1. High level of interleukin-10 in serum predicts poor prognosis in multiple myeloma.
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Wang, Hua, Wang, Liang, Chi, Pei-dong, Wang, Wei-da, Chen, Xiao-qin, Geng, Qi-rong, Xia, Zhong-jun, and Lu, Yue
- Subjects
MULTIPLE myeloma diagnosis ,INTERLEUKINS ,MULTIPLE myeloma ,PROGNOSIS ,SURVIVAL analysis (Biometry) ,PREDICTIVE tests - Abstract
Background: Interleukin-10 (IL-10) is a inhibiting inflammatory cytokine that plays an important role in immune suppressive microenvironment in multiple myeloma (MM). Whether the level of serum IL-10 could predict treatment response and survival outcomes or not needs to be investigated in MM patients.Methods: The level of IL-10 in serum was measured using enzyme-linked immunosorbent assay in 188 patients with newly diagnosed MM.Results: The best cutoff value for IL-10 in predicting survival is 169.69 pg ml(-1) with an area under the curve (AUC) value of 0.747 (P<0.001). In all, 92 patients (48.9%) were classified as high-IL-10 group (>169.96 pg ml(-1)) and 96 patients (51.1%) as low-IL-10 group (⩽169.96 pg ml(-1)). The overall response rate (ORR) was 79.2% in low-IL-10 group, significantly higher than that in high-IL-10 group (53.3%, P<0.001). Patients in low-IL-10 group had significantly better survival compared with those in high-IL-10 group (3-year PFS rate: 69.3% vs 13.3%, P<0.001; 3-year OS rate: 93.6% vs 51.9%, P<0.001). Multivariate analysis revealed that serum IL-10 level >169.96 pg ml(-1) at diagnosis and certain cytogenetic abnormalities were two adverse factors for PFS and OS.Conclusions: Our data suggest that serum IL-10 at diagnosis is a novel, powerful predictor of prognosis for MM. [ABSTRACT FROM AUTHOR]- Published
- 2016
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