Search

In hybrid automatic insulin delivery (HAID) systems, meal disturbance is compensated by feedforward control, which requires the announcement of the meal by the patient with type 1 diabetes (DM1) to achieve the desired glycemic control performance. The calculation of insulin bolus in the HAID system is based on the amount of carbohydrates (CHO) in the meal and patient-specific parameters, i.e. carbohydrate-to-insulin ratio (CR) and insulin sensitivity-related correction factor (CF). The estimation of CHO in a meal is prone to errors and is burdensome for patients. This study proposes a fully automatic insulin delivery (FAID) system that eliminates patient intervention by compensating for unannounced meals. This study exploits the deep reinforcement learning (DRL) algorithm to calculate insulin bolus for unannounced meals without utilizing the information on CHO content. The DRL bolus calculator is integrated with a closed-loop controller and a meal detector (both previously developed by our group) to implement the FAID system. An adult cohort of 68 virtual patients based on the modified UVa/Padova simulator was used for in-silico trials. The percentage of the overall duration spent in the target range of 70–180 mg/dL was 71.2 % and 76.2 % , < 70 mg/dL was 0.9 % and 0.1 % , and > 180 mg/dL was 26.7 % and 21.1 % , respectively, for the FAID system and HAID system utilizing a standard bolus calculator (SBC) including CHO misestimation. The proposed algorithm can be exploited to realize FAID systems in the future. [ABSTRACT FROM AUTHOR]

This paper presents a support fuzzy adaptive system for a hybrid proportional derivative controller that will refine its parameters during postprandial periods to enhance performance. Even though glucose controllers have improved over the last decade, tuning them and keeping them tuned are still major challenges. Changes in a patient's lifestyle, stress, exercise, or other activities may modify their blood glucose system, making it necessary to retune or change the insulin dosing algorithm. This paper presents a strategy to adjust the parameters of a proportional derivative controller using the so-called safety auxiliary feedback element loop for type 1 diabetic patients. The main parameters, such as the insulin on board limit and proportional gain are tuned using postprandial performance indexes and the information given by the controller itself. The adaptive and robust performance of the control algorithm was assessed "in silico" on a cohort of virtual patients under challenging realistic scenarios considering mixed meals, circadian variations, time-varying uncertainties, sensor errors, and other disturbances. The results showed that an adaptive strategy can significantly improve the performance of postprandial glucose control, individualizing the tuning by directly taking into account the intra-patient variability of type 1 patients. Graphical Abstract title: Postprandial glycaemia improvement via fuzzy adaptive control A fuzzy inference engine was implemented within a clinically tested artificial pancreas control system. The aim of the fuzzy system was to adapt controller parameters to improve postprandial blood glucose control while ensuring safety. Results show a significant improvement over time of the postprandial glucose response due to the adaptation, thus demonstrating the usefulness of the fuzzy adaptive system. [ABSTRACT FROM AUTHOR]