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We explain the propagating austenite–martensite phase boundary by a Frenkel–Kontorova model for a chain of meshes along a ledge of the phase transitions. We demonstrate such steps for example chains of 16 and 47 meshes. We can represent a Langevin solution which describes possible cases of a consecutive excitation of a higher phase under a low external force. [ABSTRACT FROM AUTHOR]

Fragmentation is a common feature of rockfall that exerts a strong control on the trajectories of the generated blocks, the impact energies, and the runout. In this paper, we present a set of four real-scale rockfall tests aimed at studying the fragmentation of the rocky blocks, from the global design of the field procedure to the data analysis and the main results. A total of 124 limestone, dacite, or granite blocks ranging between 0.2 and 5 m3 were dropped from different heights (8.5 to 23.6 m) onto four slopes with different shapes (single or double bench) and slope angles (42º to 71º). The characteristics of the blocks, in particular the size, surface texture and joint condition, were measured before the drops. The trajectories of the blocks and both the initial and the impact velocities were tracked and recorded by means of three high-speed video cameras. A total of 200 block-to-ground impacts have been studied. On average, 40% of the blocks broke upon impact on the slope or on the ground, making it necessary to measure the fragments. The initial and final sizes of the blocks/fragments were measured by hand with tape, though photogrammetric techniques (UAV and terrestrial) were also used for comparison purposes. The information gathered during the field tests provides a deep insight into the fragmentation processes. On the one hand, the high-resolution slow-motion videos help to describe when and how the block breakage takes place and the spatial distribution of the pieces. On the other hand, it is possible to compute the block trajectories, the velocities, and the energy losses using videogrammetry. The results include, for instance, a block average fragmentation of 54% and 14% for the limestone and granitoids, respectively; the systematic inventory of the size fragments, which may be used for fitting the power law distributions; and after each breakage, the total angle of aperture occupied by the fragments has been measured, with values in the range 25º–145º. To figure out the different behavior of the blocks in terms of breakage/no breakage, each block-to-ground impact has been characterized with a set of parameters describing the energy level, the robustness of the substrate, and the configuration of the block contact at the impact point, among others. All these terms are combined in a function F, which is used to adjust the field data. The adjustment has been carried out, first, for the whole 200 events and later for a subset of them. The procedure and the results are described in the paper. Although the discrimination capability of F is moderately satisfactory, it is very sensitive to the test site and setup. It must be highlighted that these field tests are a unique source of data to adjust the parameters of the numerical simulation models in use for rockfall studies and risk mitigation, especially when fragmentation during the propagation is considered. [ABSTRACT FROM AUTHOR]

We explain the emergence of zero field steps (ZFS) in a Frenkel-Kontorova (FK) model for a 1D annular chain being a model for an annular Josephson junction array. We demonstrate such steps for a case with a chain of 10 phase differences. We necessarily need the periodic boundary conditions. We propose a mechanism for the jump from M fluxons to M + 1 in the chain. [ABSTRACT FROM AUTHOR]

We explain the vibrations of a Frenkel–Kontorova (FK) model under Shapiro steps by the action of an external alternating force. We demonstrate Shapiro steps for a case with soft 'springs' between an 8-particles FK chain. Shapiro steps start with a single jump over the highest SP 4 in the global valley through the PES. They finish with doubled, and again doubled oscillations. We study in this part I a traditional FK model with periodic boundary conditions. [ABSTRACT FROM AUTHOR]

We explain Shapiro steps in a Frenkel–Kontorova (FK) model for a 1D chain of particles with free boundaries. The action of an external alternating force for the oscillating structure of the chain is important here. The different 'floors' of the potential energy surface (PES) of this model play an important role. They are regions of kinks, double kinks, and so on. We will find out that the preferable movements are the sliding of kinks or antikinks through the chain. The more kinks / antikinks are included the higher is the 'floor' through the PES. We find the Shapiro steps moving and oscillating anywhere between the floors. They start with a single jump over the highest SP in the global valley through the PES, like in part I of this series. They finish with complicated oscillations in the PES, for excitations directly over the critical depinning force. We use an FK model with free boundary conditions. In contrast to other results in the past, for this model, we obtain Shapiro steps in an unexpected, inverse sequence. We demonstrate Shapiro steps for a case with soft 'springs' between an 8-particle FK chain. [ABSTRACT FROM AUTHOR]

Introduction: This study aimed to describe the efficacy of fulvestrant 500 mg in postmenopausal women with estrogen receptor (ER)-positive advanced/metastatic breast cancer who had disease progression after receiving anti-estrogen therapy in clinical practice, getting real-world data.Materials and methods: Multicenter, retrospective, observational study conducted in Spain. Postmenopausal women with locally advanced/metastatic ER-positive breast cancer who received treatment with fulvestrant 500 mg after progression with a previous anti-estrogen therapy were eligible. The primary endpoint was progression-free survival (PFS); secondary endpoints were overall survival (OS), clinical benefit rate (CBR), duration of clinical benefit (DoCB), and safety profile.Results: A total of 263 women were evaluated (median age, 65.8 years). At a median follow-up of 21.5 months, median PFS and OS were 10.6 and 43.2 months, respectively. PFS according to 1st, 2nd, 3rd, and ≥ 4th lines were 11.5, 10.6, 9.9, and 8.5 months, respectively (p = 0.0245). PFS in patients with visceral involvement was 10 months vs 10.6 months in patients without visceral involvement (p = 0.6604), 9.6 months in patients with high Ki67 vs 10 months in patients with low Ki67 (p = 0.7224), and 10.2 months in HER2+ patients vs 10.3 months in HER2− patients (p = 0.6809). The CBR was 56.5% and the DoCB was 18.4 months. The most frequently adverse events were injection site pain (10.3%) and musculoskeletal disorders (7.6%).Conclusions: Fulvestrant 500 mg administered in clinical practice was shown to be effective (PFS, 10.6 months; CBR, 56.5%) and well tolerated, in accordance with previous trials. [ABSTRACT FROM AUTHOR]

Metastatic breast cancer is a heterogeneous disease that presents in varying forms, and a growing number of therapeutic options makes it difficult to determine the best choice in each particular situation. When selecting a systemic treatment, it is important to consider the medication administered in the previous stages, such as acquired resistance, type of progression, time to relapse, tumor aggressiveness, age, comorbidities, pre- and post-menopausal status, and patient preferences. Moreover, tumor genomic signatures can identify different subtypes, which can be used to create patient profiles and design specific therapies. However, there is no consensus regarding the best treatment sequence for each subgroup of patients. During the SABCC Congress of 2014, specialized breast cancer oncologists from referral hospitals in Europe met to define patient profiles and to determine specific treatment sequences for each one. Conclusions were then debated in a final meeting in which a relative degree of consensus for each treatment sequence was established. Four patient profiles were defined according to established breast cancer phenotypes: pre-menopausal patients with luminal subtype, post-menopausal patients with luminal subtype, patients with triple-negative subtype, and patients with HER2-positive subtype. A treatment sequence was then defined, consisting of hormonal therapy with tamoxifen, aromatase inhibitors, fulvestrant, and mTOR inhibitors for pre- and post-menopausal patien ts; a chemotherapy sequence for the first, second, and further lines for luminal and triple-negative patients; and an optimal sequence for treatment with new antiHER2 therapies. Finally, a document detailing all treatment sequences, that had the agreement of all the oncologists, was drawn up as a guideline and advocacy tool for professionals treating patients with this disease. [ABSTRACT FROM AUTHOR]

Objective:To describe fetal macrocrania including prenatal diagnosis, delivery considerations and clinical outcomes.Study Design:A retrospective case series was developed by reviewing 26 885 ultrasounds performed between 1 March 2003 and 30 June 2007 for the prenatal diagnosis of macrocrania. Medical records of each mother/infant pair were reviewed for demographic information, ultrasound findings, obstetric management and outcomes.Result:Twenty-three fetuses were diagnosed with macrocrania. Median gestational age at diagnosis was 31.1 weeks (range 18.3–38.1) and at delivery was 36.9 weeks (range 30.7–39.9). Fifteen patients (65%) underwent amniocentesis for karyotype; none were aneuploid but one had a duplication on chromosome 7. All the 23 infants were liveborn. Twenty-one deliveries were by Cesarean (91%), with thirteen of these by classical incision (62%). Of the infants, 5 (22%) died shortly after birth, 16 (70%) were stabilized in the neonatal intensive care unit and were discharged alive and 2 (8%) were transferred to another center and subsequently died. Eighteen babies required ventriculoperitoneal shunting (78%).Conclusion:Macrocrania is a diagnosis usually made in children but can also be made prenatally. Fetal macrocrania is usually a result of ventriculomegaly due to an obstructive process to cerebrospinal fluid flow. Abdominal delivery is usually required, often necessitating a classical uterine incision. Targeted ultrasonography, extensive counseling of parents and delivery at a tertiary care center with availability of neurosurgery is recommended.Journal of Perinatology (2009) 29, 201–204; doi:10.1038/jp.2008.196; published online 4 December 2008 [ABSTRACT FROM AUTHOR]

The dynamics of collisional processes between Mg atoms and caesium ions is studied using the hemiquantal (HQ) approach with special attention to the collisional channels leading to Mg(3 1P) and Cs(6 2P) states, for which the corresponding emission excitation functions have been previously measured in our laboratory. The radial and angular non-adiabatic couplings between the manifold of quasimolecular states have been determined using an ab initio configuration interaction calculation. The cross-sections for the different channels, as a function of the laboratory collisional energy, are compared with experimental values. The dynamical calculations indicate that, for the inelastic processes considered, the range of relevant impact parameters is small, active collisions being of the head-on type. . [ABSTRACT FROM AUTHOR]

A sentence under ‘Results’ heading in the Abstract section was published incorrectly. The correct sentence should read as follows: [ABSTRACT FROM AUTHOR]