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Objectives: Mindfulness meditation has both spiritual and secular foundations. Drawing on Jerome Frank's concept of a healing "myth," this study investigated the relative influence of spiritual and secular inductions to a brief mindfulness-based intervention. We hypothesized that, compared to narrower spiritual or secular presentations, an integrated role induction to mindfulness meditation would be more effective at improving the perceived credibility of, and expectations regarding, this practice, and hence would result in a subsequent mindfulness practice having a greater effect on state mindfulness and affect. We also hypothesized that there would be congruency effects between participants' dispositional spirituality/secularity and their assigned induction group. Methods: Participants (n = 179) were randomly allocated to one of three role inductions (spiritual, secular, or integrated); all then received the same brief, online, mindfulness intervention. Dispositional measures of secularity and spirituality were taken at baseline, and state measures of credibility and expectations, mindfulness and affect were taken at baseline, post-induction, and post-intervention. Results: Following attrition and screening for participation, data from 124 completers were analyzed. Participants improved across time on measures of credibility and expectations, state mindfulness, and negative affect. Contrary to the hypotheses, the integrated induction group did not improve more than the secular or spiritual groups, nor were congruency effects found. However, there was significantly less participant attrition in the integrated group than the other two conditions. Conclusions: It is argued that a more broadly accessible "myth" may help more participants to persevere with mindfulness practice. [ABSTRACT FROM AUTHOR]

Spinosaurids are among the most distinctive and yet poorly-known of large-bodied theropod dinosaurs, a situation exacerbated by their mostly fragmentary fossil record and competing views regarding their palaeobiology. Here, we report two new Early Cretaceous spinosaurid specimens from the Wessex Formation (Barremian) of the Isle of Wight. Large-scale phylogenetic analyses using parsimony and Bayesian techniques recover the pair in a new clade within Baryonychinae that also includes the hypodigm of the African spinosaurid Suchomimus. Both specimens represent distinct and novel taxa, herein named Ceratosuchops inferodios gen. et sp. nov. and Riparovenator milnerae gen. et sp. nov. A palaeogeographic reconstruction suggests a European origin for Spinosauridae, with at least two dispersal events into Africa. These new finds provide welcome information on poorly sampled areas of spinosaurid anatomy, suggest that sympatry was present and potentially common in baryonychines and spinosaurids as a whole, and contribute to updated palaeobiogeographic reconstructions for the clade. [ABSTRACT FROM AUTHOR]

Standard units of measurement are required for the quantitative description of nature; however, few standard units have been established for genomics to date. Here, we have developed a synthetic DNA ladder that defines a quantitative standard unit that can measure DNA sequence abundance within a next-generation sequencing library. The ladder can be spiked into a DNA sample, and act as an internal scale that measures quantitative genetics features. Unlike previous spike-ins, the ladder is encoded within a single molecule, and can be equivalently and independently synthesized by different laboratories. We show how the ladder can measure diverse quantitative features, including human genetic variation and microbial abundance, and also estimate uncertainty due to technical variation and improve normalization between libraries. This ladder provides an independent quantitative unit that can be used with any organism, application or technology, thereby providing a common metric by which genomes can be measured. Standard units of measurement are required for a quantitative description of the genome. Here, the authors present a universal synthetic DNA ladder that can measure genetic abundance in next-generation sequencing libraries. [ABSTRACT FROM AUTHOR]

Lambek elegantly characterized part of natural language. As is well-known, his substructural logic L, and its non-associative version NL, handle basic function/argument composition well, but not scope taking and syntactic displacement—at least, not in their full generality. In previous work, I propose NL λ , which is NL supplemented with a single structural inference rule ("abstraction"). Abstraction closely resembles the traditional linguistic rule of quantifier raising, and characterizes both semantic scope taking and syntactic displacement. Due to the unconventional form of the abstraction inference, there has been some doubt that NL λ should count at a legitimate substructural logic. This paper argues that NL λ is perfectly well-behaved. In particular, it enjoys cut elimination and an interpolation result. In addition, perhaps surprisingly, it is decidable. Finally, I prove that it is sound and complete with respect to the usual class of relational frames. [ABSTRACT FROM AUTHOR]

What is the communicative value of negative polarity? That is, why do so many languages maintain a stock of special indefinites (weak Negative Polarity Items) that occur only in a proper subset of the contexts in which ordinary indefinites can appear? Previous answers include: marking the validity of downward inferences; marking the invalidity of veridical inferences; or triggering strengthening implications. My starting point for exploring a new answer is the fact that an NPI must always take narrow scope with respect to its licensing context. In contrast, ordinary indefinites are notorious for taking wide scope. So whatever other functions NPIs may have, they at least serve as an utterly reliable signal that an indefinite is taking narrow scope. As also proposed in recent work of Kusumoto and Tancredi, I will show that NPIs are only licensed in contexts in which the wide scope construal of an indefinite fails to entail the narrow scope. In other words, weak NPIs occur only in contexts in which taking narrow scope matters for interpretation. Thus one part of the explanation for the ubiquity and robust stability of negative polarity is that it signals scope relations. [ABSTRACT FROM AUTHOR]

Purpose: Clinical guidelines emphasise the central role of family members in supporting people with bipolar disorder. However, there has been little focus on the challenges family members face in supporting their relative. This qualitative study explored the challenges of providing support to a relative with bipolar disorder, and how family members attempted to meet these challenges. Factors that helped or hindered their efforts were also explored, including experiences of professional support.Methods: Semi-structured interviews were conducted with 18 family members (partners, parents, adult children, and siblings). Transcripts were analysed using the Framework approach.Results: Participants faced numerous challenges pertaining to the nature of the disorder and specific illness phases, their relative's responses to their attempts to help, and the limitations of support from healthcare professionals. Although participants were resourceful in managing these challenges, they strongly valued professional input. Six themes were identified: 'Not knowing: like being in a minefield', 'It's out of my control: sitting waiting for the next thing to happen', 'Treading on eggshells', 'Picking up on signs', 'Times of crisis: between a rock and a hard place', and 'I have to make my voice heard'.Conclusions: Family members supporting a relative with bipolar disorder face significant challenges but show considerable resourcefulness in managing them. The findings underline the importance of input from healthcare professionals to help family members effectively support their relative and manage the challenges they face. Professional support should be strengths-based, and tailored to family members' needs. [ABSTRACT FROM AUTHOR]

Purpose: Continuous observation of psychiatric inpatients aims to protect those who pose an acute risk of harm to self or others, but involves intrusive privacy restrictions. Initiating, conducting and ending continuous observation requires complex decision-making about keeping patients safe whilst protecting their privacy. There is little published guidance about how to balance privacy and safety concerns, and how staff and patients negotiate this in practice is unknown. To inform best practice, the present study, therefore, aimed to understand how staff and patients experience negotiating the balance between privacy and safety during decision-making about continuous observation.Methods: Thematic analysis of qualitative interviews with thirty-one inpatient psychiatric staff and twenty-eight inpatients.Results: Most patients struggled with the lack of privacy but valued feeling safe during continuous observation. Staff and patients linked good decision-making to using continuous observation for short periods and taking positive risks, understanding and collaborating with the patient, and working together as a supportive staff team. Poor decision-making was linked to insufficient consideration of observation's iatrogenic potential, insufficient collaboration with patients, and the stressful impact on staff of conducting observations and managing risk.Conclusions: Best practice in decision-making about continuous observation may be facilitated by making decisions in collaboration with patients, and by staff supporting each-other in positive risk-taking. To achieve truly patient-centred decision-making, decisions about observation should not be influenced by staff's own stress levels. To address the negative impact of staff stress on decision-making, it may be helpful to improve staff training, education and support structures. [ABSTRACT FROM AUTHOR]

Brasoveanu (Linguist Philos 34:93–168, 2011 ) argues that “different” exhibits what he calls association with distributivity: a distributive operator such as “each” creates a two-part context that propagates through the compositional semantics in a way that can be accessed by a subordinate “different”. We show that Brasoveanu’s analysis systematically undergenerates, failing to provide interpretations of sentences such as “Every 1 boy claimed every girl read a different 1 poem”, in which “different” can associate with a non-local distributive operator. We provide a generalized version of association with distributivity, implemented using de Groote’s (in: Proceedings of semantics and linguistic theory XVI, 2006 ) continuation-based dynamic semantics. We compare our analysis with the one in Brasoveanu ( 2011 ), drawing conclusions about computational tractability, scope of indefinites, and whether it is possible or even desirable to arrive at a unified analysis of internal and external readings of “different”. [ABSTRACT FROM AUTHOR]

This paper analyzes sluicing as anaphora to an anti-constituent (a continuation), that is, to the semantic remnant of a clause from which a subconstituent has been removed. For instance, in Mary said that [ John saw someone yesterday], but she didn't say who, the antecedent clause is John saw someone yesterday, the subconstituent targeted for removal is someone, and the ellipsis site following who is anaphoric to the scope remnant John saw ___ yesterday. I provide a compositional syntax and semantics on which the relationship between the targeted subconstituent and the rest of the antecedent clause is one of scopability, not movement or binding. This correctly predicts that sluicing should be sensitive to scope islands, but not to syntactic islands. Unlike the currently dominant approaches to sluicing, there is no need to posit syntactic structure internal to the ellipsis site, nor is there any need for a semantic mutual-entailment requirement. Nevertheless, the fragment handles phenomena usually taken to suggest a close syntactic correspondence between the antecedent and the sluice, including case matching, voice matching, and verbal argument structure matching. In addition, the analysis handles phenomena exhibiting antecedent/sluice mismatches, including examples such as John remembers meeting someone, but he doesn't remember who, [InlineMediaObject not available: see fulltext.], and especially so-called sprouting examples such as John left, but I don't know when, in which there is no overt subconstituent to target for removal. In Sect. 5, I show how the analysis accounts for Andrews Amalgams such as Sally ate [ I don't know what] today, in which the antecedent surrounds the sluiced clause. Finally, in Sect. 6, I propose a new semantic constraint on sluicing: the Answer Ban, which says that the antecedent clause must not resolve, or even partially resolve, the issue raised by the sluiced interrogative. [ABSTRACT FROM AUTHOR]

This paper examines whether the psychological sequelae of rape relate to rape case attrition by leading police to see the victim as less reliable. A mixed methods approach with two linked studies, one qualitative and one quantitative, was used. In Study 1, the qualitative study, interviews with 12 specialist police officers were analysed using Framework Analysis. In Study 2, the quantitative study, 76 specialist officers completed an online questionnaire to assess the generalisability of Study 1's findings. In Study 1, officers' perceptions of victims clustered into three stereotypes, which we label 'the real victim', 'the mad discloser', and 'the bad discloser'. Victims who exhibited signs of shame, self-blame, and post-traumatic stress reactions which impeded their ability to give a coherent account of the rape were perceived as less reliable 'mad' or 'bad' victims. The findings of Study 2 supported these results. Although police interview strategies have improved in recent years, there is evidence that signs of trauma and shame in the victim are sometimes misinterpreted as signs of lying. This may affect attrition by impacting on victim-officer relationships. Further training on recognising trauma and understanding its consequences is recommended both for specialist officers and front-line staff. [ABSTRACT FROM AUTHOR]

This exploratory study investigated whether rape victims' subjective perceptions of whether to proceed with legal action were associated with their experience of disclosing to the police during their initial interview. Specifically, the study investigated associations between symptoms of PTSD, shame and self-blame post-rape, subjective perceptions of police empathy and subjective perception of victims' intentions to take the case to court. Participants (N = 22) were found to have elevated levels of PTSD severity, shame and self-blame. Police empathy was positively correlated with victims' ratings of likelihood of taking the case to court, and negatively correlated with PTSD severity and shame. These preliminary findings suggest that training police officers how to respond more empathically to psychologically distressed rape victims may potentially help reduce victim attrition rates. [ABSTRACT FROM AUTHOR]

I propose the first strictly compositional semantic account of same. New data, including especially NP-internal uses such as two men with the same name, suggests that same in its basic use is a quantificational element taking scope over nominals. Given type-lifting as a generally available mechanism, I show that this follows naturally from the fact that same is an adjective. Independently-motivated assumptions extend the analysis to standard examples such as Anna and Bill read the same book via a mechanism I call PARASITIC SCOPE, in which the scope of same depends on the scope of some other scopetaking element in the sentence. Although I will initially discuss the analysis in terms of a familiar Quantifier Raising framework, I go on to implement the analysis within an innovative continuation-based Type-Logical Grammar. The empirical payoff for dealing in continuations is that a simple generalization of the basic analysis gives the first ever formal account of cases in which same distributes over objects other than NP denotations, as in the relevant interpretation of John hit and killed the same man. [ABSTRACT FROM AUTHOR]

Using the programming-language concept of continuations, we propose a new, multimodal analysis of quantification in Type Logical Grammar. Our approach provides a geometric view of in-situ quantification in terms of graphs, and motivates the limited use of empty antecedents in derivations. Just as continuations are the tool of choice for reasoning about evaluation order and side effects in programming languages, our system provides a principled, type-logical way to model evaluation order and side effects in natural language. We illustrate with an improved account of quantificational binding, weak crossover, wh-questions, superiority, and polarity licensing. [ABSTRACT FROM AUTHOR]

We present a general theory of scope and binding in which both crossover and superiority violations are ruled out by one key assumption: that natural language expressions are normally evaluated (processed) from left to right. Our theory is an extension of Shan’s (2002) account of multiple- wh questions, combining continuations (Barker, 2002) and dynamic type-shifting. Like other continuation-based analyses, but unlike most other treatments of crossover or superiority, our analysis is directly compositional (in the sense of, e.g., Jacobson, 1999). In particular, it does not postulate a level of Logical Form or any other representation distinct from surface syntax. One advantage of using continuations is that they are the standard tool for modeling order-of-evaluation in programming languages. This provides us with a natural and independently motivated characterization of what it means to evaluate expressions from left to right. We give a combinatory categorial grammar that models the syntax and the semantics of quantifier scope and wh-question formation. It allows quantificational binding but not crossover, in-situ wh but not superiority violations. In addition, the analysis automatically accounts for a variety of sentence types involving binding in the presence of pied piping, including reconstruction cases such as Whose criticism of his i mother did each person i resent? [ABSTRACT FROM AUTHOR]

Shows how to incorporate Herman Hendriks' Flexible Types approach to quantifier scope with excellent results, making good on a major promissory note in Pauline Jacobson's variable-free program. Strengths and the weaknesses of the variable-free program in the course of extending the fragment in Jacobson to handle a more complete range of binding constructions; Jacobson's development of a novel and provocative theory of binding that does entirely without movement or variables.

The article provides an explicit formal analysis of how a use of a vague predicate affects the context against which other expressions get evaluated. In the article author argued that taking an explicitly dynamic perspective on vagueness can lead to new insights into the nature of vagueness in general and the semantics of gradable adjectives in particular. Some linguists have mentioned in passing that asserting a sentence containing a vague predicate causes the context to change in certain ways, but none spell out in detail the mechanism of those changes. At more length, one of the linguists examined vagueness as a problem for effective communication.

Most studies of the so-called proportion problem seek to understand how lexical and structural properties of sentences containing adverbial quantifiers give rise to various proportional readings. This paper explores a related but distinct problem: given a use of a particular sentence in context, why do only some of the expected proportional readings seem to be available? That is, why do some sentences allow an asymmetric reading when other, structurally similar sentences seem to require a symmetric reading? Potential factors suggested in the literature include the distribution of donkey pronouns, certain uniqueness implications, and focus structures. I argue here that the use of an adverbial quantifier presupposes HOMOGENEITY: all individual situations that get lumped into a single case for the purposes of evaluating the quantification must agree on whether they satisfy the nuclear scope. For instance, in order for a token of Usually, if a farmer owns a donkey, he beats it to be felicitous when construed under a farmer-dominant asymmetric reading, the context must be consistent with the proposition that each farmer either beats all or none of his donkeys. Thus proportional sentences are indeed systematically ambiguous, but only some readings will be felicitous in a given context. [ABSTRACT FROM AUTHOR]

Chirality is a property describing any object that is inequivalent to its mirror image. Due to its 5′-3′ directionality, a DNA sequence is distinct from a mirrored sequence arranged in reverse nucleotide-order, and is therefore chiral. A given sequence and its opposing chiral partner sequence share many properties, such as nucleotide composition and sequence entropy. Here we demonstrate that chiral DNA sequence pairs also perform equivalently during molecular and bioinformatic techniques that underpin genetic analysis, including PCR amplification, hybridization, whole-genome, target-enriched and nanopore sequencing, sequence alignment and variant detection. Given these shared properties, synthetic DNA sequences mirroring clinically relevant or analytically challenging regions of the human genome are ideal controls for clinical genomics. The addition of synthetic chiral sequences (sequins) to patient tumor samples can prevent false-positive and false-negative mutation detection to improve diagnosis. Accordingly, we propose that sequins can fulfill the need for commutable internal controls in precision medicine. Any DNA sequence can be represented by a chiral partner sequence - an exact copy arranged in reverse nucleotide order. Here, the authors show that chiral DNA sequence pairs share important properties and show the utility of synthetic chiral sequences (sequins) as controls for clinical genomics. [ABSTRACT FROM AUTHOR]

Aim To review physico-chemical data supplied for commercially available detergents marketed for manual and/or ultrasonic cleansing of reusable dental instruments.Method Manufacturers/suppliers of commercially available detergents for manual or ultrasonic cleaning of dental instruments within primary dental care were invited to supply product information. A structured questionnaire requested details on a range of physical and chemical properties for each detergent.Results Seventeen detergent manufacturers/suppliers, encompassing 31 commercially available detergents were identified. Ten of the 17 manufacturers provided information on 23 (74%) of the detergent formulations. Nine detergents were of neutral pH, ten mild alkalis (pH 7.5-10.5) and four strong alkalis (pH >10.5). Sixteen detergents were recommended for ultrasonic and manual cleaning, four stated ultrasonic use and three manual only. Ten detergents cited enzymatic activity as their main mode of action, but only six manufacturers provided detailed information. Four detergents recommended by manufacturers as suitable for manual washing had a strong alkaline pH (>10.5), presenting chemical hazards to users. Two strong alkaline detergents did not warn users of potential adverse effects of such alkaline solutions (corrosion) upon aluminium containing instruments. Only one detergent had investigated the potential toxicity of detergent residuals remaining on instruments after reprocessing.Conclusion It has proven challenging to collate physico-chemical data on detergents suitable for use in manual and/or ultrasonic cleaning of dental instruments in general dental practice. Standardisation of information on the nature and efficacy of dental detergents in a readily accessible form would be beneficial to dental practice. [ABSTRACT FROM AUTHOR]

Presents an abstract for the article on the reproducibility factor in differential gene expression analysis by DNA microarray technology.