size-fits-all modelling approach is limited. [ABSTRACT FROM AUTHOR]

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent childhood neurodevelopmental disorder. It shares some genetic risk with Autism Spectrum Disorder (ASD), and the conditions often occur together. Both are potentially associated with abnormal glutamate and GABA neurotransmission, which can be modelled by measuring the synaptic activity in the retina with an electroretinogram (ERG). Reduction of retinal responses in ASD has been reported, but little is known about retinal activity in ADHD. In this study, we compared the light-adapted ERGs of individuals with ADHD, ASD and controls to investigate whether retinal responses differ between these neurodevelopmental conditions. Methods: Full field light-adapted ERGs were recorded from 15 ADHD, 57 ASD (without ADHD) and 59 control participants, aged from 5.4 to 27.3 years old. A Troland protocol was used with a random series of nine flash strengths from −0.367 to 1.204 log photopic cd.s.m−2. The time-to-peak and amplitude of the a- and b-waves and the parameters of the Photopic Negative Response (PhNR) were compared amongst the three groups of participants, using generalised estimating equations. Results: Statistically significant elevations of the ERG b-wave amplitudes, PhNR responses and faster timings of the b-wave time-to-peak were found in those with ADHD compared with both the control and ASD groups. The greatest elevation in the b-wave amplitudes associated with ADHD were observed at 1.204 log phot cd.s.m−2 flash strength (p <.0001), at which the b-wave amplitude in ASD was significantly lower than that in the controls. Using this measure, ADHD could be distinguished from ASD with an area under the curve of 0.88. Conclusions: The ERG b-wave amplitude appears to be a distinctive differential feature for both ADHD and ASD, which produced a reversed pattern of b-wave responses. These findings imply imbalances between glutamate and GABA neurotransmission which primarily regulate the b-wave formation. Abnormalities in the b-wave amplitude could provisionally serve as a biomarker for both neurodevelopmental conditions. [ABSTRACT FROM AUTHOR]

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Noisy 32 × 32 × 32 patches cropped from reduced acquisition time OSEM images were used as model input and model gave denoised 32 × 32 × 32 patches as output. Output patches were later combined using weighted averaging to produce images at the original reconstruction matrix size The original article [[1]] has been updated. B Correction: EJNMMI Physics (2023) 10:9 b https://doi.org/10.1186/s40658-023-00531-0 Following publication of the original article [[1]], the authors identified an error in Fig. [Extracted from the article]

Surveys of key cucurbit production regions in New South Wales, Australia were undertaken to catalogue the diversity of viral pathogens affecting field grown cropping systems. Analysis of the collected isolates confirmed a detection of watermelon crinkle leaf associated virus-1 (WCLaV-1) in watermelon constituting the first report of WCLaV-1 in Australia. A mixed infection of WCLaV-1 and watermelon mosaic virus (WMV) was also detected constituting the first report of this type of pathogen combination. [ABSTRACT FROM AUTHOR]

Proactive and coordinated action to mitigate and adapt to climate change will be essential for achieving the healthy, resilient, safe, sustainably harvested and biodiverse ocean that the UN Decade of Ocean Science and sustainable development goals (SDGs) seek. Ocean-based mitigation actions could contribute 12% of the emissions reductions required by 2030 to keep warming to less than 1.5 ºC but, because substantial warming is already locked in, extensive adaptation action is also needed. Here, as part of the Future Seas project, we use a "foresighting/hindcasting" technique to describe two scenarios for 2030 in the context of climate change mitigation and adaptation for ocean systems. The "business-as-usual" future is expected if current trends continue, while an alternative future could be realised if society were to effectively use available data and knowledge to push as far as possible towards achieving the UN SDGs. We identify three drivers that differentiate between these alternative futures: (i) appetite for climate action, (ii) handling extreme events, and (iii) climate interventions. Actions that could navigate towards the optimistic, sustainable and technically achievable future include: proactive creation and enhancement of economic incentives for mitigation and adaptation; supporting the proliferation of local initiatives to spur a global transformation; enhancing proactive coastal adaptation management; investing in research to support adaptation to emerging risks; deploying marine-based renewable energy; deploying marine-based negative emissions technologies; developing and assessing solar radiation management approaches; and deploying appropriate solar radiation management approaches to help safeguard critical ecosystems. [ABSTRACT FROM AUTHOR]

We study the topological G2 and Spin(7) strings at 1-loop. We define new double complexes for supersymmetric NSNS backgrounds of string theory using generalised geometry. The 1-loop partition function then has a target-space interpretation as a particular alternating product of determinants of Laplacians, which we have dubbed the analytic torsion. In the case without flux where these backgrounds have special holonomy, we reproduce the worldsheet calculation of the G2 string and give a new prediction for the Spin(7) string. We also comment on connections with topological strings on Calabi-Yau and K3 backgrounds. [ABSTRACT FROM AUTHOR]

Purpose: To investigate if a lower luminance monochromatic LED stimulus could be used as an alternative to a high luminance white light for the clinical electrooculogram. Methods: Clinical electrooculograms were recorded in color normal participants (N = 23) aged 22.6 ± 1.2 years, 7 male and 16 female using the standard 100 cd.m−2 white illuminant and four monochromatic LEDs with peak wavelengths of 448, 534, 596 and 634 nm at 30 cd.m−2. Pupils were dilated and there was a 30 cd.m−2pre-adaptation to white light for 2 min followed by 15 min dark adaptation and 20 min recording in the light stimulus using a Ganzfeld stimulator. Results: The normalized LP:DTratio for the short wavelength LED (448 nm) was equivalent in amplitude and timing to the ISCEV standard EOG (p =.99). The LP:DTratio for the white (100 cd.m−2) and 448 nm (30 cd.m−2) were (median ± SEM): 2.49 ±.11 and 2.47 ±.11. The time to light-rise peak was also equivalent being 9.0 ±.2 and 8.0 ±.4 min (p =.54). Conclusions: Consideration may be given to using a short wavelength monochromatic stimulus that is more comfortable for the subject than the current 100 cd.m−2 illuminant. [ABSTRACT FROM AUTHOR]

Wilson disease (WD) can manifest with hepatic or neuropsychiatric symptoms. Our understanding of the in vivo brain changes in WD, particularly in the hepatic phenotype, is limited. Thirty subjects with WD and 30 age- and gender-matched controls participated. WD group underwent neuropsychiatric assessment. Unified WD Rating Scale neurological exam scores were used to determine neurological (WDN, score > 0) and hepatic-only (WDH, score 0) subgroups. All subjects underwent 3 Tesla anatomical and resting-state functional MRI. Diffusion tensor imaging (DTI) and susceptibility-weighted imaging (SWI) were performed only in the WD group. Volumetric, DTI, and functional connectivity analyses were performed to determine between-group differences. WDN and WDH groups were matched in demographic and psychiatric profiles. The entire WD group compared to controls showed significant thinning in the bilateral superior frontal cortex. The WDN group compared to control and WDH groups showed prominent structural brain changes including significant striatal and thalamic atrophy, more subcortical hypointense lesions on SWI, and diminished white matter integrity in the bilateral anterior corona radiata and corpus callosum. However, the WDH group also showed significant white matter volume loss compared to controls. The functional connectivity between the frontostriatal nodes was significantly reduced in the WDN group, whereas that of the hippocampus was significantly increased in the WDH group compared to controls. In summary, structural and functional brain changes were present even in neurologically non-manifesting WD patients in this cross-sectional study. Longitudinal brain MRI scans may be useful as biomarkers for prognostication and optimization of treatment strategies in WD. [ABSTRACT FROM AUTHOR]

Summary: It is unclear how physical activity intensity and vitamin D status are related to bone health in prepubertal children. We found positive associations between vitamin D status and moderate-to-vigorous physical activity with bone in boys and girls. This highlights the importance of lifestyle factors for skeletal health prepuberty. Introduction: The sex-specific independent and interactive associations of physical activity (PA) intensity and serum 25-hydroxyvitamin D (25(OH)D) levels with areal bone mineral density (aBMD) were investigated in prepubertal children. Methods: The participants were 366 prepubertal Finnish children (190 boys, 176 girls) aged 6–8 years. Linear regression analysed the associations of sedentary time (ST), light PA (LPA), moderate PA (MPA), moderate-to-vigorous PA (MVPA) and vigorous PA (VPA) measured by accelerometery, and serum 25(OH)D with total body less head (TBLH) and lower-limb aBMD, measured by dual-energy X-ray absorptiometry. Results: There was no interaction between PA intensity or serum 25(OH)D and sex with aBMD. MPA and MVPA were positively associated with TBLH and lower-limb aBMD (β = 0.11, 95% CI 0.02–0.20, p = 0.01). Serum 25(OH)D was positively associated with TBLH and lower-limb aBMD (β = 0.09, 95% CI 0.01–0.18, p = 0.03). There were no interactions between PA intensity and serum 25(OH)D with aBMD. Conclusion: Vitamin D status, MPA and MVPA levels in active prepubertal children were positively associated with aBMD. The influence of MVPA is due to the MPA component, though our findings regarding the role of VPA should be interpreted with caution, as shorter accelerometer epochs are needed to more accurately assess VPA. This study adds evidence to the promotion of MPA and behaviours to encourage optimal vitamin D status in supporting skeletal health in childhood, though these need not be used in conjunction to be beneficial, and a sex-specific approach is not necessary in prepubertal children. Trial registration number: NCT01803776. Date of registration: 4/03/2013 [ABSTRACT FROM AUTHOR]

Purpose: The c.1430A > G (Asp477Gly) variant in RPE65 has been reported in Irish and Scottish families with either an autosomal dominant retinal dystrophy (adRD) that resembles choroideremia, a vitelliform macular dystrophy or an isolated macular atrophy. We report novel features on multimodal imaging and the natural history of a family harbouring this variant in combination with the BEST1 c.37C > T (Arg13Cys) variant. Methods: Members of a family with an adRD were examined clinically to ascertain phenotype and underwent genetic testing. Multimodal imaging included widefield colour fundus photography, quantitative autofluorescence (qAF) and spectral domain optical coherence tomography. Electrophysiology and microperimetry were also performed. Results: Vision loss was attributed to foveal atrophy in the proband and choroidal neovascularisation and a vitello-eruptive lesion in one affected son. Peripheral retinal white dots corresponding to subretinal deposits were seen in three patients. The median qAF8 values in the proband (I:1) were low (40 and 101 in OD and OS) at age 79. Similarly, the qAF8 values for the middle son (II:2) were also low (100 and 87 in ODS and OS) at age 60. Electrophysiology showed disproportionate reduction in Arden ratio prior to the gradual loss of full-field responses. Microperimetry demonstrated an enlarging scotoma in the proband. Conclusions: The coexistence of the pathogenic BEST1 c.37C > T variant may modify clinical features observed in RPE65 adRD. This study expands our understanding of RPE65 adRD as a retinoid cycle disorder supported by the reduced qAF, fine white retinal dots and corresponding subretinal deposits on OCT in affected members. [ABSTRACT FROM AUTHOR]

Understanding the relationship between complexity and stability in large dynamical systems—such as ecosystems—remains a key open question in complexity theory which has inspired a rich body of work developed over more than fifty years. The vast majority of this theory addresses asymptotic linear stability around equilibrium points, but the idea of 'stability' in fact has other uses in the empirical ecological literature. The important notion of 'temporal stability' describes the character of fluctuations in population dynamics, driven by intrinsic or extrinsic noise. Here we apply tools from random matrix theory to the problem of temporal stability, deriving analytical predictions for the fluctuation spectra of complex ecological networks. We show that different network structures leave distinct signatures in the spectrum of fluctuations, and demonstrate the application of our theory to the analysis of ecological time-series data of plankton abundances. Fluctuations in ecosystems and other large dynamical systems are driven by intrinsic and extrinsic noise and contain hidden information which is difficult to extract. Here, the authors derive analytical characterizations of fluctuations in random interacting systems, allowing inference of network properties from time series data. [ABSTRACT FROM AUTHOR]

Recall of, and physical interaction with, self-owned items is privileged over items owned by other people (Constable et al. in Cognition 119(3):430–437, 2011; Cunningham et al. in Conscious Cognit 17(1):312–318, 2008). Here, we investigate approach (towards the item), compared with avoidance (away from the item) movements to images of self- and experimenter-owned items. We asked if initiation time and movement duration of button-press approach responses to self-owned items are associated with a systematic self-bias (overall faster responses), compared with avoidance movements, similar to findings of paradigms investigating affective evaluation of (unowned) items. Participants were gifted mugs to use, and after a few days they completed an approach–avoidance task (Chen and Bargh in Pers Soc Psychol Bull 25(2):215–224, 1999; Seibt et al. in J Exp Soc Psychol 44:713–720, 2008; Truong et al. in J Exp Psychol Hum Percept Perform 42(3), 375-385, 2016) to images of their own or the experimenter's mug, using either congruent or incongruent movement direction mappings. There was a self-bias effect for initiation time to the self-owned mug, for both congruent and incongruent mappings, and for movement duration in the congruent mapping. The effect was abolished in Experiment 2 when participants responded based on a shape on the handle rather than mug ownership. We speculate that ownership status requires conscious processing to modulate responses. Moreover, ownership status judgements and affective evaluation may employ different mechanisms. [ABSTRACT FROM AUTHOR]

Parkinson's disease (PD) is associated with neuronal damage in the brain and gut. This work compares changes in the enteric nervous system (ENS) of commonly used mouse models of PD that exhibit central neuropathy and a gut phenotype. Enteric neuropathy was assessed in five mouse models: peripheral injection of MPTP; intracerebral injection of 6-OHDA; oral rotenone; and mice transgenic for A53T variant human α-synuclein with and without rotenone. Changes in the ENS of the colon were quantified using pan-neuronal marker, Hu, and neuronal nitric oxide synthase (nNOS) and were correlated with GI function. MPTP had no effect on the number of Hu+ neurons but was associated with an increase in Hu+ nuclear translocation (P < 0.04). 6-OHDA lesioned mice had significantly fewer Hu+ neurons/ganglion (P < 0.02) and a reduced proportion of nNOS+ neurons in colon (P < 0.001). A53T mice had significantly fewer Hu+ neurons/area (P < 0.001) and exhibited larger soma size (P < 0.03). Treatment with rotenone reduced the number of Hu+ cells/mm2 in WT mice (P < 0.006) and increased the proportion of Hu+ translocated cells in both WT (P < 0.02) and A53T mice (P < 0.04). All PD models exhibited a degree of enteric neuropathy, the extent and type of damage to the ENS, however, was dependent on the model. [ABSTRACT FROM AUTHOR]

Seeds of three important cucurbit species (cucumber, melon and zucchini) were obtained through on-line mail-order providers and tested for selected viruses of biosecurity and agronomic concern. One or more of the targeted viruses were detected in 23 of the 31 seed lots tested. The quarantine pest melon necrotic spot virus was detected by ELISA in melon seeds. Multiple instances of contamination with the quarantine pest cucumber green mottle mosaic virus were also detected, and its presence in seeds of all three plant species was confirmed by inoculation and re-isolation from indicator plants. Cucumber mosaic virus, squash mosaic virus and potyviruses were repeatedly detected, and instances of insect pest and plant trash contamination were also observed. Seeds imported into Australia from some on-line sources have potential to introduce organisms of biosecurity concern. [ABSTRACT FROM AUTHOR]

We develop an inverted long-baseline (ILBL) acoustic navigation system for determining the position of deep-towed instruments, such as controlled-source electromagnetic transmitters and receivers. The ILBL system uses a deep-tow mounted acoustic transceiver system to measure travel times to a pair of surface transponders towed on paravanes behind the survey vessel. The travel times, transponder positions and pressure depth data are inverted for the lateral position of the deep-tow vehicle, as well as the positions of any relay transponders on the antenna and receiver array that are towed horizontal behind the deep-tow vehicle. Three example applications demonstrate position accuracies of about 5 and 37 m in the inline and crossline directions for 3 km water depths and around 6 m for 1 km depth. The portability and generality of the system make it suitable for deep-tow applications for geophysical, geochemical and geological surveying purposes. We have shown that the accuracy of the ILBL system is similar to that of commercial USBL systems, but is considerably more cost effective than even portable USBL systems, and can be used on vessels lacking permanently installed USBL transceiver heads. Further, it can be used in water depths of 5,000 m or more. It could also be readily modified for further improving its position accuracy if desired. [ABSTRACT FROM AUTHOR]

Archaeological deposits build up inside standing buildings both under and between floors and these have the potential to provide considerable information about human behavior in the past. Under and between floor spaces provide a unique depositional environment that allow the survival of rare and fragile organic materials that typically do not survive in other archaeological contexts, including paper, cardboard, fabric and other fibres, seeds, leather, and human hair and skin cells. However, they require a clear understanding of depositional processes to allow their interpretation. Experimental archaeology was conducted to understand the process of artifact deposition and the interpretation of underfloor deposits in twelve standing buildings in Western Australia. Floors were built and a range of artifacts swept across them to determine how artifacts travelled across floorboards or fell through gaps between boards. Size, shape, and angularity of artifacts were key determinants of the likelihood of deposition. Sweeping activity makes it more likely that material will be deposited around the margins of rooms, and particularly, to either side of doorways. Underfloor deposits excavated from two specific Western Australian buildings, Ellensbrook Homestead, and the York Residency Museum, are interpreted based on the results of these experiments. [ABSTRACT FROM AUTHOR]

Background: Bone SPECT/CT has been shown to offer superior sensitivity and specificity compared to conventional whole-body planar scanning. Furthermore, bone SPECT/CT allows quantitative imaging, which is challenging with planar methods. In order to gain better quantitative accuracy, Bayesian reconstruction algorithms, including both image derived and anatomically guided priors, have been utilized in reconstruction in PET/CT scanning, but they have not been widely used in SPECT/CT studies. Therefore, the aim of this work was to evaluate the performance of CT-guided reconstruction in quantitative bone SPECT. Methods: Three Bayesian reconstruction methods were evaluated against the conventional ordered subsets expectation maximization (OSEM) reconstruction method. One of the studied Bayesian methods was the relative difference prior (RDP), which has recently gained popularity in PET reconstruction. The other two methods, anatomically guided smoothing prior (AMAP-S) and anatomically guided relative difference prior (AMAP-R), utilized anatomical information from the CT scan. The reconstruction methods were evaluated in terms of quantitative accuracy with artificial lesions inserted in clinical patient studies and with 20 real clinical patients. Maximum and mean standardized uptake values (SUVs) of the lesions were defined. Results: The analyses showed that all studied Bayesian methods performed better than OSEM and the anatomical priors also outperformed RDP. The average relative error in mean SUV for the artificial lesion study for OSEM, RDP, AMAP-S, and AMAP-R was − 53%, − 35%, − 15%, and − 10%, when the CT study had matching lesions. In the patient study, the RDP method gave 16 ± 9% higher maximum SUV values than OSEM, while AMAP-S and AMAP-R offered increases of 36 ± 8% and 36 ± 9%, respectively. Mean SUV increased for RDP, AMAP-S, and AMAP-R by 18 ± 9%, 26 ± 5%, and 33 ± 5% when compared to OSEM. Conclusions: The Bayesian methods with anatomical prior, especially the relative difference prior-based method (AMAP-R), outperformed OSEM and reconstruction without anatomical prior in terms of quantitative accuracy. [ABSTRACT FROM AUTHOR]

Among the allowed representations of extended supersymmetry in six dimensions there are exotic chiral multiplets that, instead of a graviton, contain mixed-symmetry spin-2 tensor fields. Notably, an N = (4, 0) multiplet has a four index exotic graviton and it was conjectured that an interacting theory based on this multiplet could arise as a strong coupling limit of M theory compactified on T6. We present an algebraic study of these multiplets and their possible embedding into the framework of exceptional field theory, finding in particular that the six-dimensional momenta do not correspond to a conventional space-time section. When compactified on a circle, the six-dimensional multiplets give rise to the same degrees of freedom as five-dimensional supergravity theories with the same number of supersymmetries. However, by considering anomalies (computed using the product multiplets construction) and the generation of Chern-Simons couplings, we find reason to doubt that their dynamics will agree with the five-dimensional gravity theories. We propose an alternative picture, similar to F-theory, in which particular fixed-volume T3-fibered space-times play a central role, suggesting that only on compactification to three-dimensions will one make contact with the dynamics of supergravity. [ABSTRACT FROM AUTHOR]

We analyse the geometry of generic Minkowski N = 1, D = 4 flux compactifications in string theory, the default backgrounds for string model building. In M-theory they are the natural string theoretic extensions of G2 holonomy manifolds. In type II theories, they extend the notion of Calabi-Yau geometry and include the class of flux backgrounds based on generalised complex structures first considered by Graña et al. (GMPT). Using E7(7) × ℝ+ generalised geometry we show that these compactifications are characterised by an SU(7) ⊂ E7(7) structure defining an involutive subbundle of the generalised tangent space, and with a vanishing moment map, corresponding to the action of the diffeomorphism and gauge symmetries of the theory. The Kähler potential on the space of structures defines a natural extension of Hitchin’s G2 functional. Using this framework we are able to count, for the first time, the massless scalar moduli of GMPT solutions in terms of generalised geometry cohomology groups. It also provides an intriguing new perspective on the existence of G2 manifolds, suggesting possible connections to Geometrical Invariant Theory and stability. [ABSTRACT FROM AUTHOR]

Objective: Brain dopamine transporter imaging with I-123-labeled radioligands is technically demanding due to the small size of the imaging target relative to the spatial resolution of most SPECT systems. In addition, I-123 has high-energy peaks which can penetrate or scatter in the collimator and be detected in the imaging energy window. The aim of this study was to implement Monte Carlo (MC)-based full collimator–detector response (CDR) compensation algorithm for I-123 into a third-party commercial SPECT reconstruction software package and to evaluate its effect on the quantitative accuracy of dopaminergic-image analysis compared to a method where only the geometric component of the CDR is compensated. Methods: In this work, we utilized a full Monte Carlo collimator–detector model and incorporated it into an iterative SPECT reconstruction algorithm. The full Monte Carlo model reconstruction was compared to standard reconstruction using an anthropomorphic striatal phantom filled with different I-123 striatal/cortex uptake ratios and with clinical I-123 Ioflupane DaTScan studies. Results: Reconstruction with the full model yielded higher (13–25%) striatal uptake ratios than the conventional reconstruction, but the uptake ratios were still much lower than the true ratios due to partial volume effect. Visually, images reconstructed with the full Monte Carlo model had better contrast and resolution than the conventional images, with both phantom and patient studies. Conclusions: Reconstruction with full Monte Carlo collimator–detector model yields higher quantitative accuracy than conventional reconstruction. Additional work to reduce the partial volume effect related errors would improve the accuracy further. [ABSTRACT FROM AUTHOR]

Performing functional magnetic resonance imaging (fMRI) scans of children can be a difficult task, as participants tend to move while being scanned. Head motion represents a significant confound in fMRI connectivity analyses. One approach to limit motion has been to use shorter MRI protocols, though this reduces the reliability of results. Hence, there is a need to implement methods to achieve high-quality, low-motion data while not sacrificing data quantity. Here we show that by using a mock scan protocol prior to a scan, in conjunction with other in-scan steps (weighted blanket and incentive system), it is possible to achieve low-motion fMRI data in pediatric participants (age range: 7–17 years old) undergoing a 60 min MRI session. We also observe that motion is low during the MRI protocol in a separate replication group of participants, including some with autism spectrum disorder. Collectively, the results indicate it is possible to conduct long scan protocols in difficult-to-scan populations and still achieve high-quality data, thus potentially allowing more reliable fMRI findings. [ABSTRACT FROM AUTHOR]

We describe the geometry of generic heterotic backgrounds preserving minimal supersymmetry in four dimensions using the language of generalised geometry. They are characterised by an SU(3) × Spin(6 + n) structure within O(6, 6 + n) × ℝ+ generalised geometry. Supersymmetry of the background is encoded in the existence of an involutive subbundle of the generalised tangent bundle and the vanishing of a moment map for the action of diffeomorphisms and gauge symmetries. We give both the superpotential and the Kähler potential for a generic background, showing that the latter defines a natural Hitchin functional for heterotic geometries. Intriguingly, this formulation suggests new connections to geometric invariant theory and an extended notion of stability. Finally we show that the analysis of infinitesimal deformations of these geometric structures naturally reproduces the known cohomologies that count the massless moduli of supersymmetric heterotic backgrounds. [ABSTRACT FROM AUTHOR]

In this study, we determined the complete genome sequence of a new blunervirus isolated from tomato plants grown in an open field in Italy in the fall of 2018. Like other blunerviruses, the RNA genome of this virus is quadripartite, positive-sense, and single-stranded. Excluding the polyA tail present in each segment, the RNAs 1 and 2 are 5790 nucleotides (nt) and 3621 nt in size, respectively, and each contains a single open reading frame (ORF). The RNAs 3 and 4 are 2842 and 1924 nt long and encode five and two ORFs, respectively. BLASTp analysis of the predicted products of RNA1 and RNA2 ORF1 showed the highest sequence identity (31% and 42%) to tea plant necrotic ring blotch virus (TPNRBV), while the protein encoded by RNA 4 ORF2 had the highest sequence identity (38%) to blueberry necrotic ring blotch virus (BNRBV). These are the only two recognized members in the genus Blunervirus. When the RNA3 ORF3 and ORF5 products were compared with the blunerviruses-encoded proteins, they had the highest sequence identity (30% and 32%) to their TPNRBV-encoded homologs; however, general comparisons showed stronger matches to two different proteins from Acinetobacter baumannii. The proteins encoded by ORFs 1, 2 and 4 of RNA3 and ORF 1 of RNA4 showed no significant BLASTp hits to any known proteins in the databases. Given the limited genetic similarity of this virus to those currently available in the databases, we suggest that this is a new virus, for which we propose the name "tomato fruit blotch virus" (ToFBV). A distinct isolate of the same virus was also detected in Australia. [ABSTRACT FROM AUTHOR]

Only a few transcription factors (TFs) regulating which cells of the ovule epidermis differentiate into lint fibres have been identified in cotton (Gossypium hirsutum L.). In this study, the effect on lint yield and fibre quality of over-expressing three TFs in cotton, GhHD-1, GhMYB25 and GhMYB25Like, and their double and triple combinations, were evaluated in field experiments over two seasons. The expression of single or stacked TFs were all driven either by an ovule-specific promoter, FBP 7, or a constitutive promoter, Stunt 7, in a Coker 315 background. TF type, either singly or in combination, was found to be the most significant factor affecting lint yield. Among 64 transgenic lines tested, seven were higher yielding than null segregant lines in one or both seasons and were all from the sets with single and double over-expressed TF combinations. A reduced yield was associated with the set of triple combinations. The two most stable high yielding lines across the seasons recorded 12–22% higher yields than the nulls, although were not competitive to locally adapted commercial controls. Over-expression of TFs singly or in combination did not significantly alter fibre length and strength, but sometimes increased fibre micronaire. There were positive relationships between lint yield and lint percentage and lint yield and fibre density amongst the transgenic lines. Our preliminary results suggest that manipulating TF expression, either singly or in pairs, can increase the density of fibres initiated on developing seeds and fibre yields under field conditions while maintaining overall fibre quality. [ABSTRACT FROM AUTHOR]

The increasing number of taxa being translocated across the globe is leading to many non-native species encountering indigenous taxa as well as other non-native species. Environmental heterogeneity may strongly influence the spatial distribution, habitat use and refuge availability for these taxa. Using a series of 24-h mesocosm experiments we examined the predator–prey interactions between an invasive crayfish (Pacifastacus leniusculus) and four amphipod taxa, one indigenous (Gammarus pulex) and three non-native species (Crangonyx pseudogracilis, Dikerogammarus villosus and Gammarus tigrinus) to Great Britain. The potential mediating effect of physical habitat on predator–prey interactions was examined via the use of different substrate particle sizes; cobbles, gravels and, sand. Survivorship of amphipods in response to crayfish predation varied significantly with the highest rates recorded for the non-native species D. villosus, followed by G. tigrinus, and C. pseudogracilis, with the lowest survivorship recorded for the indigenous species G. pulex for all substrates except cobble. However, total biomass consumption of the indigenous G. pulex and the non-native D. villosus by P. leniusculus were similar suggesting that crayfish may have been satiated by larger D. villosus individuals. Substrate size had a significant influence on the predation success of P. leniusculus, with larger substrate clasts typically resulting in increased survivorship rates for all species except C. pseudogracilis, which displayed lower predation rates for sand substrates. The findings of this study highlight the risks that naïve indigenous taxa may face from new invasive species and the importance of characterising physical habitat (complexity and refugia potential) when considering the potential ecological effects of invaders on predation success. [ABSTRACT FROM AUTHOR]

Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m−2 white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p <.001) and slower b-wave peak times (p <.001). Photopic hill models showed the peaks of the component Gaussian (p =.035) and logistic functions (p =.014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD. [ABSTRACT FROM AUTHOR]

Extreme variations in the direction of Earth's magnetic field contain important information regarding the operation of the geodynamo. Paleomagnetic studies have reported rapid directional changes reaching 1° yr−1, although the observations are controversial and their relation to physical processes in Earth's core unknown. Here we show excellent agreement between amplitudes and latitude ranges of extreme directional changes in a suite of geodynamo simulations and a recent observational field model spanning the past 100 kyrs. Remarkably, maximum rates of directional change reach ~10° yr−1, typically during times of decreasing field strength, almost 100 times faster than current changes. Detailed analysis of the simulations and a simple analogue model indicate that extreme directional changes are associated with movement of reversed flux across the core surface. Our results demonstrate that such rapid variations are compatible with the physics of the dynamo process and suggest that future searches for rapid directional changes should focus on low latitudes. The authors here use numerical simulations combined with a time-dependent model of Earth's magnetic field spanning the last 100 kyrs. They identify field directional changes to be 10 times faster than previously thought. [ABSTRACT FROM AUTHOR]

Although the feeling of stress is ubiquitous, the neural mechanisms underlying this affective experience remain unclear. Here, we investigate functional hippocampal connectivity throughout the brain during an acute stressor and use machine learning to demonstrate that these networks can specifically predict the subjective feeling of stress. During a stressor, hippocampal connectivity with a network including the hypothalamus (known to regulate physiological stress) predicts feeling more stressed, whereas connectivity with regions such as dorsolateral prefrontal cortex (associated with emotion regulation) predicts less stress. These networks do not predict a subjective state unrelated to stress, and a nonhippocampal network does not predict subjective stress. Hippocampal networks are consistent, specific to the construct of subjective stress, and broadly informative across measures of subjective stress. This approach provides opportunities for relating hypothesis-driven functional connectivity networks to clinically meaningful subjective states. Together, these results identify hippocampal networks that modulate the feeling of stress. Although the feeling of being stressed is ubiquitous and clinically significant, the underlying neural mechanisms are unclear. Using a novel predictive modeling approach, the authors show that functional hippocampal networks specifically and consistently predict the feeling of stress. [ABSTRACT FROM AUTHOR]

Previous work has revealed that social cues, such as gaze and pointed fingers, can lead to a shift in the focus of another person's attention. Research investigating the mechanisms of these shifts of attention has typically employed detection or localization button-pressing tasks. Because in-depth analyses of the spatiotemporal characteristics of aiming movements can provide additional insights into the dynamics of the processing of stimuli, in the present study we used a reaching paradigm to further explore the processing of social cues. In Experiments 1 and 2, participants aimed to a left or right location after a nonpredictive eye gaze cue toward one of these target locations. Seven stimulus onset asynchronies (SOAs), from 100 to 2,400 ms, were used. Both the temporal (reaction time, RT) and spatial (initial movement angle, IMA) characteristics of the movements were analyzed. RTs were shorter for cued (gazed-at) than for uncued targets across most SOAs. There were, however, no statistical differences in IMAs between movements to cued and uncued targets, suggesting that action planning was not affected by the gaze cue. In Experiment 3, the social cue was a finger pointing to one of the two target locations. Finger-pointing cues generated significant cueing effects in both RTs and IMAs. Overall, these results indicate that eye gaze and finger-pointing social cues are processed differently. Perception–action coupling (i.e., a tight link between the response and the social cue that is presented) might play roles in both the generation of action and the deviation of trajectories toward cued and uncued targets. [ABSTRACT FROM AUTHOR]

Self-prioritization is a robust phenomenon whereby judgments concerning self-representational stimuli are faster than judgments toward other stimuli. The present paper examines if and how self-prioritization causes more vivid short-term memories for self-related objects by giving geometric shapes arbitrary identities (self, mother, stranger). In Experiment 1 participants were presented with an array of the three shapes and required to retain the location and color of each in memory. Participants were then probed regarding the identity of one of the shapes and subsequently asked to indicate the color of the probed shape or an unprobed shape on a color wheel. Results indicated no benefit for self-stimuli in either response time for the identification probe or for color fidelity in memory. Yet, a cuing benefit was observed such that the cued stimulus in the identity probe did have higher fidelity within memory. Experiments 2 and 3 reduced the cognitive load by only requiring that participants process the identity and color of one shape at a time. For Experiment 2, the identity probe was memory-based, whereas the stimulus was presented alongside the identity probe for Experiment 3. Results demonstrated a robust self-prioritization effect: self-related shapes were classified faster than non-self-shapes, but this self-advantage did not lead to an increase in the fidelity of memory for self-related shapes' colors. Overall, these results suggest that self-prioritization effects may be restricted to an improvement in the ability to recognize that the self-representational stimulus is present without devoting more perceptual and short-term memory resources to such stimuli. [ABSTRACT FROM AUTHOR]