1. Anterior cingulate cortex provides the neural substrates for feedback-driven iteration of decision and value representation.
- Author
-
Chen, Wenqi, Liang, Jiejunyi, Wu, Qiyun, and Han, Yunyun
- Subjects
CINGULATE cortex ,NEURONS ,MOTOR unit - Abstract
Adjusting decision-making under uncertain and dynamic situations is the hallmark of intelligence. It requires a system capable of converting feedback information to renew the internal value. The anterior cingulate cortex (ACC) involves in error and reward events that prompt switching or maintenance of current decision strategies. However, it is unclear whether and how the changes of stimulus-action mapping during behavioral adaptation are encoded, nor how such computation drives decision adaptation. Here, we tracked ACC activity in male mice performing go/no-go auditory discrimination tasks with manipulated stimulus-reward contingencies. Individual ACC neurons integrate the outcome information to the value representation in the next-run trials. Dynamic recruitment of them determines the learning rate of error-guided value iteration and decision adaptation, forming a non-linear feedback-driven updating system to secure the appropriate decision switch. Optogenetically suppressing ACC significantly slowed down feedback-driven decision switching without interfering with the execution of the established strategy. The anterior cingulate cortex (ACC) is involved in decision strategies. Here the authors show that individual ACC neurons can be dynamically recruited to encode outcome information and promptly update internal value representations, thereby forming a non-linear feedback-driven updating system that ensures robust and agile decision adaptation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF