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The rock mass cracks caused by the surge of water pressure may become an important part of the water inrush channel. A large number of weak vibration signals will be induced during the hydraulic fracturing process. The source signal can be obtained by monitoring technology such as microseismic (MS) or acoustic emission. In the paper, the disaster-causing mechanism of water inrush disaster in tunnels is analyzed. The relationship between water inrush disaster and microseism is established. The main MS event is fracture development in the rock mass progressive failure water inrush. The main MS event is the impact activity of fillings and channel rock wall driven by water flow in the filling structure instability water inrush. The hydraulic fracturing test of rock-like materials is carried out. The effectiveness of acoustic emission (AE) monitoring technology is verified by comparing the fracture shape and AE positioning results. This study provides a theoretical basis for monitoring and early warning of water inrush disaster. At the same time, this research idea can provide reference for the study of engineering geological disasters such as large deformation and rockburst, and provide strong support for the safety construction of major infrastructure projects. [ABSTRACT FROM AUTHOR]

Hydrogels can relieve wound pain and provide a moist environment for wound healing. Although hydrogels based on natural materials have proven to be biocompatible and biodegradable, their antibacterial and anti-inflammatory properties are not desirable. Natural extracts with antimicrobial and antioxidant properties are becoming increasingly attractive because of their environmentally friendly nature and good biocompatibility. Herein, composite cellulose/silk fibroin/polyacrylic acid hydrogels based on natural materials were fabricated by crosslinking between oxidized cellulose and silk fibroin together with radical polymerization of acrylic acid. The fabricated hydrogels displayed a uniform hierarchical topography with high porosity, as well as good mechanical properties, swelling properties, air permeability and biocompatibility. With the addition of tea polyphenols to natural extracts, the composite hydrogels exhibited significant antimicrobial and antioxidant properties such that they could prevent bacterial infection and relieve wound inflammation in the inflammation stage and could promote the synthesis of extracellular matrix (ECM), angiogenesis, collagenization and re-epithelization during wound healing. The tea polyphenols/cellulose/silk fibroin/polyacrylic acid hydrogels fabricated in this study can accelerate wound healing, demonstrating their great potential for application in wound dressings. [ABSTRACT FROM AUTHOR]

Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars: physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant. [ABSTRACT FROM AUTHOR]

The early phase lipid accumulation is essential for liver regeneration. However, whether this acute lipid accumulation can serve as signals to direct liver regeneration rather than simply providing building blocks for cell proliferation remains unclear. Through in vivo CRISPR screening, we identify MIER1 (mesoderm induction early response 1) as a key epigenetic regulator that bridges the acute lipid accumulation and cell cycle gene expression during liver regeneration in male animals. Physiologically, liver acute lipid accumulation induces the phosphorylation of EIF2S1(eukaryotic translation initiation factor 2), which consequently attenuated Mier1 translation. MIER1 downregulation in turn promotes cell cycle gene expression and regeneration through chromatin remodeling. Importantly, the lipids-EIF2S1-MIER1 pathway is impaired in animals with chronic liver steatosis; whereas MIER1 depletion significantly improves regeneration in these animals. Taken together, our studies identify an epigenetic mechanism by which the early phase lipid redistribution from adipose tissue to liver during regeneration impacts hepatocyte proliferation, and suggest a potential strategy to boost liver regeneration. Early lipid accumulation is thought to contribute to liver regeneration through unclear functional mechanisms. Here the authors identify an epigenetic regulator, MIER1, that bridges the acute lipid accumulation and cell cycle gene transcription during liver regeneration after surgical resection in male mice. [ABSTRACT FROM AUTHOR]

The extraction of effective signals of microseismic event caused by water inrush in tunnels is an important prerequisite for accurate location of event. In this paper, based on the characteristics of the main frequency components of the tunnel water burst signal, the variational modal method (VMD) with good frequency decomposition ability is adopted to effectively extract the high-frequency components of the water inrush signal. The effective modes are identified by the method of detrend analysis, and the modal decomposition number K is determined. At the same time, the boundary between noise and effective signal is determined. The method proposed in this paper solves the problem that noise in some modal components is mixed with effective signals, and further improves the ability of extracting weak high-frequency signals. Through the analysis of case data, the validity of the research results in this paper is verified, and an effective signal extraction method of tunnel water inrush microseismic event based on VMD-DFA principle is formed. [ABSTRACT FROM AUTHOR]

The rhythmic regulation of transcriptional processes is intimately linked to lipid homeostasis, to anticipate daily changes in energy access. The Rev-erbα-HDAC3 complex was previously discovered to execute the rhythmic repression of lipid genes; however, the epigenetic switch that turns on these genes is less clear. Here, we show that genomic recruitment of MRG15, which is encoded by the mortality factor on chromosome 4 (MORF4)-related gene on chromosome 15, displays a significant diurnal rhythm and activates lipid genes in the mouse liver. RNA polymerase II (Pol II) recruitment and histone acetylation correspond to MRG15 binding, and the rhythm is impaired upon MRG15 depletion, establishing MRG15 as a key modulator in global rhythmic transcriptional regulation. MRG15 interacts with the nuclear receptor LRH-1, rather than with known core clock proteins, and is recruited to genomic loci near lipid genes via LRH-1. Blocking of MRG15 by CRISPR targeting or by the FDA-approved drug argatroban, which is an antagonist to MRG15, attenuates liver steatosis. This work highlights MRG15 as a targetable master regulator in the rhythmic regulation of hepatic lipid metabolism.