1. HIV is an independent predictor of aortic stiffness
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Alex Pitcher, Emma Wainwright, Stefan Neubauer, Genevieve Clutton, Cameron J. Holloway, Ntobeko A.B. Ntusi, Katherine Samaras, Kieran Clarke, Oliver J Rider, Mina Asaad, Lucy Dorrell, Rajarshi Banerjee, and Gemma Hancock
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Adult ,medicine.medical_specialty ,Magnetic Resonance Imaging, Cine ,Blood Pressure ,HIV Infections ,Pulse Wave Analysis ,Vascular Stiffness ,Predictive Value of Tests ,Risk Factors ,Antiretroviral Therapy, Highly Active ,medicine.artery ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Risk factor ,Pulse wave velocity ,Aorta ,Angiology ,Metabolic Syndrome ,Medicine(all) ,Radiological and Ultrasound Technology ,business.industry ,Research ,Age Factors ,Case-control study ,HIV ,virus diseases ,Middle Aged ,medicine.disease ,Surgery ,Blood pressure ,Cardiovascular Diseases ,Case-Control Studies ,Multivariate Analysis ,HIV-1 ,Cardiology ,cardiovascular system ,Cardiovascular magnetic resonance ,Aortic stiffness ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Patients with treated Human Immunodeficiency Virus-1 (HIV) infection are at increased risk of cardiovascular events. Traditionally much of this risk has been attributed to metabolic and anthropometric abnormalities associated with HIV, which are similar to the metabolic syndrome (MS), an established risk factor for cardiovascular mortality. It remains unclear whether treated HIV infection is itself associated with increased risk, via increase vascular stiffness. Methods 226 subjects (90 with HIV) were divided into 4 groups based on HIV and MS status: 1) HIV-ve/MS-ve, 2) HIV-ve/MS + ve, 3) HIV + ve/MS-ve and 4)HIV + ve/MS + ve. CMR was used to determine aortic pulse wave velocity (PWV) and regional aortic distensibility (AD). Results PWV was 11% higher and regional AD up to 14% lower in the HIV + ve/MS-ve group when compared to HIV-ve/MS-ve (p 0.99 all analyses). The HIV + ve/MS + ve group had 32% higher PWV and 30-34% lower AD than the HIV-ve/MS-ve group (all p
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