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Objective: To determine the prevalence of postoperative urinary extravasation (POUE) following anterior urethroplasty, to analyze factors associated with its occurrence, and to study the impact of POUE on surgical success. Materials and methods: Retrospective cohort study including all male patients who have undergone a urethroplasty at our center between 2011 and 2018. Subjects with posterior location stricture, those who did not undergo routine radiographic follow-up, or patients with inadequate follow-up were excluded. Urinary extravasation was defined as presence of evident contrast extravasation on the postoperative voiding cystourethrogram (VCUG). Impact was determined as "need-for-reoperation". Uni- and multivariate analysis were performed to determine clinical and demographic variables associated with occurrence of extravasation and postoperative stricture. Results: A total of 783 men underwent a urethroplasty and 630 fulfilled inclusion criteria. Urinary extravasation prevalence was 12.2%, and there was a "need-for-reoperation" in 1.1% of cases. On uni- and multivariate analysis, greatest stricture length (HR: 1.07 (1–1.2), p = 0.05) and penile urethral location (HR: 2.29 (1.1–4.6), p = 0.021) showed to be POUE predictors. POUE did not show to be a risk factor for postoperative stricture (HR: 1.57, 95% CI (0.8–3), p = 0.173). However, reoperation group showed to be a risk factor (HR: 6.6, 95% CI 1.4–31, p = 0.019). Conclusions: Prevalence of POUE was 12.2%. Stricture length and penile urethral strictures were POUE predictors. POUE occurrence with successful conservative management did not appear to have impact on urethroplasty outcomes as it did not predict re-stricture. POUE was reoperation cause in 1.1% of total cases. [ABSTRACT FROM AUTHOR]

Purpose: The aim of the present study is to investigate the impact of the near-infrared (NIRF) technology with indocyanine green (ICG) in robotic urologic surgery by performing a systematic literature review and to provide evidence-based expert recommendations on best practices in this field. Methods: All English language publications on NIRF/ICG-guided robotic urologic procedures were evaluated. We followed the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) statement to evaluate PubMed®, Scopus® and Web of Science™ databases (up to April 2019). Experts in the field provided detailed pictures and intraoperative video-clips of different NIRF/ICG-guided robotic surgeries with recommendations for each procedure. A unique QRcode was generated and linked to each underlying video-clip. This new exclusive feature makes the present the first "dynamic paper" that merges text and figure description with their own video providing readers an innovative, immersive, high-quality and user-friendly experience. Results: Our electronic search identified a total of 576 papers. Of these, 36 studies included in the present systematic review reporting the use of NIRF/ICG in robotic partial nephrectomy (n = 13), robotic radical prostatectomy and lymphadenectomy (n = 7), robotic ureteral re-implantation and reconstruction (n = 5), robotic adrenalectomy (n = 4), robotic radical cystectomy (n = 3), penectomy and robotic inguinal lymphadenectomy (n = 2), robotic simple prostatectomy (n = 1), robotic kidney transplantation (n = 1) and robotic sacrocolpopexy (n = 1). Conclusion: NIRF/ICG technology has now emerged as a safe, feasible and useful tool that may facilitate urologic robotic surgery. It has been shown to improve the identification of key anatomical landmarks and pathological structures for oncological and non-oncological procedures. Level of evidence is predominantly low. Larger series with longer follow-up are needed, especially in assessing the quality of the nodal dissection and the feasibility of the identification of sentinel nodes and the impact of these novel technologies on long-term oncological and functional outcomes. [ABSTRACT FROM AUTHOR]

Massively parallel pyrosequencing allows sensitive deep sequencing to detect molecular aberrations. Thus far, data are limited on the technical performance in a clinical diagnostic setting. Here, we investigated as an international consortium the robustness, precision and reproducibility of amplicon next-generation deep sequencing across 10 laboratories in eight countries. In a cohort of 18 chronic myelomonocytic leukemia patients, mutational analyses were performed on TET2, a frequently mutated gene in myeloproliferative neoplasms. Additionally, hotspot regions of CBL and KRAS were investigated. The study was executed using GS FLX sequencing instruments and the small volume 454 Life Sciences Titanium emulsion PCR setup. We report a high concordance in mutation detection across all laboratories, including a robust detection of novel variants, which were undetected by standard Sanger sequencing. The sensitivity to detect low-level variants present with as low as 1-2% frequency, compared with the 20% threshold for Sanger-based sequencing is increased. Together with the output of high-quality long reads and fast run time, we demonstrate the utility of deep sequencing in clinical applications. In conclusion, this multicenter analysis demonstrated that amplicon-based deep sequencing is technically feasible, achieves high concordance across multiple laboratories and allows a broad and in-depth molecular characterization of cancer specimens with high diagnostic sensitivity. [ABSTRACT FROM AUTHOR]

This article reports the results of a post hoc analysis of the multicenter, randomized, double-blind Combination of Avodart and Tamsulosin (CombAT) study, which aimed to investigate the effects of dutasteride (0.5 mg), tamsulosin (0.4 mg), and their combination on storage and voiding symptoms in 4844 men aged 50 years with moderate-to-severe lower urinary tract symptoms (International Prostate Symptom Score 12), prostate volume (PV) 30 cm3 and PSA 1.5–10 ng ml−1. After 24 months, combination treatment achieved significantly greater mean reductions in both voiding and storage symptoms than either monotherapy, in each of the three baseline PV tertiles (30 to <42, 42 to <58, 58 cm3). Dutasteride was as effective as tamsulosin for control of storage symptoms, but provided significantly greater relief of voiding symptoms than tamsulosin. [ABSTRACT FROM AUTHOR]

The objective of this study consisted in assessing the prevalence of erectile dysfunction (ED) and other sexual dysfunctions in a group of men who attended a prostate awareness week campaign. In total, 2715 men attended to ‘Semana de la Prostata 2001’ campaign and received an additional questionnaire on sexual health. The prevalence of ED, desire and ejaculatory disorders was of 41.7, 33.8 and 49.3%, respectively; however, not all of them lived these difficulties as a real sexual problem because only 918 men (37.8%) acknowledged having ‘any sexual difficulty’. Only 13.7% of the attendees consulted a physician for this reason in the past. This first Argentinean study proves the high prevalence of sexual dysfunctions in our population.International Journal of Impotence Research (2004) 16, 69-72. doi:10.1038/sj.ijir.3901140 [ABSTRACT FROM AUTHOR]

Assesses the efficacy and safety of oral sildenafil citrate in the treatment of male erectile dysfunction (ED) in southern Latin America. Tolerability of sildenafil citrate; Correlation of Rigiscan measurements assessing ED etiology with the investigator's assessment.

Urinary incontinence resulting from impaired bladder storage abilities, which is unresponsive to conservative treatments, presents a therapeutic challenge. Carefully selected patients with neurogenic bladder dysfunction, a structurally or anatomically smallcapacity bladder, idiopathic bladder instability, and interstitial cystitis may benefit from augmentation enterocystoplasty. The preoperative evaluation should include a complete assessment of the urinary tract, renal function, and the continence mechanism, along with a careful assessment of urethral accessibility and patency and the patient's willingness and ability to perform lifelong intermittent self-catheterization. Although any segment of bowel is suitable for bladder augmentation, it is advisable to avoid the ileocecal segment in patients with neurogenic bladder dysfunction. The bowel segment should be detubularized and anastomosed to the widely spatulated bladder to avoid an hour-glass deformity. In the immediate postoperative period, patency of the catheter is maintained by frequent, gentle irrigations. Long-term follow-up is mandatory to monitor the chronic bacteriuria and because of the low incidence of spontaneous bladder perforation and carcinogenesis in the augmented bladder. Augmentation enterocystoplasty is an effective treatment for urinary storage problems. It increases the functional and anatomical capacity of the bladder, decreases intravesical pressure, and protects the upper urinary tract. [ABSTRACT FROM AUTHOR]

Introduces the articles published in the August 2, 2002 issue of the 'International Journal of Impotence Research.' Topics of the articles; Authors who contributed to the issue.