1. Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know.
- Author
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Alessandrino, Francesco, DiPiro, Pamela J., Jagannathan, Jyothi P., Babina, Gosangi, Krajewski, Katherine M., Ramaiya, Nikhil H., and Giardino, Angela A.
- Subjects
B cells ,CANCER diagnosis ,MUCOSA-associated lymphoid tissue lymphoma ,HODGKIN'S disease ,RADIOLOGISTS ,CROSS-sectional imaging - Abstract
Indolent B cell lymphomas are a group of lymphoid malignancies characterized by their potential to undergo histologic transformation to aggressive lymphomas. While different subtypes of indolent B cell lymphomas demonstrate specific clinical and imaging features, histologic transformation can be suspected on cross-sectional imaging when disproportionate lymph node enlargement or new focal lesions in extranodal organs are seen. On PET/CT, transformed indolent lymphoma may show new or increased nodal FDG avidity or new FDG-avid lesions in different organs. In this article, we will (1) review the imaging features of different subtypes of indolent B cell lymphomas, (2) discuss the imaging features of histologic transformation, and (3) propose a diagnostic algorithm for transformed indolent lymphoma. The purpose of this review is to familiarize radiologists with the spectrum of clinical and imaging features of indolent B cell lymphomas and to define the role of imaging in raising concern for transformation and in guiding biopsy for confirmation. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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