1. Crossing the border between epileptic and vascular pathology: a report of CACNA1A-related treatment-resistant hemiplegic migraine.
- Author
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Rubin, M., Cutillo, G., Zanandrea, L., Montini, F., Zanetta, C., Bellini, A., Cecchetti, G., Fanelli, G. F., Falini, A., Scotti, R., Calloni, S. F., Di Bella, D., Filippi, M., and Colombo, B.
- Subjects
EPILEPSY ,PATHOLOGY ,MIGRAINE aura ,MIGRAINE ,GAIN-of-function mutations ,PEOPLE with epilepsy ,BORDER crossing - Abstract
27156207 15 Lampl C. Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura. HM and the I CACNA1A i disease spectrum in general, establish a tight link between the pathophysiology behind migraine and epilepsy, underlining the predominant role of presynaptic calcium-mediated neurotransmitters exocytosis burst in causing the neuronal desynchronization responsible for the HM typical hyperexcitability and neurovascular damage [[1]]. Dear Sirs, Hemiplegic migraine (HM) is a rare form of genetic channelopathy presenting as migraine attacks with unilateral motor aura, often accompanied by heterogeneous symptoms i.e., aphasia, sensitive, visual, cerebellar or trigeminal symptoms, according to the International Headache Society [[1]]. [Extracted from the article] more...
- Published
- 2023
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