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Portal vein aneurysms are rare abnormal dilations of the portal vein and represent less than 3% of all visceral aneurysms. They may be congenital or acquired, symptomatic or asymptomatic, complicated or uncomplicated. Portal vein aneurysms may be fusiform or saccular and this last one has a low prevalence. Due to the small number of cases reported in the medical literature and the lack of specific guidelines, the management and treatment of this condition is still undefined. In this review, we report a case of saccular portal vein aneurysm in a 73-year old man with liver cirrhosis and discuss all cases of portal vein aneurysms reported in literature. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ultrasound is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Describes a case study on assessing and improving the quality of the data in the Italian Public Administration. Problems prioritized by the administration on data quality; Dimensions of data quality; Elements of a proposed process abstraction for data quality.

Non-steroidal anti-inflammatory drugs (NSAIDs) have a damaging effect on gastric and intestinal mucosa due to their inhibitory action of prostaglandin (PG) synthesis by blocking cyclooxygenase activity. Prostacyclin (PGI) is the main metabolite of arachidonic acid in gastric mucosa and its production is inhibited by NSAIDs. Indomethacin or aspirin administration produce erosions and ulcers by inhibiting PGI generation in the stomach. Other NSAIDs such as diflunisal, and even more sodium salicylate in rats, produce a lower degree of gastric ulcerogenity than that observed when indomethacin or aspirin were given alone. In the present work tests were carried out to confirm if combinations of indomethacin or aspirin with diflunisal or sodium salicylate block PGI release from gastric mucosa less than the administration of the compounds alone. PGI generation by gastric mucosa was determined on aliquots of incubated mucosal strips tested for ADP-induced aggregation of human platelet rich plasma (PRP). The results were compared with those obtained with known amounts of authentic PGI on ADP-induced aggregation of PRP. The obtained data indicate that the PGI production found in rats treated with indomethacin or aspirin combined with diflunisal or sodium salicylate was higher than that found in rats treated with indomethacin or aspirin alone. This effect may be explained by competition between salicylates and other NSAIDs for binding sites on PG-synthetase and plasma proteins. [ABSTRACT FROM AUTHOR]

High concentrations of the non-steroid anti-inflammatory drugs, alone and in association, reduce the blastogenesis of human lymphocytes in vitro. This effect is probably due to the toxicity of these agents and not to the inhibition of prostaglandin (PG) prosuction. Therefore drugs, such as, salicylates and associations of salicylates with other non-steroid anti-inflammatory drugs, which have a weak action on PG-synthesis, also inhibit proliferation of lymphocytes. [ABSTRACT FROM AUTHOR]

We have measured the formation of prostacyclin (PGI) in the rat gastric mucosa ex vivo following oral administration of indomethacin, protacine and sodium salicylate (SS). It has been found that protacine, like indomethacin but in contrast to SS, markedly reduces PGI synthesis as measured by inhibition of ADP-induced platelet aggregation. Parallel gastro-ulcerogenic studies demonstrate that protacine has very weak gastric irritancy when compared with indomethacin. In addition, the effect of these drugs has been evaluated on thromboxane B (TXB) release by human polymorphonuclears (PMNs) stimulated with A23187 ionophore in vitro. It has been shown that protacine, like indomethacin, strongly inhibits cyclooxygenase activity as measured by radioimmunoassay of TXB. SS partially prevents the inhibitory effect of either [ABSTRACT FROM AUTHOR]

Copyright of Experientia is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The biological effect has been investigated of a specific protein with a growth-stimulating activity on epidermal cells. Injection of minute amounts of this factor (EGF) into newborn rats produces hyperplasia of the epidermis with a marked increase in the protein and nucleic acid content per unit of skin area. The activity of a number of epidermal enzymes per unit area is also increased by the epidermal growth factor. [ABSTRACT FROM AUTHOR]

Human peripheral blood polymorphonuclear leukocytes (PMNs) and murine peritoneal macrophages (Mø) were stimulated to generate thromboxane upon treatment with highly purified human interleukin 1/leukocytic pyrogen (IL1/LP) at various concentrations. Thromboxane B was measured by radioimmunoassay in the cell-free supernatants of cell suspensions after 1 hour incubation at 37°C. Thromboxane B amounts increased in a way which depended on the dose of IL1 added to the cell cultures. [ABSTRACT FROM AUTHOR]

Copyright of Experientia is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Experientia is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Experientia is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)